| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Huan Tian, Songyin Huang, Qing Luo, Zhuochen Lin, Huanhuan Liu, Zhixian Zhang, Wengcheng Fong, Jinghua Zhao, Fengyan Y. Akt pathway activation reduces platelet apoptosis and contributes to the increase of platelet counts in solid tumor patients. Platelets. 2022-01-24. PMID:35068286. |
mk2206, the inhibitor of akt, reduced the phosphorylation level of akt and bad, and induced apoptosis of platelets. |
2022-01-24 |
2023-08-13 |
Not clear |
| Huan Tian, Songyin Huang, Qing Luo, Zhuochen Lin, Huanhuan Liu, Zhixian Zhang, Wengcheng Fong, Jinghua Zhao, Fengyan Y. Akt pathway activation reduces platelet apoptosis and contributes to the increase of platelet counts in solid tumor patients. Platelets. 2022-01-24. PMID:35068286. |
when platelets from healthy controls cocultured with the cultural supernatant of cancer cells, the phosphorylation level of akt and bad in the platelets was elevated and the cultural supernatant of cancer cells could rescue the apoptosis of platelet induced by mk2206. |
2022-01-24 |
2023-08-13 |
Not clear |
| Huan Tian, Songyin Huang, Qing Luo, Zhuochen Lin, Huanhuan Liu, Zhixian Zhang, Wengcheng Fong, Jinghua Zhao, Fengyan Y. Akt pathway activation reduces platelet apoptosis and contributes to the increase of platelet counts in solid tumor patients. Platelets. 2022-01-24. PMID:35068286. |
the cross-talking between tumor and platelets could affect platelet apoptosis by regulating akt signaling pathway in platelets. |
2022-01-24 |
2023-08-13 |
Not clear |
| Yazhou Gao, Liming Wang, Zequn Niu, Hui Feng, Jie Liu, Jiangli Sun, Yanxia Gao, Longfei Pa. miR-340-5p inhibits pancreatic acinar cell inflammation and apoptosis via targeted inhibition of HMGB1. Experimental and therapeutic medicine. vol 23. issue 2. 2022-01-24. PMID:35069821. |
the results suggest that mir-340-5p attenuates the induction of hmgb1 by lps, thereby inhibiting inflammation and apoptosis via blunted activation of toll-like receptor 4 and enhanced akt signaling. |
2022-01-24 |
2023-08-13 |
Not clear |
| Xuan Zhao, Limei Ren, Xiaoru Wang, Guangxin Han, Shuo Wang, Qingguo Yao, Yonghao Q. Benzoyl-xanthone derivative induces apoptosis in MCF-7 cells by binding TRAF6. Experimental and therapeutic medicine. vol 23. issue 2. 2022-01-24. PMID:35069862. |
the purpose of the present study was to explore the mechanism of 2-benzoyl-3-hydroxy-4-methyl-9h-xanthen-9-one leading to the inhibition of the activation of akt and tgf-β-activated kinase 1 (tak1), and to the apoptosis of mcf-7 cells. |
2022-01-24 |
2023-08-13 |
Not clear |
| Zi-Qi Liao, Yi-Nong Jiang, Zhuo-Lin Su, Hai-Lian Bi, Jia-Tian Li, Cheng-Lin Li, Xiao-Lei Yang, Ying Zhang, Xin Xi. Rutaecarpine Inhibits Doxorubicin-Induced Oxidative Stress and Apoptosis by Activating AKT Signaling Pathway. Frontiers in cardiovascular medicine. vol 8. 2022-01-24. PMID:35071368. |
rutaecarpine inhibits doxorubicin-induced oxidative stress and apoptosis by activating akt signaling pathway. |
2022-01-24 |
2023-08-13 |
Not clear |
| Sridhar Tatarao Narla, Daniel Scott Bushnell, Joanne Lindsey Duara, Carlton Matthew Bate. AKT signaling downstream of KGF is necessary and sufficient for blocking cyclophosphamide bladder injury. The American journal of pathology. 2022-01-22. PMID:35063403. |
