| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Rekha Koravadi Narasimhamurthy, Daicy Andrade, Kamalesh Dattaram Mumbreka. Modulation of CREB and its associated upstream signaling pathways in pesticide-induced neurotoxicity. Molecular and cellular biochemistry. 2022-05-21. PMID:35596844. |
several genes, as well as protein kinases, are involved in the phosphorylation of creb, including bdnf (brain-derived neurotrophic factor), pi3k (phosphoinositide 3-kinase), akt (protein kinase b), ras (rat sarcoma), mek (mitogen-activated protein kinase), plc (phospholipase c), and pkc (protein kinase c) that play an essential role in neuronal plasticity, long-term potentiation, neuronal survival, learning, and memory formation, cognitive function, synaptic transmission, and suppressing apoptosis. |
2022-05-21 |
2023-08-13 |
human |
| Yuqin Zeng, Yiyang Zhao, Yan Chen, Shan Cai, Ping Che. PECAM EMPs regulate apoptosis in pulmonary microvascular endothelial cells in COPD by activating the Akt signaling pathway. Tobacco induced diseases. vol 20. 2022-05-20. PMID:35592594. |
pecam emps regulate apoptosis in pulmonary microvascular endothelial cells in copd by activating the akt signaling pathway. |
2022-05-20 |
2023-08-13 |
human |
| Yuhao Deng, Huantao Wen, Hanjie Yang, Zhengqiang Zhu, Qiongzhen Huang, Yuewei Bi, Pengfei Wang, Ming Zhou, Jianwei Guan, Wangming Zhang, Min L. Identification of PBK as a hub gene and potential therapeutic target for medulloblastoma. Oncology reports. vol 48. issue 1. 2022-05-20. PMID:35593307. |
furthermore, targeting pbk with its inhibitor, hi‑topk‑032, impaired the proliferation and induced the apoptosis of two mb cell lines, with the diminished phosphorylation of downstream effectors of pbk, including erk1/2 and akt, and the activation of caspase‑3. |
2022-05-20 |
2023-08-13 |
Not clear |
| Tie Liu, Zhuang-Qin Zhang, Xia Xiao, Xiao-Qian L. Bioassay-guided isolation of anti-tumor polyprenylphloroglucinols from Calophyllum polyanthum and primary mechanism. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 151. 2022-05-20. PMID:35594705. |
it could significantly up-regulate the expression levels of apoptosis-related genes (bax, caspase-9,) and proteins (bax, cleaved-caspase-9, cleaved-caspase-3) and down-regulated the expression of inhibitor of apoptosis gene (bcl-2) and proteins (bcl-2, phosphorylated akt). |
2022-05-20 |
2023-08-13 |
Not clear |
| Pei Wang, Hongbing Ma, Yong Li, Dong Chen, Xiaohui Li, Xiang Ga. Retracted Article: FOXC1 silencing promotes A549 cell apoptosis through inhibiting the PI3K/AKT/hedgehog/Gli2 signaling pathway. RSC advances. vol 8. issue 59. 2022-05-13. PMID:35548824. |
overexpressed akt or gli2 reversed the effects of foxc1 silencing on a549 cell survival and apoptosis. |
2022-05-13 |
2023-08-13 |
human |
| Qi-Qi Luo, Yu Tian, Guang-Jin Qu, Kun-Huang, Shan-Shun Lu. Functional mechanism and clinical implications of miR-141 in human cancers. Cellular signalling. 2022-05-13. PMID:35550172. |
as a member of the mirna family, mir-141 acts as a suppressor or an oncomir in various cancers and regulates cancer cell proliferation, apoptosis, invasion, and metastasis through a variety of signaling pathways, such as phosphatidylinositol-3-kinase (pi3k)/protein kinase b (akt) and constitutive activation of nuclear factor-κb (nf-κb). |
2022-05-13 |
2023-08-13 |
human |
| Yi Zhang, Yong Qu, Yun-Zhong Che. Influence of 6-shogaol potentiated on 5-fluorouracil treatment of liver cancer by promoting apoptosis and cell cycle arrest by regulating AKT/mTOR/MRP1 signalling. Chinese journal of natural medicines. vol 20. issue 5. 2022-05-13. PMID:35551770. |
