| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Elena A Goncharova, Dmitry A Goncharov, Amelia Chisolm, Matthew S Spaits, Poay N Lim, Gregory Cesarone, Irene Khavin, Omar Tliba, Yassine Amrani, Reynold A Panettieri, Vera P Krymskay. Interferon beta augments tuberous sclerosis complex 2 (TSC2)-dependent inhibition of TSC2-null ELT3 and human lymphangioleiomyomatosis-derived cell proliferation. Molecular pharmacology. vol 73. issue 3. 2008-04-07. PMID:18094073. |
interferon beta augments tuberous sclerosis complex 2 (tsc2)-dependent inhibition of tsc2-null elt3 and human lymphangioleiomyomatosis-derived cell proliferation. |
2008-04-07 |
2023-08-12 |
human |
| Elena A Goncharova, Dmitry A Goncharov, Amelia Chisolm, Matthew S Spaits, Poay N Lim, Gregory Cesarone, Irene Khavin, Omar Tliba, Yassine Amrani, Reynold A Panettieri, Vera P Krymskay. Interferon beta augments tuberous sclerosis complex 2 (TSC2)-dependent inhibition of TSC2-null ELT3 and human lymphangioleiomyomatosis-derived cell proliferation. Molecular pharmacology. vol 73. issue 3. 2008-04-07. PMID:18094073. |
mutational inactivation of tumor suppressor tuberous sclerosis complex 2 (tsc2) in lam constitutively activates the mammalian target of rapamycin (mtor)/p70 s6 kinase 1 (s6k1) signaling pathway and promotes neoplastic growth of lam cells. |
2008-04-07 |
2023-08-12 |
human |
| Cheng-Da Yuan, Xiao-Li Chang, Min Gao, Feng-Li Xiao, Yao-Qun Wu, Qin Liu, Song-Ke Shen, Jun-Lin Liu, Wen-Hui Du, Jian-Jun Liu, Sen Yang, Xue-Jun Zhang, Fu-Sheng Zhou, Qiao-Yun Fan. A novel mutation (insTCCG) in the TSC2 gene in a Chinese patient with tuberous sclerosis complex. Journal of dermatological science. vol 49. issue 1. 2008-03-19. PMID:17888633. |
a novel mutation (instccg) in the tsc2 gene in a chinese patient with tuberous sclerosis complex. |
2008-03-19 |
2023-08-12 |
Not clear |
| Vera P Krymskay. Smooth muscle-like cells in pulmonary lymphangioleiomyomatosis. Proceedings of the American Thoracic Society. vol 5. issue 1. 2008-03-07. PMID:18094094. |
pathogenetically, lam occurs from somatic or genetic mutations of tumor suppressor genes tuberous sclerosis complex 1 (tsc1) or tsc2. |
2008-03-07 |
2023-08-12 |
Not clear |
| Agus Suryawan, Renan A Orellana, Hanh V Nguyen, Asumthia S Jeyapalan, Jillian R Fleming, Teresa A Davi. Activation by insulin and amino acids of signaling components leading to translation initiation in skeletal muscle of neonatal pigs is developmentally regulated. American journal of physiology. Endocrinology and metabolism. vol 293. issue 6. 2008-02-25. PMID:17878222. |
ins, but not aa, increased the phosphorylation of protein kinase b (pkb) and tuberous sclerosis 2 (tsc2). |
2008-02-25 |
2023-08-12 |
Not clear |
| Z-X Xu, J Liang, V Haridas, A Gaikwad, F P Connolly, G B Mills, J U Gutterma. A plant triterpenoid, avicin D, induces autophagy by activation of AMP-activated protein kinase. Cell death and differentiation. vol 14. issue 11. 2008-01-22. PMID:17690712. |
furthermore, avicin d-induced autophagic cell death can be abrogated by knockdown of tuberous sclerosis complex 2 (tsc2), a key mediator linking ampk to mtor inhibition, suggesting that ampk activation is a crucial event targeted by avicin d. these findings indicate the therapeutic potential of avicins by triggering autophagic cell death. |
2008-01-22 |
2023-08-12 |
Not clear |
| Michael J Ravitz, Li Chen, Mary Lynch, Emmett V Schmid. c-myc Repression of TSC2 contributes to control of translation initiation and Myc-induced transformation. Cancer research. vol 67. issue 23. 2008-01-22. PMID:18056446. |
