| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Boris Sabirzhanov, Alan I Faden, Taryn Aubrecht, Rebecca Henry, Ethan Glaser, Bogdan A Stoic. MicroRNA-711-Induced Downregulation of Angiopoietin-1 Mediates Neuronal Cell Death. Journal of neurotrauma. vol 35. issue 20. 2019-12-20. PMID:29774773. |
administration of mir-711 inhibitor elevates ang-1 after tbi whereas ang-1 administration increases akt activation; reduces puma, noxa, bim, and bax levels; and attenuates caspase-dependent and -independent neuronal apoptosis 24 h after tbi. |
2019-12-20 |
2023-08-13 |
mouse |
| Ying Li, Yilin Yang, Yunpeng Zhao, Jingmin Zhang, Baolin Liu, Shujie Jiao, Xiaojian Zhan. Astragaloside IV reduces neuronal apoptosis and parthanatos in ischemic injury by preserving mitochondrial hexokinase-II. Free radical biology & medicine. vol 131. 2019-12-20. PMID:30502455. |
aiv activated akt to promote hk-ii binding to mitochondria, and the structural and functional integrity of mitochondria contributed to protecting neurons from apoptosis and dna damage. |
2019-12-20 |
2023-08-13 |
mouse |
| Ekaterina S Ivanova, Victor V Tatarskiy, Margarita A Yastrebova, Alvina I Khamidullina, Alexei V Shunaev, Anastasia A Kalinina, Alexei A Zeifman, Fedor N Novikov, Yulia V Dutikova, Ghermes G Chilov, Alexander A Shti. PF‑114, a novel selective inhibitor of BCR‑ABL tyrosine kinase, is a potent inducer of apoptosis in chronic myelogenous leukemia cells. International journal of oncology. vol 55. issue 1. 2019-12-20. PMID:31115499. |
the molecular ordering of events mechanistically associated with k562 cell death included the dephosphorylation of crkl adaptor protein followed by inhibition of erk1/2 and akt, g1 arrest, a decrease of phosphorylated bcl‑2‑associated death promoter, bcl‑2‑like protein 11, bh3 interacting‑domain death agonist, bcl‑extra large and bcl‑2 family apoptosis regulator, and reduced mitochondrial transmembrane potential. |
2019-12-20 |
2023-08-13 |
Not clear |
| Haifang Zhang, Hui Li, Zhenguo Liu, Ang Ge, Enyu Guo, Shuxia Liu, Zhiping Che. Triptolide inhibits the proliferation and migration of medulloblastoma Daoy cells by upregulation of microRNA-138. Journal of cellular biochemistry. vol 119. issue 12. 2019-12-17. PMID:30156009. |
western blot analysis was used to analyze the expression of key factors involved in cell apoptosis, cell migration, the phosphatidylinositol 3-kinase (pi3k)/protein kinase 3 (akt) pathway, and the notch pathway in daoy cells. |
2019-12-17 |
2023-08-13 |
Not clear |
| Yitong Shen, Rui Bian, Yaxiong Li, Yuan Gao, Yingbin Liu, Yuzhen Xu, Xiaoling Song, Yijian Zhan. Liensinine induces gallbladder cancer apoptosis and G2/M arrest by inhibiting ZFX-induced PI3K/AKT pathway. Acta biochimica et biophysica Sinica. vol 51. issue 6. 2019-12-16. PMID:31074773. |
liensinine also affected gbc cell cycle progression and induced apoptosis by down-regulating phosphorylated protein kinase b (akt), phosphorylated protein kinase b (p-akt), phosphatidylinositol 3-kinase (pi3k), and zinc finger x-chromosomal protein (zfx) proteins. |
2019-12-16 |
2023-08-13 |
human |
| Dong-Mei Wu, Xiao-Wu Hong, Xin Wen, Xin-Rui Han, Shan Wang, Yong-Jian Wang, Min Shen, Shao-Hua Fan, Juan Zhuang, Zi-Feng Zhang, Qun Shan, Meng-Qiu Li, Bin Hu, Chun-Hui Sun, Jun Lu, Yuan-Lin Zhen. MCL1 gene silencing promotes senescence and apoptosis of glioma cells via inhibition of the PI3K/Akt signaling pathway. IUBMB life. vol 71. issue 1. 2019-12-13. PMID:30296359. |
therefore, the present study was conducted with aims of exploring the ability of mcl1 silencing to influence glioma cell senescence and apoptosis through the mediation of the phosphatidylinositol 3-kinase (pi3k)/protein kinase b (akt) signaling pathway. |
2019-12-13 |
2023-08-13 |
human |
| Joe A Arosh, Sakhila K Ban. Dual inhibition of ERK1/2 and AKT pathways is required to suppress the growth and survival of endometriotic cells and lesions. Molecular and cellular endocrinology. vol 484. 2019-12-13. PMID:30578826. |
