| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Eric Mayo. Neurotrophic effects of intermittent fasting, calorie restriction and exercise: a review and annotated bibliography. Frontiers in aging. vol 4. 2023-06-19. PMID:37334045. |
the most researched signaling pathways (pi3k, akt, mtor, ampk, gsk3β, ulk, mapk, pgc-1α, nf-κb, sirtuins, notch, sonic hedgehog and wnt) and processes (e.g., anti-inflammation, autophagy, apoptosis) that support or thwart neuroprotection, synaptic plasticity and neurogenesis are then briefly presented. |
2023-06-19 |
2023-08-14 |
Not clear |
| Lili Zhang, Jie Yang, Zhoujing Ji, Jie Zhang, Shengju Yan. PRR14 acts a novel oncogene activating the PI3K signal pathway in human cutaneous squamous cell carcinoma. Journal of Cancer. vol 14. issue 9. 2023-06-16. PMID:37325059. |
prr14 inhibition with rna interfering (rnai) method resulted in the suppression of cell proliferation, migration and invasion but promotion the apoptosis of cscc cells, and upregulation of the protein phosphorylation levels of mammalian target of rapamycin (mtor), phosphoinositide 3-kinase (pi3k) and akt. |
2023-06-16 |
2023-08-14 |
human |
| Sojin Kim, Yong Keun Song, Chang Sik Cho, Hyo Jung Kim, Sungsoon Fang, Dong Hyun Jo, Hyunkyung Ki. Inhibition of protein arginine deiminase II suppresses retinoblastoma in orthotopic transplantation in mice. Oncology reports. vol 50. issue 1. 2023-06-16. PMID:37326108. |
by inhibiting padi2 activity, the expression of phosphorylated akt was reduced, and cleaved poly (adp‑ribose) polymerase level was increased, leading to induced apoptosis. |
2023-06-16 |
2023-08-14 |
mouse |
| Liangzi Cao, Hao Li, Xiaofang Liu, Yubang Wang, Bowen Zheng, Chengzhong Xing, Naijin Zhang, Jingwei Li. Expression and regulatory network of E3 ubiquitin ligase NEDD4 family in cancers. BMC cancer. vol 23. issue 1. 2023-06-08. PMID:37291499. |
nedd4 family members interacted proteins were enriched in various pathways including p53, akt, apoptosis and autophagy, which were confirmed by further western blot and flow cytometric analysis in a549 and h1299 lung cancer cells. |
2023-06-08 |
2023-08-14 |
Not clear |
| Yi Yang, Yan-E Hu, Mao-Yuan Zhao, Yi-Fang Jiang, Xi Fu, Feng-Ming Yo. [Decursin affects proliferation, apoptosis, and migration of colorectal cancer cells through PI3K/Akt signaling pathway]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 48. issue 9. 2023-06-07. PMID:37282862. |
we investigated the effects of decursin on the proliferation, apoptosis, and migration of colorectal cancer ht29 and hct116 cells through the phosphatidylinositol 3-kinase(pi3k)/serine-threonine kinase(akt) pathway. |
2023-06-07 |
2023-08-14 |
Not clear |
| Y Li, M Li, K Ahmed, J Yang, L Song, Z G Cui, Y Hirak. Mechanistic Study of Macranthoside B Effects on Apoptotic Cell Death in Human Cervical Adenocarcinoma Cells. Folia biologica. vol 68. issue 5-6. 2023-05-31. PMID:37256553. |
in hela cells, mb induced down-regulation of sod2 and gpx1, phosphorylation of akt and pdk1, and thus promoted ros-mediated apoptosis. |
2023-05-31 |
2023-08-14 |
human |
| Huibin Zhang, Jinglin Wang, Fan Xie, Yangguang Liu, Mengyao Qiu, Zheng Han, Yueyun Ding, Xianrui Zheng, Zongjun Yin, Xiaodong Zhan. Identification of microRNAs implicated in modulating resveratrol-induced apoptosis in porcine granulosa cells. Frontiers in cell and developmental biology. vol 11. 2023-05-30. PMID:37250898. |
in the high vs. con group, rsv functions were associated with metabolic processes and responses to stimuli, while the pathways were related to pi3k24, akt, wnt, and apoptosis. |
2023-05-30 |