among mtor signaling components, myc directly affected transcription of tuberous sclerosis 2 (tsc2), as shown by quantitative mrna analysis and by myc binding to its promoter in chromatin immunoprecipitation assays. |
2008-01-22 |
2023-08-12 |
Not clear |
| Jaroslaw Jozwiak, Sergiusz Jozwiak, Pawel Wlodarsk. Possible mechanisms of disease development in tuberous sclerosis. The Lancet. Oncology. vol 9. issue 1. 2008-01-17. PMID:18177819. |
hamartomas in patients with tuberous sclerosis usually fit into this model, the first hit is a congenital lesion of either of the tuberous sclerosis genes (tsc1 or tsc2), and the second hit is loss of heterozygosity of this gene. |
2008-01-17 |
2023-08-12 |
Not clear |
| Quanri Jin, Lei Feng, Carmen Behrens, B Nebiyou Bekele, Ignacio I Wistuba, Waun-Ki Hong, Ho-Young Le. Implication of AMP-activated protein kinase and Akt-regulated survivin in lung cancer chemopreventive activities of deguelin. Cancer research. vol 67. issue 24. 2008-01-15. PMID:18089792. |
deguelin inhibited survivin expression in tuberous sclerosis complex 2 (tsc2) wild-type mouse embryonic fibroblasts (mef) but not in tsc2-knockout mefs in which mammalian target of rapamycin (mtor) is constitutively active. |
2008-01-15 |
2023-08-12 |
mouse |
| Eleonora Aronica, Karin Boer, Marianna Baybis, Jia Yu, Peter Crin. Co-expression of cyclin D1 and phosphorylated ribosomal S6 proteins in hemimegalencephaly. Acta neuropathologica. vol 114. issue 3. 2007-12-26. PMID:17483958. |
we hypothesized that mutations in pten (a cause of hmeg associated with proteus syndrome), tsc1 or tsc2 (tuberous sclerosis complex) genes, which are known to modulate beta-catenin and mtor signaling could cause sporadic hmeg. |
2007-12-26 |
2023-08-12 |
Not clear |
| Eleonora Aronica, Karin Boer, Marianna Baybis, Jia Yu, Peter Crin. Co-expression of cyclin D1 and phosphorylated ribosomal S6 proteins in hemimegalencephaly. Acta neuropathologica. vol 114. issue 3. 2007-12-26. PMID:17483958. |
pten, tsc1, or tsc2 gene mutations were not detected suggesting that sporadic hmeg is distinct from hmeg associated with proteus syndrome or tuberous sclerosis complex. |
2007-12-26 |
2023-08-12 |
Not clear |
| Petrus J de Vries, Christopher J How. The tuberous sclerosis complex proteins--a GRIPP on cognition and neurodevelopment. Trends in molecular medicine. vol 13. issue 8. 2007-12-14. PMID:17632034. |
tuberous sclerosis complex (tsc) is a multi-system disorder associated with mutations in the tsc1 (hamartin) or tsc2 (tuberin) genes. |
2007-12-14 |
2023-08-12 |
Not clear |
| Geraldine A Finlay, Amy J Malhowski, Yingling Liu, Barry L Fanburg, David J Kwiatkowski, Deniz Tokso. Selective inhibition of growth of tuberous sclerosis complex 2 null cells by atorvastatin is associated with impaired Rheb and Rho GTPase function and reduced mTOR/S6 kinase activity. Cancer research. vol 67. issue 20. 2007-12-12. PMID:17942919. |
inactivating mutations in the tuberous sclerosis complex 2 (tsc2) gene, which encodes tuberin, result in the development of tsc and lymphangioleiomyomatosis (lam). |
2007-12-12 |
2023-08-12 |
mouse |
| Ryan J O Dowling, Mahvash Zakikhani, I George Fantus, Michael Pollak, Nahum Sonenber. Metformin inhibits mammalian target of rapamycin-dependent translation initiation in breast cancer cells. Cancer research. vol 67. issue 22. 2007-12-03. PMID:18006825. |
