| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Zhengzhong Zhang, Yongmei Lyu, Yunzhu Mu, Hao Yang, Ping Yang, Yiping Liu, Linli Liu, Xing Chen, Weichi Su. [Analysis of TSC gene mutation in a patient with tuberous sclerosis]. Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics. vol 32. issue 4. 2015-11-16. PMID:26252095. |
to identify pathogenic mutation of the tsc1 and tsc2 genes in a patient with tuberous sclerosis. |
2015-11-16 |
2023-08-13 |
Not clear |
| Xin Wu, Yannong Dou, Yan Yang, Difei Bian, Jinque Luo, Bei Tong, Yufeng Xia, Yue Da. Arctigenin exerts anti-colitis efficacy through inhibiting the differentiation of Th1 and Th17 cells via an mTORC1-dependent pathway. Biochemical pharmacology. vol 96. issue 4. 2015-11-09. PMID:26074264. |
interestingly, the inhibitory effect of arctigenin on t cell differentiation disappeared under a status of mtorc1 overactivation via knockdown of tuberous sclerosis complex 2 (tsc2, a negative regulator of mtorc1) or pretreatment of leucine (an agonist of mtor). |
2015-11-09 |
2023-08-13 |
mouse |
| N Lozovaya, S Gataullina, T Tsintsadze, V Tsintsadze, E Pallesi-Pocachard, M Minlebaev, N A Goriounova, E Buhler, F Watrin, S Shityakov, A J Becker, A Bordey, M Milh, D Scavarda, C Bulteau, G Dorfmuller, O Delalande, A Represa, C Cardoso, O Dulac, Y Ben-Ari, N Burnashe. Selective suppression of excessive GluN2C expression rescues early epilepsy in a tuberous sclerosis murine model. Nature communications. vol 5. 2015-11-02. PMID:25081057. |
tuberous sclerosis complex (tsc), caused by dominant mutations in either tsc1 or tsc2 tumour suppressor genes is characterized by the presence of brain malformations, the cortical tubers that are thought to contribute to the generation of pharmacoresistant epilepsy. |
2015-11-02 |
2023-08-13 |
mouse |
| Shin Yasuda, Hiroko Sugiura, Shutaro Katsurabayashi, Tadayuki Shimada, Hidekazu Tanaka, Kotaro Takasaki, Katsunori Iwasaki, Toshiyuki Kobayashi, Okio Hino, Kanato Yamagat. Activation of Rheb, but not of mTORC1, impairs spine synapse morphogenesis in tuberous sclerosis complex. Scientific reports. vol 4. 2015-10-26. PMID:24889507. |
mutations in the tsc1 or tsc2 genes cause tuberous sclerosis complex (tsc). |
2015-10-26 |
2023-08-13 |
Not clear |
| A Tarasewicz, A Dębska-Ślizień, M Bułanowski, A Więcek, B Rutkowsk. Everolimus in immunosuppressive treatment after kidney transplantation in a patient with tuberous sclerosis: case report. Transplantation proceedings. vol 46. issue 8. 2015-10-26. PMID:25380949. |
tuberous sclerosis complex (tsc) is an inherited disorder caused by mutations of tsc1 or tsc2 genes, resulting in constitutive activation of the mammalian target of rapamycin (mtor) and impairment of the cell cycle. |
2015-10-26 |
2023-08-13 |
Not clear |
| Duyu Nie, Zehua Chen, Darius Ebrahimi-Fakhari, Alessia Di Nardo, Kristina Julich, Victoria K Robson, Yung-Chih Cheng, Clifford J Woolf, Myriam Heiman, Mustafa Sahi. The Stress-Induced Atf3-Gelsolin Cascade Underlies Dendritic Spine Deficits in Neuronal Models of Tuberous Sclerosis Complex. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 35. issue 30. 2015-10-16. PMID:26224859. |
hyperactivation of the mechanistic target of rapamycin (mtor) kinase, as a result of loss-of-function mutations in tuberous sclerosis complex 1 (tsc1) or tsc2 genes, causes protein synthesis dysregulation, increased cell size, and aberrant neuronal connectivity. |
2015-10-16 |
2023-08-13 |
mouse |
