| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Hai-Feng Zhang, Xiang Gao, Xuan Wang, Xin Chen, Yu Huang, Lang Wang, Zhou-Wei X. The mechanisms of renin-angiotensin system in hepatocellular carcinoma: From the perspective of liver fibrosis, HCC cell proliferation, metastasis and angiogenesis, and corresponding protection measures. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 141. 2021-09-08. PMID:34328104. |
some important cytokines, such as tgf-β, pi3k, protein kinase b (akt), vegf and nf-κb, can regulate the growth, proliferation, diffusion, metastasis, and apoptosis of hcc cells by acting on the corresponding signaling pathways. |
2021-09-08 |
2023-08-13 |
Not clear |
| Blaz Lupse, Karthika Annamalai, Hazem Ibrahim, Supreet Kaur, Shirin Geravandi, Bhavishya Sarma, Anasua Pal, Sushil Awal, Arundhati Joshi, Sahar Rafizadeh, Murali Krishna Madduri, Mona Khazaei, Huan Liu, Ting Yuan, Wei He, Kanaka Durga Devi Gorrepati, Zahra Azizi, Qi Qi, Keqiang Ye, Jose Oberholzer, Kathrin Maedler, Amin Ardestan. Inhibition of PHLPP1/2 phosphatases rescues pancreatic β-cells in diabetes. Cell reports. vol 36. issue 5. 2021-09-08. PMID:34348155. |
phlpps directly dephosphorylate and regulate activities of β-cell survival-dependent kinases akt and mst1, constituting a regulatory triangle loop to control β-cell apoptosis. |
2021-09-08 |
2023-08-13 |
human |
| Young Mi Kim, Sung-Hwa Ko, Yong-Il Shin, Yeonye Kim, Taehyung Kim, Jaehoon Jung, Sang-Yull Lee, Nam Gyun Kim, Kyoung-Jun Park, Ji Hyeon Ry. Light-emitting diode irradiation induces AKT/mTOR-mediated apoptosis in human pancreatic cancer cells and xenograft mouse model. Journal of cellular physiology. vol 236. issue 2. 2021-09-07. PMID:32749680. |
herein, we demonstrated that blue led of 460 nm regulated pancreatic cancer cell proliferation and apoptosis by suppressing the expression of apoptosis-related factors, such as mutant p53 and b-cell lymphoma 2 (bcl-2), and decreasing the expression of rac-β serine/threonine kinase 2 (akt2), the phosphorylation of protein kinase b (akt), and mammalian target of rapamycin (mtor). |
2021-09-07 |
2023-08-13 |
mouse |
| Daniela Miricescu, Alexandra Totan, Iulia-Ioana Stanescu-Spinu, Silviu Constantin Badoiu, Constantin Stefani, Maria Greab. PI3K/AKT/mTOR Signaling Pathway in Breast Cancer: From Molecular Landscape to Clinical Aspects. International journal of molecular sciences. vol 22. issue 1. 2021-09-07. PMID:33375317. |
the phosphatidylinositol 3-kinase (pi3k)/protein kinase b (akt)/mammalian target of rapamycin (mtor) is a signaling pathway involved in cell proliferation, survival, invasion, migration, apoptosis, glucose metabolism and dna repair. |
2021-09-07 |
2023-08-13 |
human |
| Tao Song, Zhongxu Hu, Jie Liu, Wei Huan. FLOT2 upregulation promotes growth and invasion by interacting and stabilizing EphA2 in gliomas. Biochemical and biophysical research communications. vol 548. 2021-09-07. PMID:33631676. |
simultaneously, flot2 depletion suppressed akt and nf-κb activities, induced apoptosis, cell cycle arrest, and epithelial-mesenchymal transition (emt) inhibition, demonstrated by expression alterations of key proteins of the above processes. |
2021-09-07 |
2023-08-13 |
Not clear |
| José M Muñoz-Félix, Carlos Martínez-Salgad. Dissecting the Involvement of Ras GTPases in Kidney Fibrosis. Genes. vol 12. issue 6. 2021-09-07. PMID:34073961. |
in this review, we update the available in vitro and in vivo knowledge on the role of ras and its main effectors, such as erk and akt, in the cellular mechanisms that occur during the regulation of kidney fibrosis (ecm synthesis, accumulation and activation of myofibroblasts, apoptosis and survival of tubular epithelial cells), as well as the therapeutic strategies for targeting the ras pathway to intervene on the development of renal fibrosis. |