2023-08-14 |
Not clear |
| P Kurowska, K Gazdzik, A Jasinska, E Mlyczynska, D Wachowska, A Ra. Resistin as a new player in the regulation of porcine corpus luteum luteolysis: in vitro effect on proliferation/viability, apoptosis and autophagy. Journal of physiology and pharmacology : an official journal of the Polish Physiological Society. vol 74. issue 1. 2023-05-28. PMID:37245230. |
thus, the aim of the present study was to examine the in vitro effect of resistin on the proliferation/viability, apoptosis and autophagy of porcine luteal cells as well as the involvement of mitogen-activated kinase (map3/1), protein kinase b (akt) and signal transducer and activator of transcription 3 (stat3) in these processes. |
2023-05-28 |
2023-08-14 |
Not clear |
| Mohamed F Balaha, Ahmed A Alamer, Alaa A Eisa, Hashim M Aljohan. Shikonin Alleviates Gentamicin-Induced Renal Injury in Rats by Targeting Renal Endocytosis, SIRT1/Nrf2/HO-1, TLR-4/NF-κB/MAPK, and PI3K/Akt Cascades. Antibiotics (Basel, Switzerland). vol 12. issue 5. 2023-05-27. PMID:37237729. |
these potentials could be attributed to the modulation of the renal sirt1/nrf2/ho-1, tlr-4/nf-κb/mapk, and pi3k/akt cascades, which enhanced the renal antioxidant system and suppressed renal inflammation and apoptosis, as indicated by enhancements of sirt1, nrf2, ho-1, gsh, sod, tac, iκb-α, bcl-2, pi3k, and akt levels and mrna expressions, with reduction of tlr-4, nf-κb, mapk, il-1β, tnf-α, mda, inos, no, cytochrome c, caspase-3, bax levels, and bax/bcl-2 ratio. |
2023-05-27 |
2023-08-14 |
rat |
| Phateep Hankittichai, Phatarawat Thaklaewphan, Nitwara Wikan, Jirapak Ruttanapattanakul, Saranyapin Potikanond, Duncan R Smith, Wutigri Nimlamoo. Resveratrol Enhances Cytotoxic Effects of Cisplatin by Inducing Cell Cycle Arrest and Apoptosis in Ovarian Adenocarcinoma SKOV-3 Cells through Activating the p38 MAPK and Suppressing AKT. Pharmaceuticals (Basel, Switzerland). vol 16. issue 5. 2023-05-27. PMID:37242538. |
resveratrol enhances cytotoxic effects of cisplatin by inducing cell cycle arrest and apoptosis in ovarian adenocarcinoma skov-3 cells through activating the p38 mapk and suppressing akt. |
2023-05-27 |
2023-08-14 |
human |
| Yunjian Li, Liang Du, Kaiqin Ye, Xiao Sun, Lei Hu, Shan Gao, Haiming Da. AKT inhibition sensitizes acute leukemia cells to S63845-induced apoptosis. Hematology (Amsterdam, Netherlands). vol 28. issue 1. 2023-05-24. PMID:37222135. |
akt inhibition sensitizes acute leukemia cells to s63845-induced apoptosis. |
2023-05-24 |
2023-08-14 |
Not clear |
| Chinmayee Goda, Sofia Kolovich, Alexander Rudich, Malith Karunasiri, Rohan Kulkarni, Girish Rajgolikar, Lotus Neidemire-Colley, Satishkumar Singh, Anuvrat Sircar, Parvathi Ranganathan, Ramiro Garzon, Lalit Sehgal, Adrienne M Dorranc. Epidermal Growth Factor Like -7 is a novel therapeutic target in mantle cell lymphoma. Experimental hematology. 2023-05-20. PMID:37209901. |
we further show that egfl7 binds to egfr and activates akt signaling pathway in mcl cells and that blocking egfl7 in mcl: patient and cell lines decreases cell growth and increases apoptosis in vitro. |
2023-05-20 |
2023-08-14 |
mouse |
| Na Zhuang, Zhiyun Gu, Juan Feng, Zixuan Chai, Juanjuan Shan, Cheng Qia. BEX1 mediates sorafenib resistance in hepatocellular carcinoma by regulating AKT signaling. Cellular signalling. 2023-05-20. PMID:37209973. |
further studies revealed that bex1 renders hcc cells sensitive to sorafenib via induction of apoptosis and negatively regulates the phosphorylation of akt. |
2023-05-20 |
2023-08-14 |
Not clear |