| James W Wheless, Paul Klim. Subependymal giant cell astrocytomas in patients with tuberous sclerosis complex: considerations for surgical or pharmacotherapeutic intervention. Journal of child neurology. vol 29. issue 11. 2015-10-15. PMID:24105488. |
tuberous sclerosis complex is a genetic disorder caused by mutations in either the tsc1 or tsc2 gene that can result in the growth of hamartomas in multiple organ systems. |
2015-10-15 |
2023-08-12 |
Not clear |
| Yadan Bai, Baoqin Xuan, Haiyan Liu, Jin Zhong, Dong Yu, Zhikang Qia. Tuberous Sclerosis Complex Protein 2-Independent Activation of mTORC1 by Human Cytomegalovirus pUL38. Journal of virology. vol 89. issue 15. 2015-10-09. PMID:25972538. |
the multifunctional hcmv protein pul38 previously has been reported to activate mtorc1 by binding to and antagonizing tuberous sclerosis complex protein 2 (tsc2) (j. n. moorman et al., cell host microbe 3:253-262, 2008, http://dx.doi.org/10.1016/j.chom.2008.03.002). |
2015-10-09 |
2023-08-13 |
human |
| Olympia Pikiou, Anna Vasilaki, George Leondaritis, Nikos Vamvakopoulos, Ioannis E Messini. Effects of metformin on fertilisation of bovine oocytes and early embryo development: possible involvement of AMPK3-mediated TSC2 activation. Zygote (Cambridge, England). vol 23. issue 1. 2015-09-28. PMID:23870192. |
tuberous sclerosis complex 2 (tsc2) has been identified as a downstream target of ampk. |
2015-09-28 |
2023-08-12 |
cattle |
| Doug Medvetz, Carmen Priolo, Elizabeth P Hensk. Therapeutic targeting of cellular metabolism in cells with hyperactive mTORC1: a paradigm shift. Molecular cancer research : MCR. vol 13. issue 1. 2015-09-16. PMID:25298408. |
mtorc1 is hyperactive in the human disease tuberous sclerosis complex (tsc), an autosomal dominant disorder caused by germline mutations in the tsc1 or tsc2 gene. |
2015-09-16 |
2023-08-13 |
human |
| Elena N Atochina-Vasserman, Chang-Jiang Guo, Elena Abramova, Thea N Golden, Michael Sims, Melane L James, Michael F Beers, Andrew J Gow, Vera P Krymskay. Surfactant dysfunction and lung inflammation in the female mouse model of lymphangioleiomyomatosis. American journal of respiratory cell and molecular biology. vol 53. issue 1. 2015-09-16. PMID:25474372. |
pulmonary lymphangioleiomyomatosis (lam) is a rare lung disease caused by mutations of the tumor suppressor genes, tuberous sclerosis complex (tsc) 1 or tsc2. |
2015-09-16 |
2023-08-13 |
mouse |
| Y Zhou, P Rychahou, Q Wang, H L Weiss, B M Ever. TSC2/mTORC1 signaling controls Paneth and goblet cell differentiation in the intestinal epithelium. Cell death & disease. vol 6. 2015-09-11. PMID:25654764. |
previously, we have shown that tuberous sclerosis 2 (tsc2) positively regulates the expression of the goblet cell differentiation marker, muc2, in intestinal cells. |
2015-09-11 |
2023-08-13 |
mouse |
| A Sato, Y Takamatsu, Y Kasai, S Kobayashi, T Hino, K Ikeda, M Mizuguch. [JSNP Excellent Presentation Award for CINP2014: Tsc2 haploinsufficiency is associated with more severe autism-related behavioral deficits in mouse models of tuberous sclerosis complex]. Nihon shinkei seishin yakurigaku zasshi = Japanese journal of psychopharmacology. vol 35. issue 2. 2015-08-21. PMID:26027069. |
[jsnp excellent presentation award for cinp2014: tsc2 haploinsufficiency is associated with more severe autism-related behavioral deficits in mouse models of tuberous sclerosis complex]. |
2015-08-21 |
2023-08-13 |
mouse |
| Kristen N Pollizzi, Chirag H Patel, Im-Hong Sun, Min-Hee Oh, Adam T Waickman, Jiayu Wen, Greg M Delgoffe, Jonathan D Powel. mTORC1 and mTORC2 selectively regulate CD8⁺ T cell differentiation. The Journal of clinical investigation. vol 125. issue 5. 2015-08-17. PMID:25893604. |
