| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Uyanga Chuluunbaatar, Richard Roller, Morris E Feldman, Stuart Brown, Kevan M Shokat, Ian Moh. Constitutive mTORC1 activation by a herpesvirus Akt surrogate stimulates mRNA translation and viral replication. Genes & development. vol 24. issue 23. 2010-12-21. PMID:21123650. |
remarkably, us3 displays no sequence homology with the cellular kinase akt, yet directly phosphorylates tuberous sclerosis complex 2 (tsc2) on the same sites as akt. |
2010-12-21 |
2023-08-12 |
Not clear |
| Magdalena Ewa Tyburczy, Katarzyna Kotulska, Piotr Pokarowski, Jakub Mieczkowski, Joanna Kucharska, Wieslawa Grajkowska, Maciej Roszkowski, Sergiusz Jozwiak, Bozena Kaminsk. Novel proteins regulated by mTOR in subependymal giant cell astrocytomas of patients with tuberous sclerosis complex and new therapeutic implications. The American journal of pathology. vol 176. issue 4. 2010-12-14. PMID:20133820. |
subependymal giant cell astrocytomas (segas) are rare brain tumors associated with tuberous sclerosis complex (tsc), a disease caused by mutations in tsc1 or tsc2, resulting in enhancement of mammalian target of rapamycin (mtor) activity, dysregulation of cell growth, and tumorigenesis. |
2010-12-14 |
2023-08-12 |
human |
| Samy L Habib, Besant K Bhandari, Nahed Sadek, Sherry L Abboud-Werner, Hanna E Abbou. Novel mechanism of regulation of the DNA repair enzyme OGG1 in tuberin-deficient cells. Carcinogenesis. vol 31. issue 11. 2010-11-16. PMID:20837600. |
tuberin (protein encodes by tuberous sclerosis complex 2, tsc2) deficiency is associated with the decrease in the dna repair enzyme 8-oxog-dna glycosylase (ogg1) in tumour kidney of tuberous sclerosis complex (tsc) patients. |
2010-11-16 |
2023-08-12 |
human |
| Shyama Prasad Sajankila, Praveen V Manthena, Sanjay Adhikari, Sujata Choudhury, Keisuke Izumi, Rabindra Ro. Suppression of tumor suppressor Tsc2 and DNA repair glycosylase Nth1 during spontaneous liver tumorigenesis in Long-Evans Cinnamon rats. Molecular and cellular biochemistry. vol 338. issue 1-2. 2010-10-21. PMID:20033472. |
nth1 and a tumor suppressor gene tuberous sclerosis 2 (tsc2) are bi-directionally regulated in humans, mice, and rats by a common minimal promoter containing two ets-binding sites (ebss). |
2010-10-21 |
2023-08-12 |
mouse |
| Namiko Abe, Steven H Borson, Michael J Gambello, Fan Wang, Valeria Cavall. Mammalian target of rapamycin (mTOR) activation increases axonal growth capacity of injured peripheral nerves. The Journal of biological chemistry. vol 285. issue 36. 2010-10-05. PMID:20615870. |
furthermore, genetic up-regulation of mtor activity by deletion of tuberous sclerosis complex 2 (tsc2) in drgs is sufficient to enhance axonal growth capacity in vitro and in vivo. |
2010-10-05 |
2023-08-12 |
Not clear |
| Ruhee Dere, Patricia D Wilson, Richard N Sandford, Cheryl Lyn Walke. Carboxy terminal tail of polycystin-1 regulates localization of TSC2 to repress mTOR. PloS one. vol 5. issue 2. 2010-09-30. PMID:20169078. |
here we demonstrate a mechanism by which the intracellular, carboxy-terminal tail of polycystin-1 (cp1) regulates mtor signaling by altering the subcellular localization of the tuberous sclerosis complex 2 (tsc2) tumor suppressor, a gatekeeper for mtor activity. |
2010-09-30 |
2023-08-12 |
human |
| Yan Larson, Jianyu Liu, Payton D Stevens, Xin Li, Jing Li, B Mark Evers, Tianyan Ga. Tuberous sclerosis complex 2 (TSC2) regulates cell migration and polarity through activation of CDC42 and RAC1. The Journal of biological chemistry. vol 285. issue 32. 2010-09-20. PMID:20530489. |
