| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Seok-Hyung Kim, Marie L Kowalski, Robert P Carson, L Richard Bridges, Kevin C Es. Heterozygous inactivation of tsc2 enhances tumorigenesis in p53 mutant zebrafish. Disease models & mechanisms. vol 6. issue 4. 2013-10-24. PMID:23580196. |
tuberous sclerosis complex (tsc) is a multi-organ disorder caused by mutations of the tsc1 or tsc2 genes. |
2013-10-24 |
2023-08-12 |
zebrafish |
| G-X Wang, D-W Wang, C-Y Yi, J-S Qu, Y-L Wan. Mutational analyses of the TSC1 and TSC2 genes in cases of tuberous sclerosis complex in Chinese Han children. Genetics and molecular research : GMR. vol 12. issue 2. 2013-10-22. PMID:23661441. |
mutational analyses of the tsc1 and tsc2 genes in cases of tuberous sclerosis complex in chinese han children. |
2013-10-22 |
2023-08-12 |
Not clear |
| G-X Wang, D-W Wang, C-Y Yi, J-S Qu, Y-L Wan. Mutational analyses of the TSC1 and TSC2 genes in cases of tuberous sclerosis complex in Chinese Han children. Genetics and molecular research : GMR. vol 12. issue 2. 2013-10-22. PMID:23661441. |
tuberous sclerosis complex (tsc) is an autosomal dominant neurogenetic disorder characterized by hamartomas in multiple organs and is caused by a wide spectrum of mutations in 1 of 2 causative genes (tsc1 or tsc2). |
2013-10-22 |
2023-08-12 |
Not clear |
| Anil J Trindade, Douglas A Medvetz, Nicole A Neuman, Faina Myachina, Jane Yu, Carmen Priolo, Elizabeth P Hensk. MicroRNA-21 is induced by rapamycin in a model of tuberous sclerosis (TSC) and lymphangioleiomyomatosis (LAM). PloS one. vol 8. issue 3. 2013-09-30. PMID:23555865. |
lam is caused by mutations in the tuberous sclerosis complex genes (tsc1 or tsc2), resulting in hyperactive mammalian target of rapamycin (mtor) signaling. |
2013-09-30 |
2023-08-12 |
Not clear |
| Anna M Mohammadieh, Simon D Bowler, Elizabeth J Silverstone, Allan R Glanville, Deborah H Yate. Everolimus treatment of abdominal lymphangioleiomyoma in five women with sporadic lymphangioleiomyomatosis. The Medical journal of Australia. vol 199. issue 2. 2013-09-30. PMID:23879512. |
lymphangioleiomyomatosis (lam) is a rare systemic disease of young women arising from mutations in the tuberous sclerosis complex (tsc) genes, tsc1 or tsc2. |
2013-09-30 |
2023-08-12 |
Not clear |
| S A Burgos, J J M Kim, M Dai, J P Can. Energy depletion of bovine mammary epithelial cells activates AMPK and suppresses protein synthesis through inhibition of mTORC1 signaling. Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme. vol 45. issue 3. 2013-09-26. PMID:22972179. |
2-deoxyglucose increased phosphorylation of tuberous sclerosis complex 2 (tsc2) on ampk consensus sites but did not change the amount of tsc1 bound to tsc2. |
2013-09-26 |
2023-08-12 |
cattle |
| Hannah Crossland, Abid A Kazi, Charles H Lang, James A Timmons, Philippe Pierre, Daniel J Wilkinson, Kenneth Smith, Nathaniel J Szewczyk, Philip J Atherto. Focal adhesion kinase is required for IGF-I-mediated growth of skeletal muscle cells via a TSC2/mTOR/S6K1-associated pathway. American journal of physiology. Endocrinology and metabolism. vol 305. issue 2. 2013-09-19. PMID:23695213. |
igf-i-induced increases in myotube width (+41 ± 7% vs. non-igf-i-treated) and total protein (+44 ± 6%) were, after 24 h, attenuated in fak-kd cells, whereas mps was suppressed in fak-kd vs. scr after 4 h. these blunted responses were associated with attenuated igf-i-induced fak tyr³⁹⁷ phosphorylation and markedly suppressed phosphorylation of tuberous sclerosis complex 2 (tsc2) and critical downstream mtor signaling (ribosomal s6 kinase, eif4f assembly) in fak shrna cells (all p < 0.05 vs. igf-i-treated scr cells). |