evaluation of mice with a t cell-specific deletion of the gene encoding the negative regulator of mtorc1, tuberous sclerosis complex 2 (tsc2), resulted in the generation of highly glycolytic and potent effector cd8+ t cells; however, due to constitutive mtorc1 activation, these cells retained a terminally differentiated effector phenotype and were incapable of transitioning into a memory state. |
2015-08-17 |
2023-08-13 |
mouse |
| Fengjie Zhang, Qiling He, Wing Pui Tsang, W Timothy Garvey, Wai Yee Chan, Chao Wa. Insulin exerts direct, IGF-1 independent actions in growth plate chondrocytes. Bone research. vol 2. 2015-08-14. PMID:26273523. |
intriguingly, the size of hypertrophic chondrocytes was smaller in cartir (-/-) mice when compared with that of the control littermates, which was associated with upregulation of tuberous sclerosis complex 2 (tsc2). |
2015-08-14 |
2023-08-13 |
mouse |
| Irmina Grzegorek, Ewa Zuba-Surma, Mariusz Chabowski, Dariusz Janczak, Andrzej Szuba, Piotr Dziegie. Characterization of cells cultured from chylous effusion from a patient with sporadic lymphangioleiomyomatosis. Anticancer research. vol 35. issue 6. 2015-08-06. PMID:26026094. |
it is caused by a mutation in one of the tuberous sclerosis genes, tsc1 or tsc2, and constitutive activation of the mammalian target of rapamycin (mtor) pathway in smooth muscle-like cells (lam cells). |
2015-08-06 |
2023-08-13 |
Not clear |
| K Zitterbar. [Subependymal giant cell astrocytoma associated with tuberous sclerosis complex - pharmacological treatment using mTOR inhibitors]. Klinicka onkologie : casopis Ceske a Slovenske onkologicke spolecnosti. vol 27. issue 6. 2015-06-30. PMID:25493579. |
tuberous sclerosis complex is a neurocutaneous syndrome that results from a germline mutation in tsc1 or tsc2 genes. |
2015-06-30 |
2023-08-13 |
Not clear |
| Mark Nellist, Rutger W W Brouwer, Christel E M Kockx, Monique van Veghel-Plandsoen, Caroline Withagen-Hermans, Lida Prins-Bakker, Marianne Hoogeveen-Westerveld, Alan Mrsic, Mike M P van den Berg, Anna E Koopmans, Marie-Claire de Wit, Floor E Jansen, Anneke J A Maat-Kievit, Ans van den Ouweland, Dicky Halley, Annelies de Klein, Wilfred F J van IJcke. Targeted Next Generation Sequencing reveals previously unidentified TSC1 and TSC2 mutations. BMC medical genetics. vol 16. 2015-06-30. PMID:25927202. |
tuberous sclerosis complex (tsc) is an autosomal dominant disorder caused by mutations in tsc1 and tsc2. |
2015-06-30 |
2023-08-13 |
Not clear |
| Cristina Cabrera-López, Gemma Bullich, Teresa Martí, Violeta Català, Jose Ballarín, John J Bissler, Peter C Harris, Elisabet Ars, Roser Torr. Insight into response to mTOR inhibition when PKD1 and TSC2 are mutated. BMC medical genetics. vol 16. 2015-06-30. PMID:26077033. |
mutations in tsc1 or tsc2 cause the tuberous sclerosis complex (tsc), while mutations in pkd1 or pkd2 cause autosomal dominant polycystic kidney disease (adpkd). |
2015-06-30 |
2023-08-13 |
Not clear |
| Tomoko Kaneko-Tarui, Arno E Commandeur, Amanda L Patterson, Justin L DeKuiper, David Petillo, Aaron K Styer, Jose M Teixeir. Hyperplasia and fibrosis in mice with conditional loss of the TSC2 tumor suppressor in Müllerian duct mesenchyme-derived myometria. Molecular human reproduction. vol 20. issue 11. 2015-06-29. PMID:25189766. |
loss of the tuberous sclerosis 2 (tsc2) tumor suppressor has been proposed as a mechanism important for the etiology of uterine leiomyomata based on the eker rat model. |
2015-06-29 |
2023-08-13 |
mouse |