| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Michel M Ouellette, Sumin Zhou, Ying Ya. Cell Signaling Pathways That Promote Radioresistance of Cancer Cells. Diagnostics (Basel, Switzerland). vol 12. issue 3. 2022-03-25. PMID:35328212. |
however, radiation also concomitantly activates multiple prosurvival signaling pathways, which include those mediated by atm, atr, akt, erk, and nf-κb that promote dna damage checkpoint activation/dna repair, autophagy induction, and/or inhibition of apoptosis. |
2022-03-25 |
2023-08-13 |
Not clear |
| Anjiang Zhao, Dan Li, Xiongmin Mao, Mengliu Yang, Wuquan Deng, Wenjing Hu, Chen Chen, Gangyi Yang, Ling L. GNG2 acts as a tumor suppressor in breast cancer through stimulating MRAS signaling. Cell death & disease. vol 13. issue 3. 2022-03-24. PMID:35322009. |
in conclusion, the interaction between gng2 and mras likely inhibits akt and erk activity, promoting apoptosis and suppressing proliferation in bc cells. |
2022-03-24 |
2023-08-13 |
Not clear |
| Jian Wang, Yongzhen Huang, Jiawei Xu, Binglin Yue, Yifan Wen, Xiao Wang, Chuzhao Lei, Hong Che. PLAG1 promotes proliferation and inhibits apoptosis of bovine primary myoblasts through the PI3K-Akt signaling pathway. Journal of animal science. 2022-03-24. PMID:35325183. |
chromatin immunoprecipitation sequencing (chip-seq) and western blot showed plag1 upregulated phosphorylated (p)-pi3k, pi3k, p-akt, akt, cyclin d1, and cdk2 and inhibited the expression of p21 and p27 to enhance myoblast proliferation, and increased expression of bcl-2, and bcl-xl to inhibit apoptosis. |
2022-03-24 |
2023-08-13 |
cattle |
| Yuanzhou Zhang, Shunshun Liang, Bowen Xiao, Jingying Hu, Yechun Pang, Yuling Liu, Juan Yang, Junpin Ao, Lin Wei, Xiaoying Lu. MiR-323a regulates ErbB3/EGFR and blocks gefitinib resistance acquisition in colorectal cancer. Cell death & disease. vol 13. issue 3. 2022-03-23. PMID:35319011. |
mir-323a-3p promotes crc cells apoptosis by targeting erbb3-phosphoinositide 3-kinases (pi3k)/pkb protein kinase (akt)/glycogen synthase kinase 3 beta (gsk3β)/egfr-extracellular regulated map kinase (erk1/2) signaling directly. |
2022-03-23 |
2023-08-13 |
Not clear |
| Ulkan Kilic, Birsen Elibol, Ahmet Burak Caglayan, Mustafa Caglar Beker, Merve Beker, Burcugul Altug-Tasa, Omer Uysal, Bayram Yilmaz, Ertugrul Kili. Delayed Therapeutic Administration of Melatonin Enhances Neuronal Survival Through AKT and MAPK Signaling Pathways Following Focal Brain Ischemia in Mice. Journal of molecular neuroscience : MN. 2022-03-21. PMID:35307786. |
the increase of ngf, nrp1, c-jun; activation of akt; and dephosphorylation of erk and jnk at the fifty-fifth day showed that cell survival and apoptosis signaling molecules compete to contribute to the remodeling of brain. |
2022-03-21 |
2023-08-13 |
mouse |
| Xuejun Gao, Dandan Xue, Jingjing Cheng, Xin Zhang, Xia Ca. Inhibition of Axl Promotes the Therapeutic Effect of Targeted Inhibition of the PI3K/Akt Pathway in NRAS Mutant Melanoma Cells. Journal of oncology. vol 2022. 2022-03-21. PMID:35310910. |
finally, a melanoma mouse model was established, and it detected the proliferation and apoptosis of mouse tumor cells induced by axl inhibitor and akt inhibitor. |
2022-03-21 |
2023-08-13 |
mouse |
| Xuejun Gao, Dandan Xue, Jingjing Cheng, Xin Zhang, Xia Ca. Inhibition of Axl Promotes the Therapeutic Effect of Targeted Inhibition of the PI3K/Akt Pathway in NRAS Mutant Melanoma Cells. Journal of oncology. vol 2022. 2022-03-21. PMID:35310910. |