2013-09-19 |
2023-08-12 |
Not clear |
| Anne Catharina Dressler, Gernot Hudelist, Anneliese Fink-Retter, Daphne Gschwantler-Kaulich, Georg Pfeiler, Margit Rosner, Markus Hengstschläger, Christian F Singe. Tuberin and p27 expression in breast cancer patients with or without BRCA germline mutations. Journal of cancer research and clinical oncology. vol 139. issue 8. 2013-09-17. PMID:23689538. |
tuberin, the protein product of tuberous sclerosis gene 2 (tsc2), is the functional component of the tsc1/tsc2 complex and regulates cell cycle through activation of the cyclin-dependent kinase inhibitor p27. |
2013-09-17 |
2023-08-12 |
Not clear |
| Dan Ehninge. From genes to cognition in tuberous sclerosis: implications for mTOR inhibitor-based treatment approaches. Neuropharmacology. vol 68. 2013-09-09. PMID:22626986. |
tuberous sclerosis (tsc) is a neurocutaneous disorder with an autosomal-dominant pattern of inheritance and is caused by heterozygous mutations in the tsc1 or tsc2 gene. |
2013-09-09 |
2023-08-12 |
human |
| Erzsébet Kövesdi, Kinga Hadzsiev, Katalin Komlósi, Mária Kassay, Péter Barsi, Béla Meleg. [Novel TSC1 mutation associated with variable phenotypes in tuberous sclerosis]. Orvosi hetilap. vol 154. issue 23. 2013-08-09. PMID:23728315. |
tuberous sclerosis is an autosomal dominant disorder, caused by mutations of the tsc1 or tsc2 genes resulting in tumor predisposition. |
2013-08-09 |
2023-08-12 |
Not clear |
| Yan Chen Shang, Zhao Zhong Chong, Shaohui Wang, Kenneth Maies. Tuberous sclerosis protein 2 (TSC2) modulates CCN4 cytoprotection during apoptotic amyloid toxicity in microglia. Current neurovascular research. vol 10. issue 1. 2013-07-29. PMID:23244622. |
tuberous sclerosis protein 2 (tsc2) modulates ccn4 cytoprotection during apoptotic amyloid toxicity in microglia. |
2013-07-29 |
2023-08-12 |
Not clear |
| Yan Chen Shang, Zhao Zhong Chong, Shaohui Wang, Kenneth Maies. Tuberous sclerosis protein 2 (TSC2) modulates CCN4 cytoprotection during apoptotic amyloid toxicity in microglia. Current neurovascular research. vol 10. issue 1. 2013-07-29. PMID:23244622. |
here we show that wnt1 inducible signaling pathway protein 1 (wisp1/ccn4) controls the post-translational phosphorylation of akt1, p70s6k, and amp activated protein kinase (ampk) to the extent that tuberous sclerosis complex 2 (tsc2) (ser1387) phosphorylation, a target of ampk, is decreased and tsc2 (thr1462) phosphorylation, a target of akt1, is increased. |
2013-07-29 |
2023-08-12 |
Not clear |
| R Michelle Reith, James McKenna, Henry Wu, S Shahrukh Hashmi, Seo-Hee Cho, Pramod K Dash, Michael J Gambell. Loss of Tsc2 in Purkinje cells is associated with autistic-like behavior in a mouse model of tuberous sclerosis complex. Neurobiology of disease. vol 51. 2013-07-24. PMID:23123587. |
loss of tsc2 in purkinje cells is associated with autistic-like behavior in a mouse model of tuberous sclerosis complex. |
2013-07-24 |
2023-08-12 |
mouse |
| R Michelle Reith, James McKenna, Henry Wu, S Shahrukh Hashmi, Seo-Hee Cho, Pramod K Dash, Michael J Gambell. Loss of Tsc2 in Purkinje cells is associated with autistic-like behavior in a mouse model of tuberous sclerosis complex. Neurobiology of disease. vol 51. 2013-07-24. PMID:23123587. |
