| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Teresa Puig, Carlos Turrado, Bellinda Benhamú, Helena Aguilar, Joana Relat, Silvia Ortega-Gutiérrez, Gemma Casals, Pedro F Marrero, Ander Urruticoechea, Diego Haro, María Luz López-Rodríguez, Ramon Colome. Novel Inhibitors of Fatty Acid Synthase with Anticancer Activity. Clinical cancer research : an official journal of the American Association for Cancer Research. vol 15. issue 24. 2019-11-20. PMID:20008854. |
experimental design: we evaluated the in vitro effects of the compounds on breast cancer cell growth (sk-br3, mcf-7, and mda-mb-231), apoptosis [as assessed by cleavage of poly(adp-ribose) polymerase], cell signaling (her2, erk1/2, and akt), and fatty acid metabolism enzymes (fasn and cpt-1). |
2019-11-20 |
2023-08-12 |
mouse |
| Teresa Puig, Carlos Turrado, Bellinda Benhamú, Helena Aguilar, Joana Relat, Silvia Ortega-Gutiérrez, Gemma Casals, Pedro F Marrero, Ander Urruticoechea, Diego Haro, María Luz López-Rodríguez, Ramon Colome. Novel Inhibitors of Fatty Acid Synthase with Anticancer Activity. Clinical cancer research : an official journal of the American Association for Cancer Research. vol 15. issue 24. 2019-11-20. PMID:20008854. |
moreover, the compounds induced apoptosis and caused a marked decrease in the active forms of her2, akt, and erk1/2 proteins. |
2019-11-20 |
2023-08-12 |
mouse |
| To Ha Loi, Pei Dai, Stephen Carlin, Junia V Melo, David D F M. Pro-survival role of protein kinase C epsilon in Philadelphia chromosome positive acute leukemia. Leukemia & lymphoma. vol 57. issue 2. 2019-11-20. PMID:25904380. |
furthermore, the sirna-mediated knockdown or peptide inhibition of pkce in ph+ cells increased imatinib-induced apoptosis while overexpression of pkce reduced imatinib-induced apoptosis, with concomitant increase in the pro-survival factor akt. |
2019-11-20 |
2023-08-13 |
Not clear |
| Xiaoxin Jiang, Leping Zeng, Jufang Huang, Hui Zhou, Yubin Li. Arctigenin, a Natural Lignan Compound, Induces Apoptotic Death of Hepatocellular Carcinoma Cells via Suppression of PI3-K/Akt Signaling. Journal of biochemical and molecular toxicology. vol 29. issue 10. 2019-11-20. PMID:25920004. |
overexpression of a constitutively active akt mutant blocked arctigenin-induced apoptosis. |
2019-11-20 |
2023-08-13 |
human |
| Yang-An Wen, Xin Li, Tatiana Goretsky, Heidi L Weiss, Terrence A Barrett, Tianyan Ga. Loss of PHLPP protects against colitis by inhibiting intestinal epithelial cell apoptosis. Biochimica et biophysica acta. vol 1852. issue 10 Pt A. 2019-11-20. PMID:26187040. |
compared with wild-type mice, phlpp double knockout (dko) mice were protected from colitis induced by dss as demonstrated by lower histopathological scores, and this reduced susceptibility to colitis was associated with decreased apoptosis and increased akt activity in iecs in vivo. |
2019-11-20 |
2023-08-13 |
mouse |
| Yang-An Wen, Xin Li, Tatiana Goretsky, Heidi L Weiss, Terrence A Barrett, Tianyan Ga. Loss of PHLPP protects against colitis by inhibiting intestinal epithelial cell apoptosis. Biochimica et biophysica acta. vol 1852. issue 10 Pt A. 2019-11-20. PMID:26187040. |
in addition, epithelial organoids derived from phlpp dko mice were more resistant to inflammation-induced apoptosis while inhibition of akt activity abolished the protective effect of phlpp-loss. |
2019-11-20 |
2023-08-13 |
mouse |
| Jin-Hui Chen, Sen-Sen Lin, Wei-Xin Wang, Sheng-Tao Yuan, Ji-Sen Shi, Ai-Qun Ji. The extract, LXB-1, from the barks of Liriodendron × hybrid, induced apoptosis via Akt, JNK and ERK1/2 pathways in A549 lung cancer cells. Zeitschrift fur Naturforschung. C, Journal of biosciences. vol 70. issue 11-12. 2019-11-20. PMID:26618570. |
