| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Lola Buono, Simona Scalabrin, Marco De Iuliis, Adele Tanzi, Cristina Grange, Marta Tapparo, Raffaele Nuzzi, Benedetta Bussolat. Mesenchymal Stem Cell-Derived Extracellular Vesicles Protect Human Corneal Endothelial Cells from Endoplasmic Reticulum Stress-Mediated Apoptosis. International journal of molecular sciences. vol 22. issue 9. 2021-06-17. PMID:34066474. |
at variance, the effect of the serum evs was mainly limited to akt phosphorylation, with minimal or absent effects on endoplasmic reticulum stress modulation and apoptosis prevention. |
2021-06-17 |
2023-08-13 |
human |
| Shasha Yin, Liu Liu, Charles Brobbey, Viswanathan Palanisamy, Lauren E Ball, Shaun K Olsen, Michael C Ostrowski, Wenjian Ga. PRMT5-mediated arginine methylation activates AKT kinase to govern tumorigenesis. Nature communications. vol 12. issue 1. 2021-06-15. PMID:34103528. |
akt is involved in a number of key cellular processes including cell proliferation, apoptosis and metabolism. |
2021-06-15 |
2023-08-13 |
Not clear |
| Wenxin He, Xiankun Cao, Kewei Rong, Xiaojun Chen, Shuai Han, An Qi. Combination of AZD3463 and DZNep Prevents Bone Metastasis of Breast Cancer by Suppressing Akt Signaling. Frontiers in pharmacology. vol 12. 2021-06-15. PMID:34122074. |
previous studies reported that the anti-cancer agent dznep induces cancer cell apoptosis by activating akt signaling. |
2021-06-15 |
2023-08-13 |
Not clear |
| Jinting Wang, Tianwei Wu, Lan Ma, Ying Guo, Yali Huang, Linlin Zhen. Action of Akt Pathway on La-Induced Hippocampal Neuron Apoptosis of Rats in the Growth Stage. Neurotoxicity research. vol 38. issue 2. 2021-06-14. PMID:32385838. |
action of akt pathway on la-induced hippocampal neuron apoptosis of rats in the growth stage. |
2021-06-14 |
2023-08-13 |
rat |
| Muhammad M Hossain, Jason R Richardso. Nerve Growth Factor Protects Against Pyrethroid-Induced Endoplasmic Reticulum (ER) Stress in Primary Hippocampal Neurons. Toxicological sciences : an official journal of the Society of Toxicology. vol 174. issue 1. 2021-06-09. PMID:31841155. |
collectively, these results demonstrate that the loss of ngf following er stress may contribute to deltamethrin-induced apoptosis in the hippocampus through the akt signaling pathway, and that this may provide a plausible mechanism for impaired learning and memory observed following exposure of mice to deltamethrin. |
2021-06-09 |
2023-08-13 |
mouse |
| Liang Liu, Huan Geng, Chengjie Mei, Liaobin Che. Zoledronic Acid Enhanced the Antitumor Effect of Cisplatin on Orthotopic Osteosarcoma by ROS-PI3K/AKT Signaling and Attenuated Osteolysis. Oxidative medicine and cellular longevity. vol 2021. 2021-06-09. PMID:33859780. |
the results showed that in vitro, compared with the single treatment and control, the combination of za and cisplatin could significantly inhibit the activity and proliferation of 143b cells and induced their apoptosis and further promoted the generation of ros and inhibited the phosphorylation of pi3k and akt. |
2021-06-09 |
2023-08-13 |
mouse |
| Shweta Umar, Rina Soni, Sunil D Durgapal, Subhangi Soman, Suresh Balakrishna. A synthetic coumarin derivative (4-flourophenylacetamide-acetyl coumarin) impedes cell cycle at G0/G1 stage, induces apoptosis, and inhibits metastasis via ROS-mediated p53 and AKT signaling pathways in A549 cells. Journal of biochemical and molecular toxicology. vol 34. issue 10. 2021-06-08. PMID:32578917. |
a synthetic coumarin derivative (4-flourophenylacetamide-acetyl coumarin) impedes cell cycle at g0/g1 stage, induces apoptosis, and inhibits metastasis via ros-mediated p53 and akt signaling pathways in a549 cells. |
2021-06-08 |
2023-08-13 |
Not clear |
| Zhi-Lin Wu, Jacques Robert Jeppe Davis, Yi Zh. Dexmedetomidine Protects against Myocardial Ischemia/Reperfusion Injury by Ameliorating Oxidative Stress and Cell Apoptosis through the Trx1-Dependent Akt Pathway. BioMed research international. vol 2020. 2021-06-08. PMID:33299886. |
