| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Souheil El-Chemaly, Hilary J Goldberg, Allan R Glanvill. Should mammalian target of rapamycin inhibitors be stopped in women with lymphangioleiomyomatosis awaiting lung transplantation? Expert review of respiratory medicine. vol 8. issue 6. 2015-06-29. PMID:25199529. |
lymphangioleiomyomatosis (lam) is a rare cystic lung disease characterized by proliferation of smooth muscle like cells (lam cells) that have mutations in the tuberous sclerosis gene (tsc2), leading to the activation of the mammalian target of rapamycin (mtor). |
2015-06-29 |
2023-08-13 |
Not clear |
| Kazim Sahin, Brian Cross, Nurhan Sahin, Karina Ciccone, Shadeah Suleiman, Adeboye O Osunkoya, Viraj Master, Wayne Harris, Bradley Carthon, Ramzi Mohammad, Birdal Bilir, Karin Wertz, Carlos S Moreno, Cheryl L Walker, Omer Kucu. Lycopene in the prevention of renal cell cancer in the TSC2 mutant Eker rat model. Archives of biochemistry and biophysics. vol 572. 2015-06-24. PMID:25602702. |
eker rat represents a unique animal model to study rcc since these rats develop spontaneous renal tumors and leiomyoma, which may be due to tuberous sclerosis 2 (tsc2) mutation resulting in the activation of the mammalian target of rapamycin (mtor) pathway. |
2015-06-24 |
2023-08-13 |
rat |
| Jiandong Sun, Yan Liu, Stephanie Moreno, Michel Baudry, Xiaoning B. Imbalanced mechanistic target of rapamycin C1 and C2 activity in the cerebellum of Angelman syndrome mice impairs motor function. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 35. issue 11. 2015-06-15. PMID:25788687. |
levels of tuberous sclerosis complex 2 (tsc2), a negative regulator of mtor, were increased in as mice compared with wild-type mice; however, tsc2 inhibitory phosphorylation was also increased. |
2015-06-15 |
2023-08-13 |
mouse |
| Yang Sun, Erik Zhang, Taotao Lao, Ana M Pereira, Chenggang Li, Li Xiong, Tasha Morrison, Kathleen J Haley, Xiaobo Zhou, Jane J Y. Progesterone and estradiol synergistically promote the lung metastasis of tuberin-deficient cells in a preclinical model of lymphangioleiomyomatosis. Hormones & cancer. vol 5. issue 5. 2015-05-22. PMID:25069840. |
lam cells typically have inactivating tuberous sclerosis 2 (tsc2) mutations, leading to mtorc1 hyperactivation. |
2015-05-22 |
2023-08-13 |
rat |
| Julio C Valencia, Wendy K Steagall, Yi Zhang, Patricia Fetsch, Andrea Abati, Katsuya Tsukada, Eric Billings, Vincent J Hearing, Zu-Xi Yu, Gustavo Pacheco-Rodriguez, Joel Mos. Antibody αPEP13h reacts with lymphangioleiomyomatosis cells in lung nodules. Chest. vol 147. issue 3. 2015-05-12. PMID:25411763. |
lymphangioleiomyomatosis (lam) is characterized by the proliferation in the lung, axial lymphatics (eg, lymphangioleiomyomas), and kidney (eg, angiomyolipomas) of abnormal smooth muscle-like lam cells, which express melanoma antigens such as pmel17/gp100 and have dysfunctional tumor suppressor tuberous sclerosis complex (tsc) genes tsc2 or tsc1. |
2015-05-12 |
2023-08-13 |
Not clear |
| Hae-Jin Hu, Yeun-Jun Chung, Han-Wook Yoo, Young-Hoon Kim, Tae-Hoon Eo. A novel TSC2 mutation in a Korean patient with tuberous sclerosis complex. Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology. vol 35. issue 9. 2015-05-11. PMID:24770934. |
a novel tsc2 mutation in a korean patient with tuberous sclerosis complex. |
2015-05-11 |
2023-08-13 |
Not clear |
