| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jarosław Jóźwiak, Iwona Sontowska, Rafał Płosk. Frequency of TSC1 and TSC2 mutations in American, British, Polish and Taiwanese populations. Molecular medicine reports. vol 8. issue 3. 2014-04-07. PMID:23846400. |
tuberous sclerosis (ts) is caused by mutation of the tumor suppressor genes, tuberous sclerosis complex 1 (tsc1) or 2 (tsc2). |
2014-04-07 |
2023-08-12 |
Not clear |
| Brittany L Jacobs, Jae-Sung You, John W Frey, Craig A Goodman, David M Gundermann, Troy A Hornberge. Eccentric contractions increase the phosphorylation of tuberous sclerosis complex-2 (TSC2) and alter the targeting of TSC2 and the mechanistic target of rapamycin to the lysosome. The Journal of physiology. vol 591. issue 18. 2014-04-03. PMID:23732640. |
eccentric contractions increase the phosphorylation of tuberous sclerosis complex-2 (tsc2) and alter the targeting of tsc2 and the mechanistic target of rapamycin to the lysosome. |
2014-04-03 |
2023-08-12 |
mouse |
| Brittany L Jacobs, Jae-Sung You, John W Frey, Craig A Goodman, David M Gundermann, Troy A Hornberge. Eccentric contractions increase the phosphorylation of tuberous sclerosis complex-2 (TSC2) and alter the targeting of TSC2 and the mechanistic target of rapamycin to the lysosome. The Journal of physiology. vol 591. issue 18. 2014-04-03. PMID:23732640. |
the goal of this study was to determine whether the mechanical activation of mechanistic target of rapamycin (mtor) signalling is associated with changes in phosphorylation of tuberous sclerosis complex-2 (tsc2) and targeting of mtor and tsc2 to the lysosome. |
2014-04-03 |
2023-08-12 |
mouse |
| David Neal Fran. Everolimus in the treatment of subependymal giant cell astrocytomas, angiomyolipomas, and pulmonary and skin lesions associated with tuberous sclerosis complex. Biologics : targets & therapy. vol 7. 2014-04-02. PMID:24143074. |
tuberous sclerosis complex (tsc) is an autosomal dominant genetic disorder caused by inactivating mutations in either the tsc1 or tsc2 genes. |
2014-04-02 |
2023-08-12 |
Not clear |
| Hidehiro Okura, Toshiyuki Kobayashi, Masato Koike, Maki Ohsawa, Danqing Zhang, Hajime Arai, Yasuo Uchiyama, Okio Hin. Tuberin activates and controls the distribution of Rac1 via association with p62 and ubiquitin through the mTORC1 signaling pathway. International journal of oncology. vol 43. issue 2. 2014-03-20. PMID:23759924. |
recent studies indicated that the tuberous sclerosis 2 (tsc2) gene product, tuberin, regulates rac1 activity. |
2014-03-20 |
2023-08-12 |
mouse |
| Chenggang Li, Po-Shun Lee, Yang Sun, Xiaoxiao Gu, Erik Zhang, Yanan Guo, Chin-Lee Wu, Neil Auricchio, Carmen Priolo, Jing Li, Alfredo Csibi, Andrey Parkhitko, Tasha Morrison, Anna Planaguma, Shamsah Kazani, Elliot Israel, Kai-Feng Xu, Elizabeth Petri Henske, John Blenis, Bruce D Levy, David Kwiatkowski, Jane J Y. Estradiol and mTORC2 cooperate to enhance prostaglandin biosynthesis and tumorigenesis in TSC2-deficient LAM cells. The Journal of experimental medicine. vol 211. issue 1. 2014-03-10. PMID:24395886. |
lam is typically caused by tuberous sclerosis complex 2 (tsc2) mutations resulting in mtorc1 activation in proliferative smooth muscle-like cells in the lung. |
2014-03-10 |
2023-08-12 |
human |
| Baran A Ersoy, Akansha Tarun, Katharine D'Aquino, Nancy J Hancer, Chinweike Ukomadu, Morris F White, Thomas Michel, Brendan D Manning, David E Cohe. Phosphatidylcholine transfer protein interacts with thioesterase superfamily member 2 to attenuate insulin signaling. Science signaling. vol 6. issue 286. 2014-02-20. PMID:23901139. |