akt activation or mrp1 increase reversed the influence of combination treatment on liver cancer cell viability, apoptosis and cell cycle arrest. |
2022-05-13 |
2023-08-13 |
Not clear |
| Aurora Costa, Iris Maria Forte, Elisa Ventura, Francesca Pentimalli, Antonio Giordan. Pharmacological reactivation of RBL2/p130 could be an effective antitumoral strategy for malignant pleural mesothelioma. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 36 Suppl 1. 2022-05-13. PMID:35554012. |
we previously demonstrated that rbl2/p130 is a direct akt target and its reactivation following akt inhibition mediates apoptosis in mm. |
2022-05-13 |
2023-08-13 |
human |
| Gamal Badr, Leila H Sayed, Hossam El-Din M Omar, Sary Khaleel Abd Elghaffar, Medhat M Menshaw. Bee gomogenat rescues lymphoid organs from degeneration by regulating the crosstalk between apoptosis and autophagy in streptozotocin-induced diabetic mice. Environmental science and pollution research international. 2022-05-13. PMID:35554836. |
treatment with bg significantly abrogated apoptosis and autophagy in lymphoid organs in diabetic mice by restoring the expression levels of lc3, beclin-1, p62, bcl-2, and bax; decreasing inflammatory signals by downregulating the expression of mcp-1 and hsp-70; and promoting cell survival by enhancing the phosphorylation of akt. |
2022-05-13 |
2023-08-13 |
mouse |
| Ying Chen, Jinxia Hao, Jing Zhao, Ye Liu, Yuan Li, Juan Ren, Wei Wan. Retracted Article: Long non-coding RNA PCAT1 facilitates cell growth in multiple myeloma through an MTDH-mediated AKT/β-catenin signaling pathway by sponging miR-363-3p. RSC advances. vol 9. issue 58. 2022-05-09. PMID:35528923. |
furthermore, pcat1 knockdown inhibited cell proliferation, cell cycle progression, and the protein kinase b (akt) and β-catenin signaling pathway, but induced cell apoptosis by regulating mtdh. |
2022-05-09 |
2023-08-13 |
Not clear |
| Jun-Feng Huo, Xiao-Bing Che. Retracted Article: Aclarubicin regulates glioma cell growth and DNA damage through the SIRT1/PI3K/AKT signaling pathway. RSC advances. vol 9. issue 49. 2022-05-09. PMID:35529648. |
interestingly, we found that akt overexpression reversed the effects of acr on glioma cell survival, proliferation, apoptosis, and dna damage. |
2022-05-09 |
2023-08-13 |
rat |
| Li Chen, Hongmian Zhao, Chao Wang, Ning H. TUG1 knockdown enhances adriamycin cytotoxicity by inhibiting glycolysis in adriamycin-resistant acute myeloid leukemia HL60/ADR cells. RSC advances. vol 9. issue 19. 2022-05-06. PMID:35515331. |
tug1 knockdown inhibited the akt pathway and activation of the akt pathway by 740y-p attenuated the effects of tug1 knockdown on adr-induced cytotoxicity and apoptosis, as well as glycolysis in hl60/adr cells. |
2022-05-06 |
2023-08-13 |
Not clear |
| Min Zhang, Jiayi Yang, Kaibao Ji, Xuejun He, Tao He, Yiqiao Xin. Inhibition of p66Shc attenuates retinal ischemia-reperfusion injury-induced damage by activating the akt pathway. Experimental eye research. 2022-05-05. PMID:35513040. |
taken together, our study revealed that p66shc acts through the akt pathway to protect rgcs from retinal i/r injury-induced apoptosis and retinal dysfunction, making p66shc a possible therapeutic target for glaucoma treatment. |
2022-05-05 |
2023-08-13 |
mouse |
| Mingjia Zhang, Xuechun Li, Wenjing Wu, Jingxi Gao, Qin Han, Zhao Sun, Robert Chunhua Zha. Regorafenib induces the apoptosis of gastrointestinal cancer-associated fibroblasts by inhibiting AKT phosphorylation. Stem cells and development. 2022-05-03. PMID:35502476. |
