| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Robert Waltereit, Hans Welzl, Johannes Dichgans, Hans-Peter Lipp, Werner J Schmidt, Michael Welle. Enhanced episodic-like memory and kindling epilepsy in a rat model of tuberous sclerosis. Journal of neurochemistry. vol 96. issue 2. 2006-02-17. PMID:16300636. |
tuberous sclerosis complex (tsc) is a common neurological autosomal-dominant syndrome caused by mutations in the tsc1 or tsc2 genes. |
2006-02-17 |
2023-08-12 |
rat |
| Jaroslaw Jozwiak, Sergiusz Jozwiak, Tomasz Grzela, Maciej Lazarczy. Positive and negative regulation of TSC2 activity and its effects on downstream effectors of the mTOR pathway. Neuromolecular medicine. vol 7. issue 4. 2006-02-17. PMID:16391386. |
tuberous sclerosis is an autosomal-dominant disorder caused by the mutation of one of the two tumor suppressor genes: tsc1 or tsc2, encoding protein products, hamartin, and tuberin, respectively. |
2006-02-17 |
2023-08-12 |
Not clear |
| Geraldine A Finlay, Victor J Thannickal, Barry L Fanburg, David J Kwiatkowsk. Platelet-derived growth factor-induced p42/44 mitogen-activated protein kinase activation and cellular growth is mediated by reactive oxygen species in the absence of TSC2/tuberin. Cancer research. vol 65. issue 23. 2006-01-25. PMID:16322235. |
tuberous sclerosis complex (tsc) is a genetic disorder caused by inactivating mutations in the tsc1 or tsc2 genes, which encode hamartin and tuberin, respectively. |
2006-01-25 |
2023-08-12 |
Not clear |
| Sohail F Tavazoie, Veronica A Alvarez, Dennis A Ridenour, David J Kwiatkowski, Bernardo L Sabatin. Regulation of neuronal morphology and function by the tumor suppressors Tsc1 and Tsc2. Nature neuroscience. vol 8. issue 12. 2006-01-24. PMID:16286931. |
mutations in the tsc1 or tsc2 tumor suppressor genes lead to tuberous sclerosis complex (tsc), a dominant hamartomatous disorder that often presents with mental retardation, epilepsy and autism. |
2006-01-24 |
2023-08-12 |
mouse |
| Todd M Kolb, Ling Duan, Myrtle A Davi. Tsc2 expression increases the susceptibility of renal tumor cells to apoptosis. Toxicological sciences : an official journal of the Society of Toxicology. vol 88. issue 2. 2006-01-10. PMID:16150885. |
although the precise role for the tuberous sclerosis complex-2 tumor suppressor gene (tsc2) in tumor suppression is not clear, many studies have implicated tsc2 in the regulation of cell differentiation, cell cycle control, gtpase activity, transcription, polycystin-1 localization, and translation initiation. |
2006-01-10 |
2023-08-12 |
Not clear |
| J Jozwiak, S Jozwiak, P Skopinsk. Immunohistochemical and microscopic studies on giant cells in tuberous sclerosis. Histology and histopathology. vol 20. issue 4. 2006-01-06. PMID:16136513. |
tuberous sclerosis (tsc) is an autosomal dominant disease, caused by mutations in tsc1 or tsc2 genes, encoding hamartin and tuberin, respectively. |
2006-01-06 |
2023-08-12 |
Not clear |
| Marjon van Slegtenhorst, Aladdin Mustafa, Elizabeth Petri Hensk. Pas1, a G1 cyclin, regulates amino acid uptake and rescues a delay in G1 arrest in Tsc1 and Tsc2 mutants in Schizosaccharomyces pombe. Human molecular genetics. vol 14. issue 19. 2005-12-23. PMID:16115814. |
tuberous sclerosis complex is a tumor suppressor syndrome caused by mutations in either the tsc1 or the tsc2 gene. |
2005-12-23 |
2023-08-12 |
Not clear |
| Margit Rosner, Angelika Freilinger, Gert Lubec, Markus Hengstschläge. The tuberous sclerosis genes, TSC1 and TSC2, trigger different gene expression responses. International journal of oncology. vol 27. issue 5. 2005-12-15. PMID:16211238. |
the tuberous sclerosis genes, tsc1 and tsc2, trigger different gene expression responses. |
2005-12-15 |
2023-08-12 |
Not clear |
| O M Malanchuk, V Pozur, G G Panasyuk, I O Nemazanyy, V V Filonenko, I T Gout, S S Palchevsky. Identification of novel binding partners for tuberous sclerosis complex 2 (TSC2) by yeast two-hybrid approach. Experimental oncology. vol 27. issue 3. 2005-12-15. PMID:16244578. |
identification of novel binding partners for tuberous sclerosis complex 2 (tsc2) by yeast two-hybrid approach. |
2005-12-15 |
2023-08-12 |
Not clear |
| O M Malanchuk, V Pozur, G G Panasyuk, I O Nemazanyy, V V Filonenko, I T Gout, S S Palchevsky. Identification of novel binding partners for tuberous sclerosis complex 2 (TSC2) by yeast two-hybrid approach. Experimental oncology. vol 27. issue 3. 2005-12-15. PMID:16244578. |
to identify novel tuberous sclerosis complex (tsc2) binding partners by yeast two-hybrid screening. |
2005-12-15 |
2023-08-12 |
Not clear |
| Mark Rolfe, Laura E McLeod, Phillip F Pratt, Christopher G Prou. Activation of protein synthesis in cardiomyocytes by the hypertrophic agent phenylephrine requires the activation of ERK and involves phosphorylation of tuberous sclerosis complex 2 (TSC2). The Biochemical journal. vol 388. issue Pt 3. 2005-12-13. PMID:15757502. |
