| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Romana Tomasoni, Anna Mondin. The tuberous sclerosis complex: balancing proliferation and survival. Biochemical Society transactions. vol 39. issue 2. 2011-07-01. PMID:21428921. |
mutations in genes encoding either hamartin [tsc1 (tuberous sclerosis complex 1)] or tuberin (tsc2) result in a multisystem disorder characterized by the development of benign tumours and hamartomas in several organs. |
2011-07-01 |
2023-08-12 |
Not clear |
| David M Feliciano, Tiffany Su, Jean Lopez, Jean-Claude Platel, Angélique Borde. Single-cell Tsc1 knockout during corticogenesis generates tuber-like lesions and reduces seizure threshold in mice. The Journal of clinical investigation. vol 121. issue 4. 2011-06-21. PMID:21403402. |
tuberous sclerosis complex (tsc) is an autosomal dominant disorder characterized by mutations in tsc1 or tsc2 that lead to mammalian target of rapamycin (mtor) hyperactivity. |
2011-06-21 |
2023-08-12 |
mouse |
| Peggy P Hsu, Seong A Kang, Jonathan Rameseder, Yi Zhang, Kathleen A Ottina, Daniel Lim, Timothy R Peterson, Yongmun Choi, Nathanael S Gray, Michael B Yaffe, Jarrod A Marto, David M Sabatin. The mTOR-regulated phosphoproteome reveals a mechanism of mTORC1-mediated inhibition of growth factor signaling. Science (New York, N.Y.). vol 332. issue 6035. 2011-06-21. PMID:21659604. |
the adaptor protein grb10 was identified as an mtorc1 substrate that mediates the inhibition of phosphoinositide 3-kinase typical of cells lacking tuberous sclerosis complex 2 (tsc2), a tumor suppressor and negative regulator of mtorc1. |
2011-06-21 |
2023-08-12 |
Not clear |
| Seok-Hyung Kim, Christina K Speirs, Lilianna Solnica-Krezel, Kevin C Es. Zebrafish model of tuberous sclerosis complex reveals cell-autonomous and non-cell-autonomous functions of mutant tuberin. Disease models & mechanisms. vol 4. issue 2. 2011-06-15. PMID:20959633. |
tuberous sclerosis complex (tsc) is an autosomal dominant disease caused by mutations in either the tsc1 (encodes hamartin) or tsc2 (encodes tuberin) genes. |
2011-06-15 |
2023-08-12 |
human |
| Dan Ehninger, Alcino J Silv. Rapamycin for treating Tuberous sclerosis and Autism spectrum disorders. Trends in molecular medicine. vol 17. issue 2. 2011-05-26. PMID:21115397. |
tuberous sclerosis (tsc) is a genetic disorder caused by heterozygous mutations in the tsc1 or tsc2 genes and is associated with autism spectrum disorders (asd) in 20-60% of cases. |
2011-05-26 |
2023-08-12 |
Not clear |
| Liliana D Petrov. Tuberous sclerosis and epilepsy. American journal of electroneurodiagnostic technology. vol 51. issue 1. 2011-05-17. PMID:21516926. |
tuberous sclerosis complex (tsc) is an inherited disorder resulting from mutations in one of two tumor suppressor genes: tsc1 (hamartin) and tsc2 (tuberin). |
2011-05-17 |
2023-08-12 |
Not clear |
| Amy J Malhowski, Haider Hira, Sarah Bashiruddin, Rod Warburton, June Goto, Blanton Robert, David J Kwiatkowski, Geraldine A Finla. Smooth muscle protein-22-mediated deletion of Tsc1 results in cardiac hypertrophy that is mTORC1-mediated and reversed by rapamycin. Human molecular genetics. vol 20. issue 7. 2011-05-16. PMID:21212099. |
constitutive activation of mammalian target of rapamycin complex 1 (mtorc1), a key kinase complex that regulates cell size and growth, is observed with inactivating mutations of either of the tuberous sclerosis complex (tsc) genes, tsc1 and tsc2. |
2011-05-16 |
2023-08-12 |
mouse |