tuberous sclerosis complex 2 (tsc2) regulates cell migration and polarity through activation of cdc42 and rac1. |
2010-09-20 |
2023-08-12 |
Not clear |
| Jennifer M Spangle, Karl Münge. The human papillomavirus type 16 E6 oncoprotein activates mTORC1 signaling and increases protein synthesis. Journal of virology. vol 84. issue 18. 2010-09-20. PMID:20631133. |
it was previously reported that the human papillomavirus type 16 (hpv16) e6 oncoprotein may activate the s6 protein kinase (s6k) through binding and e6ap-mediated degradation of the mtor inhibitor tuberous sclerosis complex 2 (tsc2) (z. lu, x. hu, y. li, l. zheng, y. zhou, h. jiang, t. ning, z. basang, c. zhang, and y. ke, j. biol. |
2010-09-20 |
2023-08-12 |
human |
| Kaukab Naeem Sye. Tuberous sclerosis. JPMA. The Journal of the Pakistan Medical Association. vol 60. issue 8. 2010-09-09. PMID:20726205. |
tuberous sclerosis or tuberous sclerosis complex (tsc) is a genetic disorder characterized by the growth of numerous benign tumours in many parts of the body caused by mutations on either of two genes, tsc1 and tsc2. |
2010-09-09 |
2023-08-12 |
Not clear |
| Pei Sun, Zhenghui Quan, Bodi Zhang, Tuoqi Wu, Rongwen X. TSC1/2 tumour suppressor complex maintains Drosophila germline stem cells by preventing differentiation. Development (Cambridge, England). vol 137. issue 15. 2010-08-24. PMID:20573703. |
tuberous sclerosis complex human disease gene products tsc1 and tsc2 form a functional complex that negatively regulates target of rapamycin (tor), an evolutionarily conserved kinase that plays a central role in cell growth and metabolism. |
2010-08-24 |
2023-08-12 |
human |
| Samy L Habi. Tuberous sclerosis complex and DNA repair. Advances in experimental medicine and biology. vol 685. 2010-08-20. PMID:20687497. |
tuberous sclerosis complex of 2 genes, tsc2 encodes a protein called tuberin that normally exists in an active state and forms a heterodimeric complex with hamartin, the protein encoded by the tsc1. |
2010-08-20 |
2023-08-12 |
mouse |
| Manuela Mancini, Sara Petta, Giovanni Martinelli, Enza Barbieri, Maria A Santucc. RAD 001 (everolimus) prevents mTOR and Akt late re-activation in response to imatinib in chronic myeloid leukemia. Journal of cellular biochemistry. vol 109. issue 2. 2010-08-05. PMID:20014066. |
moreover, rad 001-induced inhibition of akt causes the de-phosphorylation of tuberous sclerosis tumor suppressor protein tsc2 at 14-3-3 binding sites, tsc2 release from 14-3-3 sigma (restoring its inhibitory function on mtorc1) and nuclear import (promoting the nuclear translocation of cyclin-dependent kinase [cdk] inhibitor p27(kip1), the stabilization of p27(kip1) ligand with cdk2, and the g(0)/g(1) arrest). |
2010-08-05 |
2023-08-12 |
Not clear |
| Jiumei Cao, Limin Gong, Dong-chuan Guo, Ulrike Mietzsch, Shao-Qing Kuang, Callie S Kwartler, Hazim Safi, Anthony Estrera, Michael J Gambello, Dianna M Milewic. Thoracic aortic disease in tuberous sclerosis complex: molecular pathogenesis and potential therapies in Tsc2+/- mice. Human molecular genetics. vol 19. issue 10. 2010-07-21. PMID:20159776. |
tuberous sclerosis complex (tsc) is a genetic disorder with pleiotropic manifestations caused by heterozygous mutations in either tsc1 or tsc2. |
2010-07-21 |
2023-08-12 |
mouse |
