| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yan Long, Yong-Rong Wu, Yin-Mei Guo, Xin-Jun Luo, Xian-Fu Li, Tian-Tian Huang, Zhen Huang, Zhuo Liu, Zheng-Jia Chen, Qing Zhou, Xue-Fei Tia. [Xihuang Pills and its main components inhibit PI3K/Akt/mTOR signaling pathways and promote the apoptosis of prostate cancer cells in PC-3 tumor-bearing mice]. Zhonghua nan ke xue = National journal of andrology. vol 27. issue 4. 2021-12-16. PMID:34914218. |
to evaluate the effects of xihuang pills (xhp) and its main components on pi3k, akt and mtor signaling pathways and cell apoptosis of castration-resistant human pca pc-3 cell subcutaneously transplanted tumors in nude mice. |
2021-12-16 |
2023-08-13 |
mouse |
| Jiafa Ren, Xiaohan Lu, Gentzon Hall, Jamie R Privratsky, Matthew J Robson, Randy D Blakely, Steven D Crowle. IL-1 receptor signaling in podocytes limits susceptibility to glomerular damage. American journal of physiology. Renal physiology. 2021-12-13. PMID:34894725. |
moreover, deletion of il-1r1 in podocytes drove podocyte apoptosis and glomerular injury through diminishing akt activation. |
2021-12-13 |
2023-08-13 |
mouse |
| RongXin Xiao, Hong Wang, Biao Yan. MicroRNA-98-5p modulates cervical cancer progression via controlling PI3K/AKT pathway. Bioengineered. vol 12. issue 2. 2021-12-13. PMID:34895048. |
reverse transcription quantitative polymerase chain reaction was applied to detect mir-98-5p expression in cc tissues and cell lines; cell counting kit-8 and edu analysis were performed for checking cell proliferation, flow cytometry for cell apoptosis, transwell for cell invasion and migration, western blot for proliferation-related proteins ki67 and proliferating cell nuclear antigen expression, apoptosis-related proteins bcl-2 and bax expression, epithelial-mesenchymal transition (emt)-related proteins snail, matrix metalloproteinase-3, e-cadherin and n-cadherin expression, as well as pi3k/akt pathway-related proteins pten, pi3k as well as akt expression levels, and the nude mouse tumor xenograft experiment was applied to verify |
2021-12-13 |
2023-08-13 |
mouse |
| Peixian Luan, Haoran Zhang, Xiaofeng Zhang, Guo Hu, Ziwei Zhan. Cadmium regulates FKBP5 through miR-9-5p and induces carp lymphocyte apoptosis. Fish & shellfish immunology. 2021-12-13. PMID:34896595. |
the results showed that mir-9-5p could inhibit the expression of fkbp5, increase the phosphorylation level of akt, inhibit apoptosis and improve the cell survival rate in carp head kidney lymphocytes. |
2021-12-13 |
2023-08-13 |
Not clear |
| Peixian Luan, Haoran Zhang, Xiaofeng Zhang, Guo Hu, Ziwei Zhan. Cadmium regulates FKBP5 through miR-9-5p and induces carp lymphocyte apoptosis. Fish & shellfish immunology. 2021-12-13. PMID:34896595. |
together, cd could down-regulate the expression of mir-9-5p, target up-regulate the expression of fkbp5, inhibit the phosphorylation of akt, and promote the apoptosis of carp head kidney lymphocytes through mitochondrial pathway. |
2021-12-13 |
2023-08-13 |
Not clear |
| Sanjay Awasthi, Sharad S Singhal, Jyotsana Singhal, Lokesh Nagaprashantha, Hongzhi Li, Yate-Ching Yuan, Zheng Liu, David Berz, Henry Igid, William C Green, Lukman Tijani, Vijay Tonk, Aditya Rajan, Yogesh Awasthi, Sharda P Sing. Anticancer activity of 2'-hydroxyflavanone towards lung cancer. Oncotarget. vol 9. issue 90. 2021-12-11. PMID:30546837. |
our results show that 2hf induced apoptosis in both histological types of lung cancer and inhibited proliferation and growth through suppression of cdk4, ccnb1, pik3ca, akt and rps6kb1 (p70s6k) signaling. |
2021-12-11 |
2023-08-13 |
Not clear |
