| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jianqiang Bi, Quanle Liu, Yunchuan Sun, Xiuru Hu, Xinying He, Chengzhen X. CXCL14 inhibits the growth and promotes apoptosis of hepatocellular carcinoma cells via suppressing Akt/mTOR pathway. Journal of receptor and signal transduction research. vol 41. issue 6. 2021-10-11. PMID:33108937. |
overexpressed cxcl14 suppressed cell viability and growth, but promoted the apoptosis by upregulated bax and cleaved(c) caspase-3, donwregulated bcl-2 and the inhibition of akt and mtor phosphorylation. |
2021-10-11 |
2023-08-13 |
Not clear |
| Younglan Lim, Sujin Kim, Han-Na Yoon, Nam-On K. Keratin 8/18 Regulate the Akt Signaling Pathway. International journal of molecular sciences. vol 22. issue 17. 2021-10-11. PMID:34502133. |
k18-null mice with fas-induced liver damage show enhanced apoptosis combined with the downregulation of the akt signaling pathway, i.e., lower phosphorylation levels of gsk3β and nfκb, which are the downstream signaling factors in the akt signaling pathway, in k18-null mice compared with the control mice. |
2021-10-11 |
2023-08-13 |
mouse |
| Chun-Yan Li, Wei Ma, Kuang-Pin Liu, Jin-Wei Yang, Xian-Bin Wang, Zhen Wu, Tong Zhang, Jia-Wei Wang, Wei Liu, Jie Liu, Yu Liang, Xing-Kui Zhang, Jun-Jun Li, Jian-Hui Guo, Li-Yan L. Advances in intervention methods and brain protection mechanisms of in situ and remote ischemic postconditioning. Metabolic brain disease. vol 36. issue 1. 2021-10-07. PMID:33044640. |
many studies have shown that ispostc and ripostc can reduce cerebral is injury through protective mechanisms that increase cerebral blood flow after reperfusion, decrease antioxidant stress and anti-neuronal apoptosis, reduce brain edema, and regulate autophagy as well as akt, mapk, pkc, and katp channel cell signaling pathways. |
2021-10-07 |
2023-08-13 |
Not clear |
| Parul, Akanksha Mishra, Sonu Singh, Seema Singh, Virendra Tiwari, Swati Chaturvedi, Muhammad Wahajuddin, Gautam Palit, Shubha Shukl. Chronic unpredictable stress negatively regulates hippocampal neurogenesis and promote anxious depression-like behavior via upregulating apoptosis and inflammatory signals in adult rats. Brain research bulletin. vol 172. 2021-10-07. PMID:33895271. |
additionally, cus altered adult hippocampal neurogenesis, increased gliosis and neuronal apoptosis in cerebral cortex and hippocampus which might be associated with reduced akt and increased erk signaling, as seen in the rat brain tissue. |
2021-10-07 |
2023-08-13 |
rat |
| Cui Xia Li, Zhen Xian Lin, Xian Hua Zhao, Wei Fang Zuo, Nan Wang, Zong Ying Zhang, Xue Sen Che. Differential effects of phenolic extracts from red-fleshed apple peels and flesh induced G1 cell cycle arrest and apoptosis in human breast cancer MDA-MB-231 cells. Journal of food science. vol 86. issue 9. 2021-10-07. PMID:34392532. |
besides, the significant inhibition effects of app and afp were achieved through akt pathway by inducing apoptosis (significantly upregulating reactive oxygen species [ros] levels, and downregulating expression of pakt, pbad, bcl-2, promoting cytochrome c release, activating cle-caspase 9, and inducing expressions of cle-caspase 3 and cle-parp), and inducing g0/g1 cell cycle arrest (increased expressions of p-p53 and p21 and decreased expressions of pcna and cyclin d1). |
2021-10-07 |
2023-08-13 |
human |
| Akira Sato, Nor Idayu A Rahman, Akio Shimizu, Hisakazu Ogit. Cell-to-cell contact-mediated regulation of tumor behavior in the tumor microenvironment. Cancer science. vol 112. issue 10. 2021-10-07. PMID:34420253. |
emp1 promotes tumor cell migration and metastasis via activation of the small gtpase rac1, while stomatin strongly suppresses cell proliferation and induces apoptosis of cancer cells via inhibition of akt signaling. |
2021-10-07 |
2023-08-13 |
Not clear |