the extract, lxb-1, from the barks of liriodendron × hybrid, induced apoptosis via akt, jnk and erk1/2 pathways in a549 lung cancer cells. |
2019-11-20 |
2023-08-13 |
human |
| Jin-Hui Chen, Sen-Sen Lin, Wei-Xin Wang, Sheng-Tao Yuan, Ji-Sen Shi, Ai-Qun Ji. The extract, LXB-1, from the barks of Liriodendron × hybrid, induced apoptosis via Akt, JNK and ERK1/2 pathways in A549 lung cancer cells. Zeitschrift fur Naturforschung. C, Journal of biosciences. vol 70. issue 11-12. 2019-11-20. PMID:26618570. |
the potential mechanisms of lxb-1 inducing apoptosis - the expression and phosphorylation of erk, p38, jnk and akt - were investigated by western blot. |
2019-11-20 |
2023-08-13 |
human |
| Jin-Hui Chen, Sen-Sen Lin, Wei-Xin Wang, Sheng-Tao Yuan, Ji-Sen Shi, Ai-Qun Ji. The extract, LXB-1, from the barks of Liriodendron × hybrid, induced apoptosis via Akt, JNK and ERK1/2 pathways in A549 lung cancer cells. Zeitschrift fur Naturforschung. C, Journal of biosciences. vol 70. issue 11-12. 2019-11-20. PMID:26618570. |
these results suggest that that lxb-1 induced apoptosis through jnk, erk1/2, and akt pathways in a549 cells. |
2019-11-20 |
2023-08-13 |
human |
| Re: Takada Y, Sethi G, Sung B, and Aggarwal BB (2008) Flavopiridol suppresses tumor necrosis factor-induced activation of activator protein-1, c-Jun N-terminal kinase, p38 mitogen-activated protein kinase (MAPK), p44/p42 MAPK, and Akt, inhibits expression of antiapoptotic gene products, and enhances apoptosis through cytochrome c release and caspase activation in human myeloid cells Mol Pharmacol May 2008 73:1549-1557; doi:10.1124/mol.107.041350. Molecular pharmacology. vol 90. issue 1. 2019-11-20. PMID:27301881. |
re: takada y, sethi g, sung b, and aggarwal bb (2008) flavopiridol suppresses tumor necrosis factor-induced activation of activator protein-1, c-jun n-terminal kinase, p38 mitogen-activated protein kinase (mapk), p44/p42 mapk, and akt, inhibits expression of antiapoptotic gene products, and enhances apoptosis through cytochrome c release and caspase activation in human myeloid cells mol pharmacol may 2008 73:1549-1557; doi:10.1124/mol.107.041350. |
2019-11-20 |
2023-08-13 |
human |
| Kang Fang, Shih-Ping Chen, Chia-Wei Lin, Wan-Chun Cheng, Hwei-Tien Huan. Retraction to "Ellipticine-induced apoptosis depends on Akt translocation and signaling in lung epithelial cancer cells". Lung cancer (Amsterdam, Netherlands). vol 100. 2019-11-20. PMID:27597291. |
retraction to "ellipticine-induced apoptosis depends on akt translocation and signaling in lung epithelial cancer cells". |
2019-11-20 |
2023-08-13 |
Not clear |
| Ling Wang, Delun Huang, Zongliang Jiang, Yan Luo, Carol Norris, Ming Zhang, Xiuchun Tian, Young Tan. Akt3 is responsible for the survival and proliferation of embryonic stem cells. Biology open. vol 6. issue 6. 2019-11-20. PMID:28483982. |
using mouse embryonic stem cells (escs), we show that direct inhibition of akt activity leads to esc apoptosis. |
2019-11-20 |
2023-08-13 |
mouse |
| Richard L Carpenter, Sherona Sirkisoon, Dongqin Zhu, Tadas Rimkus, Alexandria Harrison, Ashley Anderson, Ivy Paw, Shadi Qasem, Fei Xing, Yin Liu, Michael Chan, Linda Metheny-Barlow, Boris C Pasche, Waldemar Debinski, Kounosuke Watabe, Hui-Wen L. Combined inhibition of AKT and HSF1 suppresses breast cancer stem cells and tumor growth. Oncotarget. vol 8. issue 43. 2019-11-20. PMID:29088759. |