additionally, we showed that pc-tp bound to tuberous sclerosis complex 2 (tsc2) and stabilized the components of the tsc1-tsc2 complex, which functions to inhibit mtorc1. |
2014-02-20 |
2023-08-12 |
mouse |
| Wei Sun, Ye Julia Zhu, Zhizhi Wang, Qiang Zhong, Feng Gao, Jizhong Lou, Weimin Gong, Wenqing X. Crystal structure of the yeast TSC1 core domain and implications for tuberous sclerosis pathological mutations. Nature communications. vol 4. 2014-01-30. PMID:23857276. |
tuberous sclerosis complex is a disease caused by mutations in two tumor-suppressor genes, tsc1 and tsc2. |
2014-01-30 |
2023-08-12 |
human |
| Altaf Mohammed, Naveena B Janakiram, Misty Brewer, Rebekah L Ritchie, Anuj Marya, Stan Lightfoot, Vernon E Steele, Chinthalapally V Ra. Antidiabetic Drug Metformin Prevents Progression of Pancreatic Cancer by Targeting in Part Cancer Stem Cells and mTOR Signaling. Translational oncology. vol 6. issue 6. 2014-01-27. PMID:24466367. |
the pancreatic tissue and/or serum of mice fed metformin showed a significant inhibition of mammalian target of rapamycin (mtor), extracellular signal-regulated kinases (erk), phosphorylated extracellular signal-regulated kinases (perk), and insulin-like growth factor 1 (igf-1) with an increase in phosphorylated 5' adenosine monophosphate kinase (pampk), tuberous sclerosis complex 1 (tsc1, tsc2), c-protein and an autophagy related protein 2 (atg2). |
2014-01-27 |
2023-08-12 |
mouse |
| Irmina Grzegorek, Katarzyna Drozdz, Marzenna Podhorska-Okolow, Andrzej Szuba, Piotr Dziegie. LAM cells biology and lymphangioleiomyomatosis. Folia histochemica et cytobiologica. vol 51. issue 1. 2014-01-17. PMID:23690211. |
progressive lung tissue destruction in lymphangioleiomyomatosis (lam) occurs as a result of excessive proliferation of lam cells caused by a mutation in one of the tuberous sclerosis complex suppressor genes, tsc1 or tsc2. |
2014-01-17 |
2023-08-12 |
human |
| Elena N Atochina-Vasserman, Dmitry A Goncharov, Alla V Volgina, Megan Milavec, Melane L James, Vera P Krymskay. Statins in lymphangioleiomyomatosis. Simvastatin and atorvastatin induce differential effects on tuberous sclerosis complex 2-null cell growth and signaling. American journal of respiratory cell and molecular biology. vol 49. issue 5. 2013-12-27. PMID:23947572. |
mutations of the tumor suppressor genes tuberous sclerosis complex (tsc)1 and tsc2 cause pulmonary lymphangioleiomyomatosis (lam) and tuberous sclerosis (ts). |
2013-12-27 |
2023-08-12 |
mouse |
| Shilpa Prabhakar, June Goto, Xuan Zhang, Xuan Zuang, Miguel Sena-Esteves, Roderick Bronson, Jillian Brockmann, Davide Gianni, Gregory R Wojtkiewicz, John W Chen, Anat Stemmer-Rachamimov, David J Kwiatkowski, Xandra O Breakefiel. Stochastic model of Tsc1 lesions in mouse brain. PloS one. vol 8. issue 5. 2013-12-23. PMID:23696872. |
tuberous sclerosis complex (tsc) is an autosomal dominant disorder due to mutations in either tsc1 or tsc2 that affects many organs with hamartomas and tumors. |
2013-12-23 |
2023-08-12 |
mouse |
| Jiangwei Zhang, Jinhee Kim, Angela Alexander, Shengli Cai, Durga Nand Tripathi, Ruhee Dere, Andrew R Tee, Jacqueline Tait-Mulder, Alessia Di Nardo, Juliette M Han, Erica Kwiatkowski, Elaine A Dunlop, Kayleigh M Dodd, Rebecca D Folkerth, Phyllis L Faust, Michael B Kastan, Mustafa Sahin, Cheryl Lyn Walke. A tuberous sclerosis complex signalling node at the peroxisome regulates mTORC1 and autophagy in response to ROS. Nature cell biology. vol 15. issue 10. 2013-12-17. PMID:23955302. |
