| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Volker Schick, Michael Majores, Gudrun Engels, Sylvia Spitoni, Arend Koch, Christian E Elger, Matthias Simon, Christiane Knobbe, Ingmar Blümcke, Albert J Becke. Activation of Akt independent of PTEN and CTMP tumor-suppressor gene mutations in epilepsy-associated Taylor-type focal cortical dysplasias. Acta neuropathologica. vol 112. issue 6. 2007-09-12. PMID:17013611. |
due to their highly differentiated, malformative nature and glioneuronal phenotype, fcd(iib) share neuropathological characteristics with lesions observed in familial disorders such as cortical tubers present in patients with autosomal dominant tuberous sclerosis complex (tsc), related to mutations in the tsc1 or tsc2 genes, and dysplastic gangliocytomas of the cerebellum found in cowden disease. |
2007-09-12 |
2023-08-12 |
Not clear |
| Li Ma, Julie Teruya-Feldstein, Pauline Bonner, Rosa Bernardi, David Neal Franz, David Witte, Carlos Cordon-Cardo, Pier Paolo Pandolf. Identification of S664 TSC2 phosphorylation as a marker for extracellular signal-regulated kinase mediated mTOR activation in tuberous sclerosis and human cancer. Cancer research. vol 67. issue 15. 2007-09-11. PMID:17671177. |
identification of s664 tsc2 phosphorylation as a marker for extracellular signal-regulated kinase mediated mtor activation in tuberous sclerosis and human cancer. |
2007-09-11 |
2023-08-12 |
human |
| Benoit Bilanges, Rhoda Argonza-Barrett, Marina Kolesnichenko, Christina Skinner, Manoj Nair, Michelle Chen, David Stoko. Tuberous sclerosis complex proteins 1 and 2 control serum-dependent translation in a TOP-dependent and -independent manner. Molecular and cellular biology. vol 27. issue 16. 2007-09-06. PMID:17562867. |
the tuberous sclerosis complex (tsc) proteins tsc1 and tsc2 regulate protein translation by inhibiting the serine/threonine kinase mtorc1 (for mammalian target of rapamycin complex 1). |
2007-09-06 |
2023-08-12 |
mouse |
| Piotr Kozlowski, Penelope Roberts, Sandra Dabora, David Franz, John Bissler, Hope Northrup, Kit Sing Au, Ross Lazarus, Dorota Domanska-Pakiela, Katarzyna Kotulska, Sergiusz Jozwiak, David J Kwiatkowsk. Identification of 54 large deletions/duplications in TSC1 and TSC2 using MLPA, and genotype-phenotype correlations. Human genetics. vol 121. issue 3-4. 2007-07-10. PMID:17287951. |
tuberous sclerosis (tsc) is an autosomal dominant disorder caused by mutations in either of two genes, tsc1 and tsc2. |
2007-07-10 |
2023-08-12 |
Not clear |
| Gregory L Holmes, Carl E Stafstro. Tuberous sclerosis complex and epilepsy: recent developments and future challenges. Epilepsia. vol 48. issue 4. 2007-07-06. PMID:17386056. |
tuberous sclerosis complex (tsc) is a congenital syndrome characterized by the widespread development of benign tumors in multiple organs, caused by mutations in one of the tumor suppressor genes, tsc1 or tsc2. |
2007-07-06 |
2023-08-12 |
Not clear |
| Lynsey Meikle, Delia M Talos, Hiroaki Onda, Kristen Pollizzi, Alexander Rotenberg, Mustafa Sahin, Frances E Jensen, David J Kwiatkowsk. A mouse model of tuberous sclerosis: neuronal loss of Tsc1 causes dysplastic and ectopic neurons, reduced myelination, seizure activity, and limited survival. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 27. issue 21. 2007-06-22. PMID:17522300. |
tuberous sclerosis (tsc) is a hamartoma syndrome caused by mutations in tsc1 or tsc2 in which cerebral cortical tubers and seizures are major clinical issues. |
2007-06-22 |
2023-08-12 |
mouse |