| Lihua Cui, Yuanyuan Ren, Hao Yin, Yuebing Wang, Dong Li, Meng Liu, Yingjun Zhu, Wanjun Lin, Xiang D Tang, Yu Gui, Xi-Long Zhen. Increased expression of tuberin in human uterine leiomyoma. Fertility and sterility. vol 95. issue 5. 2011-05-11. PMID:21145542. |
female eker rats harboring an insertional deletion in one copy of the tuberous sclerosis complex 2 (tsc2) gene develop uterine leiomyoma, but the underlying mechanism of human uterine leiomyoma is not completely understood. |
2011-05-11 |
2023-08-12 |
human |
| Garilyn M Jentarra, Stephen G Rice, Shannon Olfers, David Saffen, Vinodh Narayana. Evidence for population variation in TSC1 and TSC2 gene expression. BMC medical genetics. vol 12. 2011-05-11. PMID:21345208. |
tuberous sclerosis complex (tsc) is an autosomal dominant neurogenetic disorder caused by mutations in one of two genes, tsc1 or tsc2, which encode the proteins hamartin and tuberin, respectively 123. |
2011-05-11 |
2023-08-12 |
human |
| Juinn-Lin Liu, Zhenyu Mao, Gary E Gallick, W K Alfred Yun. AMPK/TSC2/mTOR-signaling intermediates are not necessary for LKB1-mediated nuclear retention of PTEN tumor suppressor. Neuro-oncology. vol 13. issue 2. 2011-05-09. PMID:21123367. |
because mtor can be alternatively downregulated by tuberous sclerosis complex 2 (tsc2) activation mediated by 5' adenosine monophosphate-activated protein kinase (ampk), we proposed that the activation of ampk α1/2 by lkb1 and/or by calmodulin-dependent protein kinase kinase (camkk) would also block the nuclear export of pten in a manner similar to that of inhibitors of pi3k, mtor, and s6k. |
2011-05-09 |
2023-08-12 |
mouse |
| Michal Yalon, L Ben-Sira, S Constantini, A Tore. Regression of subependymal giant cell astrocytomas with RAD001 (Everolimus) in tuberous sclerosis complex. Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery. vol 27. issue 1. 2011-04-28. PMID:20703486. |
tuberous sclerosis complex (tsc) is a genetic disorder caused by inactivating mutations in the tsc1 or tsc2 genes and characterized by slow-growing tumors in multiple organs. |
2011-04-28 |
2023-08-12 |
Not clear |
| Min Zheng, Yan-Hai Wang, Xiao-Nan Wu, Su-Qin Wu, Bao-Ju Lu, Meng-Qiu Dong, Hongbing Zhang, Peiqing Sun, Sheng-Cai Lin, Kun-Liang Guan, Jiahuai Ha. Inactivation of Rheb by PRAK-mediated phosphorylation is essential for energy-depletion-induced suppression of mTORC1. Nature cell biology. vol 13. issue 3. 2011-04-27. PMID:21336308. |
we show that p38β-prak operates independently of the known mtorc1 inactivation pathways--phosphorylation of tuberous sclerosis protein 2 (tsc2) and raptor by amp-activated protein kinase (ampk)--and surprisingly, that prak directly regulates ras homologue enriched in brain (rheb), a key component of the mtorc1 pathway, by phosphorylation. |
2011-04-27 |
2023-08-12 |
Not clear |
| Y J Kang, M-K Lu, K-L Gua. The TSC1 and TSC2 tumor suppressors are required for proper ER stress response and protect cells from ER stress-induced apoptosis. Cell death and differentiation. vol 18. issue 1. 2011-04-14. PMID:20616807. |
tuberous sclerosis complex (tsc)1 and tsc2 are tumor suppressors that inhibit cell growth and mutation of either gene causes benign tumors in multiple tissues. |
2011-04-14 |
2023-08-12 |
Not clear |
| Elizabeth A Barnes, Heidi L Kenerson, Xiuyun Jiang, Raymond S Yeun. Tuberin regulates E-cadherin localization: implications in epithelial-mesenchymal transition. The American journal of pathology. vol 177. issue 4. 2011-03-11. PMID:20813961. |
