| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Da Xie, Jin Li, Shufei Wei, Pan Qi, Hongxia Ji, Jianzhi Su, Nan Du, Xiaoyu Zhan. Knockdown of PLOD3 suppresses the malignant progression of renal cell carcinoma via reducing TWIST1 expression. Molecular and cellular probes. vol 53. 2021-07-14. PMID:32585183. |
in addition, twist1 overexpression rescued the repressions of cell proliferation, migration, invasion, emt and the activation of β-catenin and akt signaling in addition to apoptosis promotion induced by plod3 downregulation. |
2021-07-14 |
2023-08-13 |
Not clear |
| Natsumi Fujiwara, Gary M Whitford, John D Bartlett, Maiko Suzuk. Curcumin suppresses cell growth and attenuates fluoride-mediated Caspase-3 activation in ameloblast-like LS8 cells. Environmental pollution (Barking, Essex : 1987). vol 273. 2021-07-13. PMID:33486250. |
these results suggest that curcumin inhibited fluoride-mediated apoptosis via akt activation, but dna damage was suppressed by other pathways. |
2021-07-13 |
2023-08-13 |
Not clear |
| Natsumi Fujiwara, Gary M Whitford, John D Bartlett, Maiko Suzuk. Curcumin suppresses cell growth and attenuates fluoride-mediated Caspase-3 activation in ameloblast-like LS8 cells. Environmental pollution (Barking, Essex : 1987). vol 273. 2021-07-13. PMID:33486250. |
these results suggest that curcumin-induced ac-p53 and p21 led to cell cycle arrest, while curcumin attenuated fluoride-mediated apoptosis via activation of akt and suppressed fluoride-mediated dna damage. |
2021-07-13 |
2023-08-13 |
Not clear |
| Chieh-Hsin Wu, Yi-Cheng Tsai, Tai-Hsin Tsai, Keng-Liang Kuo, Yu-Feng Su, Chih-Hui Chang, Chih-Lung Li. Valproic Acid Reduces Vasospasm through Modulation of Akt Phosphorylation and Attenuates Neuronal Apoptosis in Subarachnoid Hemorrhage Rats. International journal of molecular sciences. vol 22. issue 11. 2021-07-13. PMID:34205883. |
valproic acid reduces vasospasm through modulation of akt phosphorylation and attenuates neuronal apoptosis in subarachnoid hemorrhage rats. |
2021-07-13 |
2023-08-13 |
rat |
| Huihui Zhang, Fanlin Li, Jiang Cao, Xin Wang, Hai Cheng, Kunming Qi, Gang Wang, Kailin Xu, Junnian Zheng, Yang-Xin Fu, Xuanming Yan. A chimeric antigen receptor with antigen-independent OX40 signaling mediates potent antitumor activity. Science translational medicine. vol 13. issue 578. 2021-07-12. PMID:33504651. |
ox40 signaling reduced car-t cell apoptosis through up-regulation of genes encoding bcl-2 family members and enhanced proliferation through increased activation of the nf-κb (nuclear factor κb), mapk (mitogen-activated protein kinase), and pi3k-akt (phosphoinositide 3-kinase to the kinase akt) pathways. |
2021-07-12 |
2023-08-13 |
mouse |
| Ningjuan Liang, Siwen Li, Yuehui Liang, Yu Ma, Sixuan Tang, Shuzi Ye, Fang Xia. Clusterin inhibits Cr(VI)-induced apoptosis via enhancing mitochondrial biogenesis through AKT-associated STAT3 activation in L02 hepatocytes. Ecotoxicology and environmental safety. vol 221. 2021-07-12. PMID:34175824. |
we used the stat3 inhibitor c188-9 and the akt inhibitor uprosertib to eliminate the anti-apoptotic effect of clu, and found that clu inhibited cr(vi)-induced apoptosis by up-regulating akt/stat3 signal. |
2021-07-12 |
2023-08-13 |
Not clear |
| Ningjuan Liang, Siwen Li, Yuehui Liang, Yu Ma, Sixuan Tang, Shuzi Ye, Fang Xia. Clusterin inhibits Cr(VI)-induced apoptosis via enhancing mitochondrial biogenesis through AKT-associated STAT3 activation in L02 hepatocytes. Ecotoxicology and environmental safety. vol 221. 2021-07-12. PMID:34175824. |
based on the fact that both akt and stat3 are closely related to mitochondrial biogenesis and mitochondrial pathway-associated apoptosis, this study is the first time to link clu, stat3, akt and mitochondrial biogenesis function after cr(vi) exposure, to further enrich the experimental basis of cr(vi)-induced hepatotoxicity, clarify the molecular mechanism of clu helping cells to escape apoptosis, and also suggest that new ways can be sought to prevent and treat cr(vi)-induced hepatotoxicity by regulating mitochondrial biosynthesis. |