| Jaroslaw Jozwiak, Katarzyna Kotulska, Wieslawa Grajkowska, Sergiusz Jozwiak, Wojciech Zalewski, Monika Oldak, Magdalena Lojek, Kamila Rainko, Radosław Maksym, Maciej Lazarczyk, Piotr Skopinski, Pawel Wlodarsk. Upregulation of the WNT pathway in tuberous sclerosis-associated subependymal giant cell astrocytomas. Brain & development. vol 29. issue 5. 2007-06-20. PMID:17071037. |
tuberous sclerosis (ts), autosomal dominant disorder manifested by the formation of usually benign tumors in the brain, heart, kidneys and skin, results from an inactivating mutation in one of two tumor suppressor genes tsc1 or tsc2. |
2007-06-20 |
2023-08-12 |
Not clear |
| Xiaoming Ju, Sanjay Katiyar, Chenguang Wang, Manran Liu, Xuanmao Jiao, Shengwen Li, Jie Zhou, Jacob Turner, Michael P Lisanti, Robert G Russell, Susette C Mueller, John Ojeifo, William S Chen, Nissim Hay, Richard G Pestel. Akt1 governs breast cancer progression in vivo. Proceedings of the National Academy of Sciences of the United States of America. vol 104. issue 18. 2007-06-20. PMID:17460049. |
akt1 deficiency delayed tumor growth and reduced lung metastases, correlating with a reduction in phosphorylation of the akt1 target, tuberous sclerosis 2 (tsc2) at ser-939. |
2007-06-20 |
2023-08-12 |
mouse |
| Kerstin Stemmer, Heidrun Ellinger-Ziegelbauer, Hans-Juergen Ahr, Daniel R Dietric. Carcinogen-specific gene expression profiles in short-term treated Eker and wild-type rats indicative of pathways involved in renal tumorigenesis. Cancer research. vol 67. issue 9. 2007-06-18. PMID:17483316. |
eker rats heterozygous for a dominant germline mutation in the tuberous sclerosis 2 (tsc2) tumor suppressor gene were used as a model to study renal carcinogenesis. |
2007-06-18 |
2023-08-12 |
rat |
| Vera P Krymskay. Targeting the phosphatidylinositol 3-kinase pathway in airway smooth muscle: rationale and promise. BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy. vol 21. issue 2. 2007-06-12. PMID:17402792. |
however, recent discovery of the tumor suppressor proteins tuberous sclerosis complex 1 (tsc1) and tsc2, also known as hamartin and tuberin, as downstream effectors of pi3k and upstream regulators of the mammalian target of rapamycin (mtor) and s6 kinase 1(s6k1) shed a new light on the pi3k signaling cascade in regulating cell growth and proliferation. |
2007-06-12 |
2023-08-12 |
Not clear |
| V Schick, M Majores, J Fassunke, G Engels, M Simon, C E Elger, A J Becke. Mutational and expression analysis of CDK1, cyclinA2 and cyclinB1 in epilepsy-associated glioneuronal lesions. Neuropathology and applied neurobiology. vol 33. issue 2. 2007-05-16. PMID:17359356. |
recent data suggest several components of the insulin-pathway, including tsc1 and tsc2 mutated in tuberous sclerosis complex (tsc), to be altered in gangliogliomas and fcd with taylor type balloon cells (fcd(iib)). |
2007-05-16 |
2023-08-12 |
Not clear |
| Sheng-Li Cai, Cheryl Lyn Walke. TSC2, a key player in tumor suppression and cystic kidney disease. Nephrologie & therapeutique. vol 2 Suppl 2. 2007-05-14. PMID:17373211. |
dramatic advances over the past decade have established the tuberous sclerosis complex 2 tumor suppressor gene (tsc2) as a key player in signal transduction pathways involved in the development of cancer. |
2007-05-14 |
2023-08-12 |
Not clear |
| Sheng-Li Cai, Cheryl Lyn Walke. TSC2, a key player in tumor suppression and cystic kidney disease. Nephrologie & therapeutique. vol 2 Suppl 2. 2007-05-14. PMID:17373211. |