objectives of the present study are to determine the dual inhibitory effects of erk1/2 and akt pathways: (i) on proliferation, survival, and apoptosis of human endometrioitc epithelial cells and stromal cells in vitro; (ii) on growth and survival of endometrioitc lesions in vivo in xenograft mouse model of endometriosis of human origin; and (iii) establish the associated erk1/2 and akt downstream intracellular signaling modules in the pathogenesis of endometriosis. |
2019-12-13 |
2023-08-13 |
mouse |
| Tamires Cunha Almeida, Camila Chaves Coelho Guerra, Bárbara Letícia Gonçalves De Assis, Rodrigo Dian de Oliveira Aguiar Soares, Camila Carriao Machado Garcia, Angélica Alves Lima, Glenda Nicioli da Silv. Antiproliferative and toxicogenomic effects of resveratrol in bladder cancer cells with different TP53 status. Environmental and molecular mutagenesis. vol 60. issue 8. 2019-12-12. PMID:31095781. |
cell proliferation, clonogenic survival, morphological changes, cell cycle progression, apoptosis rates, genotoxicity, global methylation, immunocytochemistry for p53 and pcna and relative expression profiles of the akt, mtor, rassf1a, hoxb3, src, plk1, and dnmt1 were evaluated. |
2019-12-12 |
2023-08-13 |
Not clear |
| Tamires Cunha Almeida, Camila Chaves Coelho Guerra, Bárbara Letícia Gonçalves De Assis, Rodrigo Dian de Oliveira Aguiar Soares, Camila Carriao Machado Garcia, Angélica Alves Lima, Glenda Nicioli da Silv. Antiproliferative and toxicogenomic effects of resveratrol in bladder cancer cells with different TP53 status. Environmental and molecular mutagenesis. vol 60. issue 8. 2019-12-12. PMID:31095781. |
increased rates of apoptosis were found in the tp53 wild type cells and this was accompanied by akt, mtor, and src downregulation. |
2019-12-12 |
2023-08-13 |
Not clear |
| Gar Yee Koh, Anne Kane, Kyongbum Lee, Qiaobing Xu, Xian Wu, Jatin Roper, Joel B Mason, Jimmy W Crot. Parabacteroides distasonis attenuates toll-like receptor 4 signaling and Akt activation and blocks colon tumor formation in high-fat diet-fed azoxymethane-treated mice. International journal of cancer. vol 143. issue 7. 2019-12-11. PMID:29696632. |
taken together, these data suggest that pd has anti-inflammatory and anti-cancer properties that are likely mediated by the suppression of tlr4 and akt signaling, as well as promotion of apoptosis. |
2019-12-11 |
2023-08-13 |
mouse |
| Hang-Hang Jiang, Yu-Jing Zhang, Yu-Zhe Sun, Rui-Qun Qi, Hong-Duo Chen, Xing-Hua Ga. Cell wall mannoprotein of Candida albicans polarizes macrophages and affects proliferation and apoptosis through activation of the Akt signal pathway. International immunopharmacology. vol 72. 2019-12-06. PMID:31005041. |
cell wall mannoprotein of candida albicans polarizes macrophages and affects proliferation and apoptosis through activation of the akt signal pathway. |
2019-12-06 |
2023-08-13 |
human |
| Hang-Hang Jiang, Yu-Jing Zhang, Yu-Zhe Sun, Rui-Qun Qi, Hong-Duo Chen, Xing-Hua Ga. Cell wall mannoprotein of Candida albicans polarizes macrophages and affects proliferation and apoptosis through activation of the Akt signal pathway. International immunopharmacology. vol 72. 2019-12-06. PMID:31005041. |
moreover, mannoprotein within the cell wall promoted cell proliferation and inhibited apoptosis by activation of the akt signaling pathway. |
2019-12-06 |
2023-08-13 |
human |
| Stephanie L Padula, Deepti Anand, Thanh V Hoang, Blake R Chaffee, Lin Liu, Chun Liang, Salil A Lachke, Michael L Robinso. High-throughput transcriptome analysis reveals that the loss of Pten activates a novel NKX6-1/RASGRP1 regulatory module to rescue microphthalmia caused by Fgfr2-deficient lenses. Human genetics. vol 138. issue 11-12. 2019-12-06. PMID:31691004. |
mouse lenses lacking fgfr2 exhibit microphakia and reduced erk and akt phosphorylation, widespread apoptosis, and defective lens fiber cell differentiation. |
2019-12-06 |
2023-08-13 |
mouse |
| Xiaoyu Chen, Danrui Cui, Yanli Bi, Jianfeng Shu, Xiufang Xiong, Yongchao Zha. AKT inhibitor MK-2206 sensitizes breast cancer cells to MLN4924, a first-in-class NEDD8-activating enzyme (NAE) inhibitor. Cell cycle (Georgetown, Tex.). vol 17. issue 16. 2019-12-03. PMID:30198810. |
our study provides the proof-of-concept evidence for strategic drug combination of mln4924 with an akt inhibitor for maximal killing of breast cancer cells via the enhancement of apoptosis. |