2021-07-12 |
2023-08-13 |
Not clear |
| Lang Yang, Liuyi Fan, Kexin Wang, Yupeng Chen, Lan Liang, Xuemei Qin, Aiping Lu, Peng Cao, Bin Yu, Daogang Guan, Junxiang Pen. Analysis of Molecular Mechanism of Erxian Decoction in Treating Osteoporosis Based on Formula Optimization Model. Oxidative medicine and cellular longevity. vol 2021. 2021-07-10. PMID:34239693. |
functional pathway enrichment analysis showed that exd exerted therapeutic effects toward op by targeting pi3k-akt signaling (hsa04151), calcium signaling (hsa04020), apoptosis (hsa04210), estrogen signaling (hsa04915), and osteoclast differentiation (hsa04380) via jnk, akt, and erk. |
2021-07-10 |
2023-08-13 |
Not clear |
| Shujun Chen, Bo L. MiR-128-3p Post-Transcriptionally Inhibits WISP1 to Suppress Apoptosis and Inflammation in Human Articular Chondrocytes via the PI3K/AKT/NF-κB Signaling Pathway. Cell transplantation. vol 29. 2021-07-09. PMID:32830547. |
overexpression of wisp1 inhibited the proliferation of chondrocytes, which induced apoptosis, degradation of chondrocyte matrix, production of proinflammatory cytokines, and activated the phosphatidylinositol-3-kinase (pi3k)/protein kinase b (akt)/nuclear factor kappa-light-chain-enhancer of activated b cells (nf-κb) pathway. |
2021-07-09 |
2023-08-13 |
human |
| Xinyong Cai, Shu Wang, Lang Hong, Songping Yu, Bin Li, Hong Zeng, Xu Yang, Ping Zhang, Liang Sha. Inhibition of miR-322-5p Protects Cardiac Myoblast Cells Against Hypoxia-Induced Apoptosis and Injury Through Regulating CIAPIN1. Journal of cardiovascular pharmacology. vol 77. issue 2. 2021-07-09. PMID:33538533. |
in addition, mir-322-5p silencing could weaken injury and apoptosis in cardiac myoblast cells induced by hypoxia; meanwhile, inhibition of mir-322-5p activation of phosphatidylinositol-3 kinases (pi3k)/protein kinase b (akt) signal pathway. |
2021-07-09 |
2023-08-13 |
Not clear |
| X Y Shi, Z Q Guan, J N Yu, H L Li. Follicle Stimulating Hormone Inhibits the Expression of p53 Up-Regulated Modulator of Apoptosis Induced by Reactive Oxygen Species Through PI3K/Akt in Mouse Granulosa Cells. Physiological research. vol 69. issue 4. 2021-07-08. PMID:32584135. |
therefore, we examined whether fsh inhibits the expression of p53 up-regulated modulator of apoptosis (puma) induced by reactive oxygen species (ros) through phosphoinositide 3-kinase (pi3k) / protein kinase b (akt) in mouse gcs. |
2021-07-08 |
2023-08-13 |
mouse |
| Nahathai Dukaew, Kongthawat Chairatvit, Pornsiri Pitchakarn, Arisa Imsumran, Jirarat Karinchai, Wirote Tuntiwechapikul, Ariyaphong Wongnoppavic. Inactivation of AKT/NF‑κB signaling by eurycomalactone decreases human NSCLC cell viability and improves the chemosensitivity to cisplatin. Oncology reports. vol 44. issue 4. 2021-07-06. PMID:32945500. |
exposure to cisplatin alone induced the levels of phosphorylated‑akt and phosphorylated‑nf‑κb, whereas co‑treatment with ecl inhibited the cisplatin‑induced phosphorylation of akt and nf‑κb, leading to an increased sensitization effect on cisplatin‑induced apoptosis. |
2021-07-06 |
2023-08-13 |
human |
| Rongrong Zhang, Haiyan Zhu, Yufang Yuan, Yun Wang, Zhaofang Tia. SPAG6 promotes cell proliferation and inhibits apoptosis through the PTEN/PI3K/AKT pathway in Burkitt lymphoma. Oncology reports. vol 44. issue 5. 2021-07-06. PMID:33000212. |
it was further ascertained whether the phosphoinositide 3‑kinase (pi3k)/pten/protein kinase b (akt) pathway mediates the effects of spag6 on cell proliferation and apoptosis, and the results demonstrated that silencing of spag6 suppressed the viability of daudi and raji cells, whereas pten knockdown using sirna or sf1670 (a specific pten inhibitor) reversed the inhibitory effect on cell proliferation and the promoting effect on cell apoptosis induced by spag6 depletion in vitro as well as in vivo. |
2021-07-06 |
2023-08-13 |
Not clear |
