| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ya-Chieh Hsu, Joshua J Chern, Yi Cai, Mingyao Liu, Kwang-Wook Cho. Drosophila TCTP is essential for growth and proliferation through regulation of dRheb GTPase. Nature. vol 445. issue 7129. 2007-03-07. PMID:17301792. |
tuberous sclerosis (tsc) is a benign tumour syndrome caused by mutations in either tsc1 or tsc2 tumour suppressor genes. |
2007-03-07 |
2023-08-12 |
human |
| Detlef Boehm, Janina Bacher, Hartmut P H Neuman. Gross genomic rearrangement involving the TSC2-PKD1 contiguous deletion syndrome: characterization of the deletion event by quantitative polymerase chain reaction deletion assay. American journal of kidney diseases : the official journal of the National Kidney Foundation. vol 49. issue 1. 2007-02-20. PMID:17185137. |
tuberous sclerosis complex (tsc) was instrumented for identification of the gene causing autosomal dominant polycystic kidney disease type 1 (pkd1) because a patient showing both diseases gave rise to the suggestion that the tsc2 gene is located in close vicinity on chromosome 16p13. |
2007-02-20 |
2023-08-12 |
Not clear |
| Leif W Ellise. Growth control under stress: mTOR regulation through the REDD1-TSC pathway. Cell cycle (Georgetown, Tex.). vol 4. issue 11. 2007-02-12. PMID:16258273. |
the tuberous sclerosis tumor suppressors tsc1 and tsc2 form a protein complex that integrates and transmits cellular growth factor and stress signals to negatively regulate tor activity. |
2007-02-12 |
2023-08-12 |
human |
| Boyi Gan, Youngdong Yoo, Jun-Lin Gua. Association of focal adhesion kinase with tuberous sclerosis complex 2 in the regulation of s6 kinase activation and cell growth. The Journal of biological chemistry. vol 281. issue 49. 2007-01-25. PMID:17043358. |
tuberous sclerosis complex 1 (tsc1) and tsc2 tumor suppressor proteins have been shown to negatively regulate cell growth through inhibition of the mammalian target of rapamycin (mtor) pathway. |
2007-01-25 |
2023-08-12 |
Not clear |
| An C Jansen, Ozgur Sancak, Maria Daniela D'Agostino, AmanPreet Badhwar, Penelope Roberts, Gabriella Gobbi, Ralph Wilkinson, Denis Melanson, Donatella Tampieri, Robert Koenekoop, Mark Gans, Anneke Maat-Kievit, Miriam Goedbloed, Ans M W van den Ouweland, Mark Nellist, Massimo Pandolfo, Mary McQueen, Katherine Sims, Elisabeth A Thiele, François Dubeau, Frederick Andermann, David J Kwiatkowski, Dicky J J Halley, Eva Anderman. Unusually mild tuberous sclerosis phenotype is associated with TSC2 R905Q mutation. Annals of neurology. vol 60. issue 5. 2007-01-18. PMID:17120248. |
unusually mild tuberous sclerosis phenotype is associated with tsc2 r905q mutation. |
2007-01-18 |
2023-08-12 |
Not clear |
| An C Jansen, Ozgur Sancak, Maria Daniela D'Agostino, AmanPreet Badhwar, Penelope Roberts, Gabriella Gobbi, Ralph Wilkinson, Denis Melanson, Donatella Tampieri, Robert Koenekoop, Mark Gans, Anneke Maat-Kievit, Miriam Goedbloed, Ans M W van den Ouweland, Mark Nellist, Massimo Pandolfo, Mary McQueen, Katherine Sims, Elisabeth A Thiele, François Dubeau, Frederick Andermann, David J Kwiatkowski, Dicky J J Halley, Eva Anderman. Unusually mild tuberous sclerosis phenotype is associated with TSC2 R905Q mutation. Annals of neurology. vol 60. issue 5. 2007-01-18. PMID:17120248. |
to report the clinical manifestations and functional aspects of tuberous sclerosis complex (tsc), resulting from codon 905 mutations in tsc2 gene. |
2007-01-18 |
2023-08-12 |
Not clear |