| Kuan-Ho Lin, Yu-Min Wei, Chung-Hung Liu, Jian-Sheng Liu, I-Chieh Huang, Vijaya Padma Viswanadha, Chih-Yang Huang, Wei-Wen Ku. Diallyl Trisulfide Suppresses High-Glucose-Induced Cardiomyocyte Apoptosis by Targeting Reactive Oxygen Species-Mediated Hypoxia-Inducible Factor-1α/Insulin-like Growth Factor Binding Protein 3 Activation. Journal of agricultural and food chemistry. vol 69. issue 39. 2021-10-07. PMID:34558885. |
it was observed that significantly increased levels of cell apoptosis and decreased akt phosphorylation were reversed by dats in hg-exposed cardiac cells. |
2021-10-07 |
2023-08-13 |
Not clear |
| Wenqing Liang, Xiaozhen Chen, Songou Zhang, Jian Fang, Meikai Chen, Yifan Xu, Xuerong Che. Mesenchymal stem cells as a double-edged sword in tumor growth: focusing on MSC-derived cytokines. Cellular & molecular biology letters. vol 26. issue 1. 2021-10-06. PMID:33472580. |
however, other studies have shown that mscs suppress tumor growth by suppressing angiogenesis, incrementing inflammatory infiltration, apoptosis and cell cycle arrest, and inhibiting the akt and wnt signaling pathways. |
2021-10-06 |
2023-08-13 |
Not clear |
| Rongduo Wen, Hideharu Ochiai, Jumpei Uchiyama, Nanako Osawa, Mami Oba, Yukie Katayama, Kaixin Li, Tsutomu Omatsu, Kenichi Tamukai, Kaoru Suzuki, Hiroo Madarame, Shinji Makino, Tetsuya Mizutan. African pygmy hedgehog adenovirus: Virus replication, virus-induced cytopathogenesis and activation of mitogen-activated protein kinase signaling pathways in infected MDCK cells. Research in veterinary science. vol 139. 2021-10-05. PMID:34332417. |
analysis of several intracellular signal transduction pathways, which are involved in apoptosis, showed activation of p38 mapk, akt and erk1/2 pathways at 3 h p.i., and upregulation of phosphorylated sapk/jnk at 24 h p.i. |
2021-10-05 |
2023-08-13 |
Not clear |
| Shenli Zhang, Kunlin Ou, Jie Huang, Lu Fang, Chonggang Wan. In utero exposure to mixed PAHs causes heart mass reduction in adult male mice. Ecotoxicology and environmental safety. vol 225. 2021-10-05. PMID:34555720. |
the downregulated phosphatidylinositol 3-kinase and akt led to increased expression of caspase3, caspase9, bax and reduced expression of bcl-2, which was responsible for the increased cell apoptosis. |
2021-10-05 |
2023-08-13 |
mouse |
| Navneet Kumar, Chandi C Manda. Cholesterol-Lowering Drugs on Akt Signaling for Prevention of Tumorigenesis. Frontiers in genetics. vol 12. 2021-10-05. PMID:34603386. |
akt, a serine/threonine kinase, can modulate the role of several downstream proteins involved in cell proliferation, migration, invasion, metabolism, and apoptosis. |
2021-10-05 |
2023-08-13 |
Not clear |
| Congshan Li, Panpan Yang, Bo Liu, Jie Bu, Hongrui Liu, Jie Guo, Tomoka Hasegawa, Haipeng Si, Minqi L. Prednisolone induces osteocytes apoptosis by promoting Notum expression and inhibiting PI3K/AKT/GSK3β/β-catenin pathway. Journal of molecular histology. vol 52. issue 5. 2021-10-04. PMID:34297260. |
knocking down notum via sirna partially restored osteocytes apoptosis and phosphoinositide 3-kinase (pi3k)/protein kinase b (akt)/glycogen synthase kinase-3β (gsk3β)/β-catenin pathway. |
2021-10-04 |
2023-08-13 |
mouse |
| Jiankun Cui, Bo Zhang, Min Gao, Baohai Liu, Cong Dai, Yumei Dong, FanJi Men. The Protective Effect of Tetrahydroxystilbene Glucoside on High Glucose-Induced Injury in Human Umbilical Vein Endothelial Cells through the PI3K/Akt/eNOS Pathway and Regulation of Bcl-2/Bax. Journal of vascular research. vol 58. issue 5. 2021-09-29. PMID:34218226. |
in addition, we found that tsg not only increased the expression of bcl-2, while decreasing bax expression, but also activated phosphorylation of akt and endothelial nitric oxide synthase (enos) with subsequent nitric oxide production and ultimately reduced high glucose-induced apoptosis. |
2021-09-29 |