| Tao Ren, Yi-Jun Tang, Mei-Fang Wang, Han-Sheng Wang, Yan Liu, Xin Qian, Chan Chang, Ming-Wei Che. Triptolide induces apoptosis through the calcium/calmodulin‑dependent protein kinase kinaseβ/AMP‑activated protein kinase signaling pathway in non‑small cell lung cancer cells. Oncology reports. vol 44. issue 5. 2021-07-06. PMID:33000264. |
in addition, triptolide was revealed to activate the calcium (ca2+)/calmodulin‑dependent protein kinase kinase β (camkkβ)/amp‑activated protein kinase (ampk) signaling pathway by regulating the intracellular ca2+ concentration levels, which increased the phosphorylation levels of ampk and reduced the phosphorylation levels of akt, ultimately leading to apoptosis. |
2021-07-06 |
2023-08-13 |
Not clear |
| Chaoqun Wu, Guangwen Shu, Huiqi Huang, Kejian Pang, Xinzhou Yang, Guangzhong Yan. Methylgerambullin derived from plant Glyccsmis pentaphylla (Retz) correa. Mediates anti-hepatocellular carcinoma cancer effect by activating mitochondrial and endoplasmic reticulum stress signaling and inhibiting AKT and STAT3 pathways. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. vol 149. 2021-07-06. PMID:33529679. |
overall, these results suggest that methylgerambullin can inhibit hcc cells proliferation by inducing mitochondrial apoptosis, activating ers signaling pathways and inhibiting the akt and stat3 pathways. |
2021-07-06 |
2023-08-13 |
mouse |
| Kai Yang, Jie Shen, Fu-Qing Tan, Xiang-Yi Zheng, Li-Ping Xi. Antitumor Activity of Small Activating RNAs Induced PAWR Gene Activation in Human Bladder Cancer Cells. International journal of medical sciences. vol 18. issue 13. 2021-07-06. PMID:34220332. |
promisingly, we found that up-regulation of pawr by sarna inhibited the growth of bladder cancer cells by inducing cell apoptosis and cell cycle arrest which was related to inhibition of anti‑apoptotic protein bcl-2 and inactivation of the nf-κb and akt pathways. |
2021-07-06 |
2023-08-13 |
human |
| Shadia Al-Bahlani, Ikram A Burney, Buthaina Al-Dhahli, Safiya Al-Kharusi, Fakhra Al-Kharousi, Amani Al-Kalbani, Ikhlas Ahme. Boswellic acid sensitizes gastric cancer cells to Cisplatin-induced apoptosis via p53-mediated pathway. BMC pharmacology & toxicology. vol 21. issue 1. 2021-07-02. PMID:32867831. |
cisplatin (cddp) is an effective anticancer drug for gastric cancer (gc) that induces apoptosis by altering pro- (p53) and anti-apoptotic (akt and nfkb) proteins; however, chemoresistance remains a big challenge. |
2021-07-02 |
2023-08-13 |
Not clear |
| Lin Chen, Dongqiong Xiao, Fajuan Tang, Hu Gao, Xihong L. CAPN6 in disease: An emerging therapeutic target (Review). International journal of molecular medicine. vol 46. issue 5. 2021-07-02. PMID:33000175. |
in recent years, various studies have found that capn6 is one of the contributing factors associated with the tumorigenesis of uterine tumors and osteosarcoma, and that capn6 participates in the development of tumors by promoting cell proliferation and angiogenesis, and by inhibiting apoptosis, which is mainly regulated by the phosphatidylinositol 3 kinase (pi3k)/protein kinase b (akt) pathway. |
2021-07-02 |
2023-08-13 |
Not clear |
| Yu Zheng, Jin-Tao Zeng, Xiang-Yu Wang, Hai-Xiao Huang, Liang-Xiang Huang, Chang-Qing Zen. Advanced oxidation protein products trigger apoptosis and block epithelial-to-mesenchymal transition in crypt epithelial cells. Experimental and therapeutic medicine. vol 22. issue 2. 2021-07-02. PMID:34194563. |
in conclusion, aopps trigger apoptosis and inhibit the emt of rat crypt epithelial cells, which may be associated with the inhibition of akt phosphorylation and the promotion of p65 phosphorylation. |
2021-07-02 |
2023-08-13 |
rat |
| Xin Zhang, Can Hu, Chun-Yan Kong, Peng Song, Hai-Ming Wu, Si-Chi Xu, Yu-Pei Yuan, Wei Deng, Zhen-Guo Ma, Qi-Zhu Tan. FNDC5 alleviates oxidative stress and cardiomyocyte apoptosis in doxorubicin-induced cardiotoxicity via activating AKT. Cell death and differentiation. vol 27. issue 2. 2021-07-01. PMID:31209361. |
fndc5 alleviates oxidative stress and cardiomyocyte apoptosis in doxorubicin-induced cardiotoxicity via activating akt. |
2021-07-01 |
2023-08-13 |
mouse |