| Qinhao Shen, Yiwen Xiao, Bei Cheng, Zheyi Sun, Yu Hu, Hefeng Yang, Yingwei Lu. PRMT1 promotes extracellular matrix degradation and apoptosis of chondrocytes in temporomandibular joint osteoarthritis via the AKT/FOXO1 signaling pathway. The international journal of biochemistry & cell biology. vol 141. 2021-12-11. PMID:34715362. |
moreover, an inhibitor of akt (ly294002) rescued the effect of prmt1 knockdown on il-1β-induced ecm degradation and apoptosis, and ami-1, a selective inhibitor of prmt1, inhibited prmt1 expression and reversed the pathological progress of tmjoa. |
2021-12-11 |
2023-08-13 |
rat |
| Xuan Lihui, Guo Jinming, Guan Yalin, Wang Hemeng, Wu Hao, Chang Yin. Albicanol inhibits the toxicity of profenofos to grass carp hepatocytes cells through the ROS/PTEN/PI3K/AKT axis. Fish & shellfish immunology. vol 120. 2021-12-11. PMID:34856373. |
these results indicate that pff can induce oxidative stress in hepatocytes and inhibit the phosphorylation of akt and activate mitochondrial apoptosis. |
2021-12-11 |
2023-08-13 |
human |
| Bin Liu, Dao Wang, Xia Sun, Xi-Xi Zhao, Ming-Li Xiang, Li-Min Jin, Na Li, Shao-Qiong Ni. [Inhibition Effect of Eriodictyol to Growth of DG-75 Cells and the Related Action Mechanism]. Zhongguo shi yan xue ye xue za zhi. vol 29. issue 6. 2021-12-11. PMID:34893112. |
to explore the effects of eriodictyol to the growth, apoptosis and oxidative stress of burkitt lymphoma (bl) cells and phosphorylation of protein kinase b (akt) in children. |
2021-12-11 |
2023-08-13 |
Not clear |
| Rehab E Abdelrahman, Abdel Azeim A Khalaf, Mohamed A Elhady, Marwa A Ibrahim, Eman I Hassanen, Peter A Nosh. Quercetin ameliorates ochratoxin A-Induced immunotoxicity in broiler chickens by modulation of PI3K/AKT pathway. Chemico-biological interactions. vol 351. 2021-12-10. PMID:34717913. |
in addition, administration of ota resulted in apoptosis, which was evident by the increased expression level of pten, bax and caspase-3 genes and decreased expression level of pi3k, akt and bcl-2 genes. |
2021-12-10 |
2023-08-13 |
cat |
| Maryam Taheri, Nasim Hayati Roudbari, Fardin Amidi, Kazem Pariva. The protective effect of sulforaphane against oxidative stress in granulosa cells of patients with polycystic ovary syndrome (PCOS) through activation of AMPK/AKT/NRF2 signaling pathway. Reproductive biology. vol 21. issue 4. 2021-12-07. PMID:34678578. |
addition of sfn to culture medium of glcs of patients with pcos reduced intracellular ros and apoptosis levels, and increased expression of ampk, akt, and nrf2 proteins and genes. |
2021-12-07 |
2023-08-13 |
Not clear |
| Maryam Taheri, Nasim Hayati Roudbari, Fardin Amidi, Kazem Pariva. The protective effect of sulforaphane against oxidative stress in granulosa cells of patients with polycystic ovary syndrome (PCOS) through activation of AMPK/AKT/NRF2 signaling pathway. Reproductive biology. vol 21. issue 4. 2021-12-07. PMID:34678578. |
our findings demonstrated the protective effect of sfn against os by lowering level of ros and apoptosis possibly through activation of ampk, akt, and nrf2 proteins and genes expression. |
2021-12-07 |
2023-08-13 |
Not clear |
| Yingchun Zhao, Xinglong Liu, Chuanbo Ding, Yan Gu, Wencong Li. Dihydromyricetin Reverses Thioacetamide-Induced Liver Fibrosis Through Inhibiting NF-κB-Mediated Inflammation and TGF-β1-Regulated of PI3K/Akt Signaling Pathway. Frontiers in pharmacology. vol 12. 2021-12-07. PMID:34867416. |
moreover, dhm inhibited hepatocyte apoptosis by regulating the phosphorylation level of phosphatidylinositol 3-kinase (pi3k), protein kinase-b (akt) and its downstream apoptotic protein family. |
2021-12-07 |
2023-08-13 |
mouse |
| Liwen Luo, Xiuying Jian, Hui Sun, Jinghao Qin, Yanqiu Wang, Ji Zhang, Zigang Shen, Di Yang, Changqing Li, Ping Zhao, MingHan Liu, Zhiqiang Tian, Yue Zho. Cartilage endplate stem cells inhibit intervertebral disc degeneration by releasing exosomes to nucleus pulposus cells to activate Akt/autophagy. Stem cells (Dayton, Ohio). vol 39. issue 4. 2021-12-06. PMID:33459443. |