2019-12-03 |
2023-08-13 |
Not clear |
| Daqian Yang, Siyu Li, Li Gao, Zhanjun Lv, Qizheng Bing, Qingjie Lv, Xiaoyan Zheng, Ruobing Li, Zhigang Zhan. Dietary grape seed procyanidin extract protects against lead-induced heart injury in rats involving endoplasmic reticulum stress inhibition and AKT activation. The Journal of nutritional biochemistry. vol 62. 2019-11-28. PMID:30245182. |
meanwhile, gspe inhibited the protein kinase rna-like endoplasmic reticulum (er) kinase/eukaryotic initiation factor 2α signaling pathway, and promoted protein kinase b (akt) and glycogen synthase kinase 3β phosphorylation altered by lead, and regulated lead-activated apoptosis and its related signaling pathway. |
2019-11-28 |
2023-08-13 |
rat |
| Omana P Mathew, Kasturi Ranganna, Joseph Mathew, Meiling Zhu, Zivar Yousefipour, Chelliah Selvam, Shirlette G Milto. Cellular Effects of Butyrate on Vascular Smooth Muscle Cells are Mediated through Disparate Actions on Dual Targets, Histone Deacetylase (HDAC) Activity and PI3K/Akt Signaling Network. International journal of molecular sciences. vol 20. issue 12. 2019-11-27. PMID:31197106. |
along with previously reported ser9 phosphorylation-mediated gsk3 inactivation leading to stability, increased expression and accumulation of cyclin d1, and epigenetic histone modifications, inactivation of akt by butyrate results in: transcriptional activation of foxo1 and foxo3 promoting g1 arrest through p21cip1/waf1 and p15ink4b upregulation; inactivation of mtor inhibiting activation of its targets p70s6k and 4e-bp1 impeding protein synthesis; inhibition of caspase 3 cleavage and downregulation of parp preventing apoptosis. |
2019-11-27 |
2023-08-13 |
Not clear |
| Omana P Mathew, Kasturi Ranganna, Joseph Mathew, Meiling Zhu, Zivar Yousefipour, Chelliah Selvam, Shirlette G Milto. Cellular Effects of Butyrate on Vascular Smooth Muscle Cells are Mediated through Disparate Actions on Dual Targets, Histone Deacetylase (HDAC) Activity and PI3K/Akt Signaling Network. International journal of molecular sciences. vol 20. issue 12. 2019-11-27. PMID:31197106. |
our findings imply butyrate abrogates akt activation, causing differential effects on akt targets promoting convergence of cross-talk between their complimentary actions leading to vsmc growth by arresting proliferation and inhibiting apoptosis through its effect on dual targets, hdac activity and pi3k/akt pathway network. |
2019-11-27 |
2023-08-13 |
Not clear |
| Guangyan Yu, Chunhua Wang, Xiangfu Song, Shimeng Liu, Yixin Zhang, Lida Fan, Yixue Yang, Yulu Huang, Jiayi Son. Formaldehyde induces the apoptosis of BMCs of BALB/c mice via the PTEN/PI3K/Akt signal transduction pathway. Molecular medicine reports. vol 20. issue 1. 2019-11-26. PMID:31115571. |
phosphatase and tensin homologue deleted on chromosome 10 (pten) is a tumor‑suppressor gene and can negatively regulate the phosphoinositide 3‑kinase (pi3k)/protein kinase b (akt) signal transduction pathway, which is associated with cell proliferation, apoptosis and carcinogenesis. |
2019-11-26 |
2023-08-13 |
mouse |
| Guangyan Yu, Chunhua Wang, Xiangfu Song, Shimeng Liu, Yixin Zhang, Lida Fan, Yixue Yang, Yulu Huang, Jiayi Son. Formaldehyde induces the apoptosis of BMCs of BALB/c mice via the PTEN/PI3K/Akt signal transduction pathway. Molecular medicine reports. vol 20. issue 1. 2019-11-26. PMID:31115571. |
following treatment with fa for 24 h, cell viability, the cell cycle, apoptosis, and the expression of pten, pi3k and akt, as well as the protein expression of b‑cell lymphoma 2 (bcl‑2), bcl‑2‑associated x (bax), and caspases‑3 and ‑9 were examined. |
2019-11-26 |
2023-08-13 |
mouse |
| Yu-Jia Tan, Azhar Ali, Sheng-Yang Tee, Jun-Ting Teo, Yu Xi, Mei-Lin Go, Yulin La. Galloyl esters of trans-stilbenes are inhibitors of FASN with anticancer activity on non-small cell lung cancer cells. European journal of medicinal chemistry. vol 182. 2019-11-21. PMID:31422225. |
inhibition of fasn was accompanied by a loss in akt activation and profound apoptosis in several non-small cell lung cancer (nsclc) cells at the growth inhibitory concentrations of ec1 and ec5. |
2019-11-21 |
2023-08-13 |
Not clear |