| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Kevin C Es. The neurobiology of tuberous sclerosis complex. Seminars in pediatric neurology. vol 13. issue 1. 2006-09-05. PMID:16818174. |
tuberous sclerosis complex (tsc) is a multiorgan genetic disease caused by inactivation of either the tsc1 or tsc2 genes. |
2006-09-05 |
2023-08-12 |
Not clear |
| Chih-Ping Chen, Yi-Ning Su, Chia-Cheng Hung, Jin-Chung Shih, Wayseen Wan. Novel mutation in the TSC2 gene associated with prenatally diagnosed cardiac rhabdomyomas and cerebral tuberous sclerosis. Journal of the Formosan Medical Association = Taiwan yi zhi. vol 105. issue 7. 2006-08-23. PMID:16877242. |
novel mutation in the tsc2 gene associated with prenatally diagnosed cardiac rhabdomyomas and cerebral tuberous sclerosis. |
2006-08-23 |
2023-08-12 |
Not clear |
| Chih-Ping Chen, Yi-Ning Su, Chia-Cheng Hung, Jin-Chung Shih, Wayseen Wan. Novel mutation in the TSC2 gene associated with prenatally diagnosed cardiac rhabdomyomas and cerebral tuberous sclerosis. Journal of the Formosan Medical Association = Taiwan yi zhi. vol 105. issue 7. 2006-08-23. PMID:16877242. |
these findings support an association between a tsc2 de novo nonsense mutation and prenatally detected cardiac rhabdomyomas and cerebral tuberous sclerosis. |
2006-08-23 |
2023-08-12 |
Not clear |
| Chih-Ping Chen, Yi-Ning Su, Chia-Cheng Hung, Jin-Chung Shih, Wayseen Wan. Novel mutation in the TSC2 gene associated with prenatally diagnosed cardiac rhabdomyomas and cerebral tuberous sclerosis. Journal of the Formosan Medical Association = Taiwan yi zhi. vol 105. issue 7. 2006-08-23. PMID:16877242. |
familial molecular analysis of tsc1 and tsc2 in cases with prenatally diagnosed cardiac rhabdomyomas and cerebral tuberous sclerosis lesions is helpful in prenatal diagnosis and genetic counseling. |
2006-08-23 |
2023-08-12 |
Not clear |
| Julio C Valencia, Gustavo Pacheco-Rodriguez, Adriana K Carmona, Janina Xavier, Patrick Bruneval, William K Riemenschneider, Yoshihiko Ikeda, Zu-Xi Yu, Victor J Ferrans, Joel Mos. Tissue-specific renin-angiotensin system in pulmonary lymphangioleiomyomatosis. American journal of respiratory cell and molecular biology. vol 35. issue 1. 2006-08-08. PMID:16474096. |
lam cells contain mutations in the tuberous sclerosis complex tsc1 and/or tsc2 genes, which lead to dysregulation of the mammalian target of rapamycin, affecting cell growth and proliferation. |
2006-08-08 |
2023-08-12 |
Not clear |
| Victoria A Robb, Aristotelis Astrinidis, Elizabeth P Hensk. Frequent [corrected] hyperphosphorylation of ribosomal protein S6 [corrected] in lymphangioleiomyomatosis-associated angiomyolipomas. Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc. vol 19. issue 6. 2006-08-08. PMID:16575396. |
lymphangioleiomyomatosis can occur either independently of other disease or in association with tuberous sclerosis complex, a tumor-suppressor gene syndrome caused by mutations that inactivate either tsc1 or tsc2. |
2006-08-08 |
2023-08-12 |
Not clear |
| Xiuyun Jiang, Raymond S Yeun. Regulation of microtubule-dependent protein transport by the TSC2/mammalian target of rapamycin pathway. Cancer research. vol 66. issue 10. 2006-07-18. PMID:16707451. |
recent studies have identified tsc1 and tsc2, two tumor suppressor genes involved in tuberous sclerosis complex, as regulators of the mammalian target of rapamycin (mtor) pathway. |
2006-07-18 |
2023-08-12 |
Not clear |
| Aristotelis Astrinidis, William Senapedis, Elizabeth P Hensk. Hamartin, the tuberous sclerosis complex 1 gene product, interacts with polo-like kinase 1 in a phosphorylation-dependent manner. Human molecular genetics. vol 15. issue 2. 2006-07-12. PMID:16339216. |
tuberous sclerosis complex (tsc) is a tumor suppressor gene syndrome caused by mutations in tsc1 and tsc2. |
2006-07-12 |
2023-08-12 |
mouse |
| Lisa A Devlin, C H Shepherd, H Crawford, P J Morriso. Tuberous sclerosis complex: clinical features, diagnosis, and prevalence within Northern Ireland. Developmental medicine and child neurology. vol 48. issue 6. 2006-07-06. PMID:16700943. |
tuberous sclerosis complex (tsc) is an autosomal dominant disorder caused by mutations in the tsc1 and tsc2 genes on chromosomes 9 and 16 respectively. |
2006-07-06 |
2023-08-12 |
Not clear |
| Qian Yang, Ken Inoki, Eunjung Kim, Kun-Liang Gua. TSC1/TSC2 and Rheb have different effects on TORC1 and TORC2 activity. Proceedings of the National Academy of Sciences of the United States of America. vol 103. issue 18. 2006-07-05. PMID:16627617. |
furthermore, tuberous sclerosis complex 1 (tsc1) and tsc2, which are negative regulators of rheb, have negative and positive effects on torc1 and -2, respectively. |
2006-07-05 |
2023-08-12 |
human |
