| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Karin Mayer, Christa Fonatsch, Katharina Wimmer, Ans M W van den Ouweland, Anneke J A Maat-Kievi. Clinical utility gene card for: tuberous sclerosis complex (TSC1, TSC2). European journal of human genetics : EJHG. vol 22. issue 2. 2015-01-20. PMID:23756443. |
clinical utility gene card for: tuberous sclerosis complex (tsc1, tsc2). |
2015-01-20 |
2023-08-12 |
Not clear |
| Pietro Sciacca, Valentina Giacchi, Carmine Mattia, Filippo Greco, Pierluigi Smilari, Pasqua Betta, Giuseppe Distefan. Rhabdomyomas and tuberous sclerosis complex: our experience in 33 cases. BMC cardiovascular disorders. vol 14. 2015-01-20. PMID:24884933. |
typically rhabdomyomas are multiple lesions and usually regress spontaneously but are often associated with tuberous sclerosis complex (tsc), an autosomal dominant multisystem disorder caused by mutations in either of the two genes, tsc1 or tsc2. |
2015-01-20 |
2023-08-13 |
Not clear |
| Anya Alayev, Yang Sun, Rose B Snyder, Sara Malka Berger, Jane J Yu, Marina K Hol. Resveratrol prevents rapamycin-induced upregulation of autophagy and selectively induces apoptosis in TSC2-deficient cells. Cell cycle (Georgetown, Tex.). vol 13. issue 3. 2015-01-14. PMID:24304514. |
the mammalian/mechanistic target of rapamycin complex 1 (mtorc1) signaling pathway is hyperactivated in a variety of cancers and disorders, including lymphangioleiomyomatosis (lam) and tuberous sclerosis complex (tsc), which are characterized by mutations in tumor suppressors tsc1 or tsc2. |
2015-01-14 |
2023-08-12 |
Not clear |
| Angelo M Taveira-DaSilva, Joel Mos. Management of lymphangioleiomyomatosis. F1000prime reports. vol 6. 2015-01-12. PMID:25580270. |
it is caused by the proliferation of a cancer-like lam cell that possesses a mutation in either the tuberous sclerosis complex (tsc)1 or tsc2 genes. |
2015-01-12 |
2023-08-13 |
human |
| Arthur Jorge Santiago Lima, Marianne Hoogeveen-Westerveld, Akio Nakashima, Anneke Maat-Kievit, Ans van den Ouweland, Dicky Halley, Ushio Kikkawa, Mark Nellis. Identification of regions critical for the integrity of the TSC1-TSC2-TBC1D7 complex. PloS one. vol 9. issue 4. 2015-01-06. PMID:24714658. |
inactivating tsc1 and tsc2 mutations cause tuberous sclerosis complex (tsc), an autosomal dominant disorder characterised by the occurrence of benign tumours in various organs and tissues, notably the brain, skin and kidneys. |
2015-01-06 |
2023-08-13 |
Not clear |
| Jianling Chen, Ian Alberts, Xiaohong L. Dysregulation of the IGF-I/PI3K/AKT/mTOR signaling pathway in autism spectrum disorders. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. vol 35. 2014-12-18. PMID:24662006. |
tuberous sclerosis complex 1 (tsc1) and tsc2 are upstream regulators of mammalian target of rapamycin (mtor) and downstream effectors of the pi3k/akt signaling pathway. |
2014-12-18 |
2023-08-12 |
Not clear |
| Shakeel U R Mir, Steven R Schwarze, Ling Jin, Jinling Zhang, Woodrow Friend, Sumitra Miriyala, Daret St Clair, Rolf J Crave. Progesterone receptor membrane component 1/Sigma-2 receptor associates with MAP1LC3B and promotes autophagy. Autophagy. vol 9. issue 10. 2014-12-16. PMID:24113030. |
we propose that this disruption of autophagy upon pgrmc1 inhibition increases ampk activation, elevating the levels of tsc1 (tuberous sclerosis complex) and tsc2 and inactivating mtor and rps6kb/p70s6k, causing cleaved map1lc3b levels to increase. |
2014-12-16 |
2023-08-12 |
Not clear |