dexmedetomidine protects against myocardial ischemia/reperfusion injury by ameliorating oxidative stress and cell apoptosis through the trx1-dependent akt pathway. |
2021-06-08 |
2023-08-13 |
rat |
| Yigang Wang, Shijuan Xu, Lu Wang, Juanni Liu, Juan Wang, Jun Zho. Long noncoding RNA H19 promotes vincristine resistance in multiple myeloma by targeting Akt. Cellular and molecular biology (Noisy-le-Grand, France). vol 66. issue 6. 2021-06-07. PMID:33040789. |
lnc-rna h19 overexpression plasmid pcdna3.1-h19 and akt overexpression plasmid pcdna3.1-akt decreased apoptosis in rpmi 8226 cell lines without vcr resistance (***p<0.001), while the recombination of sirna-h19 and sirna-akt plasmid increased apoptosis in rpmi 8226-vcr (***p<0.001). |
2021-06-07 |
2023-08-13 |
Not clear |
| Duo Wang, Chang Liu, Huan Liu, Yilei Meng, Fang Lin, Yanqiong Gu, Hanrui Wang, Mengyue Shang, Chang Tong, Agapios Sachinidis, Qilong Ying, Li Li, Luying Pen. ERG1 plays an essential role in rat cardiomyocyte fate decision by mediating AKT signaling. Stem cells (Dayton, Ohio). vol 39. issue 4. 2021-06-07. PMID:33426760. |
activation of akt pathway promotes cardiomyocyte differentiation through two different mechanisms, (a) through phosphorylation of gsk3β to upregulate the expression levels of β-catenin and gata4; (b) through promotion of nuclear translocation of nuclear factor-κb by phosphorylating ikkβ to inhibit cell apoptosis, which occurs due to increased bcl2 expression. |
2021-06-07 |
2023-08-13 |
rat |
| Feng Bian, Yufeng Zhang, YuanLong Xie, Hongyu Fang, Mingyu Fan, Xin Wang, Hongliang Li, Tao Huang, Sheng Zhang, Lin Ca. Effects of different concentrations of metformin on osteoclast differentiation and apoptosis and its mechanism. Die Pharmazie. vol 76. issue 6. 2021-06-03. PMID:34078517. |
high concentration of metformin promoted osteoclast apoptosis and upregulated the expression of bax/bcl-2 and caspase-3; bv/tv, bs/tv, tb.n and bmd were increased while tp.sp decreased in the group of intraperitoneal metformin+femoral intramedullary osteoclast injection (met+oc) compared with the control group, 1 nm metformin downregulated akt, p44/42 mapk, jnk, p38 mapk phosphorylation, 5 nm metformin down regulated erk and akt phosphorylation. |
2021-06-03 |
2023-08-13 |
Not clear |
| Jian Wang, Xiean Ling, Min Zhou, Guanggui Ding, Bin Peng, Jun Wa. Thermal treatment decreases resistance to osimertinib in non-small cell lung cancer through the EGFR/PI3K/AKT pathway. Neoplasma. vol 68. issue 3. 2021-06-02. PMID:33724860. |
cell viability, apoptosis, sensitivity to osi, threonine-methionine amino acid substitution at position 790 (t790m) mutation levels, and protein expression of epidermal growth factor receptor (egfr), phosphatidylinositol 3-kinase (pi3k), protein kinase b (akt), hypoxia-inducible factor-1 alpha (hif-1a) were detected using different methods. |
2021-06-02 |
2023-08-13 |
mouse |
| Mingze Qin, Ye Tian, Xiao Han, Qi Cao, Shuaishuai Zheng, Chunyang Liu, Xia Wu, Lei Liu, Yangyang Meng, Xiaobo Wang, Haotian Zhang, Yunlei Ho. Structural modifications of indolinones bearing a pyrrole moiety and discovery of a multi-kinase inhibitor with potent antitumor activity. Bioorganic & medicinal chemistry. vol 28. issue 11. 2021-06-01. PMID:32305182. |
at the cellular level, compound 7h significantly attenuated phosphorylation of akt and erk proteins, potently inhibited colony formation of ht-29, mkn74, and hepg2 cancer cells, and induced cell apoptosis. |
2021-06-01 |
2023-08-13 |
human |
| Fangdong Guo, Xiaoyu Zhu, Qingquan Zhao, Qirong Huan. miR‑589‑3p sponged by the lncRNA TINCR inhibits the proliferation, migration and invasion and promotes the apoptosis of breast cancer cells by suppressing the Akt pathway via IGF1R. International journal of molecular medicine. vol 46. issue 3. 2021-06-01. PMID:32705168. |