| Antje Thien, Mirja Tamara Prentzell, Birgit Holzwarth, Kathrin Kläsener, Ineke Kuper, Christopher Boehlke, Annika G Sonntag, Stefanie Ruf, Lars Maerz, Roland Nitschke, Sushma-Nagaraja Grellscheid, Michael Reth, Gerd Walz, Ralf Baumeister, Elke Neumann-Haefelin, Kathrin Thediec. TSC1 activates TGF-β-Smad2/3 signaling in growth arrest and epithelial-to-mesenchymal transition. Developmental cell. vol 32. issue 5. 2015-05-07. PMID:25727005. |
the tuberous sclerosis proteins tsc1 and tsc2 are key integrators of growth factor signaling. |
2015-05-07 |
2023-08-13 |
Not clear |
| Lei Liang, Xi-Ling Shou, Hai-Kang Zhao, Gu-Qun Ren, Jian-Bang Wang, Xi-Hui Wang, Wen-Ting Ai, Jackie R Maris, Lindsay K Hueckstaedt, Ai-Qun Ma, Yingmei Zhan. Antioxidant catalase rescues against high fat diet-induced cardiac dysfunction via an IKKβ-AMPK-dependent regulation of autophagy. Biochimica et biophysica acta. vol 1852. issue 2. 2015-04-17. PMID:24993069. |
high fat diet intake dampened phosphorylation of inhibitor kappa b kinase β(ikkβ), amp-activated protein kinase (ampk) and tuberous sclerosis 2 (tsc2) while promoting phosphorylation of mtor, the effects of which were ablated by catalase. |
2015-04-17 |
2023-08-13 |
mouse |
| Natalia S Rozas, John B Redell, James McKenna, Anthony N Moore, Michael J Gambello, Pramod K Das. Prolonging the survival of Tsc2 conditional knockout mice by glutamine supplementation. Biochemical and biophysical research communications. vol 457. issue 4. 2015-04-17. PMID:25613864. |
the genetic disease tuberous sclerosis complex (tsc) is an autosomal dominant disorder caused by loss of function mutations in either tsc1 (hamartin) or tsc2 (tuberin), which serve as negative regulators of mechanistic target of rapamycin complex 1 (mtorc1) activity. |
2015-04-17 |
2023-08-13 |
mouse |
| Gauhar Rehman, Adeeb Shehzad, Abdul Latif Khan, Muhammad Hamayu. Role of AMP-activated protein kinase in cancer therapy. Archiv der Pharmazie. vol 347. issue 7. 2015-04-09. PMID:24677093. |
ampk has been shown to inhibit mammalian target of rapamycin (mtor) through tuberous sclerosis complex 2 (tsc2) phosphorylation and phosphatase and tensin homolog (pten), considered as central cell growth controller signals in diseases. |
2015-04-09 |
2023-08-12 |
Not clear |
| Elena Lesma, Silvia Ancona, Silvia M Sirchia, Emanuela Orpianesi, Vera Grande, Patrizia Colapietro, Eloisa Chiaramonte, Anna Maria Di Giulio, Alfredo Gori. TSC2 epigenetic defect in primary LAM cells. Evidence of an anchorage-independent survival. Journal of cellular and molecular medicine. vol 18. issue 5. 2015-04-06. PMID:24606538. |
tuberous sclerosis complex (tsc) is caused by mutations in tsc1 or tsc2 genes. |
2015-04-06 |
2023-08-12 |
Not clear |
| Zheng Yu, Xin Zhang, Hong Guo, Yun Ba. A novel TSC2 mutation in a Chinese family with tuberous sclerosis complex. Journal of genetics. vol 93. issue 1. 2015-04-06. PMID:24840834. |
a novel tsc2 mutation in a chinese family with tuberous sclerosis complex. |
2015-04-06 |
2023-08-13 |
Not clear |
| Michael D Dennis, Catherine S Coleman, Arthur Berg, Leonard S Jefferson, Scot R Kimbal. REDD1 enhances protein phosphatase 2A-mediated dephosphorylation of Akt to repress mTORC1 signaling. Science signaling. vol 7. issue 335. 2015-03-30. PMID:25056877. |
growth factors activate mtorc1 by stimulating the kinase akt, which phosphorylates and inhibits the tuberous sclerosis complex [tsc; which is composed of tsc1, tsc2, and tbc1d7 (tre2-bub2-cdc16 domain family member 7)], thereby stimulating the mtorc1 activator rheb (ras homolog enriched in brain). |
2015-03-30 |
2023-08-13 |
mouse |