| Sean P Delaney, Lisa M Julian, William L Stanfor. The neural crest lineage as a driver of disease heterogeneity in Tuberous Sclerosis Complex and Lymphangioleiomyomatosis. Frontiers in cell and developmental biology. vol 2. 2014-12-16. PMID:25505789. |
the pathological basis of lam is associated with tuberous sclerosis complex (tsc), a multi-system disorder marked by low-grade tumors in the brain, kidneys, heart, eyes, lung and skin, arising from inherited or spontaneous germ-line mutations in either of the tsc1 or tsc2 genes. |
2014-12-16 |
2023-08-13 |
Not clear |
| Jennifer Munkley, Prabhakar Rajan, Nicholas P Lafferty, Caroline Dalgliesh, Robert M Jackson, Craig N Robson, Hing Y Leung, David J Elliot. A novel androgen-regulated isoform of the TSC2 tumour suppressor gene increases cell proliferation. Oncotarget. vol 5. issue 1. 2014-12-04. PMID:24318044. |
tsc2 (tuberous sclerosis complex 2) is an important tumour suppressor gene, mutations within which are linked to the development of tuberous sclerosis and implicated in multiple tumour types. |
2014-12-04 |
2023-08-12 |
Not clear |
| Daisuke Yamada, Takayuki Hoshii, Shingo Tanaka, Ahmed M Hegazy, Masahiko Kobayashi, Yuko Tadokoro, Kumiko Ohta, Masaya Ueno, Mohamed A E Ali, Atsushi Hira. Loss of Tsc1 accelerates malignant gliomagenesis when combined with oncogenic signals. Journal of biochemistry. vol 155. issue 4. 2014-12-03. PMID:24368778. |
loss of heterozygosity of tuberous sclerosis complex 1 (tsc1) or tsc2, which together form a critical negative regulator of mtorc1, is also seen in glioblastoma; however, it is not known how loss of the tsc complex affects the development of malignant gliomas. |
2014-12-03 |
2023-08-12 |
mouse |
| Magdalena E Tyburczy, Ji-An Wang, Shaowei Li, Rajesh Thangapazham, Yvonne Chekaluk, Joel Moss, David J Kwiatkowski, Thomas N Darlin. Sun exposure causes somatic second-hit mutations and angiofibroma development in tuberous sclerosis complex. Human molecular genetics. vol 23. issue 8. 2014-11-18. PMID:24271014. |
tuberous sclerosis complex (tsc) is characterized by the formation of tumors in multiple organs and is caused by germline mutation in one of two tumor suppressor genes, tsc1 and tsc2. |
2014-11-18 |
2023-08-12 |
human |
| Karolina Pilipow, Veronica Basso, Nicola Migone, Anna Mondin. Monoallelic germline TSC1 mutations are permissive for T lymphocyte development and homeostasis in tuberous sclerosis complex individuals. PloS one. vol 9. issue 3. 2014-11-18. PMID:24633152. |
germline and somatic biallelic mutations of the tuberous sclerosis complex (tsc) 1 and tsc2 gene products cause tsc, an autosomal dominant multifocal hamartomatosis with variable neurological manifestations. |
2014-11-18 |
2023-08-12 |
mouse |
| C R Mi, H Wang, H Jiang, R P Sun, G X Wan. Mutation screening of TSC1 and TSC2 genes in Chinese Han children with tuberous sclerosis complex. Genetics and molecular research : GMR. vol 13. issue 1. 2014-11-06. PMID:24737435. |
mutation screening of tsc1 and tsc2 genes in chinese han children with tuberous sclerosis complex. |
2014-11-06 |
2023-08-13 |
Not clear |
| C R Mi, H Wang, H Jiang, R P Sun, G X Wan. Mutation screening of TSC1 and TSC2 genes in Chinese Han children with tuberous sclerosis complex. Genetics and molecular research : GMR. vol 13. issue 1. 2014-11-06. PMID:24737435. |
tuberous sclerosis complex (tsc) is an autosomal dominant neurogenetic disorder caused by mutations in the tsc1 or tsc2 genes and is frequently associated with hamartoma formation in multiple organ systems. |
