| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Thomas G Sommermann, Kathleen O'Neill, David R Plas, Ellen Cahir-McFarlan. IKKβ and NF-κB transcription govern lymphoma cell survival through AKT-induced plasma membrane trafficking of GLUT1. Cancer research. vol 71. issue 23. 2012-04-04. PMID:21987722. |
activated nf-κb promoted akt-mediated phosphorylation of the glut1 regulator, akt substrate of 160kd (as160), but was not required for akt phosphorylation of the mtor regulator tuberous sclerosis 2 (tsc2). |
2012-04-04 |
2023-08-12 |
Not clear |
| Yoshinobu Oyazato, Kazumoto Iijima, Mitsuru Emi, Takashi Sekine, Koichi Kamei, Junichi Takanashi, Hideto Nakao, Yoshiyuki Namai, Kandai Nozu, Masafumi Matsu. Molecular analysis of TSC2/PKD1 contiguous gene deletion syndrome. The Kobe journal of medical sciences. vol 57. issue 1. 2012-04-04. PMID:22169896. |
tuberous sclerosis complex (tsc) is an autosomal dominant disorder caused by mutations in either of two genes, tsc1 and tsc2. |
2012-04-04 |
2023-08-12 |
Not clear |
| Chang Hwa Jung, Minchul Seo, Neil Michael Otto, Do-Hyung Ki. ULK1 inhibits the kinase activity of mTORC1 and cell proliferation. Autophagy. vol 7. issue 10. 2012-03-30. PMID:21795849. |
the stimulatory effect of ulk1 knockdown on mtorc1 signaling occurred even in the absence of tuberous sclerosis complex 2 (tsc2), the negative regulator of mtorc1 signaling. |
2012-03-30 |
2023-08-12 |
Not clear |
| Falguni Das, Nandini Ghosh-Choudhury, Nirmalya Dey, Chandi Charan Mandal, Lenin Mahimainathan, Balakuntalam S Kasinath, Hanna E Abboud, Goutam Ghosh Choudhur. Unrestrained mammalian target of rapamycin complexes 1 and 2 increase expression of phosphatase and tensin homolog deleted on chromosome 10 to regulate phosphorylation of Akt kinase. The Journal of biological chemistry. vol 287. issue 6. 2012-03-25. PMID:22184110. |
tuberous sclerosis complex 2 (tsc2) and phosphatase and tensin homolog deleted on chromosome 10 (pten) function to block growth factor-induced mammalian target of rapamycin (mtor) signaling and are mutated in autosomal dominant hamartoma syndromes. |
2012-03-25 |
2023-08-12 |
mouse |
| Duyu Nie, Mustafa Sahi. A genetic model to dissect the role of Tsc-mTORC1 in neuronal cultures. Methods in molecular biology (Clifton, N.J.). vol 821. 2012-03-16. PMID:22125080. |
tuberous sclerosis complex (tsc) is an autosomal dominant disease caused by mutations in either of two genes, tsc1 or tsc2, whose protein products form a complex that is essential in the regulation of mammalian target of rapamycin (mtor) activity. |
2012-03-16 |
2023-08-12 |
Not clear |
| Hiroyuki Mori, Kun-Liang Gua. Tissue-specific ablation of Tsc1 in pancreatic beta-cells. Methods in molecular biology (Clifton, N.J.). vol 821. 2012-03-16. PMID:22125081. |
tuberous sclerosis complex 1 (tsc1) is a tumor suppressor that associates with tsc2 to inactivate rheb, thereby inhibiting signaling by the mammalian target of rapamycin (mtor) complex 1 (mtorc1). |
2012-03-16 |
2023-08-12 |
mouse |
| Xin Tong, Kimberly A Smith, Jill C Pellin. Apigenin, a chemopreventive bioflavonoid, induces AMP-activated protein kinase activation in human keratinocytes. Molecular carcinogenesis. vol 51. issue 3. 2012-03-09. PMID:21538580. |