| Jin Sook Lee, Byung Chan Lim, Jong-Hee Chae, Yong Seung Hwang, Moon-Woo Seong, Sung Sup Park, Ki Joong Ki. Mutational analysis of paediatric patients with tuberous sclerosis complex in Korea: genotype and epilepsy. Epileptic disorders : international epilepsy journal with videotape. vol 16. issue 4. 2015-03-26. PMID:25498131. |
to date, only a few studies have reported that, in tuberous sclerosis, tsc2 mutations are more frequently associated with infantile spasms and cognitive impairment compared to tsc1 mutations. |
2015-03-26 |
2023-08-13 |
Not clear |
| S Boronat, E A Shaaya, C M Doherty, P Caruso, E A Thiel. Tuberous sclerosis complex without tubers and subependymal nodules: a phenotype-genotype study. Clinical genetics. vol 86. issue 2. 2015-03-12. PMID:23909698. |
tuberous sclerosis complex (tsc) is caused by a mutation in the tsc1 or tsc2 genes. |
2015-03-12 |
2023-08-12 |
Not clear |
| Nadia Mariagrazia Giannantoni, Domenico Restuccia, Giacomo Della Marca, Rosa Maria Alfano, Catello Vollon. A novel TSC2 mutation causing tuberless tuberous sclerosis. Seizure. vol 23. issue 7. 2015-02-19. PMID:24794161. |
a novel tsc2 mutation causing tuberless tuberous sclerosis. |
2015-02-19 |
2023-08-13 |
Not clear |
| Alessia Di Nardo, Mary H Wertz, Erica Kwiatkowski, Peter T Tsai, Jarrett D Leech, Emily Greene-Colozzi, June Goto, Pelin Dilsiz, Delia M Talos, Clary B Clish, David J Kwiatkowski, Mustafa Sahi. Neuronal Tsc1/2 complex controls autophagy through AMPK-dependent regulation of ULK1. Human molecular genetics. vol 23. issue 14. 2015-02-09. PMID:24599401. |
tuberous sclerosis complex (tsc) is a disorder arising from mutation in the tsc1 or tsc2 gene, characterized by the development of hamartomas in various organs and neurological manifestations including epilepsy, intellectual disability and autism. |
2015-02-09 |
2023-08-12 |
mouse |
| Heung-Mo Yang, Hye-Jung Choi, Doo-Pyo Hong, Sung-Yeon Joo, Na-Eun Lee, Ji-Young Song, Yoon-La Choi, Jeeyun Lee, Dongil Choi, BoKyung Kim, Hyo-Jun Park, Jae-Berm Park, Sung Joo Ki. The analysis of mutations and exon deletions at TSC2 gene in angiomyolipomas associated with tuberous sclerosis complex. Experimental and molecular pathology. vol 97. issue 3. 2015-02-04. PMID:25281918. |
the analysis of mutations and exon deletions at tsc2 gene in angiomyolipomas associated with tuberous sclerosis complex. |
2015-02-04 |
2023-08-13 |
Not clear |
| Yang Sun, Dana Gallacchi, Erik Y Zhang, Samuel B Reynolds, Lauren Robinson, Izabela A Malinowska, Terry T Chiou, Ana M Pereira, Chenggang Li, David J Kwiatkowski, Po-Shun Lee, Jane J Y. Rapamycin-resistant poly (ADP-ribose) polymerase-1 overexpression is a potential therapeutic target in lymphangioleiomyomatosis. American journal of respiratory cell and molecular biology. vol 51. issue 6. 2015-01-30. PMID:24874429. |
lam cells typically have inactivating tuberous sclerosis complex 2 (tsc2) mutations and mammalian target of rapamycin (mtor) complex (mtorc) 1 activation. |
2015-01-30 |
2023-08-13 |
mouse |
| Han C Dan, Aaron Ebbs, Manolis Pasparakis, Terry Van Dyke, Daniela S Basseres, Albert S Baldwi. Akt-dependent activation of mTORC1 complex involves phosphorylation of mTOR (mammalian target of rapamycin) by IκB kinase α (IKKα). The Journal of biological chemistry. vol 289. issue 36. 2015-01-28. PMID:24990947. |
akt is known to stimulate mtorc1 activity through phosphorylation of tuberous sclerosis complex 2 (tsc2) and pras40, both negative regulators of mtor activity. |
2015-01-28 |
2023-08-13 |
Not clear |