2021-09-07 |
2023-08-13 |
Not clear |
| Hsin-Yu Ho, Ping-Ju Chen, Yu-Sheng Lo, Chia-Chieh Lin, Yi-Ching Chuang, Ming-Ju Hsieh, Mu-Kuan Che. Luteolin-7-O-glucoside inhibits cell proliferation and modulates apoptosis through the AKT signaling pathway in human nasopharyngeal carcinoma. Environmental toxicology. vol 36. issue 10. 2021-09-06. PMID:34165247. |
luteolin-7-o-glucoside inhibits cell proliferation and modulates apoptosis through the akt signaling pathway in human nasopharyngeal carcinoma. |
2021-09-06 |
2023-08-13 |
human |
| HongFei Xiang, WeiLiang Su, XiaoLin Wu, WuJun Chen, WenBin Cong, Shuai Yang, Chang Liu, ChenSheng Qiu, Shang-You Yang, Yan Wang, GuoQing Zhang, Zhu Guo, DongMing Xing, BoHua Che. Exosomes Derived from Human Urine-Derived Stem Cells Inhibit Intervertebral Disc Degeneration by Ameliorating Endoplasmic Reticulum Stress. Oxidative medicine and cellular longevity. vol 2020. 2021-09-03. PMID:33488928. |
this study is aimed at determining the effects of human urine-derived stem cell-derived exosomes (uscs-exos) on pressure-induced nucleus pulposus cell (npc) apoptosis and intervertebral disc degeneration (idd) and on the erk and akt signaling pathways. |
2021-09-03 |
2023-08-13 |
human |
| Alba Sansa, Sandra de la Fuente, Joan X Comella, Ana Garcera, Rosa M Sole. Intracellular pathways involved in cell survival are deregulated in mouse and human spinal muscular atrophy motoneurons. Neurobiology of disease. vol 155. 2021-09-02. PMID:33845129. |
our observations suggest that apoptosis is activated in sma mns and that akt phosphorylation reduction may control cell degeneration, thereby regulating the transcription of smn and other genes related to smn function. |
2021-09-02 |
2023-08-13 |
mouse |
| Hong Ye, Ying Men. Honokiol regulates endoplasmic reticulum stress by promoting the activation of the sirtuin 1-mediated protein kinase B pathway and ameliorates high glucose/high fat-induced dysfunction in human umbilical vein endothelial cells. Endocrine journal. vol 68. issue 8. 2021-08-30. PMID:33952780. |
finally, the viability, apoptosis, and the contents of ros, mda, and sod, as well as the expressions of chop, grp78, p-perk, p-ire1α, cleaved caspase-3, akt, p-akt, and sirt1 in the cells transfected with small interfering rna sirt1 (sisirt1) were detected by the previously mentioned methods. |
2021-08-30 |
2023-08-13 |
human |
| Hong Ye, Ying Men. Honokiol regulates endoplasmic reticulum stress by promoting the activation of the sirtuin 1-mediated protein kinase B pathway and ameliorates high glucose/high fat-induced dysfunction in human umbilical vein endothelial cells. Endocrine journal. vol 68. issue 8. 2021-08-30. PMID:33952780. |
therefore, honokiol activates the akt pathway by regulating sirt1 expression to regulate endoplasmic reticulum stress, promotes cell viability and inhibits the apoptosis of hg/hf-induced huvecs. |
2021-08-30 |
2023-08-13 |
human |
| Min-Chun Chuang, Jr-Hau Lung, Yi-Chuan Chen, Yu-Ching Lin, Ya-Chin Li, Ming-Szu Hun. The Association of Annexin A1 and Chemosensitivity to Osimertinib in Lung Cancer Cells. Cancers. vol 13. issue 16. 2021-08-30. PMID:34439260. |
further study showed that the knockdown of anxa1 inhibited the phosphorylation of egfr and down-stream akt pathways and promoted apoptosis in lung cancer cells treated with osimertinib. |
2021-08-30 |
2023-08-13 |
mouse |
| Cong Li, Suling Hu, Yan Yu. Ultrasound Microbubble-Mediated VHL Regulates the Biological Behavior of Ovarian Cancer Cells. Ultrasound in medicine & biology. vol 47. issue 3. 2021-08-26. PMID:33261909. |
overexpression of liposome-mediated vhl inhibited the proliferation and migration; caused cell-cycle arrest; promoted apoptosis: downregulated the expressions of mmp2, mmp9, e-cadherin, akt and bcl-2; and upregulated the expressions of vhl and bcl2-associated x protein (bax) in ovcar-3 cells. |