regorafenib induces the apoptosis of gastrointestinal cancer-associated fibroblasts by inhibiting akt phosphorylation. |
2022-05-03 |
2023-08-13 |
Not clear |
| Mingjia Zhang, Xuechun Li, Wenjing Wu, Jingxi Gao, Qin Han, Zhao Sun, Robert Chunhua Zha. Regorafenib induces the apoptosis of gastrointestinal cancer-associated fibroblasts by inhibiting AKT phosphorylation. Stem cells and development. 2022-05-03. PMID:35502476. |
in conclusion, our results provide a model in which regorafenib induces cafs apoptosis by inhibiting the phosphorylation of akt, and regorafenib affects macrophage infiltration by reducing the proportion of cafs in tumor tissues. |
2022-05-03 |
2023-08-13 |
Not clear |
| Ji Young Kim, Tae-Min Cho, Jung Min Park, Soeun Park, Minsu Park, Kee Dal Nam, Dongmi Ko, Juyeon Seo, Seongjae Kim, Eunsun Jung, Lee Farrand, Cong-Truong Nguyen, Van-Hai Hoang, Minh Thanh La, Jihyae Ann, Gibeom Nam, Hyun-Ju Park, Jeewoo Lee, Yoon-Jae Kim, Jae Hong Se. A novel HSP90 inhibitor SL-145 suppresses metastatic triple-negative breast cancer without triggering the heat shock response. Oncogene. 2022-05-02. PMID:35501463. |
sl-145 is a novel, rationally-designed c-terminal hsp90 inhibitor that induces apoptosis in tnbc cells via the suppression of oncogenic akt, mek/erk, and jak2/stat3 signaling and does not trigger the hsr, in contrast to other inhibitors. |
2022-05-02 |
2023-08-13 |
Not clear |
| Jie Zhang, Xuejie Han, Jing Chang, Jian Liu, Yingming Liu, Hongxia Wang, Fenghe Du, Xiangjun Zeng, Caixia Gu. Soluble RAGE attenuates myocardial I/R injuries via FoxO3-Bnip3 pathway. Cellular and molecular life sciences : CMLS. vol 79. issue 5. 2022-05-02. PMID:35501612. |
srage inhibited mitochondrial depolarization and cardiac apoptosis during i/r, which correlated with reduced expression of bnip3, sirt2, phosphorylation of akt and foxo3a which translocated into nucleus in cultured cardiomyocytes. |
2022-05-02 |
2023-08-13 |
mouse |
| Ae Lim Jo, Ji Won Han, Ji In An, Kyung-Hyun Cho, Nam Ho Jeoun. Cuban Policosanol Prevents the Apoptosis and the Mitochondrial Dysfunction Induced by Lipopolysaccharide in C2C12 Myoblast via Activation of Akt and Erk Pathways. Journal of nutritional science and vitaminology. vol 68. issue 2. 2022-05-01. PMID:35491208. |
cuban policosanol prevents the apoptosis and the mitochondrial dysfunction induced by lipopolysaccharide in c2c12 myoblast via activation of akt and erk pathways. |
2022-05-01 |
2023-08-13 |
Not clear |
| Ae Lim Jo, Ji Won Han, Ji In An, Kyung-Hyun Cho, Nam Ho Jeoun. Cuban Policosanol Prevents the Apoptosis and the Mitochondrial Dysfunction Induced by Lipopolysaccharide in C2C12 Myoblast via Activation of Akt and Erk Pathways. Journal of nutritional science and vitaminology. vol 68. issue 2. 2022-05-01. PMID:35491208. |
our results demonstrated that policosanol significantly rescued cell survival (40% vs. 88%; lps vs. lps+policosanol) via activation of the akt pathway, resulting in inhibition of apoptosis (p<0.05). |
2022-05-01 |
2023-08-13 |
Not clear |
| Tao Wang, Zhen Li, Shuyun Xia, Zhixin Xu, Xiaofang Chen, Hu Su. Dexmedetomidine promotes cell proliferation and inhibits cell apoptosis by regulating LINC00982 and activating the phosphoinositide-3-kinase (PI3K)/protein kinase B (AKT) signaling in hypoxia/reoxygenation-induced H9c2 cells. Bioengineered. vol 13. issue 4. 2022-04-25. PMID:35466860. |
dexmedetomidine promotes cell proliferation and inhibits cell apoptosis by regulating linc00982 and activating the phosphoinositide-3-kinase (pi3k)/protein kinase b (akt) signaling in hypoxia/reoxygenation-induced h9c2 cells. |
2022-04-25 |
2023-08-13 |
Not clear |