| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Atsushi Sato, Shinya Kasai, Toshiyuki Kobayashi, Yukio Takamatsu, Okio Hino, Kazutaka Ikeda, Masashi Mizuguch. Rapamycin reverses impaired social interaction in mouse models of tuberous sclerosis complex. Nature communications. vol 3. 2013-06-11. PMID:23250422. |
genetic disorders frequently accompany autism spectrum disorder, such as tuberous sclerosis complex caused by haploinsufficiency of the tsc1 and tsc2 genes. |
2013-06-11 |
2023-08-12 |
mouse |
| Shehab Jabir, Samir Al-Hyassa. Histological diagnosis of cardiac lipoma in an adult with tuberous sclerosis. BMJ case reports. vol 2013. 2013-06-03. PMID:23291812. |
tuberous sclerosis complex (tsc) is an autosomal dominant multisystem disorder caused by mutations in either of the two genes, tsc1 or tsc2, which code for the proteins hamartin and tuberin, respectively. |
2013-06-03 |
2023-08-12 |
Not clear |
| Avanita S Prabowo, Jasper J Anink, Martin Lammens, Mark Nellist, Ans M W van den Ouweland, Homa Adle-Biassette, Harvey B Sarnat, Laura Flores-Sarnat, Peter B Crino, Eleonora Aronic. Fetal brain lesions in tuberous sclerosis complex: TORC1 activation and inflammation. Brain pathology (Zurich, Switzerland). vol 23. issue 1. 2013-05-23. PMID:22805177. |
tuberous sclerosis complex (tsc) is an autosomal dominant disorder caused by mutations in either the tsc1 or tsc2 genes and characterized by developmental brain abnormalities. |
2013-05-23 |
2023-08-12 |
Not clear |
| Subir Kapuria, Jason Karpac, Benoit Biteau, DaeSung Hwangbo, Heinrich Jaspe. Notch-mediated suppression of TSC2 expression regulates cell differentiation in the Drosophila intestinal stem cell lineage. PLoS genetics. vol 8. issue 11. 2013-05-13. PMID:23144631. |
here we identify notch-mediated repression of tuberous sclerosis complex 2 (tsc2) in ebs as a required step in the commitment of ebs into the ec fate. |
2013-05-13 |
2023-08-12 |
drosophila_melanogaster |
| Marianne Hoogeveen-Westerveld, Leontine van Unen, Ans van den Ouweland, Dicky Halley, Andre Hoogeveen, Mark Nellis. The TSC1-TSC2 complex consists of multiple TSC1 and TSC2 subunits. BMC biochemistry. vol 13. 2013-05-01. PMID:23006675. |
mutations to the tsc1 and tsc2 genes cause the disease tuberous sclerosis complex. |
2013-05-01 |
2023-08-12 |
Not clear |
| B Duchemann, B Duchemain, S Wong, V Baruch-Hennequin, S Rivera, L Quero, C Hennequi. [Hypersensitivity to radiation therapy in a patient with tuberous sclerosis: biological considerations about a clinical case]. Cancer radiotherapie : journal de la Societe francaise de radiotherapie oncologique. vol 17. issue 1. 2013-04-18. PMID:23270679. |
tuberous sclerosis is characterized by a loss of the tsc2 function, with a permanent activation of the mtor pathway. |
2013-04-18 |
2023-08-12 |
Not clear |
| Wenjuan Ru, Yanxi Peng, Ling Zhong, Shao-Jun Tan. A role of the mammalian target of rapamycin (mTOR) in glutamate-induced down-regulation of tuberous sclerosis complex proteins 2 (TSC2). Journal of molecular neuroscience : MN. vol 47. issue 2. 2013-03-26. PMID:22492229. |
a role of the mammalian target of rapamycin (mtor) in glutamate-induced down-regulation of tuberous sclerosis complex proteins 2 (tsc2). |
2013-03-26 |
2023-08-12 |
Not clear |
| Elizabeth Yuan, Peter T Tsai, Emily Greene-Colozzi, Mustafa Sahin, David J Kwiatkowski, Izabela A Malinowsk. Graded loss of tuberin in an allelic series of brain models of TSC correlates with survival, and biochemical, histological and behavioral features. Human molecular genetics. vol 21. issue 19. 2013-03-14. PMID:22752306. |
tuberous sclerosis complex (tsc) is a neurodevelopmental disorder with prominent brain manifestations due to mutations in either tsc1 or tsc2. |
2013-03-14 |
2023-08-12 |
mouse |
| Z-H Wen, Y-C Su, P-L Lai, Y Zhang, Y-F Xu, A Zhao, G-Y Yao, C-H Jia, J Lin, S Xu, L Wang, X-K Wang, A-L Liu, Y Jiang, Y-F Dai, X-C Ba. Critical role of arachidonic acid-activated mTOR signaling in breast carcinogenesis and angiogenesis. Oncogene. vol 32. issue 2. 2013-03-05. PMID:22349822. |
interestingly, aa-stimulated mtorc1 activation was independent of amino acids, phosphatidylinositol 3-kinase (pi3-k) and tuberous sclerosis complex 2 (tsc2), which suggests a novel mechanism for mtorc1 activation. |
2013-03-05 |
2023-08-12 |
human |
| Heather L D Brown, Karla R Kaun, Bruce A Edga. The small GTPase Rheb affects central brain neuronal morphology and memory formation in Drosophila. PloS one. vol 7. issue 9. 2013-03-05. PMID:23028662. |
mutations in either of two tumor suppressor genes, tsc1 or tsc2, cause tuberous sclerosis complex (tsc), a syndrome resulting in benign hamartomatous tumors and neurological disorders. |
