| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Zhongwei Xu, Jun Bao, Xiaohan Jin, Heng Li, Kaiyuan Fan, Zhidong Wu, Min Yao, Yan Zhang, Gang Liu, Dan Wang, Xiaoping Yu, Jia Guo, Ruicheng Xu, Qian Gong, Fengmei Wang, Jin Wan. The Effects of Cinobufagin on Hepatocellular Carcinoma Cells Enhanced by MRT68921, an Autophagy Inhibitor. The American journal of Chinese medicine. 2023-07-25. PMID:37489112. |
as determined using transcriptome analysis, cinobufagin-triggered protective autophagy suppressed cell apoptosis in liver cancer hepg2 and huh-7 cells by inhibiting the phosphoinositide-3-kinase (pi3k)-akt serine/threonine kinase (akt)-mammalian target of rapamycin (mtor) pathway. |
2023-07-25 |
2023-08-14 |
Not clear |
| Minerva, Amrita Bhat, Sonali Verma, Gresh Chander, Rajeshwer Singh Jamwal, Bhawani Sharma, Audesh Bhat, Taruna Katyal, Rakesh Kumar, Ruchi Sha. Cisplatin-based combination therapy for cancer. Journal of cancer research and therapeutics. vol 19. issue 3. 2023-07-20. PMID:37470570. |
dna damage is followed by several signaling pathways like induced oxidative stress, upregulated p53, mitogen-activated protein kinase (mapk), and jun n-terminal kinases (jnk) or akt pathways along with induced apoptosis. |
2023-07-20 |
2023-08-14 |
Not clear |
| Chao-Feng Shi, Fei Han, Xiao Jiang, Zhonghao Zhang, Yingqing Li, Jiankang Wang, Shengqi Sun, Jin-Yi Liu, Jia Ca. Benzo[b]fluoranthene induces male reproductive toxicity and apoptosis via Akt-Mdm2-p53 signaling axis in mouse Leydig cells: Integrating computational toxicology and experimental approaches. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2023-07-20. PMID:37473983. |
further, compared with bbf group, akt activator sc79 significantly reduced cell apoptosis rate, improved cell viability, promoted the expressions of p-akt and p-mdm2, and reversed the above molecular expressions. |
2023-07-20 |
2023-08-14 |
mouse |
| Bita Firouzan, Farideh Iravanpour, Fatemeh Abbaszadeh, Valery Akparov, Jalal Zaringhalam, Rasoul Ghasemi, Nader Maghsoud. Dipeptide mimetic of BDNF ameliorates motor dysfunction and striatal apoptosis in 6-OHDA-induced Parkinson's rat model: Considering Akt and MAPKs signaling. Behavioural brain research. 2023-07-19. PMID:37467964. |
dipeptide mimetic of bdnf ameliorates motor dysfunction and striatal apoptosis in 6-ohda-induced parkinson's rat model: considering akt and mapks signaling. |
2023-07-19 |
2023-08-14 |
rat |
| Guang-Yi Liu, Huan Wang, Rui Ran, Yi-Cheng Wang, Yang L. Dimethyladenosine Transferase 1 Homolog Promotes Human Gastric Carcinoma Cell Proliferation and Inhibits Apoptosis via the AKT Pathway. The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology. 2023-07-18. PMID:37462231. |
dimethyladenosine transferase 1 homolog promotes human gastric carcinoma cell proliferation and inhibits apoptosis via the akt pathway. |
2023-07-18 |
2023-08-14 |
human |
| Joseph Festa, Aamir Hussain, Amon Hackney, Unmesh Desai, Tarsem S Sahota, Harprit Singh, Mariasole Da Boi. Elderberry extract improves molecular markers of endothelial dysfunction linked to atherosclerosis. Food science & nutrition. vol 11. issue 7. 2023-07-17. PMID:37457144. |
cell viability, apoptosis, oxidative stress; enos, akt, nrf2, nox-4, and nf-κb at the protein level were measured. |
2023-07-17 |
2023-08-14 |
human |
| Oxana V Denisova, Joni Merisaari, Riikka Huhtaniemi, Xi Qiao, Laxman Yetukuri, Mikael Jumppanen, Amanpreet Kaur, Mirva Pääkkönen, Сarina von Schantz-Fant, Michael Ohlmeyer, Krister Wennerberg, Otto Kauko, Raphael Koch, Tero Aittokallio, Mikko Taipale, Jukka Westermarc. PP2A-based triple-strike therapy overcomes mitochondrial apoptosis resistance in brain cancer cells. Molecular oncology. 2023-07-17. PMID:37458534. |