2021-08-26 |
2023-08-13 |
Not clear |
| T L B G Lins, R S Barberino, A P O Monte, J G C Pinto, D S P Campinho, R C Palheta, M H T Mato. Rutin promotes activation and reduces apoptosis of primordial follicles by regulating Akt phosphorylation after in vitro culture of ovine ovarian tissue. Theriogenology. vol 173. 2021-08-26. PMID:34339905. |
rutin promotes activation and reduces apoptosis of primordial follicles by regulating akt phosphorylation after in vitro culture of ovine ovarian tissue. |
2021-08-26 |
2023-08-13 |
Not clear |
| Xian-Sheng Ye, Wen-Jing Tian, Mi Zhou, De-Quan Zeng, Ting Lin, Guang-Hui Wang, Xin-Sheng Yao, Hai-Feng Che. Prenylated flavonoids from Ficus hirta induces HeLa cells apoptosis via MAPK and AKT signaling pathways. Bioorganic & medicinal chemistry letters. vol 38. 2021-08-25. PMID:33609662. |
prenylated flavonoids from ficus hirta induces hela cells apoptosis via mapk and akt signaling pathways. |
2021-08-25 |
2023-08-13 |
Not clear |
| Monika E Grabowska, Bryan Chun, Raquel Moya, Jeffrey J Saucerma. Computational model of cardiomyocyte apoptosis identifies mechanisms of tyrosine kinase inhibitor-induced cardiotoxicity. Journal of molecular and cellular cardiology. vol 155. 2021-08-25. PMID:33667419. |
overexpression simulations identified akt, igf1, pdk1, and pi3k among the negative functional regulators of sorafenib-induced cardiomyocyte apoptosis. |
2021-08-25 |
2023-08-13 |
Not clear |
| Hui Chen, Su-Xiang Guo, Sai Zhang, Xiao-Dan Li, Hao Wang, Xiao-Wei L. MiRNA-620 promotes TGF-β1-induced proliferation of airway smooth muscle cell through controlling PTEN/AKT signaling pathway. The Kaohsiung journal of medical sciences. vol 36. issue 11. 2021-08-20. PMID:32583575. |
moreover, knocking down mir-620 alone efficiently reduced the phosphorylation of protein kinase b (akt), decreased tgf-β1-induced proliferation and promoted apoptosis in asmcs, whereas downregulation of pten in mir-620 inhibitor-transfected cells restored the activation of akt, increased tgf-β1-triggered proliferation, and partially inhibited asmc apoptosis. |
2021-08-20 |
2023-08-13 |
Not clear |
| Hui Chen, Su-Xiang Guo, Sai Zhang, Xiao-Dan Li, Hao Wang, Xiao-Wei L. MiRNA-620 promotes TGF-β1-induced proliferation of airway smooth muscle cell through controlling PTEN/AKT signaling pathway. The Kaohsiung journal of medical sciences. vol 36. issue 11. 2021-08-20. PMID:32583575. |
taken together, the present study provided evidence that mir-620 increased tgf-β1-mediated proliferation and suppressed apoptosis in asmcs via the regulation of pten and akt expression. |
2021-08-20 |
2023-08-13 |
Not clear |
| Chunying Wang, Shimeng Li, Jin Liu, Ming Cheng, Dewen Wang, Yuxin Wang, Bin L. Silencing of S-phase kinase-associated protein 2 enhances radiosensitivity of esophageal cancer cells through inhibition of PI3K/AKT signaling pathway. Genomics. vol 112. issue 5. 2021-08-17. PMID:32360515. |
skp2 silencing downregulated mrna and protein expression of pi3k, akt and bcl-2 but increased p27 protein expression, and inhibited the cell survival rate while promoting cell apoptosis. |
2021-08-17 |
2023-08-13 |
Not clear |
| Yuhui Liu, Chengjian Shi, Zheng He, Feng Zhu, Min Wang, Ruizhi He, Chunle Zhao, Xiuhui Shi, Min Zhou, Shutao Pan, Yang Gao, Xu Li, Renyi Qi. Inhibition of PI3K/AKT signaling via ROS regulation is involved in Rhein-induced apoptosis and enhancement of oxaliplatin sensitivity in pancreatic cancer cells. International journal of biological sciences. vol 17. issue 2. 2021-08-17. PMID:33613115. |
pre-treatment with the ros scavenger n-acetyl-l-cysteine attenuated the combined treatment-induced apoptosis and restored the level of phosphorylated akt, indicating that ros is an upstream regulator of the pi3k/akt pathway. |
2021-08-17 |
2023-08-13 |
Not clear |