the addition of axl inhibitor can synergistically promote the effect of akt inhibitor, slow down the proliferation of tumor cells, and induce cell apoptosis. |
2022-03-21 |
2023-08-13 |
mouse |
| Ya-Nan Jiao, Jing-Sheng Zhang, Wen-Jun Qiao, Shu-Yu Tian, Yi-Bin Wang, Chun-Yan Wang, Yan-Hui Zhang, Qi Zhang, Wen Li, Dong-Yu Min, Zhan-You Wan. Kai-Xin-San Inhibits Tau Pathology and Neuronal Apoptosis in Aged SAMP8 Mice. Molecular neurobiology. 2022-03-18. PMID:35303280. |
we observed that kxs upregulated akt phosphorylation, suppressed gsk3β and cdk5 activation, and inhibited the tlr4/myd88/nf-κb signaling pathway to attenuate tau hyperphosphorylation and neuroinflammation, thus suppressing neuronal apoptosis and improving the cognitive impairment of aged samp8 mice. |
2022-03-18 |
2023-08-13 |
mouse |
| Guohua Jin, Ruihong Zhao, Jianguang Zhang, Tingting Cao, Tongyu Tan. SSRP1 affects the growth and apoptosis of gastric cancer cells through AKT pathway. Journal of medical biochemistry. vol 41. issue 1. 2022-03-16. PMID:35291495. |
ssrp1 affects the growth and apoptosis of gastric cancer cells through akt pathway. |
2022-03-16 |
2023-08-13 |
Not clear |
| Zhen-Jie Fu, Yan Chen, Yu-Qin Xu, Mei-Ai Lin, Hang Wen, Yi-Tao Chen, Pei-Lei Pa. Regulation of miR-30b in cancer development, apoptosis, and drug resistance. Open life sciences. vol 17. issue 1. 2022-03-16. PMID:35291564. |
moreover, mir-30b can inhibit the pi3k/akt signaling pathway through the regulation of egfr, akt, derlin-1, gna13, six1, and other target genes, thus inhibiting the emt process of tumor cells and promoting apoptosis. |
2022-03-16 |
2023-08-13 |
Not clear |
| Jin Zhang, Qianli Ma, Yu Han, Huanshun Wen, Zhenrong Zhang, Yang Hao, Fei Xiao, Chaoyang Lian. Downregulated RPL6 inhibits lung cancer cell proliferation and migration and promotes cell apoptosis by regulating the AKT signaling pathway. Journal of thoracic disease. vol 14. issue 2. 2022-03-14. PMID:35280491. |
downregulated rpl6 inhibits lung cancer cell proliferation and migration and promotes cell apoptosis by regulating the akt signaling pathway. |
2022-03-14 |
2023-08-13 |
Not clear |
| Zhihua Li, Youbing Gao, Lijun Li, Shanshan Xi. Curcumin Inhibits Papillary Thyroid Cancer Cell Proliferation by Regulating lncRNA LINC00691. Analytical cellular pathology (Amsterdam). vol 2022. 2022-03-08. PMID:35256924. |
akt inhibition promoted apoptosis and suppressed the warburg effect in b-cpap cells. |
2022-03-08 |
2023-08-13 |
Not clear |
| Yu Qi, Jianzhou Chen, Junfeng Duan, Lina Kang, Kun Wang, Ziwei Chen, Biao Xu, Rong G. Major vault protein attenuates cardiomyocyte injury in doxorubicin-induced cardiomyopathy through activating AKT. BMC cardiovascular disorders. vol 22. issue 1. 2022-03-05. PMID:35246039. |
increasing studies proved that activation of akt prevented cardiomyocyte apoptosis and cardiac dysfunction in response to dox insult. |
2022-03-05 |
2023-08-13 |
Not clear |
| Yoshie Tsujiya, Ai Hasegawa, Motohiro Yamamori, Noboru Okamur. Troglitazone-Induced Autophagic Cytotoxicity in Lung Adenocarcinoma Cell Lines. Biological & pharmaceutical bulletin. vol 45. issue 3. 2022-03-01. PMID:35228393. |
to assess this mechanism and the anticancer effects of tgz in human lung adenocarcinoma cell lines (a549 and h1975), we investigated the involvement of pparγ, apoptosis, the mitogen-activated protein kinase (mapk) pathway, protein kinase b (akt)/mammalian target of rapamycin (mtor) pathway, and autophagy. |