although ampk is traditionally thought to play a major role in the regulation of cellular lipid and protein metabolism, recent discoveries reveal that ampk inhibits mammalian target of rapamycin (mtor) signaling and connects with several tumor suppressors such as liver kinase b1 (lkb1), p53, and tuberous sclerosis complex 2 (tsc2), indicating that ampk may be a potential target for cancer prevention and treatment. |
2012-03-09 |
2023-08-12 |
human |
| Yoshihiro Tanaka, Joo Hyun Park, Pradeep S Tanwar, Tomoko Kaneko-Tarui, Shilpi Mittal, Ho-Joon Lee, Jose M Teixeir. Deletion of tuberous sclerosis 1 in somatic cells of the murine reproductive tract causes female infertility. Endocrinology. vol 153. issue 1. 2012-03-05. PMID:22128018. |
tumors develop with dysregulated activation of mammalian target of rapamycin (mtor), the kinase activity of which is kept in an inactive state by a tumor suppressor dimer containing tuberous sclerosis 1 (tsc1) and tsc2. |
2012-03-05 |
2023-08-12 |
mouse |
| Maya Chopra, John A Lawson, Meredith Wilson, Sean E Kennedy, Peter Taylor, Michael F Buckley, Orli Wargon, Gayathri Parasivam, Christoph Camphausen, Deborah Yates, David Mowa. An Australian tuberous sclerosis cohort: are surveillance guidelines being met? Journal of paediatrics and child health. vol 47. issue 10. 2012-03-01. PMID:21449900. |
this study aims to describe the phenotypic and genotypic characteristics of 45 australian patients with tuberous sclerosis complex (tsc), to assess risk factors for intellectual disability, to compare patients with tsc1 and tsc2 mutations and to assess adherence to surveillance recommendations. |
2012-03-01 |
2023-08-12 |
Not clear |
| Sandra L Dabora, David Neal Franz, Stephen Ashwal, Arthur Sagalowsky, Francis J DiMario, Daniel Miles, Drew Cutler, Darcy Krueger, Raul N Uppot, Rahmin Rabenou, Susana Camposano, Jan Paolini, Fiona Fennessy, Nancy Lee, Chelsey Woodrum, Judith Manola, Judy Garber, Elizabeth A Thiel. Multicenter phase 2 trial of sirolimus for tuberous sclerosis: kidney angiomyolipomas and other tumors regress and VEGF- D levels decrease. PloS one. vol 6. issue 9. 2012-02-14. PMID:21915260. |
tuberous sclerosis (tsc) related tumors are characterized by constitutively activated mtor signaling due to mutations in tsc1 or tsc2. |
2012-02-14 |
2023-08-12 |
Not clear |
| M Rosner, M Hengstschläge. Nucleocytoplasmic localization of p70 S6K1, but not of its isoforms p85 and p31, is regulated by TSC2/mTOR. Oncogene. vol 30. issue 44. 2012-01-26. PMID:21602892. |
the tuberous sclerosis complex gene 2 (tsc2)/mammalian target of rapamycin (mtor) pathway controls many cellular functions via phosphorylation of ribosomal protein s6 kinases (s6ks). |
2012-01-26 |
2023-08-12 |
Not clear |
| Anna-Kaisa Niemi, Hope Northrup, Louanne Hudgins, Jonathan A Bernstei. Horseshoe kidney and a rare TSC2 variant in two unrelated individuals with tuberous sclerosis complex. American journal of medical genetics. Part A. vol 155A. issue 10. 2012-01-18. PMID:21910228. |
horseshoe kidney and a rare tsc2 variant in two unrelated individuals with tuberous sclerosis complex. |
2012-01-18 |
2023-08-12 |
Not clear |
| Scott G Turner, Katherine B Peters, James J Vredenburgh, Annick Desjardins, Henry S Friedman, David A Reardo. Everolimus tablets for patients with subependymal giant cell astrocytoma. Expert opinion on pharmacotherapy. vol 12. issue 14. 2012-01-13. PMID:21806479. |
abnormal mammalian target of rapamycin (mtor) complex signaling and defects in tsc1 and tsc2 have been associated with the development of subependymal giant cell astrocytomas (segas) in tuberous sclerosis complex (tsc) patients. |
