| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Geraldine A Finlay, Amy J Malhowski, Kristen Polizzi, Izabela Malinowska-Kolodziej, David J Kwiatkowsk. Renal and liver tumors in Tsc2(+/-) mice, a model of tuberous sclerosis complex, do not respond to treatment with atorvastatin, a 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor. Molecular cancer therapeutics. vol 8. issue 7. 2009-10-19. PMID:19584242. |
renal and liver tumors in tsc2(+/-) mice, a model of tuberous sclerosis complex, do not respond to treatment with atorvastatin, a 3-hydroxy-3-methylglutaryl coenzyme a reductase inhibitor. |
2009-10-19 |
2023-08-12 |
mouse |
| Geraldine A Finlay, Amy J Malhowski, Kristen Polizzi, Izabela Malinowska-Kolodziej, David J Kwiatkowsk. Renal and liver tumors in Tsc2(+/-) mice, a model of tuberous sclerosis complex, do not respond to treatment with atorvastatin, a 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor. Molecular cancer therapeutics. vol 8. issue 7. 2009-10-19. PMID:19584242. |
inactivating mutations of the tumor suppressor gene tsc2 are associated with tumorigenesis in tuberous sclerosis complex (tsc) and lymphangioleiomyomatosis. |
2009-10-19 |
2023-08-12 |
mouse |
| Xianghua Piao, Toshiyuki Kobayashi, Lu Wang, Masatoshi Shiono, Yumiko Takagi, Guodong Sun, Masaaki Abe, Yoshiaki Hagiwara, Danqing Zhang, Kazuo Okimoto, Mami Kouchi, Izumi Matsumoto, Okio Hin. Regulation of folliculin (the BHD gene product) phosphorylation by Tsc2-mTOR pathway. Biochemical and biophysical research communications. vol 389. issue 1. 2009-10-08. PMID:19695222. |
however, precise mechanism of flcn phosphorylation and functional interaction of flcn with tuberin, the product of tuberous sclerosis 2 gene (tsc2) which is a negative regulator of mtorc1, are unclear. |
2009-10-08 |
2023-08-12 |
Not clear |
| Bobby Bhatia, Paul A Northcott, Dolores Hambardzumyan, Baskaran Govindarajan, Daniel J Brat, Jack L Arbiser, Eric C Holland, Michael D Taylor, Anna Marie Kenne. Tuberous sclerosis complex suppression in cerebellar development and medulloblastoma: separate regulation of mammalian target of rapamycin activity and p27 Kip1 localization. Cancer research. vol 69. issue 18. 2009-10-07. PMID:19738049. |
one of the consequences of igf signaling is inactivation of the mammalian target of rapamycin (mtor)-suppressing tuberous sclerosis complex (tsc), comprised of tsc1 and tsc2, leading to increased mrna translation. |
2009-10-07 |
2023-08-12 |
mouse |
| Denisa Kacerovska, Radek Vrtel, Michal Michal, Tomas Vanecek, Radek Vodicka, Boris Kreuzberg, Renata Ricarova, Karel Pizinger, Dusan Danis, Tomas Reischig, Dmitry V Kazako. TSC2/PKD1 contiguous gene syndrome: a report of 2 cases with emphasis on dermatopathologic findings. The American Journal of dermatopathology. vol 31. issue 6. 2009-10-01. PMID:19590422. |
the association of tuberous sclerosis complex (tsc) and autosomal dominant polycystic kidney disease (adpkd), termed tsc2/pkd1 contiguous gene syndrome, is a result of molecular defect demonstrating by deletion disrupting tsc2 and pkd1. |
2009-10-01 |
2023-08-12 |
Not clear |
| D A Muzykewicz, A Sharma, V Muse, A L Numis, J Rajagopal, E A Thiel. TSC1 and TSC2 mutations in patients with lymphangioleiomyomatosis and tuberous sclerosis complex. Journal of medical genetics. vol 46. issue 7. 2009-09-23. PMID:19419980. |
tsc1 and tsc2 mutations in patients with lymphangioleiomyomatosis and tuberous sclerosis complex. |
2009-09-23 |
2023-08-12 |
