| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Hui Yang, Yuting Chen, Minjuan Zeng, Haipeng Wu, Xiangli Zou, Tiantian Fang, Lu Zhai, Hairong Liang, Hao Luo, Gaiqin Tian, Qizhan Liu, Huanwen Tan. Long non-coding RNA LINC01480 is activated by Foxo3a and promotes hydroquinone-induced TK6 cell apoptosis by inhibiting the PI3K/AKT pathway. Ecotoxicology and environmental safety. vol 255. 2023-03-19. PMID:36934544. |
meanwhile, the phosphorylation levels of pi3k and akt decreased, and apoptosis increased. |
2023-03-19 |
2023-08-14 |
Not clear |
| Benjawan Wudtiwai, Kanchanok Kodchakorn, Thuzar Hla Shwe, Peraphan Pothacharoen, Thanyaluck Phitak, Raksa Suninthaboonrana, Prachya Kongtaweler. Brazilein inhibits epithelial-mesenchymal transition (EMT) and programmed death ligand 1 (PD-L1) expression in breast cancer cells. International immunopharmacology. vol 118. 2023-03-18. PMID:36933493. |
we found that brazilein exerts an anti-cancer effect by reducing cell viability via induction of apoptosis, while it also downregulated emt and pd-l1 through suppression of phosphorylation of akt, nf-κb, and gsk3β/β-catenin. |
2023-03-18 |
2023-08-14 |
Not clear |
| Zeinab Babaei, Mojtaba Panjehpour, Seyedeh Sara Ghorbanhosseini, Hadi Parsian, Mahsa Khademi, Mahmoud Aghae. VEGFR3 suppression through miR-1236 inhibits proliferation and induces apoptosis in ovarian cancer via ERK1/2 and AKT signaling pathways. Journal of cellular biochemistry. 2023-03-16. PMID:36922713. |
vegfr3 suppression through mir-1236 inhibits proliferation and induces apoptosis in ovarian cancer via erk1/2 and akt signaling pathways. |
2023-03-16 |
2023-08-14 |
Not clear |
| Yiling Fang, Tianheng Zhao, Haibo Ni, Yajun Li, Yongkui Zhu, Rong Gao, Li Zhang, Zhenyu Jia, Gang Che. USP11 exacerbates neuronal apoptosis after traumatic brain injury via PKM2-mediated PI3K/AKT signaling pathway. Brain research. 2023-03-10. PMID:36898475. |
moreover, we hypothesize that pkm2-induced neuronal apoptosis is mediated by the phosphoinositide 3-kinase (pi3k)/protein kinase b (akt) signaling pathway. |
2023-03-10 |
2023-08-14 |
rat |
| Yi Huang, Yun Huang, Ge Zhu, Bingzhi Zhang, Yujia Zhu, Bin Chen, Xiaoxia Gao, Jie Yua. A Meroterpenoid from Tibetan Medicine Induces Lung Cancer Cells Apoptosis through ROS-Mediated Inactivation of the AKT Pathway. Molecules (Basel, Switzerland). vol 28. issue 4. 2023-02-25. PMID:36838927. |
a meroterpenoid from tibetan medicine induces lung cancer cells apoptosis through ros-mediated inactivation of the akt pathway. |
2023-02-25 |
2023-08-14 |
Not clear |
| Gautam Sethi, Prangya Rath, Abhishek Chauhan, Anuj Ranjan, Renuka Choudhary, Seema Ramniwas, Katrin Sak, Diwakar Aggarwal, Isha Rani, Hardeep Singh Tul. Apoptotic Mechanisms of Quercetin in Liver Cancer: Recent Trends and Advancements. Pharmaceutics. vol 15. issue 2. 2023-02-25. PMID:36840034. |
quercetin targets apoptosis, by upregulating bax, caspase-3, and p21 while downregulating akt, plk-1, cyclin-b1, cyclin-a, cdc-2, cdk-2, and bcl-2. |
2023-02-25 |
2023-08-14 |
Not clear |
| Yanxiong Shao, Chaoran Li, Guojun Miao, Yubo X. Fangchinoline, an extract of the Stephania tetrandra S. Moore root, promoted oxidative stress-induced DNA damage and apoptosis and inhibited Akt signaling in Jurkat T cells. Current molecular pharmacology. 2023-02-22. PMID:36809961. |