2013-03-05 |
2023-08-12 |
drosophila_melanogaster |
| Gheona Altarescu, Rachel Beeri, Talia Eldar-Geva, Irit Varshaver, Ehud J Margalioth, Ephrat Levy-Lahad, Paul Renbau. PGD for germline mosaicism. Reproductive biomedicine online. vol 25. issue 4. 2013-03-01. PMID:22884613. |
family 2 had two children with tuberous sclerosis (tsc2 c1327t) and two healthy children. |
2013-03-01 |
2023-08-12 |
Not clear |
| Gheona Altarescu, Rachel Beeri, Talia Eldar-Geva, Irit Varshaver, Ehud J Margalioth, Ephrat Levy-Lahad, Paul Renbau. PGD for germline mosaicism. Reproductive biomedicine online. vol 25. issue 4. 2013-03-01. PMID:22884613. |
for tuberous sclerosis, single spermatozoa were analysed using a multiplex assay that included six informative markers and the tsc2 mutation. |
2013-03-01 |
2023-08-12 |
Not clear |
| Moe R Mahjoub, Tim Stearn. Supernumerary centrosomes nucleate extra cilia and compromise primary cilium signaling. Current biology : CB. vol 22. issue 17. 2013-02-21. PMID:22840514. |
cells mutant for the tuberous sclerosis gene tsc2 also had extra cilia and diluted ciliary protein. |
2013-02-21 |
2023-08-12 |
Not clear |
| Elena A Goncharova, Dmitry A Goncharov, Melane Fehrenbach, Irene Khavin, Blerina Ducka, Okio Hino, Thomas V Colby, Mervyn J Merrilees, Angela Haczku, Steven M Albelda, Vera P Krymskay. Prevention of alveolar destruction and airspace enlargement in a mouse model of pulmonary lymphangioleiomyomatosis (LAM). Science translational medicine. vol 4. issue 154. 2013-02-13. PMID:23035046. |
the disease is caused by mutational inactivation of the tumor suppressor gene tuberous sclerosis complex 1 (tsc1) or tsc2. |
2013-02-13 |
2023-08-12 |
mouse |
| Rachel Hardy, Charles W Shepherd, Deirdre E Donnelly, Shane A McKee, Patrick J Morriso. Constellation of five facial features of tuberous sclerosis in a child with a TSC2 1808A>G mutation. The oncologist. vol 17. issue 7. 2013-02-07. PMID:22707510. |
constellation of five facial features of tuberous sclerosis in a child with a tsc2 1808a>g mutation. |
2013-02-07 |
2023-08-12 |
Not clear |
| M Luz Ruiz-Falcó Roja. [Therapeutic update in tuberous sclerosis complex: the role of mTOR pathway inhibitors]. Revista de neurologia. vol 54 Suppl 3. 2013-01-29. PMID:22605628. |
it has been shown that in tuberous sclerosis complex the genes tsc1 and tsc2 alter the mtor enzyme cascade, which sets off inhibition of this pathway. |
2013-01-29 |
2023-08-12 |
Not clear |
| Sharon W Way, Natalia S Rozas, Henry C Wu, James McKenna, R Michelle Reith, S Shahrukh Hashmi, Pramod K Dash, Michael J Gambell. The differential effects of prenatal and/or postnatal rapamycin on neurodevelopmental defects and cognition in a neuroglial mouse model of tuberous sclerosis complex. Human molecular genetics. vol 21. issue 14. 2013-01-14. PMID:22532572. |
tuberous sclerosis complex (tsc) is caused by heterozygous mutations in either the tsc1 (hamartin) or the tsc2 (tuberin) gene. |
2013-01-14 |
2023-08-12 |
mouse |
| Brian J Siroky, Hong Yin, Justin T Babcock, Lu Lu, Anna R Hellmann, Bradley P Dixon, Lawrence A Quilliam, John J Bissle. Human TSC-associated renal angiomyolipoma cells are hypersensitive to ER stress. American journal of physiology. Renal physiology. vol 303. issue 6. 2012-12-26. PMID:22791333. |
tuberous sclerosis complex (tsc), an inherited tumor predisposition syndrome associated with mutations in tsc1 or tsc2, affects ∼1 in 6,000 individuals. |
2012-12-26 |
2023-08-12 |
human |
| Lyn M Moir, Judith L Black, Vera P Krymskay. TSC2 modulates cell adhesion and migration via integrin-α1β1. American journal of physiology. Lung cellular and molecular physiology. vol 303. issue 8. 2012-12-26. PMID:22923640. |
dysfunction of the tumor suppressor genes tuberous sclerosis complex (tsc), in particular mutational inactivation of tsc2, enhances both cell proliferation and migration. |
2012-12-26 |
2023-08-12 |
mouse |
| Pradeep S Tanwar, Tomoko Kaneko-Tarui, Lihua Zhang, Yoshihiro Tanaka, Christopher P Crum, Jose M Teixeir. Stromal liver kinase B1 [STK11] signaling loss induces oviductal adenomas and endometrial cancer by activating mammalian Target of Rapamycin Complex 1. PLoS genetics. vol 8. issue 8. 2012-12-17. PMID:22916036. |
deletion of the genes for tuberous sclerosis 1 (tsc1) or tsc2, regulators of mtorc1 that are downstream of lkb1 signaling, in the oviductal and uterine stroma phenocopies some of the defects observed in lkb1 mutant mice, confirming that dysregulated mtorc1 activation in the lkb1-deleted stroma contributes to the phenotype. |
2012-12-17 |
2023-08-12 |
mouse |