n-exos inhibited npcs apoptosis and attenuated ivdd in rat via activation of the akt and autophagy pathways. |
2021-12-06 |
2023-08-13 |
rat |
| Jia Chen, Mingyang Wang, Hanli Wang, Miao Lon. Zearalenone promotes apoptosis of mouse Leydig cells by targeting phosphatase and tensin homolog and thus inhibiting the PI3K/AKT signal pathway. Environmental science and pollution research international. vol 28. issue 47. 2021-12-06. PMID:34264493. |
apoptosis was detected cytometrically and the protein expression levels of pten, akt, p-akt, bax, and bcl-2 were evaluated via western blot analysis. |
2021-12-06 |
2023-08-13 |
mouse |
| Sudeshna Nandi, Priyanka Upadhyay, Ayan Roy, Adhiraj Dasgupta, Arnab Sen, Arghya Adhikary, Krishnendu Achary. A natural derivative from ethnomedicinal mushroom potentiates apoptosis, autophagy and attenuates cell migration, via fine tuning the Akt signaling in human lung adenocarcinoma cells (A549). Environmental toxicology. vol 37. issue 1. 2021-12-06. PMID:34581487. |
a natural derivative from ethnomedicinal mushroom potentiates apoptosis, autophagy and attenuates cell migration, via fine tuning the akt signaling in human lung adenocarcinoma cells (a549). |
2021-12-06 |
2023-08-13 |
human |
| Shui Lian Chou, Samiraj Ramesh, Chia-Hua Kuo, Ayaz Ali, Tsung-Jung Ho, Ko Peng Chang, Dennis Jine-Yuan Hsieh, V Bharath Kumar, Yueh-Shan Weng, Wei-Wen Kuo, Chih-Yang Huan. Tanshinone IIA inhibits Leu27IGF-II-induced insulin-like growth factor receptor II signaling and myocardial apoptosis via estrogen receptor-mediated Akt activation. Environmental toxicology. vol 37. issue 1. 2021-12-06. PMID:34655285. |
tanshinone iia inhibits leu27igf-ii-induced insulin-like growth factor receptor ii signaling and myocardial apoptosis via estrogen receptor-mediated akt activation. |
2021-12-06 |
2023-08-13 |
Not clear |
| Shui Lian Chou, Samiraj Ramesh, Chia-Hua Kuo, Ayaz Ali, Tsung-Jung Ho, Ko Peng Chang, Dennis Jine-Yuan Hsieh, V Bharath Kumar, Yueh-Shan Weng, Wei-Wen Kuo, Chih-Yang Huan. Tanshinone IIA inhibits Leu27IGF-II-induced insulin-like growth factor receptor II signaling and myocardial apoptosis via estrogen receptor-mediated Akt activation. Environmental toxicology. vol 37. issue 1. 2021-12-06. PMID:34655285. |
further, akt activation considerably suppressed the leu27igf-ii induced igf-iir expression level and the downstream effectors, including gαq and calcineurin as well as mitochondrial dependent apoptosis proteins including bad, cytochrome c, and active caspase-3 that result in cardiac apoptosis resistance. |
2021-12-06 |
2023-08-13 |
Not clear |
| Sandeep Appunni, Deepika Gupta, Muni Rubens, Venkataraghavan Ramamoorthy, Himanshu Narayan Singh, Vishnu Swaru. Deregulated Protein Kinases: Friend and Foe in Ischemic Stroke. Molecular neurobiology. vol 58. issue 12. 2021-12-03. PMID:34549335. |
conversely, protein kinases such as pka, akt, pkcα, pkcε, trk, and perk salvage neurons post-ischemia by mechanisms including enhanced toxin metabolism, restoring bbb integrity, neurotrophic effects, and apoptosis suppression. |
2021-12-03 |
2023-08-13 |
Not clear |
| Chen Wang, Na Zhao, Fuyuki Sato, Keiji Tanimoto, Hiroyuki Okada, Yang Liu, Ujjal K Bhawa. The roles of Y-box-binding protein (YB)-1 and C-X-C motif chemokine ligand 14 (CXCL14) in the progression of prostate cancer via extracellular-signal-regulated kinase (ERK) signaling. Bioengineered. vol 12. issue 2. 2021-12-02. PMID:34696665. |
egf rescues cell cycle and apoptosis via the akt and erk pathways. |
2021-12-02 |
2023-08-13 |
human |