fangchinoline, an extract of the stephania tetrandra s. moore root, promoted oxidative stress-induced dna damage and apoptosis and inhibited akt signaling in jurkat t cells. |
2023-02-22 |
2023-08-14 |
Not clear |
| Yueyue Sun, Mengnan Yang, Shujun Li, Ying Hu, Biao Yang, Xu Li, Rong Yan, Kesheng Da. Alantolactone induces platelet apoptosis by activating the Akt pathway. Platelets. 2023-02-22. PMID:36813739. |
alantolactone induces platelet apoptosis by activating the akt pathway. |
2023-02-22 |
2023-08-14 |
Not clear |
| Yong Zhang, Qiyu Zhao, Yufeng Ren, Ping Zhang, Yao Zhen. Clinicopathological Significance and Molecular Mechanism of AKT/GSK3β Pathway-based Fibrillin-1 Expression in Gastric Cancer Progression. Cellular and molecular biology (Noisy-le-Grand, France). vol 68. issue 8. 2023-02-21. PMID:36800836. |
overexpression of fbn1 promoted the proliferation and colony formation of gastric cancer cells, inhibited apoptosis, and promoted the phosphorylation of akt and gsk3β. |
2023-02-21 |
2023-08-14 |
Not clear |
| Yong Zhang, Qiyu Zhao, Yufeng Ren, Ping Zhang, Yao Zhen. Clinicopathological Significance and Molecular Mechanism of AKT/GSK3β Pathway-based Fibrillin-1 Expression in Gastric Cancer Progression. Cellular and molecular biology (Noisy-le-Grand, France). vol 68. issue 8. 2023-02-21. PMID:36800836. |
silencing fbn1 expression inhibited the proliferation and clonal formation of gastric cancer cells, promoted apoptosis, and inhibited the phosphorylation of akt and gsk3β. |
2023-02-21 |
2023-08-14 |
Not clear |
| Thi Thuy Nguyen, Er-Yuan Chuang, Ya-Ping Chen, Po-Chun Tseng, Ming-Kai Jhan, Chun-Yi Lai, Yung-Ting Wang, Yu-Ping Hung, Chun Austin Changou, Chi-Ming Lee, Chia-Ling Chen, Chiou-Feng Li. Anticancer polypyrrole-polyethylenimine drug-free nanozyme for precise B-cell lymphoma therapy. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 160. 2023-02-16. PMID:36796279. |
deregulated akt and erk signaling contributed to glycogen synthase kinase-3-regulated cell apoptosis following deregulation of mcl-1 and mtp loss. |
2023-02-16 |
2023-08-14 |
mouse |
| Jiaqi Wu, Danrui Xiao, Kaiwen Yu, Kudureti Shalamu, Ben He, Min Zhan. The protective effect of the mitochondrial-derived peptide MOTS-c on LPS-induced septic cardiomyopathy. Acta biochimica et biophysica Sinica. 2023-02-14. PMID:36786072. |
our results demonstrate that mots-c treatment reduces the mrna levels of inflammatory cytokines ( il-1β, il-4, il-6, and tnfα) in cardiomyocytes and the levels of circulating myocardial injury markers, such as ck-mb and tnt, alleviates cardiomyocyte mitochondrial dysfunction and oxidative stress, reduces cardiomyocyte apoptosis, activates cardioprotection-related signaling pathways, including ampk, akt, and erk, and inhibits the inflammation-related signaling pathways jnk and stat3. |
2023-02-14 |
2023-08-14 |
Not clear |
| Giovanna Azzarito, Margit Henry, Tamara Rotshteyn, Brigitte Leeners, Raghvendra K Dube. Transcriptomic and Functional Evidence That miRNA193a-3p Inhibits Lymphatic Endothelial Cell (LEC) and LEC + MCF-7 Spheroid Growth Directly and by Altering MCF-7 Secretome. Cells. vol 12. issue 3. 2023-02-11. PMID:36766731. |
moreover, mir193a-3p alters factors in mcf-7 secretome, which represses erk1/2 and akt phosphorylation, induces pro-apoptotic protein and apoptosis in lecs, and downregulates interferon-associated proteins known to promote cancer growth and metastasis. |