the tuberous sclerosis complex 2 (tsc2) gene encodes the protein tuberin, which functions as a key negative regulator of both mammalian target of rapamycin (mtor) c1-dependent cell growth and proliferation. |
2011-03-11 |
2023-08-12 |
human |
| Elizabeth A Barnes, Heidi L Kenerson, Xiuyun Jiang, Raymond S Yeun. Tuberin regulates E-cadherin localization: implications in epithelial-mesenchymal transition. The American journal of pathology. vol 177. issue 4. 2011-03-11. PMID:20813961. |
loss-of-function mutations of tsc2 result in mtorc1 hyperactivity and predispose individuals to both tuberous sclerosis and lymphangioleiomyomatosis. |
2011-03-11 |
2023-08-12 |
human |
| Chih-Ping Chen, Yi-Ning Su, Tung-Yao Chang, Yu-Peng Liu, Fuu-Jen Tsai, Ming-Ren Chen, Jonathan Kwei Hwang, Teresa Hsiao-Tien Chen, Wayseen Wan. Prenatal diagnosis of rhabdomyomas and cerebral tuberous sclerosis by magnetic resonance imaging in one fetus of a dizygotic twin pregnancy associated with a frameshift mutation in the TSC2 gene. Taiwanese journal of obstetrics & gynecology. vol 49. issue 3. 2011-02-24. PMID:21056333. |
prenatal diagnosis of rhabdomyomas and cerebral tuberous sclerosis by magnetic resonance imaging in one fetus of a dizygotic twin pregnancy associated with a frameshift mutation in the tsc2 gene. |
2011-02-24 |
2023-08-12 |
Not clear |
| Xiong Cai, Gustavo Pacheco-Rodriguez, Qing-Yuan Fan, Mary Haughey, Leigh Samsel, Souheil El-Chemaly, Hai-Ping Wu, J Philip McCoy, Wendy K Steagall, Jing-Ping Lin, Thomas N Darling, Joel Mos. Phenotypic characterization of disseminated cells with TSC2 loss of heterozygosity in patients with lymphangioleiomyomatosis. American journal of respiratory and critical care medicine. vol 182. issue 11. 2011-02-11. PMID:20639436. |
lymphangioleiomyomatosis (lam), occurring sporadically (s-lam) or in patients with tuberous sclerosis complex (tsc), results from abnormal proliferation of lam cells exhibiting mutations or loss of heterozygosity (loh) of the tsc genes, tsc1 or tsc2. |
2011-02-11 |
2023-08-12 |
Not clear |
| Xuchen Zhang, William D Travi. Pulmonary lymphangioleiomyomatosis. Archives of pathology & laboratory medicine. vol 134. issue 12. 2011-01-06. PMID:21128782. |
somatic or genetic mutations of tumor suppressor genes tuberous sclerosis complex (tsc) 1 or tsc2 are closely related to lymphangioleiomyomatosis. |
2011-01-06 |
2023-08-12 |
Not clear |
| Connie G Glasgow, Wendy K Steagall, Angelo Taveira-Dasilva, Gustavo Pacheco-Rodriguez, Xiong Cai, Souheil El-Chemaly, Marsha Moses, Thomas Darling, Joel Mos. Lymphangioleiomyomatosis (LAM): molecular insights lead to targeted therapies. Respiratory medicine. vol 104 Suppl 1. 2010-12-21. PMID:20630348. |
the disease results from proliferation of a neoplastic cell, termed the lam cell, which has mutations in either of the tuberous sclerosis complex (tsc) 1 or tsc2 genes. |
2010-12-21 |
2023-08-12 |
Not clear |
| Kara L Norman, Peter Sarno. Herpes Simplex Virus is Akt-ing in translational control. Genes & development. vol 24. issue 23. 2010-12-21. PMID:21123644. |
2627-2639) demonstrate that herpes simplex virus-1 counteracts this response through viral kinase us3, which mimics cellular kinase akt to phosphorylate and repress tuberous sclerosis complex 2 (tsc2), resulting in the activation of mammalian target of rapamycin complex 1 (mtorc1) and enhancement of mrna translation. |
2010-12-21 |
2023-08-12 |
Not clear |