furthermore, translation in mda-mb-231 cells, which lack the ampk kinase lkb1, and in tuberous sclerosis complex 2 null (tsc2(-/-)) mouse embryonic fibroblasts was unaffected by metformin, indicating that lkb1 and tsc2 are involved in the mechanism of action of metformin. |
2007-12-03 |
2023-08-12 |
mouse |
| Gustavo Pacheco-Rodriguez, Wendy K Steagall, Denise M Crooks, Linda A Stevens, Hiroshi Hashimoto, Shaowei Li, Ji-an Wang, Thomas N Darling, Joel Mos. TSC2 loss in lymphangioleiomyomatosis cells correlated with expression of CD44v6, a molecular determinant of metastasis. Cancer research. vol 67. issue 21. 2007-11-27. PMID:17975002. |
proliferation of lam cells results, in part, from dysfunction in tuberous sclerosis complex (tsc) genes tsc1 (hamartin) and/or tsc2 (tuberin). |
2007-11-27 |
2023-08-12 |
human |
| Catherine Wilson, Cleo Bonnet, Carol Guy, Shelley Idziaszczyk, James Colley, Vikki Humphreys, Julie Maynard, Julian R Sampson, Jeremy P Cheadl. Tsc1 haploinsufficiency without mammalian target of rapamycin activation is sufficient for renal cyst formation in Tsc1+/- mice. Cancer research. vol 66. issue 16. 2007-11-13. PMID:16912167. |
tuberous sclerosis complex (tsc) is caused by mutations in either the tsc1 or tsc2 gene. |
2007-11-13 |
2023-08-12 |
mouse |
| Yu Gui, Gordon H He, Michael P Walsh, Xi-Long Zhen. Predisposition to tetraploidy in pulmonary vascular smooth muscle cells derived from the Eker rats. American journal of physiology. Lung cellular and molecular physiology. vol 293. issue 3. 2007-10-17. PMID:17575014. |
somatic mutations in the tuberous sclerosis complex-2 (tsc2) gene are associated with pulmonary lymphangioleiomyomatosis (lam), a disorder characterized by benign lesions of smooth muscle and/or smooth muscle-like cells in the lung. |
2007-10-17 |
2023-08-12 |
rat |
| Ronit Weisman, Irina Roitburg, Miriam Schonbrun, Rona Harari, Martin Kupie. Opposite effects of tor1 and tor2 on nitrogen starvation responses in fission yeast. Genetics. vol 175. issue 3. 2007-10-15. PMID:17179073. |
tsc1 and tsc2, the genes mutated in the human tuberous sclerosis complex syndrome, negatively regulate the mammalian tor via inactivation of the gtpase rheb. |
2007-10-15 |
2023-08-12 |
human |
| Asumthia S Jeyapalan, Renan A Orellana, Agus Suryawan, Pamela M J O'Connor, Hanh V Nguyen, Jeffery Escobar, Jason W Frank, Teresa A Davi. Glucose stimulates protein synthesis in skeletal muscle of neonatal pigs through an AMPK- and mTOR-independent process. American journal of physiology. Endocrinology and metabolism. vol 293. issue 2. 2007-09-24. PMID:17551002. |
the response in muscle was associated with increased phosphorylation of protein kinase b (pkb) and enhanced formation of the active eif4e.eif4g complex but no change in phosphorylation of amp-activated protein kinase (ampk), tuberous sclerosis complex 2 (tsc2), mammalian target of rapamycin (mtor), 4e-binding protein-1 (4e-bp1), ribosomal protein s6 kinase (s6k1), or eukaryotic elongation factor 2 (eef2). |
2007-09-24 |
2023-08-12 |
Not clear |
| Margit Rosner, Angelika Freilinger, Michaela Hanneder, Naoya Fujita, Gert Lubec, Takashi Tsuruo, Markus Hengstschläge. p27Kip1 localization depends on the tumor suppressor protein tuberin. Human molecular genetics. vol 16. issue 13. 2007-09-14. PMID:17470459. |
tuberin, encoded by the tuberous sclerosis tumor suppressor gene tsc2, is a potent negative cell cycle regulator. |
2007-09-14 |
2023-08-12 |
Not clear |