| Xianghan Mei, Peitong Qiao, Hengheng Ma, Siyu Qin, Xia Song, Qiaoling Zhao, Dongxu She. Bombyx mori Tetraspanin A (BmTsp.A) is a facilitator in BmNPV invasion by regulating apoptosis. Developmental and comparative immunology. 2023-05-19. PMID:37207976. |
on the other hand, bmtsp.a inhibits the expression of bmpten and bmpkc through the phosphatidylinositol 3 kinase (pi3k)/protein kinaseb(akt) signaling pathway, thus affecting the regulation of apoptosis. |
2023-05-19 |
2023-08-14 |
Not clear |
| Xiangmin Wang, Yi Zhou, Qian Sun, Qing Zhang, Hongyuan Zhou, Jiaoli Zhang, Yuwei Du, Yuhan Wang, Ke Yuan, Linyan Xu, Meng Zhang, Dongmei Yan, Lingyu Zeng, Kailin Xu, Wei San. Thymosin β4 exerts cytoprotective function and attenuates liver injury in murine hepatic sinusoidal obstruction syndrome after hematopoietic stem cell transplantation. Transplantation and cellular therapy. 2023-05-16. PMID:37192732. |
in addition, tβ4 resisted γ irradiation-induced hsecs growth arrest and apoptosis in parallel with upregulation of anti-apoptotic protein b-cell lymphoma-extra-large (bcl-xl) and b-cell lymphoma-2 (bcl-2), which may be associated with activation of akt. |
2023-05-16 |
2023-08-14 |
Not clear |
| Guangying Zhou, Shasha Wan. YTHDC2 Retards Cell Proliferation and Triggers Apoptosis in Papillary Thyroid Cancer by Regulating CYLD-Mediated Inactivation of Akt Signaling. Applied biochemistry and biotechnology. 2023-05-10. PMID:37162682. |
ythdc2 retards cell proliferation and triggers apoptosis in papillary thyroid cancer by regulating cyld-mediated inactivation of akt signaling. |
2023-05-10 |
2023-08-14 |
Not clear |
| Cheng Wang, Hongqi Shang, Shuyu Zhang, Xiangkun Wang, Defeng Liu, Mingyue Shen, Ning Li, Yunxuan Jiang, Kai Wei, Ruiliang Zh. Hexavalent chromium disrupts the skin barrier by targeting ROS-mediated mitochondrial pathway apoptosis in keratinocytes. Chemico-biological interactions. 2023-05-05. PMID:37146930. |
in addition, it was discovered that cr(vi) promoted cell apoptosis and inhibited akt activation. |
2023-05-05 |
2023-08-14 |
mouse |
| Cheng Wang, Hongqi Shang, Shuyu Zhang, Xiangkun Wang, Defeng Liu, Mingyue Shen, Ning Li, Yunxuan Jiang, Kai Wei, Ruiliang Zh. Hexavalent chromium disrupts the skin barrier by targeting ROS-mediated mitochondrial pathway apoptosis in keratinocytes. Chemico-biological interactions. 2023-05-05. PMID:37146930. |
however, the addition of a caspase inhibitor and an akt activator prevented cr(vi)-induced injury to the cell membrane barrier, indicating that apoptosis plays a crucial role in this process. |
2023-05-05 |
2023-08-14 |
mouse |
| Xuehua Zhang, Leilei Zhao, Jinlong Xiao, Yudi Wang, Yunmeng Li, Chaoqun Zhu, He Zhang, Yurui Zhang, Xiao Zhu, Yucui Don. 5-Demethylnobiletin mediates cell cycle arrest and apoptosis Frontiers in oncology. vol 13. 2023-05-04. PMID:37139163. |
mechanically, 5-demethylnobiletin trigged g0/g1 phase arrest and apoptosis by inhibiting the erk1/2, akt and stat3 signaling pathway. |
2023-05-04 |
2023-08-14 |
Not clear |
| Carmen Amititeloaie, Liliana Chelaru, Gabriela Luminiţa Geleţu, Anca Sava, Alexandra Jităreanu, Andreea Mihaela Tibeică, Marcel Costulean. Apoptosis of pro-B lymphocytes induced by NR4A1 activation in the presence of gingival fibroblast exosomes and TNFα, caspase 8, STAT3, and Akt pathways modulators. Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie. vol 64. issue 1. 2023-05-02. PMID:37128789. |
apoptosis of pro-b lymphocytes induced by nr4a1 activation in the presence of gingival fibroblast exosomes and tnfα, caspase 8, stat3, and akt pathways modulators. |
2023-05-02 |
2023-08-14 |
Not clear |