importantly, the discovery of the functional link between tsc2 and the polycystic kidney disease 1 gene (pkd1) is beginning to build a foundation for understanding the heritable diseases associated with defects in each of these genes, namely, tuberous sclerosis complex and polycystic kidney disease. |
2007-05-14 |
2023-08-12 |
Not clear |
| Hongbing Zhang, Natalia Bajraszewski, Erxi Wu, Hongwei Wang, Annie P Moseman, Sandra L Dabora, James D Griffin, David J Kwiatkowsk. PDGFRs are critical for PI3K/Akt activation and negatively regulated by mTOR. The Journal of clinical investigation. vol 117. issue 3. 2007-05-04. PMID:17290308. |
inactivating mutations of either the tsc1 or the tsc2 tumor-suppressor genes cause tuberous sclerosis complex (tsc), a benign tumor syndrome in which there is both hyperactivation of mtor and inhibition of rtk/pi3k/akt signaling, partially due to reduced pdgfr expression. |
2007-05-04 |
2023-08-12 |
mouse |
| Emilie Vander Haar, Seong-Il Lee, Sricharan Bandhakavi, Timothy J Griffin, Do-Hyung Ki. Insulin signalling to mTOR mediated by the Akt/PKB substrate PRAS40. Nature cell biology. vol 9. issue 3. 2007-04-24. PMID:17277771. |
it was reported that akt activates mtor by phosphorylation and inhibition of tuberous sclerosis complex 2 (tsc2). |
2007-04-24 |
2023-08-12 |
Not clear |
| Masashi Mizuguch. Abnormal giant cells in the cerebral lesions of tuberous sclerosis complex. Congenital anomalies. vol 47. issue 1. 2007-04-20. PMID:17300684. |
tuberous sclerosis complex (tsc) is an autosomal dominant disorder caused by mutations of either of the two tumor suppressor genes, tsc1 and tsc2, encoding hamartin and tuberin, respectively. |
2007-04-20 |
2023-08-12 |
human |
| Omar Hernandez, Sharon Way, James McKenna, Michael J Gambell. Generation of a conditional disruption of the Tsc2 gene. Genesis (New York, N.Y. : 2000). vol 45. issue 2. 2007-04-18. PMID:17245776. |
tuberous sclerosis complex (tsc) is an autosomal dominant disorder caused by mutations in the tsc1 or tsc2 gene. |
2007-04-18 |
2023-08-12 |
mouse |
| T Culty, V Molinie, T Lebret, L Savareux, M Souid, M Delahousse, H Bott. TSC2/PKD1 contiguous gene syndrome in an adult. Minerva urologica e nefrologica = The Italian journal of urology and nephrology. vol 58. issue 4. 2007-04-18. PMID:17268401. |
the clinical and pathological presentation is consistent with the diagnosis of tsc2/pkd1 contiguous gene syndrome, caused by the simultaneous loss of tsc2 and pkd1, the two major genes for tuberous sclerosis complex and adpkd. |
2007-04-18 |
2023-08-12 |
Not clear |
| Ryosuke Watanabe, Yukihiro Tambe, Hirokazu Inoue, Takahiro Isono, Masataka Haneda, Ken-Ichi Isobe, Toshiyuki Kobayashi, Okio Hino, Hidetoshi Okabe, Tokuhiro Chan. GADD34 inhibits mammalian target of rapamycin signaling via tuberous sclerosis complex and controls cell survival under bioenergetic stress. International journal of molecular medicine. vol 19. issue 3. 2007-03-16. PMID:17273797. |
during conditions of cell stress, gadd34 forms a stable complex with tuberous sclerosis complex (tsc) 1/2, causes tsc2 dephosphorylation, and inhibits signaling by mammalian target of the rapamycin (mtor). |
2007-03-16 |
2023-08-12 |
Not clear |
| X Y Zhao, S Yang, H L Zhou, Y G Zhu, L Wei, W H Du, Y Q Ren, Y H Liang, Y X Hou, J J Chen, X J Zhan. Two novel TSC2 mutations in Chinese patients with tuberous sclerosis complex and a literature review of 20 patients reported in China. The British journal of dermatology. vol 155. issue 5. 2007-03-15. PMID:17034546. |
two novel tsc2 mutations in chinese patients with tuberous sclerosis complex and a literature review of 20 patients reported in china. |
2007-03-15 |
2023-08-12 |
Not clear |