2023-02-11 |
2023-08-14 |
Not clear |
| Chenxi Wang, Chenyang Huang, Jiali Wang, Jianfeng Ye, Zhiqiang Xue, Jian Zhang, Yuke Re. Ginsenoside Rg5 attenuates hypoxia-induced cardiomyocyte apoptosis via regulating theAkt pathway. Chemical biology & drug design. 2023-02-10. PMID:36762503. |
akt signaling activation was found to be the mechanism of ginsenoside rg5's protective effect on hypoxia-induced nrms apoptosis, as an akt inhibitor eliminated the anti-apoptotic effects of ginsenoside rg5. |
2023-02-10 |
2023-08-14 |
rat |
| Chenxi Wang, Chenyang Huang, Jiali Wang, Jianfeng Ye, Zhiqiang Xue, Jian Zhang, Yuke Re. Ginsenoside Rg5 attenuates hypoxia-induced cardiomyocyte apoptosis via regulating theAkt pathway. Chemical biology & drug design. 2023-02-10. PMID:36762503. |
various analyses were performed and verified, ginsenoside rg5 suppressed hypoxia-induced apoptosis in nrms via activation of the akt signaling. |
2023-02-10 |
2023-08-14 |
rat |
| Weiguo Ding, Weixing Xu, Di Lu, Hongfeng Sheng, Xinwei Xu, Bin Xu, Aote Zhen. Inhibition of TERC inhibits neural apoptosis and inflammation in spinal cord injury through Akt activation and p-38 inhibition via the miR-34a-5p/XBP-1 axis. Open medicine (Warsaw, Poland). vol 18. issue 1. 2023-02-06. PMID:36742154. |
inhibition of terc inhibits neural apoptosis and inflammation in spinal cord injury through akt activation and p-38 inhibition via the mir-34a-5p/xbp-1 axis. |
2023-02-06 |
2023-08-14 |
rat |
| Journal Of Oncolog. Retracted: TMEM60 Promotes the Proliferation and Migration and Inhibits the Apoptosis of Glioma through Modulating AKT Signaling. Journal of oncology. vol 2023. 2023-02-02. PMID:36727156. |
retracted: tmem60 promotes the proliferation and migration and inhibits the apoptosis of glioma through modulating akt signaling. |
2023-02-02 |
2023-08-14 |
Not clear |
| Zhoufan Xie, Jie Xu, Di Xiao, Jiachuan Lei, Jianqing Y. Dual regulation of Akt and glutathione caused by isoalantolactone effectively triggers human ovarian cancer cell apoptosis. Acta biochimica et biophysica Sinica. 2023-02-02. PMID:36727416. |
dual regulation of akt and glutathione caused by isoalantolactone effectively triggers human ovarian cancer cell apoptosis. |
2023-02-02 |
2023-08-14 |
human |
| Beini Sun, Hongce Chen, Xiaoping Wang, Tongsheng Che. Regorafenib induces Bim-mediated intrinsic apoptosis by blocking AKT-mediated FOXO3a nuclear export. Cell death discovery. vol 9. issue 1. 2023-01-31. PMID:36720853. |
most importantly, akt agonist (sc79) not only inhibited rego-induced foxo3a nuclear localization and apoptosis but also restored the proliferation and migration ability of cancer cells, further demonstrating that rego prevented foxo3a nuclear export by deactivating pi3k/akt. |
2023-01-31 |
2023-08-14 |
Not clear |
| Xi Zhang, Sutong Xu, Yong Hu, Qiulu Liu, Chenming Liu, Huazhen Chai, Yuping Luo, Lingjing Jin, Siguang L. Irisin exhibits neuroprotection by preventing mitochondrial damage in Parkinson's disease. NPJ Parkinson's disease. vol 9. issue 1. 2023-01-31. PMID:36720890. |
with the use of small-molecule inhibitors, it was found that irisin can reduce apoptosis, restore normal mitochondrial biogenesis, and improve mitochondrial morphology and dynamic balance in pd models by activating akt signaling pathway and erk1/2 signaling pathway. |
2023-01-31 |
2023-08-14 |
Not clear |