| J Lawrence Merritt, Dawn Marie R Davis, Mark R Pittelkow, Dusica Babovic-Vuksanovi. Extensive acrochordons and pancreatic islet-cell tumors in tuberous sclerosis associated with TSC2 mutations. American journal of medical genetics. Part A. vol 140. issue 15. 2007-01-16. PMID:16835931. |
extensive acrochordons and pancreatic islet-cell tumors in tuberous sclerosis associated with tsc2 mutations. |
2007-01-16 |
2023-08-12 |
Not clear |
| Brian York, Dingyuan Lou, Daniel J Noona. Tuberin nuclear localization can be regulated by phosphorylation of its carboxyl terminus. Molecular cancer research : MCR. vol 4. issue 11. 2007-01-09. PMID:17114346. |
tuberin, the tuberous sclerosis 2 (tsc2) gene product, has been identified as a tumor suppressor protein genetically implicated in the pathology of tuberous sclerosis and the female-specific lung disease lymphangioleiomyomatosis. |
2007-01-09 |
2023-08-12 |
Not clear |
| S K Rakowski, E B Winterkorn, E Paul, D J R Steele, E F Halpern, E A Thiel. Renal manifestations of tuberous sclerosis complex: Incidence, prognosis, and predictive factors. Kidney international. vol 70. issue 10. 2007-01-08. PMID:17003820. |
we conducted a retrospective review of the clinical and radiographic records of 167 patients with tuberous sclerosis to determine the frequency of renal disease, the likelihood of significant renal morbidity, and the effects of genotype (tsc1 vs tsc2) and gender on renal phenotype. |
2007-01-08 |
2023-08-12 |
Not clear |
| Jaroslaw Jozwiak, Pawel Wlodarsk. Hamartin and tuberin modulate gene transcription via beta-catenin. Journal of neuro-oncology. vol 79. issue 3. 2007-01-04. PMID:16552619. |
studies on tuberous sclerosis allowed identification of two tumor suppressor genes, tsc1 and tsc2, encoding proteins implicated in the disease: hamartin and tuberin, respectively. |
2007-01-04 |
2023-08-12 |
Not clear |
| Ken Inoki, Hongjiao Ouyang, Tianqing Zhu, Charlotta Lindvall, Yian Wang, Xiaojie Zhang, Qian Yang, Christina Bennett, Yuko Harada, Kryn Stankunas, Cun-Yu Wang, Xi He, Ormond A MacDougald, Ming You, Bart O Williams, Kun-Liang Gua. TSC2 integrates Wnt and energy signals via a coordinated phosphorylation by AMPK and GSK3 to regulate cell growth. Cell. vol 126. issue 5. 2006-11-29. PMID:16959574. |
mutation in the tsc2 tumor suppressor causes tuberous sclerosis complex, a disease characterized by hamartoma formation in multiple tissues. |
2006-11-29 |
2023-08-12 |
Not clear |
| Cristina Malagelada, Elizabeth J Ryu, Subhas C Biswas, Vernice Jackson-Lewis, Lloyd A Green. RTP801 is elevated in Parkinson brain substantia nigral neurons and mediates death in cellular models of Parkinson's disease by a mechanism involving mammalian target of rapamycin inactivation. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 26. issue 39. 2006-11-27. PMID:17005863. |
the mechanism by which 6-ohda and rtp801 induce neuron death appears to involve repression of mammalian target of rapamycin (mtor) kinase activity, and such death is inhibited by shrnas targeting tsc2 (tuberous sclerosis complex), a protein with which rtp801 interacts to block mtor activation. |
2006-11-27 |
2023-08-12 |
Not clear |
| Michelangelo La Placa, Davide Gibellini, Tommaso Bianchi, Annalisa Patriz. Overexpression of MLH-1 and psoriasin genes in cutaneous angiofibromas from tuberous sclerosis complex patients. Journal of cutaneous pathology. vol 33. issue 9. 2006-11-14. PMID:16965334. |