biochemically, the combined akt and pdk inhibition resulted in the shutdown of both target pathways and priming to mitochondrial apoptosis but failed to induce apoptosis. |
2023-07-17 |
2023-08-14 |
Not clear |
| Hyung-Mun Yun, Bomi Kim, Soo Hyun Kim, Seung-Hae Kwon, Kyung-Ran Par. Xanol Promotes Apoptosis and Autophagy and Inhibits Necroptosis and Metastasis via the Inhibition of AKT Signaling in Human Oral Squamous Cell Carcinoma. Cells. vol 12. issue 13. 2023-07-14. PMID:37443802. |
xanol promotes apoptosis and autophagy and inhibits necroptosis and metastasis via the inhibition of akt signaling in human oral squamous cell carcinoma. |
2023-07-14 |
2023-08-14 |
human |
| Wei Zheng, Xiao Han, Bing Han, Gang Li, Jing Gan, Tian Wang, Bo Xu, Jie He, Wenxiao Du, Xiaolin Cao, Zhenhua Wan. LAR Downregulation Protects the Astrocytic U251 and Cocultured SH-SY5Y Cells in a Rotenone-Induced Parkinson's Disease Cell Model. International journal of molecular sciences. vol 24. issue 13. 2023-07-14. PMID:37446291. |
the enhanced akt and gsk-3β phosphorylation contributed to a reduced bax/bcl2 ratio and suppressed apoptosis after rotenone exposure. |
2023-07-14 |
2023-08-14 |
Not clear |
| Chaogang Wang, Mingyang Du, Zhuxiang Jiang, Rihao Cong, Wei Wang, Guofan Zhang, Li L. Comparative proteomic and phosphoproteomic analysis reveals differential heat response mechanism in two congeneric oyster species. Ecotoxicology and environmental safety. vol 263. 2023-07-14. PMID:37451098. |
furthermore, the protein kinase a, mitogen-activated protein kinase 1, tyrosine-protein kinase src, and serine/threonine kinase akt, exhibiting differential phosphorylation modification patterns, were identified as hub regulators that may enhance glycolysis and tca cycle to increase the energy supply, distribute protein synthesis, inhibit caspase-dependent apoptosis activated by endogenous mitochondrial cytochrome release and maintain cytoskeletal stability, ultimately shaping the higher thermal resistance of c. angulata. |
2023-07-14 |
2023-08-14 |
Not clear |
| Tuo Ji, Meng Chen, Yinyin Liu, Haixing Jiang, Na Li, Xianghu H. Artesunate alleviates intestinal ischemia/reperfusion induced acute lung injury via up-regulating AKT and HO-1 signal pathway in mice. International immunopharmacology. vol 122. 2023-07-13. PMID:37441813. |
then the akt inhibitor triciribin and ho-1 inhibitor tin-protoporphyrin ix were administered which reversed the protein expression of apoptosis, akt and ho-1. |
2023-07-13 |
2023-08-14 |
mouse |
| Tuo Ji, Meng Chen, Yinyin Liu, Haixing Jiang, Na Li, Xianghu H. Artesunate alleviates intestinal ischemia/reperfusion induced acute lung injury via up-regulating AKT and HO-1 signal pathway in mice. International immunopharmacology. vol 122. 2023-07-13. PMID:37441813. |
our study suggests that art mitigated the ii/r induced acute lung injury by targeting the oxidative stress, inflammatory response and apoptosis which is associated with the activating of akt and ho-1, providing novel insights into the therapeutic candidate for the treatment of ii/r induced acute lung injury. |
2023-07-13 |
2023-08-14 |
mouse |
| Xiaochen Qiu, Juan Wang, Nan Zhang, Tongde Du, Lin Chen, Hongqing X. Estradiol cypionate inhibits proliferation and promotes apoptosis of gastric cancer by regulating AKT ubiquitination. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 165. 2023-07-01. PMID:37392652. |
estradiol cypionate inhibits proliferation and promotes apoptosis of gastric cancer by regulating akt ubiquitination. |
2023-07-01 |
2023-08-14 |
Not clear |
| Xiaochen Qiu, Juan Wang, Nan Zhang, Tongde Du, Lin Chen, Hongqing X. Estradiol cypionate inhibits proliferation and promotes apoptosis of gastric cancer by regulating AKT ubiquitination. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 165. 2023-07-01. PMID:37392652. |