tuberous sclerosis complex (tsc) is a dominant tumor suppressor disorder caused by mutations in either tsc1 or tsc2. |
2013-07-24 |
2023-08-12 |
mouse |
| Regina M Young, Daniel Ackerman, Zachary L Quinn, Anthony Mancuso, Michaela Gruber, Liping Liu, Dionysios N Giannoukos, Ekaterina Bobrovnikova-Marjon, J Alan Diehl, Brian Keith, M Celeste Simo. Dysregulated mTORC1 renders cells critically dependent on desaturated lipids for survival under tumor-like stress. Genes & development. vol 27. issue 10. 2013-07-22. PMID:23699409. |
specifically, we demonstrate that hypoxic tsc2(-/-) (tuberous sclerosis complex 2(-/-)) cells deprived of serum lipids exhibit a magnified unfolded protein response (upr) but fail to appropriately expand their endoplasmic reticulum (er), leading to inositol-requiring protein-1 (ire1)-dependent cell death that can be reversed by the addition of unsaturated lipids. |
2013-07-22 |
2023-08-12 |
human |
| Jiabao You, Hong Liu, Xi'an Fu, Mingfei Chen, Guiye Niu, Hongqing Tian, Furen Zhan. Two novel TSC2 mutations in Chinese patients with tuberous sclerosis complex. Indian journal of dermatology, venereology and leprology. vol 79. issue 1. 2013-07-18. PMID:23254740. |
two novel tsc2 mutations in chinese patients with tuberous sclerosis complex. |
2013-07-18 |
2023-08-12 |
Not clear |
| Marianne Hoogeveen-Westerveld, Rosemary Ekong, Sue Povey, Karin Mayer, Nathalie Lannoy, Frances Elmslie, Martina Bebin, Kira Dies, Catherine Thompson, Steven P Sparagana, Peter Davies, Agnies M van Eeghen, Elizabeth A Thiele, Ans van den Ouweland, Dicky Halley, Mark Nellis. Functional assessment of TSC2 variants identified in individuals with tuberous sclerosis complex. Human mutation. vol 34. issue 1. 2013-07-01. PMID:22903760. |
functional assessment of tsc2 variants identified in individuals with tuberous sclerosis complex. |
2013-07-01 |
2023-08-12 |
Not clear |
| Marianne Hoogeveen-Westerveld, Rosemary Ekong, Sue Povey, Karin Mayer, Nathalie Lannoy, Frances Elmslie, Martina Bebin, Kira Dies, Catherine Thompson, Steven P Sparagana, Peter Davies, Agnies M van Eeghen, Elizabeth A Thiele, Ans van den Ouweland, Dicky Halley, Mark Nellis. Functional assessment of TSC2 variants identified in individuals with tuberous sclerosis complex. Human mutation. vol 34. issue 1. 2013-07-01. PMID:22903760. |
tuberous sclerosis complex (tsc) is an autosomal dominant disorder caused by mutations in the tsc1 or tsc2 genes. |
2013-07-01 |
2023-08-12 |
Not clear |
| Maki Ohsawa, Toshiyuki Kobayashi, Hidehiro Okura, Takashi Igarashi, Masashi Mizuguchi, Okio Hin. TSC1 controls distribution of actin fibers through its effect on function of Rho family of small GTPases and regulates cell migration and polarity. PloS one. vol 8. issue 1. 2013-06-24. PMID:23355874. |
the tumor-suppressor genes tsc1 and tsc2 are mutated in tuberous sclerosis, an autosomal dominant multisystem disorder. |
2013-06-24 |
2023-08-12 |
mouse |
| Elena Lesma, Silvia Ancona, Emanuela Orpianesi, Vera Grande, Anna Maria Di Giulio, Alfredo Gori. Chromatin remodeling by rosuvastatin normalizes TSC2-/meth cell phenotype through the expression of tuberin. The Journal of pharmacology and experimental therapeutics. vol 345. issue 2. 2013-06-17. PMID:23426956. |
tuberous sclerosis complex (tsc) is a multi-systemic syndrome caused by mutations in tsc1 or tsc2 gene. |
2013-06-17 |
2023-08-12 |
human |