tuberous sclerosis complex (tsc) is associated with mutations in two likely tumor-suppressor genes (tsc1 and tsc2) and characterized by the development of tumor-like growths (angiofibromas) in a variety of tissues and organs, particularly brain and skin. |
2006-11-14 |
2023-08-12 |
Not clear |
| A Freilinger, M Rosner, G Krupitza, M Nishino, G Lubec, S J Korsmeyer, M Hengstschläge. Tuberin activates the proapoptotic molecule BAD. Oncogene. vol 25. issue 49. 2006-11-09. PMID:16702951. |
tsc1, encoding hamartin, and tsc2, encoding tuberin, are tumor suppressor genes responsible for the autosomal dominantly inherited disease tuberous sclerosis (tsc). |
2006-11-09 |
2023-08-12 |
human |
| Edward W Arvisais, Angela Romanelli, Xiaoying Hou, John S Davi. AKT-independent phosphorylation of TSC2 and activation of mTOR and ribosomal protein S6 kinase signaling by prostaglandin F2alpha. The Journal of biological chemistry. vol 281. issue 37. 2006-10-31. PMID:16816403. |
treatment with pgf2alpha did not increase akt phosphorylation but increased the phosphorylation of erk and the tumor suppressor protein tuberous sclerosis complex 2 (tsc2), an upstream regulator of mtor. |
2006-10-31 |
2023-08-12 |
Not clear |
| Sourav Ghosh, Vinay Tergaonkar, Carla V Rothlin, Ricardo G Correa, Virginie Bottero, Pradeep Bist, Inder M Verma, Tony Hunte. Essential role of tuberous sclerosis genes TSC1 and TSC2 in NF-kappaB activation and cell survival. Cancer cell. vol 10. issue 3. 2006-10-24. PMID:16959613. |
essential role of tuberous sclerosis genes tsc1 and tsc2 in nf-kappab activation and cell survival. |
2006-10-24 |
2023-08-12 |
Not clear |
| Sergiusz Jóźwiak, Katarzyna Kotulska, Jolanta Kasprzyk-Obara, Dorota Domańska-Pakieła, Małgorzata Tomyn-Drabik, Penelope Roberts, David Kwiatkowsk. Clinical and genotype studies of cardiac tumors in 154 patients with tuberous sclerosis complex. Pediatrics. vol 118. issue 4. 2006-10-11. PMID:16940165. |
our aim for this study was to characterize the incidence, progression, and clinical consequences of tuberous sclerosis complex-associated rhabdomyomas in a large cohort of patients with tsc1 and tsc2 genotypes. |
2006-10-11 |
2023-08-12 |
Not clear |
| Virginia Won. Study of the relationship between tuberous sclerosis complex and autistic disorder. Journal of child neurology. vol 21. issue 3. 2006-09-26. PMID:16901420. |
future studies should be directed toward looking at the various behavioral phenotypes in tuberous sclerosis complex and defining these with standardized criteria to look for any real association with the underlying genetic mutation of tsc1 or tsc2 gene or even the site of tubers in the brain. |
2006-09-26 |
2023-08-12 |
Not clear |
| Ji-Eun Choi, Jong-Hee Chae, Yong-Seung Hwang, Ki-Joong Ki. Mutational analysis of TSC1 and TSC2 in Korean patients with tuberous sclerosis complex. Brain & development. vol 28. issue 7. 2006-09-19. PMID:16554133. |
mutational analysis of tsc1 and tsc2 in korean patients with tuberous sclerosis complex. |
2006-09-19 |
2023-08-12 |
Not clear |
| Yukiko Nakase, Keiko Fukuda, Yuji Chikashige, Chihiro Tsutsumi, Daisuke Morita, Shinpei Kawamoto, Mari Ohnuki, Yasushi Hiraoka, Tomohiro Matsumot. A defect in protein farnesylation suppresses a loss of Schizosaccharomyces pombe tsc2+, a homolog of the human gene predisposing to tuberous sclerosis complex. Genetics. vol 173. issue 2. 2006-09-08. PMID:16624901. |
mutations in the human tsc1 and tsc2 genes predispose to tuberous sclerosis complex (tsc), a disorder characterized by the wide spread of benign tumors. |
2006-09-08 |
2023-08-12 |
human |