| Longhua Guo, Wantao Ying, Jiyang Zhang, Yanzhi Yuan, Xiaohong Qian, Jian Wang, Xiaoming Yang, Fuchu H. Tandem affinity purification and identification of the human TSC1 protein complex. Acta biochimica et biophysica Sinica. vol 42. issue 4. 2010-07-21. PMID:20383465. |
mutations in the tsc1 and tsc2 genes lead to tuberous sclerosis complex (tsc), which is characterized clinically by mental retardation, epilepsy, and benign tumors affecting multiple tissues. |
2010-07-21 |
2023-08-12 |
human |
| Elena A Goncharova, Poay N Lim, Amelia Chisolm, Homer W Fogle, Jerome H Taylor, Dmitry A Goncharov, Andrew Eszterhas, Reynold A Panettieri, Vera P Krymskay. Interferons modulate mitogen-induced protein synthesis in airway smooth muscle. American journal of physiology. Lung cellular and molecular physiology. vol 299. issue 1. 2010-07-08. PMID:20382746. |
furthermore, overexpression of tumor suppressor protein tuberous sclerosis complex 2 (tsc2), which is an upstream negative regulator of mtor/s6k1 signaling, also inhibited mitogen-induced protein synthesis in asm cells. |
2010-07-08 |
2023-08-12 |
human |
| L Krischock, R Beach, J Taylo. Sirolimus and tuberous sclerosis-associated renal angiomyolipomas. Archives of disease in childhood. vol 95. issue 5. 2010-07-07. PMID:20457704. |
tuberous sclerosis, caused by germline mutations in the tsc1 or tsc2 genes, is associated with aberrant upregulation of the mammalian target of rapamycin (mtor) signalling pathway, resulting in growth of tumours, including renal angiomyolipomas (amls). |
2010-07-07 |
2023-08-12 |
Not clear |
| Jane Yu, Elizabeth Petri Hensk. mTOR activation, lymphangiogenesis, and estrogen-mediated cell survival: the "perfect storm" of pro-metastatic factors in LAM pathogenesis. Lymphatic research and biology. vol 8. issue 1. 2010-06-24. PMID:20235886. |
there are at least two reasons for this: first, the discovery in the year 2000 that lam cells carry tsc2 gene mutations, linking lam with cellular pathways including the pi3k/akt/mtor axis, and allowing the tuberous sclerosis complex (tsc)-regulated pathways that are believed to underlie lam pathogenesis to be studied in cells, yeast, drosophila, and mice. |
2010-06-24 |
2023-08-12 |
mouse |
| Peter B Crino, Eleonora Aronica, Gordon Baltuch, Katherine L Nathanso. Biallelic TSC gene inactivation in tuberous sclerosis complex. Neurology. vol 74. issue 21. 2010-06-15. PMID:20498439. |
a pivotal developmental question is whether tubers in tuberous sclerosis complex (tsc) form by germline and somatic tsc1 or tsc2 gene mutations. |
2010-06-15 |
2023-08-12 |
Not clear |
| Jane Yu, Andrey A Parkhitko, Elizabeth Petri Hensk. Mammalian target of rapamycin signaling and autophagy: roles in lymphangioleiomyomatosis therapy. Proceedings of the American Thoracic Society. vol 7. issue 1. 2010-06-10. PMID:20160148. |
in the year 2000, tsc2 gene mutations were found in lam cells; in 2001 the tuberous sclerosis complex (tsc) genes were discovered to regulate cell size in drosophila via the kinase tor (target of rapamycin); and in 2008 the results were published of a clinical trial of rapamycin, a specific inhibitor of tor, in patients with tsc and lam with renal angiomyolipomas. |
2010-06-10 |
2023-08-12 |
drosophila_melanogaster |
| Kevin C Es. Tuberous sclerosis complex: a brave new world? Current opinion in neurology. vol 23. issue 2. 2010-06-07. PMID:20087180. |
tuberous sclerosis complex (tsc) is a multiorgan genetic disease caused by mutations in the tsc1 or tsc2 genes. |
2010-06-07 |
2023-08-12 |
Not clear |