2023-08-13 |
human |
| Julia C Gutjahr, Elisabeth Bayer, Xiaobing Yu, Julia M Laufer, Jan P Höpner, Suzana Tesanovic, Andrea Härzschel, Georg Auer, Tanja Rieß, Astrid Salmhofer, Eva Szenes, Theresa Haslauer, Valerie Durand-Onayli, Andrea Ramspacher, Sandra P Pennisi, Marc Artinger, Nadja Zaborsky, Alexandre Chigaev, Fritz Aberger, Daniel Neureiter, Lisa Pleyer, Daniel F Legler, Veronique Orian-Rousseau, Richard Greil, Tanja N Hartman. CD44 engagement enhances acute myeloid leukemia cell adhesion to the bone marrow microenvironment by increasing VLA-4 avidity. Haematologica. vol 106. issue 8. 2021-09-28. PMID:32616529. |
thereby vla-4/vcam-1 interaction promoted activation of akt, mapk, nf-kb and mtor signaling and decreased aml cell apoptosis. |
2021-09-28 |
2023-08-13 |
Not clear |
| Diba Borzabadi Farahani, Hassan Akrami, Behrouz Moradi, Kiumars Mehdizadeh, Mohammad Reza Fattah. The Effect of hsa-miR-451b Knockdown on Biological Functions of Gastric Cancer Stem-Like Cells. Biochemical genetics. vol 59. issue 5. 2021-09-28. PMID:33725258. |
first, gastric cancer stem-like cells were transfected by hsa-mir-451b inhibitor then we used real-time rt-pcr to evaluate its effect on the expression of hsa-mir-451b and two of its direct target genes, stemness markers such as klf4, sox2, cd44, oct3/4 and nanog genes and finally akt, pi3k, bcl-2, bax, casp3 and pcna genes involved in apoptosis. |
2021-09-28 |
2023-08-13 |
Not clear |
| Diba Borzabadi Farahani, Hassan Akrami, Behrouz Moradi, Kiumars Mehdizadeh, Mohammad Reza Fattah. The Effect of hsa-miR-451b Knockdown on Biological Functions of Gastric Cancer Stem-Like Cells. Biochemical genetics. vol 59. issue 5. 2021-09-28. PMID:33725258. |
even, under hsa-mir-451b inhibition, downregulation of akt, pi3k, bcl-2 and pcna as well as upregulation of bax and casp3 revealed a movement towards apoptosis in mkn-45 stem-like cells. |
2021-09-28 |
2023-08-13 |
Not clear |
| P Xie, J G Zhu, Y Liu, T W Liu, Y G Xu, D Q Gon. Effect of Akt activation on apoptosis-related gene expression in the crop tissues of male and female pigeons (Columba livia). Poultry science. vol 100. issue 10. 2021-09-28. PMID:34425554. |
the current study investigated whether the expression of apoptosis genes in the pigeon crops was affected by the akt signaling pathway during crop milk formation. |
2021-09-28 |
2023-08-13 |
chicken |
| P Xie, J G Zhu, Y Liu, T W Liu, Y G Xu, D Q Gon. Effect of Akt activation on apoptosis-related gene expression in the crop tissues of male and female pigeons (Columba livia). Poultry science. vol 100. issue 10. 2021-09-28. PMID:34425554. |
in conclusion, the expression of genes related to mitochondria-dependent apoptosis can be regulated by the akt signaling pathway, which may play a potential role in pigeon milk formation. |
2021-09-28 |
2023-08-13 |
chicken |
| Bernd Niemann, Ling Li, Andreas Simm, Nicole Molenda, Jens Kockskämper, Andreas Boening, Susanne Rohrbac. Caloric restriction reduces sympathetic activity similar to beta-blockers but conveys additional mitochondrio-protective effects in aged myocardium. Scientific reports. vol 11. issue 1. 2021-09-23. PMID:33479375. |
only cr reduced lv oxidative damage and apoptosis, induced ampk and akt phosphorylation and increased mitochondrial biogenesis. |
2021-09-23 |
2023-08-13 |
rat |
| Xianping Che, Jiangtao Zhan, Fan Zhao, Zunhe Zhong, Mianchuan Chen, Ruifa Han, Yi Wan. Oridonin Promotes Apoptosis and Restrains the Viability and Migration of Bladder Cancer by Impeding TRPM7 Expression via the ERK and AKT Signaling Pathways. BioMed research international. vol 2021. 2021-09-23. PMID:34285910. |
oridonin promotes apoptosis and restrains the viability and migration of bladder cancer by impeding trpm7 expression via the erk and akt signaling pathways. |
2021-09-23 |
2023-08-13 |
Not clear |