| Nanna D Rendtorff, Bolette Bjerregaard, Morten Frödin, Susanne Kjaergaard, Hanne Hove, Flemming Skovby, Karen Brøndum-Nielsen, Marianne Schwart. Analysis of 65 tuberous sclerosis complex (TSC) patients by TSC2 DGGE, TSC1/TSC2 MLPA, and TSC1 long-range PCR sequencing, and report of 28 novel mutations. Human mutation. vol 26. issue 4. 2006-06-19. PMID:16114042. |
analysis of 65 tuberous sclerosis complex (tsc) patients by tsc2 dgge, tsc1/tsc2 mlpa, and tsc1 long-range pcr sequencing, and report of 28 novel mutations. |
2006-06-19 |
2023-08-12 |
Not clear |
| Eileen Connolly, Steve Braunstein, Silvia Formenti, Robert J Schneide. Hypoxia inhibits protein synthesis through a 4E-BP1 and elongation factor 2 kinase pathway controlled by mTOR and uncoupled in breast cancer cells. Molecular and cellular biology. vol 26. issue 10. 2006-06-09. PMID:16648488. |
in transformed breast epithelial cells under hypoxia, the mtor and s6 kinases are constitutively activated and the mtor negative regulator tuberous sclerosis complex 2 (tsc2) protein fails to function. |
2006-06-09 |
2023-08-12 |
Not clear |
| David J Kwiatkowski, Brendan D Mannin. Tuberous sclerosis: a GAP at the crossroads of multiple signaling pathways. Human molecular genetics. vol 14 Spec No. 2. 2006-05-23. PMID:16244323. |
tuberous sclerosis complex (tsc) is an autosomal dominant disorder that is characterized by benign tumors (hamartomas and hamartias) involving multiple organ systems, due to inactivating mutations in tsc1 or tsc2. |
2006-05-23 |
2023-08-12 |
drosophila_melanogaster |
| Xiaobo Zhou, Jinmin Zhu, Kuang-Yu Liu, Bernardo L Sabatini, Stephen T C Won. Mutual information-based feature selection in studying perturbation of dendritic structure caused by TSC2 inactivation. Neuroinformatics. vol 4. issue 1. 2006-05-22. PMID:16595860. |
in this study, the effect of protein tuberous sclerosis 2 (tsc2) on the dendritic spine density and length was demonstrated by using tsc2-rnainactivation. |
2006-05-22 |
2023-08-12 |
rat |
| Christian von der Brelie, Robert Waltereit, Lian Zhang, Heinz Beck, Timo Kirschstei. Impaired synaptic plasticity in a rat model of tuberous sclerosis. The European journal of neuroscience. vol 23. issue 3. 2006-05-09. PMID:16487150. |
tuberous sclerosis complex (tsc) is a common hereditary disorder caused by mutations in either the tsc1 or tsc2 genes, and characterized by severe epilepsy, cerebral hamartomas and mental retardation. |
2006-05-09 |
2023-08-12 |
rat |
| Todd McCall, Steven S Chin, Karen L Salzman, Daniel W Fult. Tuberous sclerosis: a syndrome of incomplete tumor suppression. Neurosurgical focus. vol 20. issue 1. 2006-05-02. PMID:16459993. |
tuberous sclerosis is caused by loss-of-function mutations in one of two genes, tsc1 or tsc2. |
2006-05-02 |
2023-08-12 |
Not clear |
| Hong Liu, Derek C Radisky, Celeste M Nelson, Hui Zhang, Jimmie E Fata, Richard A Roth, Mina J Bissel. Mechanism of Akt1 inhibition of breast cancer cell invasion reveals a protumorigenic role for TSC2. Proceedings of the National Academy of Sciences of the United States of America. vol 103. issue 11. 2006-04-25. PMID:16537497. |
here we show that overexpression of activated myr-akt1 in human breast cancer cells phosphorylates and thereby targets the tumor suppressor tuberous sclerosis complex 2 (tsc2) for degradation, leading to reduced rho-gtpase activity, decreased actin stress fibers and focal adhesions, and reduced motility and invasion. |
2006-04-25 |
2023-08-12 |
human |
| Christopher T Cassett. Tuberous sclerosis complex (Bourneville disease). Dermatology online journal. vol 10. issue 3. 2006-04-10. PMID:15748587. |
tuberous sclerosis is a hamartomatous disease with defects in either hamartin (tsc1) or tuberin (tsc2) that can be of autosomal dominant inheritance or spontaneous mutation. |
2006-04-10 |
2023-08-12 |
Not clear |
| M A Weber, R A Risdon, M Malone, P G Duffy, N J Sebir. Isolated unilateral tuberous sclerosis-associated renal cystic disease in a neonate. Fetal and pediatric pathology. vol 24. issue 4-5. 2006-03-14. PMID:16396832. |
the major genes involved in tuberous sclerosis are now well described, and early onset of severe renal cystic disease in affected children often is related to the presence of a contiguous gene deletion syndrome involving tsc2 and pkd1 on chromosome 16. |
2006-03-14 |
2023-08-12 |
Not clear |
| Shaowei Li, Fumiko Takeuchi, Ji-an Wang, Christopher Fuller, Gustavo Pacheco-Rodriguez, Joel Moss, Thomas N Darlin. MCP-1 overexpressed in tuberous sclerosis lesions acts as a paracrine factor for tumor development. The Journal of experimental medicine. vol 202. issue 5. 2006-02-27. PMID:16129702. |
patients with tuberous sclerosis complex (tsc) develop hamartomatous tumors showing loss of function of the tumor suppressor tsc1 (hamartin) or tsc2 (tuberin) and increased angiogenesis, fibrosis, and abundant mononuclear phagocytes. |
2006-02-27 |
2023-08-12 |
human |