Not clear |
| Jingxiang Huang, Shulin Wu, Chin-Lee Wu, Brendan D Mannin. Signaling events downstream of mammalian target of rapamycin complex 2 are attenuated in cells and tumors deficient for the tuberous sclerosis complex tumor suppressors. Cancer research. vol 69. issue 15. 2009-09-11. PMID:19602587. |
mutations in the tsc1 and tsc2 tumor suppressor genes give rise to the neoplastic disorders tuberous sclerosis complex (tsc) and lymphangioleiomyomatosis. |
2009-09-11 |
2023-08-12 |
mouse |
| Iris Unterberger, Giorgi Kuchukhidze, Gerald Walser, Judith Dobesberger, Florian Koppelstaetter, Martin Ortler, Richard Bauer, Eugen Trink. Successful surgery in late onset epilepsy with tuberous sclerosis complex. Epileptic disorders : international epilepsy journal with videotape. vol 11. issue 1. 2009-08-05. PMID:19349254. |
tuberous sclerosis complex (tsc) is a multisystem genetic disorder with variable phenotypic expression, caused by mutations in one of the two tumor suppressor genes, tsc1 or tsc2. |
2009-08-05 |
2023-08-12 |
Not clear |
| Elena Lesma, Silvia Maria Sirchia, Silvia Ancona, Stephana Carelli, Silvano Bosari, Filippo Ghelma, Emanuele Montanari, Anna Maria Di Giulio, Alfredo Gori. The methylation of the TSC2 promoter underlies the abnormal growth of TSC2 angiomyolipoma-derived smooth muscle cells. The American journal of pathology. vol 174. issue 6. 2009-06-23. PMID:19443708. |
tuberous sclerosis complex (tsc) is an autosomal-dominant disease that is caused by mutations in either the tsc1 or tsc2 gene. |
2009-06-23 |
2023-08-12 |
Not clear |
| Kwang-Wook Choi, Ya-Chieh Hs. To cease or to proliferate: new insights into TCTP function from a Drosophila study. Cell adhesion & migration. vol 1. issue 3. 2009-06-09. PMID:19262129. |
tsc2 (tuberous sclerosis complex 2), a gene mutated in an autosomal dominant disease tuberous sclerosis, was shown to be the rheb-gap (gtpase activating protein). |
2009-06-09 |
2023-08-12 |
human |
| Zhifang Xu, Min Wang, Lin Wang, Yang Wang, Xin Zhao, Qing Rao, Jianxiang Wan. Aberrant expression of TSC2 gene in the newly diagnosed acute leukemia. Leukemia research. vol 33. issue 7. 2009-05-28. PMID:19250671. |
the tuberous sclerosis (tsc) genes, tsc1 and tsc2, encode hamartin and tuberin, respectively, and are putative tumor suppressor genes that were originally identified due to their involvement in the inherited autosomal dominant disorder tuberous sclerosis. |
2009-05-28 |
2023-08-12 |
Not clear |
| Margit Rosner, Christiane Fuchs, Nicol Siegel, Alessandro Valli, Markus Hengstschläge. New insights into the role of the tuberous sclerosis genes in leukemia. Leukemia research. vol 33. issue 7. 2009-05-28. PMID:19286253. |
the genes tsc1 and tsc2, encoding hamartin and tuberin, respectively, have been shown to be involved in the development of the autosomal dominantly inherited tumor syndrome tuberous sclerosis (tsc). |
2009-05-28 |
2023-08-12 |
human |
| Alessia Di Nardo, Ioannis Kramvis, Namjik Cho, Abbey Sadowski, Lynsey Meikle, David J Kwiatkowski, Mustafa Sahi. Tuberous sclerosis complex activity is required to control neuronal stress responses in an mTOR-dependent manner. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 29. issue 18. 2009-05-28. PMID:19420259. |
tuberous sclerosis complex (tsc) is a neurogenetic disorder caused by loss-of-function mutations in either the tsc1 or tsc2 genes and frequently results in prominent cns manifestations, including epilepsy, mental retardation, and autism spectrum disorder. |