mir‑589‑3p sponged by the lncrna tincr inhibits the proliferation, migration and invasion and promotes the apoptosis of breast cancer cells by suppressing the akt pathway via igf1r. |
2021-06-01 |
2023-08-13 |
Not clear |
| Zhao-Hui Yu, Yi-Chao Ji, Kun Li, Ting Liang, Bo Liu, Hai-Lei Chen, Li Ni, Zong-Ping Luo, Hui-Lin Yan. Stiffness of the extracellular matrix affects apoptosis of nucleus pulposus cells by regulating the cytoskeleton and activating the TRPV2 channel protein. Cellular signalling. vol 84. 2021-05-31. PMID:33862152. |
after trpv2 was specifically knocked out, the activation of the pi3k / akt signaling pathway decreased, and the release of cyt c and np apoptosis were reduced. |
2021-05-31 |
2023-08-13 |
Not clear |
| Neeraj Sood, Dev Kumar Verma, Anutosh Paria, Shrish Chandra Yadav, Manoj Kumar Yadav, Megha Kadam Bedekar, Saurav Kumar, Thangaraj Raja Swaminathan, Chadag Vishnumurthy Mohan, K V Rajendran, Pravata Kumar Pradha. Transcriptome analysis of liver elucidates key immune-related pathways in Nile tilapia Oreochromis niloticus following infection with tilapia lake virus. Fish & shellfish immunology. vol 111. 2021-05-25. PMID:33577877. |
however, upregulation of some of the key genes such as bcl2l1 in apoptosis pathway; nfkbia in nf-kb pathway; trfc in acute phase response; and socs, epor, pi3k and akt in jak-stat pathway and downregulation of the genes, namely map3k7 in mapk pathway; ifit1 in interferon; and trim25 in nf-kb pathway suggested that tilv was able to subvert the host immune response to successfully establish the infection. |
2021-05-25 |
2023-08-13 |
Not clear |
| Jisheng Wang, Binghao Bao, Junlong Feng, Qi Zhao, Hengheng Dai, Fanchao Meng, Sheng Deng, Bin Wang, Haisong L. Effects of Diabetes Mellitus on Sperm Quality in the Db/Db Mouse Model and the Role of the FoxO1 Pathway. Medical science monitor : international medical journal of experimental and clinical research. vol 27. 2021-05-24. PMID:33589581. |
conclusions this study demonstrated that dm inhibited the expression of pi3k, akt, and stat3 proteins and mrnas in the foxo1 pathway and promoted the expression of foxo1, fasl, and il-6 proteins and mrnas, leading to abnormal apoptosis of testicular tissue cells and functional damage, and eventually spermatogenic dysfunction. |
2021-05-24 |
2023-08-13 |
mouse |
| Yen-Tze Liu, Hsin-Yu Ho, Chia-Chieh Lin, Yi-Ching Chuang, Yu-Sheng Lo, Ming-Ju Hsieh, Mu-Kuan Che. Platyphyllenone Induces Autophagy and Apoptosis by Modulating the AKT and JNK Mitogen-Activated Protein Kinase Pathways in Oral Cancer Cells. International journal of molecular sciences. vol 22. issue 8. 2021-05-24. PMID:33921647. |
platyphyllenone induces autophagy and apoptosis by modulating the akt and jnk mitogen-activated protein kinase pathways in oral cancer cells. |
2021-05-24 |
2023-08-13 |
Not clear |
| Jang Mi Han, Hong Lae Kim, Hye Jin Jun. Ampelopsin Inhibits Cell Proliferation and Induces Apoptosis in HL60 and K562 Leukemia Cells by Downregulating AKT and NF-κB Signaling Pathways. International journal of molecular sciences. vol 22. issue 8. 2021-05-24. PMID:33924032. |
ampelopsin inhibits cell proliferation and induces apoptosis in hl60 and k562 leukemia cells by downregulating akt and nf-κb signaling pathways. |
2021-05-24 |
2023-08-13 |
Not clear |
| Yifeng Ni, Hao Zhang, Jing Zhang, Zhi Li, Zubing L. Inhibition of JAK2 by AG490 promotes TNF-α-induced apoptosis by inhibiting autophagy in MC3T3-E1 cells. Die Pharmazie. vol 75. issue 6. 2021-05-20. PMID:32539921. |
this study demonstrated for the first time that jak2 inhibition by ag490 may play a crucial role in tnf-α-induced apoptosis by inhibiting autophagy and inhibiting the stat3, akt, and erk signaling pathways. |
2021-05-20 |
2023-08-13 |
Not clear |