2012-01-13 |
2023-08-12 |
Not clear |
| Alise Hyrskyluoto, Sami Reijonen, Jenny Kivinen, Dan Lindholm, Laura Korhone. GADD34 mediates cytoprotective autophagy in mutant huntingtin expressing cells via the mTOR pathway. Experimental cell research. vol 318. issue 1. 2012-01-13. PMID:21925170. |
tuberous sclerosis complex (tsc) 1/2 interacted with growth arrest and dna damage protein 34 (gadd34), which caused tsc2 dephosphorylation and induction of autophagy in mutant huntingtin expressing cells. |
2012-01-13 |
2023-08-12 |
Not clear |
| Blanka Kucejova, Samuel Peña-Llopis, Toshinari Yamasaki, Sharanya Sivanand, Tram Anh T Tran, Shane Alexander, Nicholas C Wolff, Yair Lotan, Xian-Jin Xie, Wareef Kabbani, Payal Kapur, James Brugarola. Interplay between pVHL and mTORC1 pathways in clear-cell renal cell carcinoma. Molecular cancer research : MCR. vol 9. issue 9. 2012-01-12. PMID:21798997. |
redd1-induced mtorc1 inhibition is dependent on a protein complex formed by the tuberous sclerosis complex (tsc)1 and 2 (tsc2) proteins. |
2012-01-12 |
2023-08-12 |
mouse |
| Maki Koyanagi, Shun-ichiro Asahara, Tomokazu Matsuda, Naoko Hashimoto, Yutaka Shigeyama, Yuki Shibutani, Ayumi Kanno, Megumi Fuchita, Tomoko Mikami, Tetsutya Hosooka, Hiroshi Inoue, Michihiro Matsumoto, Masato Koike, Yasuo Uchiyama, Tetsuo Noda, Susumu Seino, Masato Kasuga, Yoshiaki Kid. Ablation of TSC2 enhances insulin secretion by increasing the number of mitochondria through activation of mTORC1. PloS one. vol 6. issue 8. 2012-01-11. PMID:21886784. |
we previously found that chronic tuberous sclerosis protein 2 (tsc2) deletion induces activation of mammalian target of rapamycin complex 1 (mtorc1) and leads to hypertrophy of pancreatic beta cells from pancreatic beta cell-specific tsc2 knockout (βtsc2(-/-)) mice. |
2012-01-11 |
2023-08-12 |
mouse |
| Camille Taillé, Raphaël Borie, Bruno Crestan. Current management of lymphangioleiomyomatosis. Current opinion in pulmonary medicine. vol 17. issue 5. 2012-01-04. PMID:21760507. |
considerable progress for comprehension of the disease has been made when mutations of the tuberous sclerosis genes tsc1 and tsc2, were discovered in lam cells. |
2012-01-04 |
2023-08-12 |
Not clear |
| G-X Wang, D-W Wang, J-S Zhao, S-F Wang, R-P Su. A novel TSC1 mutation (c.1964delA) in a Chinese patient with tuberous sclerosis complex. Genetics and molecular research : GMR. vol 10. issue 1. 2011-12-16. PMID:21268779. |
tuberous sclerosis complex is an autosomal-dominant heritable disease caused by mutations in the tsc1 and tsc2 genes. |
2011-12-16 |
2023-08-12 |
Not clear |
| Dan Ehninger, Alcino J Silv. Increased levels of anxiety-related behaviors in a Tsc2 dominant negative transgenic mouse model of tuberous sclerosis. Behavior genetics. vol 41. issue 3. 2011-12-15. PMID:20882401. |
increased levels of anxiety-related behaviors in a tsc2 dominant negative transgenic mouse model of tuberous sclerosis. |
2011-12-15 |
2023-08-12 |
mouse |
| Dan Ehninger, Alcino J Silv. Increased levels of anxiety-related behaviors in a Tsc2 dominant negative transgenic mouse model of tuberous sclerosis. Behavior genetics. vol 41. issue 3. 2011-12-15. PMID:20882401. |
tuberous sclerosis (tsc) is a single-gene disorder caused by heterozygous mutations in the tsc1 or tsc2 gene. |
2011-12-15 |
2023-08-12 |
mouse |