we report that the tuberous sclerosis complex (tsc) signalling node, tsc1, tsc2 and rheb, localizes to peroxisomes, where it regulates mtorc1 in response to reactive oxygen species (ros). |
2013-12-17 |
2023-08-12 |
Not clear |
| T Padma Priya, Ashwin B Dala. Tuberous sclerosis: diagnosis and prenatal diagnosis by MLPA. Indian journal of pediatrics. vol 79. issue 10. 2013-12-09. PMID:21541650. |
tuberous sclerosis complex (tsc) is an autosomal dominant disorder, caused due to mutations in the tsc1 and tsc2 genes. |
2013-12-09 |
2023-08-12 |
Not clear |
| H Peng, J Liu, Q Sun, R Chen, Y Wang, J Duan, C Li, B Li, Y Jing, X Chen, Q Mao, K-F Xu, C L Walker, J Li, J Wang, H Zhan. mTORC1 enhancement of STIM1-mediated store-operated Ca2+ entry constrains tuberous sclerosis complex-related tumor development. Oncogene. vol 32. issue 39. 2013-11-15. PMID:23108404. |
the protein complex of tuberous sclerosis complex (tsc)1 and tsc2 tumor suppressors is a key negative regulator of mammalian target of rapamycin (mtor). |
2013-11-15 |
2023-08-12 |
Not clear |
| Yo Niida, Akiko Wakisaka, Takanori Tsuji, Hiroshi Yamada, Mondo Kuroda, Yusuke Mitani, Akiko Okumura, Ayano Yoko. Mutational analysis of TSC1 and TSC2 in Japanese patients with tuberous sclerosis complex revealed higher incidence of TSC1 patients than previously reported. Journal of human genetics. vol 58. issue 4. 2013-11-15. PMID:23389244. |
mutational analysis of tsc1 and tsc2 in japanese patients with tuberous sclerosis complex revealed higher incidence of tsc1 patients than previously reported. |
2013-11-15 |
2023-08-12 |
Not clear |
| David M Feliciano, Shiliang Zhang, Jennifer L Quon, Angélique Borde. Hypoxia-inducible factor 1a is a Tsc1-regulated survival factor in newborn neurons in tuberous sclerosis complex. Human molecular genetics. vol 22. issue 9. 2013-11-14. PMID:23349360. |
tuberous sclerosis complex (tsc) is a genetic disorder caused by mutations in tsc1 or tsc2 resulting in hyperactivity of the mammalian target of rapamycin and disabling brain lesions. |
2013-11-14 |
2023-08-12 |
mouse |
| Marco Cambiaghi, Marco Cursi, Laura Magri, Valerio Castoldi, Giancarlo Comi, Fabio Minicucci, Rossella Galli, Letizia Leocan. Behavioural and EEG effects of chronic rapamycin treatment in a mouse model of tuberous sclerosis complex. Neuropharmacology. vol 67. 2013-11-04. PMID:23159330. |
tuberous sclerosis complex (tsc) is a multisystem genetic disorder caused by mutation in either tsc1 or tsc2 genes that leads to the hyper activation of the mtor pathway, a key signalling pathway for synaptic plasticity. |
2013-11-04 |
2023-08-12 |
mouse |
| James L Figarola, Samuel Rahba. Small‑molecule COH-SR4 inhibits adipocyte differentiation via AMPK activation. International journal of molecular medicine. vol 31. issue 5. 2013-10-29. PMID:23525347. |
ampk activation by coh-sr4 also resulted in the phosphorylation of raptor and tuberous sclerosis protein 2 (tsc2), two proteins involved in the mammalian target of rapamycin (mtor) signaling pathways. |
2013-10-29 |
2023-08-12 |
Not clear |
| Juan José García-Peñas, Inmaculada Carreras-Sááe. [Autism, epilepsy and tuberous sclerosis complex: a functional model linked to mTOR pathway]. Revista de neurologia. vol 56 Suppl 1. 2013-10-28. PMID:23446718. |
tuberous sclerosis complex (tsc) is an autosomal dominant disorder that results from mutations in the tsc1 or tsc2 genes and is associated with hamartoma formation in multiple organ systems. |
2013-10-28 |
2023-08-12 |
Not clear |