2014-11-06 |
2023-08-13 |
Not clear |
| Kathleen Sturgeon, Keri Schadler, Geetha Muthukumaran, Dennis Ding, Akinyemi Bajulaiye, Nicholas J Thomas, Victor Ferrari, Sandra Ryeom, Joseph R Libonat. Concomitant low-dose doxorubicin treatment and exercise. American journal of physiology. Regulatory, integrative and comparative physiology. vol 307. issue 6. 2014-11-06. PMID:25009215. |
myocardial protein kinase b activity was increased with both dox and ex treatments, and tuberous sclerosis 2 (tsc2) abundance was reduced with ex. |
2014-11-06 |
2023-08-13 |
mouse |
| F Wang, X Chen, C Li, Q Sun, Y Chen, Y Wang, H Peng, Z Liu, R Chen, K Liu, H Yan, B H Ye, D J Kwiatkowski, H Zhan. Pivotal role of augmented αB-crystallin in tumor development induced by deficient TSC1/2 complex. Oncogene. vol 33. issue 34. 2014-10-15. PMID:24077282. |
tuberous sclerosis complex 1 (tsc1) and tsc2 are suppressors of mechanistic target of rapamycin (mtor). |
2014-10-15 |
2023-08-12 |
mouse |
| Yinan Zhang, Justin Nicholatos, John R Dreier, Stéphane J H Ricoult, Scott B Widenmaier, Gökhan S Hotamisligil, David J Kwiatkowski, Brendan D Mannin. Coordinated regulation of protein synthesis and degradation by mTORC1. Nature. vol 513. issue 7518. 2014-10-14. PMID:25043031. |
genetic activation of mtorc1 through loss of the tuberous sclerosis complex tumour suppressors, tsc1 or tsc2, or physiological activation of mtorc1 in response to growth factors or feeding resulted in increased nrf1 expression in cells and tissues. |
2014-10-14 |
2023-08-13 |
mouse |
| Ka-Te Huang, Yue-Han Huang, Peng Li, Bin He, Zhen-Kun Chen, Xia Yu, Jian-Ou Chen, Qi-Yu Zhang, Hong-Qi Shi, Yun-Feng Sha. Correlation between tuberous sclerosis complex 2 and glycogen synthase kinase 3 beta levels, and outcomes of patients with hepatocellular carcinoma treated by hepatectomy. Hepatology research : the official journal of the Japan Society of Hepatology. vol 44. issue 11. 2014-10-11. PMID:24119083. |
tuberous sclerosis complex 2 (tsc2), a tumor suppressor, may play an essential role in the regulation of cell growth and cell survival under energy stress conditions. |
2014-10-11 |
2023-08-12 |
Not clear |
| Angela Fuchs, Katharina König, Lukas C Heukamp, Jana Fassunke, Jutta Kirfel, Sebastian Huss, Albert J Becker, Reinhard Büttner, Michael Majore. Tuberous-sclerosis complex-related cell signaling in the pathogenesis of lung cancer. Diagnostic pathology. vol 9. 2014-09-04. PMID:24593867. |
hamartin (tsc1) and tuberin (tsc2), encoded by the tuberous sclerosis complex (tsc) genes, form a tumor-suppressor heterodimer which is implicated in pi3k-akt signaling and acts as a functional inhibitor of the mammalian target of rapamycin (mtor). |
2014-09-04 |
2023-08-12 |
Not clear |
| Ting Zhang, Pengyuan Dai, Dong Cheng, Liang Zhang, Zijiang Chen, Xiaoqian Meng, Fumiao Zhang, Xiaoying Han, Jianwei Liu, Jie Pan, Guiwen Yang, Cong Zhan. Obesity occurring in apolipoprotein E-knockout mice has mild effects on fertility. Reproduction (Cambridge, England). vol 147. issue 2. 2014-08-26. PMID:24196014. |
quantitative pcr analysis demonstrated that at d 100 the expression of cytochromep450 aromatase (cyp19a1), 3β-hydroxysteroid dehydrogenase (hsd3b), mechanistic target of rapamycin (mtor), and nuclear factor-κb (nfkb) decreased significantly, while that of bcl2-associated agonist of cell death (bad) and tuberous sclerosis complex 2 (tsc2) increased significantly in the apoe(-/-) mice. |
2014-08-26 |
2023-08-12 |
mouse |