2022-03-01 |
2023-08-13 |
human |
| Golam Iftakhar Khandakar, Ryosuke Satoh, Teruaki Takasaki, Kana Fujitani, Genzoh Tanabe, Kazuko Sakai, Kazuto Nishio, Reiko Sugiur. ACAGT-007a, an ERK MAPK Signaling Modulator, in Combination with AKT Signaling Inhibition Induces Apoptosis in KRAS Mutant Pancreatic Cancer T3M4 and MIA-Pa-Ca-2 Cells. Cells. vol 11. issue 4. 2022-02-25. PMID:35203351. |
acagt-007a, an erk mapk signaling modulator, in combination with akt signaling inhibition induces apoptosis in kras mutant pancreatic cancer t3m4 and mia-pa-ca-2 cells. |
2022-02-25 |
2023-08-13 |
human |
| Golam Iftakhar Khandakar, Ryosuke Satoh, Teruaki Takasaki, Kana Fujitani, Genzoh Tanabe, Kazuko Sakai, Kazuto Nishio, Reiko Sugiur. ACAGT-007a, an ERK MAPK Signaling Modulator, in Combination with AKT Signaling Inhibition Induces Apoptosis in KRAS Mutant Pancreatic Cancer T3M4 and MIA-Pa-Ca-2 Cells. Cells. vol 11. issue 4. 2022-02-25. PMID:35203351. |
furthermore, gt-7 induced a marked down-regulation of akt phosphorylation after a transient peak in t3m4, whereas panc-1 displayed the strongest and most sustained akt activation, followed by mia-pa-ca-2, suggesting that sustained akt phosphorylation as a determinant for the resistance to gt-7-mediated apoptosis. |
2022-02-25 |
2023-08-13 |
human |
| Golam Iftakhar Khandakar, Ryosuke Satoh, Teruaki Takasaki, Kana Fujitani, Genzoh Tanabe, Kazuko Sakai, Kazuto Nishio, Reiko Sugiur. ACAGT-007a, an ERK MAPK Signaling Modulator, in Combination with AKT Signaling Inhibition Induces Apoptosis in KRAS Mutant Pancreatic Cancer T3M4 and MIA-Pa-Ca-2 Cells. Cells. vol 11. issue 4. 2022-02-25. PMID:35203351. |
consistently, a pi3k inhibitor, wortmannin, abolished akt phosphorylation and enhanced gt-7-mediated apoptosis in t3m4 and mia-pa-ca-2, but not in panc-1, which showed residual akt phosphorylation. |
2022-02-25 |
2023-08-13 |
human |
| Golam Iftakhar Khandakar, Ryosuke Satoh, Teruaki Takasaki, Kana Fujitani, Genzoh Tanabe, Kazuko Sakai, Kazuto Nishio, Reiko Sugiur. ACAGT-007a, an ERK MAPK Signaling Modulator, in Combination with AKT Signaling Inhibition Induces Apoptosis in KRAS Mutant Pancreatic Cancer T3M4 and MIA-Pa-Ca-2 Cells. Cells. vol 11. issue 4. 2022-02-25. PMID:35203351. |
this is the first report that erk stimulation alone or in combination with akt signaling inhibition can effectively induce apoptosis in pdac and provides a rationale for a novel concurrent targeting of the pi3k/akt and erk pathways. |
2022-02-25 |
2023-08-13 |
human |
| Juan Carlos Juárez-Cruz, Michal Okoniewski, Mónica Ramírez, Carlos Ortuño-Pineda, Napoleón Navarro-Tito, Eduardo Castañeda-Sauced. Chronic Leptin Treatment Induces Epithelial-Mesenchymal Transition in MCF10A Mammary Epithelial Cells. Journal of mammary gland biology and neoplasia. 2022-02-23. PMID:35195812. |
furthermore, when cultured in non-adherent conditions leptin treated cells exhibited reduced cell aggregation, increased survival, and decreased apoptosis, which correlates with increased fak and akt phosphorylation. |
2022-02-23 |
2023-08-13 |
Not clear |
| Yafang Qian, Peng Ding, Jie Xu, Xiaohu Nie, Bin L. CCL2 activates AKT signaling to promote glycolysis and chemoresistance in glioma cells. Cell biology international. 2022-02-18. PMID:35178826. |
overexpression of ccl2 reduced tmz-induced apoptosis through activation of the akt pathway and promotion of glycolysis. |
2022-02-18 |
2023-08-13 |
Not clear |