2009-05-28 |
2023-08-12 |
mouse |
| Georgia Ramantani, Pascal Niggemann, Gabriele Hahn, Andrea Näke, Raimund Fahsold, Min Ae Lee-Kirsc. Unusual radiological presentation of tuberous sclerosis complex with leptomeningeal angiomatosis associated with a hypomorphic mutation in the TSC2 gene. Journal of child neurology. vol 24. issue 3. 2009-05-19. PMID:19258292. |
unusual radiological presentation of tuberous sclerosis complex with leptomeningeal angiomatosis associated with a hypomorphic mutation in the tsc2 gene. |
2009-05-19 |
2023-08-12 |
Not clear |
| Georgia Ramantani, Pascal Niggemann, Gabriele Hahn, Andrea Näke, Raimund Fahsold, Min Ae Lee-Kirsc. Unusual radiological presentation of tuberous sclerosis complex with leptomeningeal angiomatosis associated with a hypomorphic mutation in the TSC2 gene. Journal of child neurology. vol 24. issue 3. 2009-05-19. PMID:19258292. |
tuberous sclerosis complex is an autosomal dominant disorder affecting primarily the central nervous system, skin, and kidney caused by mutations in the tsc1 and tsc2 genes. |
2009-05-19 |
2023-08-12 |
Not clear |
| Georgia Ramantani, Pascal Niggemann, Gabriele Hahn, Andrea Näke, Raimund Fahsold, Min Ae Lee-Kirsc. Unusual radiological presentation of tuberous sclerosis complex with leptomeningeal angiomatosis associated with a hypomorphic mutation in the TSC2 gene. Journal of child neurology. vol 24. issue 3. 2009-05-19. PMID:19258292. |
thus, mild tuberous sclerosis due to a hypomorphic mutation in tsc2 may present with isolated leptomeningeal angiomatosis. |
2009-05-19 |
2023-08-12 |
Not clear |
| Sharon W Way, James McKenna, Ulrike Mietzsch, R Michelle Reith, Henry Cheng-Ju Wu, Michael J Gambell. Loss of Tsc2 in radial glia models the brain pathology of tuberous sclerosis complex in the mouse. Human molecular genetics. vol 18. issue 7. 2009-05-18. PMID:19150975. |
loss of tsc2 in radial glia models the brain pathology of tuberous sclerosis complex in the mouse. |
2009-05-18 |
2023-08-12 |
mouse |
| Mitsunori Miyazaki, Karyn A Esse. REDD2 is enriched in skeletal muscle and inhibits mTOR signaling in response to leucine and stretch. American journal of physiology. Cell physiology. vol 296. issue 3. 2009-04-27. PMID:19129461. |
knock down of tuberous sclerosis complex 2 (tsc2) using small interfering (si)rna potently activated mtor signaling and was sufficient to rescue redd2 inhibition of mtor activity, suggesting that redd2 functions by modulating tsc2 function. |
2009-04-27 |
2023-08-12 |
Not clear |
| Catherine J Chu-Shore, Philippe Major, Maria Montenegro, Elizabeth Thiel. Cyst-like tubers are associated with TSC2 and epilepsy in tuberous sclerosis complex. Neurology. vol 72. issue 13. 2009-04-27. PMID:19332694. |
cyst-like tubers are associated with tsc2 and epilepsy in tuberous sclerosis complex. |
2009-04-27 |
2023-08-12 |
Not clear |
| Katarzyna Kotulska, Magdalena Larysz-Brysz, Wieslława Grajkowska, Jarosław Jóźwiak, Paweł Włodarski, Mustafa Sahin, Joanna Lewin-Kowalik, Dorota Domańska-Pakieła, Sergiusz Jóźwia. Cardiac rhabdomyomas in tuberous sclerosis complex show apoptosis regulation and mTOR pathway abnormalities. Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society. vol 12. issue 2. 2009-04-24. PMID:17990907. |
tuberous sclerosis complex is a genetic disorder caused by a mutation in either of 2 genes (tsc1 or tsc2) and characterized by the formation of hamartomas in multiple organs. |
2009-04-24 |
2023-08-12 |
Not clear |