activation of protein synthesis in cardiomyocytes by the hypertrophic agent phenylephrine requires the activation of erk and involves phosphorylation of tuberous sclerosis complex 2 (tsc2). |
2005-12-13 |
2023-08-12 |
Not clear |
| Mark Rolfe, Laura E McLeod, Phillip F Pratt, Christopher G Prou. Activation of protein synthesis in cardiomyocytes by the hypertrophic agent phenylephrine requires the activation of ERK and involves phosphorylation of tuberous sclerosis complex 2 (TSC2). The Biochemical journal. vol 388. issue Pt 3. 2005-12-13. PMID:15757502. |
pe stimulation of cardiomyocytes induced the phosphorylation of tsc2 (tuberous sclerosis complex 2), a negative regulator of mtor activity. |
2005-12-13 |
2023-08-12 |
Not clear |
| Jaroslaw Jozwia. Hamartin and tuberin: working together for tumour suppression. International journal of cancer. vol 118. issue 1. 2005-12-13. PMID:16206276. |
tsc1 and tsc2 are two recently identified tumour suppressor genes encoding hamartin and tuberin, respectively, and involved in pathogenesis of tuberous sclerosis, neurological disorder connected with the development of hamartomas in numerous organ systems, including the brain, kidneys, heart and liver. |
2005-12-13 |
2023-08-12 |
Not clear |
| Aristotelis Astrinidis, Elizabeth P Hensk. Tuberous sclerosis complex: linking growth and energy signaling pathways with human disease. Oncogene. vol 24. issue 50. 2005-12-07. PMID:16288294. |
the most exciting advances in the tuberous sclerosis complex (tsc) field occurred in 1993 and 1997 with the cloning of the tsc2 and tsc1 genes, respectively, and in 2003 with the identification of rheb as the target of tuberin's (tsc2) gtpase activating protein (gap) domain. |
2005-12-07 |
2023-08-12 |
human |
| Aubrey Milunsky, Sung Han Shim, Masamichi Ito, Ronald K Jaekle, Lori L Bassett, Michael R Brumund, Jeff M Milunsk. Precise prenatal diagnosis of tuberous sclerosis by sequencing the TSC2 gene. Prenatal diagnosis. vol 25. issue 7. 2005-12-01. PMID:16032769. |
precise prenatal diagnosis of tuberous sclerosis by sequencing the tsc2 gene. |
2005-12-01 |
2023-08-12 |
Not clear |
| Elena Lesma, Vera Grande, Stephana Carelli, Diego Brancaccio, Maria Paola Canevini, Rosa Maria Alfano, Guido Coggi, Anna Maria Di Giulio, Alfredo Gori. Isolation and growth of smooth muscle-like cells derived from tuberous sclerosis complex-2 human renal angiomyolipoma: epidermal growth factor is the required growth factor. The American journal of pathology. vol 167. issue 4. 2005-11-21. PMID:16192644. |
tuberous sclerosis complex (tsc) is a tumor suppressor gene disorder characterized by mutations in the tsc1 or tsc2 genes. |
2005-11-21 |
2023-08-12 |
human |
| Kozo Kataoka, Koji Fujimoto, Daisuke Ito, Masayuki Koizumi, Eiji Toyoda, Tomohiko Mori, Kazuhiro Kami, Ryuichiro Do. Expression and prognostic value of tuberous sclerosis complex 2 gene product tuberin in human pancreatic cancer. Surgery. vol 138. issue 3. 2005-11-15. PMID:16213898. |
tuberous sclerosis complex (tsc) is an autosomal dominant disorder caused by mutation of either of 2 tumor suppressor genes, tsc1 or tsc2, which encode hamartin and tuberin, respectively. |
2005-11-15 |
2023-08-12 |
human |
| Lynsey Meikle, Julie R McMullen, Megan C Sherwood, Alan S Lader, Victoria Walker, Jennifer A Chan, David J Kwiatkowsk. A mouse model of cardiac rhabdomyoma generated by loss of Tsc1 in ventricular myocytes. Human molecular genetics. vol 14. issue 3. 2005-11-08. PMID:15601645. |
tuberous sclerosis is a hamartoma syndrome due to mutations in tsc1 or tsc2 in which cardiac rhabdomyomas are seen in approximately 60% of patients. |
2005-11-08 |
2023-08-12 |
mouse |
| Annett Hahn-Windgassen, Veronique Nogueira, Chia-Chen Chen, Jennifer E Skeen, Nahum Sonenberg, Nissim Ha. Akt activates the mammalian target of rapamycin by regulating cellular ATP level and AMPK activity. The Journal of biological chemistry. vol 280. issue 37. 2005-10-20. PMID:16027121. |
the known pathway by which akt activates mtor is via direct phosphorylation and inhibition of tuberous sclerosis complex 2 (tsc2), which is a negative regulator of mtor. |
2005-10-20 |
2023-08-12 |
Not clear |
| Catherine Wilson, Shelley Idziaszczyk, Lee Parry, Carol Guy, David F R Griffiths, Edward Lazda, Rosemary A L Bayne, Andrew J H Smith, Julian R Sampson, Jeremy P Cheadl. A mouse model of tuberous sclerosis 1 showing background specific early post-natal mortality and metastatic renal cell carcinoma. Human molecular genetics. vol 14. issue 13. 2005-10-11. PMID:15888477. |
tuberous sclerosis complex (tsc) is an autosomal dominant disorder caused by mutations in either the tsc1 or the tsc2 genes and characterized by the development of benign hamartomatous growths in multiple organ systems. |
2005-10-11 |
2023-08-12 |
mouse |