it was determined whether kgf modified akt targets (bad and mtorc1) that could block apoptosis, if akt signaling is required for kgf cytoprotection and whether direct akt activation can drive cytoprotection. |
2022-01-22 |
2023-08-13 |
mouse |
| Xingyi Cheng, Meng Xie, Lu Luo, Yao Tian, Guixiang Yu, Qi Wu, Xiaolan Fan, Deying Yang, Xueping Mao, Uma Gaur, Mingyao Yan. Inhibitor GSK690693 extends Drosophila lifespan via reduce AKT signaling pathway. Mechanisms of ageing and development. 2022-01-22. PMID:35065134. |
furthermore, gsk690693 treatment reduced the activation of akt and erk, consequently activating foxo, gsk-3β and apoptosis to modulate longevity of flies. |
2022-01-22 |
2023-08-13 |
drosophila_melanogaster |
| Jingwen Wu, Xinghua Tang, Xuejuan Yu, Xiaoli Zhang, Wenjun Yang, Ashima Seth, Qiuan Yan. TMEM60 Promotes the Proliferation and Migration and Inhibits the Apoptosis of Glioma through Modulating AKT Signaling. Journal of oncology. vol 2022. 2022-01-14. PMID:35027926. |
tmem60 promotes the proliferation and migration and inhibits the apoptosis of glioma through modulating akt signaling. |
2022-01-14 |
2023-08-13 |
Not clear |
| Yuki Katayama, Tadaaki Yamada, Shinsaku Tokuda, Naoko Okura, Naoya Nishioka, Kenji Morimoto, Keiko Tanimura, Yoshie Morimoto, Masahiro Iwasaku, Mano Horinaka, Toshiyuki Sakai, Kenji Kita, Seiji Yano, Koichi Takayam. Heterogeneity among tumors with acquired resistance to EGFR tyrosine kinase inhibitors harboring EGFR-T790M mutation in non-small cell lung cancer cells. Cancer medicine. 2022-01-14. PMID:35029047. |
second-generation egfr-tki dacomitinib-resistant cells with t790m-exhibited higher sensitivity to osimertinib than first-generation egfr-tki gefitinib-resistant cells with t790m via inhibition of akt and erk signaling and promotion of apoptosis. |
2022-01-14 |
2023-08-13 |
Not clear |
| Rong Tian, Gengsheng Ma. Ghrelin reduces cerebral ischemic injury in rats by reducing M1 microglia/macrophages. European journal of histochemistry : EJH. vol 66. issue 1. 2022-01-12. PMID:35016495. |
its mechanism may be related to activating akt to selectively reduce m1 microglia/macrophages, reducing inflammation and cell apoptosis in brain tissue. |
2022-01-12 |
2023-08-13 |
rat |
| Guy Nadel, Zhong Yao, Ehud Wainstein, Izel Cohen, Ido Ben-Ami, Amir Schajnovitz, Galia Maik-Rachline, Zvi Naor, Benjamin A Horwitz, Rony Sege. GqPCR-stimulated dephosphorylation of AKT is induced by an IGBP1-mediated PP2A switch. Cell communication and signaling : CCS. vol 20. issue 1. 2022-01-09. PMID:34998390. |
however, we have previously shown that in several cell lines, gqpcrs induce immediate inactivation of the akt pathway, which leads to jnk-dependent apoptosis. |
2022-01-09 |
2023-08-13 |
Not clear |
| Mohammad Fareed Khan, Alpana Mathur, Vivek Kumar Pandey, Poonam Kakka. Endoplasmic reticulum stress-dependent activation of TRB3-FoxO1 signaling pathway exacerbates hyperglycemic nephrotoxicity: Protection accorded by naringenin. European journal of pharmacology. 2022-01-09. PMID:34998792. |
gene silencing of trb3 enhanced akt and foxo1 phosphorylation and alleviated foxo1 mediated apoptosis during hyperglycemic nephrotoxicity. |
2022-01-09 |
2023-08-13 |
rat |
| Luxi Lin, Pengfei Fu, Nuoman Chen, Ningyu Gao, Qinqin Cao, Ke Yue, Tingting Xu, Chaodong Zhang, Cai Zhang, Fang Liu, Xuebing Wang, Shucheng Huan. Total flavonoids of Rhizoma Drynariae protect hepatocytes against aflatoxin B1-induced oxidative stress and apoptosis in broiler chickens. Ecotoxicology and environmental safety. vol 230. 2022-01-07. PMID:34995912. |