using an orthotopic xenograft mouse model, we found that combined targeting of akt and hsf1 to significantly reduce tumor growth, induce tumor apoptosis, delay time to metastasis, and prolong host survival. |
2019-11-20 |
2023-08-13 |
mouse |
| Su Ji Jo, Pil-Gu Park, Hye-Ran Cha, Sung Gwe Ahn, Min Jung Kim, Hyemi Kim, Ja Seung Koo, Joon Jeong, Jeon Han Park, Seung Myung Dong, Jae Myun Le. Cellular inhibitor of apoptosis protein 2 promotes the epithelial-mesenchymal transition in triple-negative breast cancer cells through activation of the AKT signaling pathway. Oncotarget. vol 8. issue 45. 2019-11-20. PMID:29108265. |
cellular inhibitor of apoptosis protein 2 promotes the epithelial-mesenchymal transition in triple-negative breast cancer cells through activation of the akt signaling pathway. |
2019-11-20 |
2023-08-13 |
Not clear |
| Hang Zhou, Wei Luo, Chao Zeng, Yu Zhang, Liyang Wang, Wenxiu Yao, Chunlai Ni. PP2A mediates apoptosis or autophagic cell death in multiple myeloma cell lines. Oncotarget. vol 8. issue 46. 2019-11-20. PMID:29113343. |
this association inactivates akt to initiate apoptosis. |
2019-11-20 |
2023-08-13 |
Not clear |
| Hang Zhou, Wei Luo, Chao Zeng, Yu Zhang, Liyang Wang, Wenxiu Yao, Chunlai Ni. PP2A mediates apoptosis or autophagic cell death in multiple myeloma cell lines. Oncotarget. vol 8. issue 46. 2019-11-20. PMID:29113343. |
overexpression of bcl-2 attenuates the mitochondrial apoptosis pathway, resulting in caspase-3 inactivation and the dissociation of pp2a and akt. |
2019-11-20 |
2023-08-13 |
Not clear |
| Chen Zhu, Yi Wang, Hua Liu, Haiman Mu, Yue Lu, Jiayi Zhang, Jianhua Huan. Oral administration of Ginsenoside Rg1 prevents cardiac toxicity induced by doxorubicin in mice through anti-apoptosis. Oncotarget. vol 8. issue 48. 2019-11-20. PMID:29137383. |
the underlying mechanisms include increased phosphorylation of akt and erk by rg1, increased ratio of bcl-2 and bax, and decreased release of cytochrome c from mitochondria, thereby protecting the heart from doxorubicin-induced apoptosis. |
2019-11-20 |
2023-08-13 |
mouse |
| Ho Hyun Nam, Dae Won Jun, Kiseok Jang, Waqar Khalid Saeed, Jai Sun Lee, Hyeon Tae Kang, Yeon Ji Cha. Granulocyte colony stimulating factor treatment in non-alcoholic fatty liver disease: beyond marrow cell mobilization. Oncotarget. vol 8. issue 58. 2019-11-20. PMID:29228666. |
not only high dose g-csf (once daily for 5 days) but also hepatotropic dose g-csf (twice a week) significantly reduced hepatocyte apoptosis via pi3k and akt pathway activation without marrow cell mobilization in nafld animal model. |
2019-11-20 |
2023-08-13 |
Not clear |
| Guangming Tang, Huiyun Yang, Jing Chen, Mengrao Shi, Lingqing Ge, Xuhua Ge, Guoji Zh. Metformin ameliorates sepsis-induced brain injury by inhibiting apoptosis, oxidative stress and neuroinflammation via the PI3K/Akt signaling pathway. Oncotarget. vol 8. issue 58. 2019-11-20. PMID:29228667. |
metformin also reduced the neuronal apoptosis induced by sepsis and increased the phosphorylation of akt. |
2019-11-20 |
2023-08-13 |
mouse |
| Jiahui Du, Peng Yang, Fanhua Kong, Haiyan Li. Aberrant expression of translationally controlled tumor protein (TCTP) can lead to radioactive susceptibility and chemosensitivity in lung cancer cells. Oncotarget. vol 8. issue 60. 2019-11-20. PMID:29254214. |
tctp and p53 formed a feedback signal pathway and through it to regulate the downstream akt signal pathways to make the lung cancer cells keep a higher metabolism level and protect cancer cells from apoptosis induced by outside stress. |
2019-11-20 |
2023-08-13 |
Not clear |