the mechanism by which ecp promoted apoptosis of gastric cancer cells was related to the downregulation of akt protein expression caused by the increased ubiquitination modification levels of akt, which finally inhibited the over-activation of the pi3k-akt-mtor signaling pathway. |
2023-07-01 |
2023-08-14 |
Not clear |
| Min Guo, Danyang Chen, Mingqi Zhao, Tiantian Xu, Yingying Zhang, Misi Xiao, Yinghua Li, Bing Zh. 5-Nitrobenzo[c][1, 2, 5]selenadiazole as therapeutic agents in the regulation of oxidative stress and inflammation induced by influenza A(H1N1)pdm09 in vitro and in vivo. Journal of medical virology. vol 95. issue 7. 2023-06-30. PMID:37386905. |
immunohistochemical assays were performed to further explore the mechanism that sed-3 inhibited h1n1-induced apoptosis via reactive oxygen species-mediated mapk, akt, and p53 signaling pathways. |
2023-06-30 |
2023-08-14 |
Not clear |
| Xiaohua Zhang, Shan Shan Liu, Jingru Ma, Wei Q. Secretory leukocyte protease inhibitor (SLPI) in cancer pathophysiology: Mechanisms of action and clinical implications. Pathology, research and practice. vol 248. 2023-06-25. PMID:37356220. |
furthermore, slpi interacts intricately with other cancer-promoting factors, including matrix metalloproteinase-2 (mmp-2), mmp-9, the nf-κb and akt pathways, and the p53-upregulated modulator of apoptosis (puma). |
2023-06-25 |
2023-08-14 |
Not clear |
| Peng Huang, Jinliang Du, Liping Cao, Jiancao Gao, Quanjie Li, Yi Sun, Nailin Shao, Yuning Zhang, Gangchun X. Effects of prometryn on oxidative stress, immune response and apoptosis in the hepatopancreas of Eriocheir sinensis (Crustacea: Decapoda). Ecotoxicology and environmental safety. vol 262. 2023-06-25. PMID:37356403. |
histopathology showed that prometryn damaged the structure of the hepatopancreas cells and induced apoptosis, suggesting that the pi3k-akt signaling pathway may be involved in the damage process of hepatopancreas cells (pi3k, pdk and akt were downregulated whereas bax was upregulated), leading to their apoptosis. |
2023-06-25 |
2023-08-14 |
cat |
| Sirinthip Klaophimai, Phisit Pouyfung, Ariyaphong Wongnoppavich, Kongthawat Chairatvi. Induction of S arrest and apoptosis in human oral cancer cells by Rhinacanthin-C extracted from Rhinacanthus nasutus via modulating Akt and p38 signaling pathways. Journal of ethnopharmacology. 2023-06-22. PMID:37348799. |
induction of s arrest and apoptosis in human oral cancer cells by rhinacanthin-c extracted from rhinacanthus nasutus via modulating akt and p38 signaling pathways. |
2023-06-22 |
2023-08-14 |
human |
| Sofia Mônaco Gama, Vanessa Araújo Varela, Natalia Mazini Ribeiro, Bruna Bizzarro, Camila Hernandes, Thiago Pinheiro Arrais Aloia, Mariane Tami Amano, Welbert Oliveira Pereir. AKT inhibition interferes with the expression of immune checkpoint proteins and increases NK-induced killing of HL60-AML cells. Einstein (Sao Paulo, Brazil). vol 21. 2023-06-21. PMID:37341216. |
to determine the role of the akt pathway in the regulating of natural killer-induced apoptosis of acute myeloid leukemia cells and to characterize the associated molecular mechanisms. |
2023-06-21 |
2023-08-14 |
Not clear |
| Xi Yuan, Xiangdong Sun, Bin Zhou, Shuang Zhao, Yikun Li, Haolang Min. HSPA4 regulated glioma progression via activation of AKT signaling pathway. Biochemistry and cell biology = Biochimie et biologie cellulaire. 2023-06-20. PMID:37339521. |
the regulatory effect of the akt activator sc79 on cell proliferation and apoptosis was suppressed by hspa4 knockdown, indicating that hspa4 is capable of promoting glioma development. |
2023-06-20 |
2023-08-14 |
Not clear |