at the same time, tfrd treatment inhibited afb1-induced apoptosis and significantly changed mrna expression of apoptosis-related genes, including pi3k, akt, bax, and bcl-2 (p < 0.05). |
2022-01-07 |
2023-08-13 |
cat |
| Wei Cao, Renhui Shen, Seth Richard, Yu Liu, Mohammad Jalalirad, Margot P Cleary, Antonio B D'Assoro, Sergio A Gradilone, Da-Qing Yan. Inhibition of triple‑negative breast cancer proliferation and motility by reactivating p53 and inhibiting overactivated Akt. Oncology reports. vol 47. issue 2. 2021-12-27. PMID:34958116. |
furthermore, acy‑1215 displayed a synergistic effect with specific inhibitors of atm, an activator of akt, in inducing cancer cell apoptosis and inhibiting their motility. |
2021-12-27 |
2023-08-13 |
mouse |
| Benoîte Mery, Coralie Poulard, Muriel Le Romancer, Olivier Tréda. Targeting AKT in ER-Positive HER2-Negative Metastatic Breast Cancer: From Molecular Promises to Real Life Pitfalls? International journal of molecular sciences. vol 22. issue 24. 2021-12-24. PMID:34948307. |
the akt protein kinase plays a central role in several interconnected molecular pathways involved in growth, apoptosis, angiogenesis, and cell metabolism. |
2021-12-24 |
2023-08-13 |
Not clear |
| Xinghua Gao, Jikai Liu, Daming Fan, Xiaofeng Li, Zhiqing Fang, Keqiang Yan, Yidong Fa. Berberine enhances gemcitabine‑induced cytotoxicity in bladder cancer by downregulating Rad51 expression through inactivating the PI3K/Akt pathway. Oncology reports. vol 47. issue 2. 2021-12-22. PMID:34935059. |
ber enhanced gem‑induced cytotoxicity, apoptosis and inhibition of migration, whilst attenuating the gem‑induced upregulation of phosphorylated akt and rad51 expression. |
2021-12-22 |
2023-08-13 |
mouse |
| Hao Chen, Zhenhan Li, Fei Wu, Wenyan Ji, Linming Lu, Zhihao Wu, Yujin Huang, Wenxiang Wang, Shu L. BCL10 correlates with bad prognosis and immune infiltration of tumor microenvironment in hepatocellular carcinoma. IUBMB life. 2021-12-20. PMID:34928543. |
when bcl10 was knocked down in hcc cells, their proliferation ability was significantly inhibited, their migration was significantly decreased, their apoptosis was significantly increased, and akt signaling pathway was inhibited. |
2021-12-20 |
2023-08-13 |
Not clear |
| Chunyan Guo, Lei Zhang, Yaoxing Gao, Junzhi Sun, Lingling Fan, Yuguang Bai, Jing Zhang, Gaowa Naren, Jiwen Yang, Libiao L. Cox-2 Antagonizes the Protective Effect of Sevoflurane on Hypoxia/Reoxygenation-Induced Cardiomyocyte Apoptosis through Inhibiting the Akt Pathway. Disease markers. vol 2021. 2021-12-17. PMID:34917200. |
cox-2 antagonizes the protective effect of sevoflurane on hypoxia/reoxygenation-induced cardiomyocyte apoptosis through inhibiting the akt pathway. |
2021-12-17 |
2023-08-13 |
Not clear |
| Chunyan Guo, Lei Zhang, Yaoxing Gao, Junzhi Sun, Lingling Fan, Yuguang Bai, Jing Zhang, Gaowa Naren, Jiwen Yang, Libiao L. Cox-2 Antagonizes the Protective Effect of Sevoflurane on Hypoxia/Reoxygenation-Induced Cardiomyocyte Apoptosis through Inhibiting the Akt Pathway. Disease markers. vol 2021. 2021-12-17. PMID:34917200. |
to uncover the protective role of sevoflurane on hypoxia/reoxygenation-induced cardiomyocyte apoptosis through the protein kinase b (akt) pathway. |
2021-12-17 |
2023-08-13 |
Not clear |