| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| M Ali, S C Girimaji, M Markandaya, A K Shukla, S Sacchidanand, A Kuma. Mutation and polymorphism analysis of TSC1 and TSC2 genes in Indian patients with tuberous sclerosis complex. Acta neurologica Scandinavica. vol 111. issue 1. 2005-03-23. PMID:15595939. |
mutation and polymorphism analysis of tsc1 and tsc2 genes in indian patients with tuberous sclerosis complex. |
2005-03-23 |
2023-08-12 |
Not clear |
| M Ali, S C Girimaji, M Markandaya, A K Shukla, S Sacchidanand, A Kuma. Mutation and polymorphism analysis of TSC1 and TSC2 genes in Indian patients with tuberous sclerosis complex. Acta neurologica Scandinavica. vol 111. issue 1. 2005-03-23. PMID:15595939. |
to find the mutation and polymorphism spectrum of tsc1 and tsc2 genes in patients affected with tuberous sclerosis complex from the indian population. |
2005-03-23 |
2023-08-12 |
Not clear |
| Bryan A Ballif, Philippe P Roux, Scott A Gerber, Jeffrey P MacKeigan, John Blenis, Steven P Gyg. Quantitative phosphorylation profiling of the ERK/p90 ribosomal S6 kinase-signaling cassette and its targets, the tuberous sclerosis tumor suppressors. Proceedings of the National Academy of Sciences of the United States of America. vol 102. issue 3. 2005-03-15. PMID:15647351. |
additionally, we monitored 14 previously uncharacterized and six known phosphorylation events after phorbol ester stimulation in the erk/p90 ribosomal s6 kinase-signaling targets, the tuberous sclerosis complex (tsc) tumor suppressors tsc1 and tsc2. |
2005-03-15 |
2023-08-12 |
Not clear |
| Raymond S Yeun. Lessons from the Eker rat model: from cage to bedside. Current molecular medicine. vol 4. issue 8. 2005-03-07. PMID:15579026. |
following the identification of the tsc2 germline mutation in the eker rat, it became the first rodent model of tuberous sclerosis and has since been exploited in many areas of tumor biology as illustrated in the content of this issue. |
2005-03-07 |
2023-08-12 |
mouse |
| Zheming Lu, Xiuhua Hu, Yong Li, Li Zheng, Yue Zhou, Haidi Jiang, Tao Ning, Zhuoma Basang, Chunfeng Zhang, Yang K. Human papillomavirus 16 E6 oncoprotein interferences with insulin signaling pathway by binding to tuberin. The Journal of biological chemistry. vol 279. issue 34. 2005-02-15. PMID:15175323. |
tuberous sclerosis complex (tsc) is a genetic disorder caused by mutations in either tsc1 or tsc2 tumor suppressor gene. |
2005-02-15 |
2023-08-12 |
human |
| Patrick F Bolto. Neuroepileptic correlates of autistic symptomatology in tuberous sclerosis. Mental retardation and developmental disabilities research reviews. vol 10. issue 2. 2005-02-08. PMID:15362169. |
current evidence indicates that the likelihood of a child with tuberous sclerosis developing an autism spectrum disorder is greater if the child has a mutation in the tsc2 gene, although autism can and does develop in children with tsc1 mutations. |
2005-02-08 |
2023-08-12 |
Not clear |
| Elena Goncharova, Dmitry Goncharov, Daniel Noonan, Vera P Krymskay. TSC2 modulates actin cytoskeleton and focal adhesion through TSC1-binding domain and the Rac1 GTPase. The Journal of cell biology. vol 167. issue 6. 2005-02-08. PMID:15611338. |
tuberous sclerosis complex (tsc) 1 and tsc2 are thought to be involved in protein translational regulation and cell growth, and loss of their function is a cause of tsc and lymphangioleiomyomatosis (lam). |
2005-02-08 |
2023-08-12 |
Not clear |
| O Jameel Shah, Zhiyong Wang, Tony Hunte. Inappropriate activation of the TSC/Rheb/mTOR/S6K cassette induces IRS1/2 depletion, insulin resistance, and cell survival deficiencies. Current biology : CB. vol 14. issue 18. 2005-02-07. PMID:15380067. |
tuberous sclerosis is a largely benign tumor syndrome derived from the acquisition of somatic lesions in genes encoding the tumor suppressor products, tsc1 or tsc2. |
2005-02-07 |
2023-08-12 |
Not clear |
| Jennifer A Chan, Hongbing Zhang, Penelope S Roberts, Sergiusz Jozwiak, Grajkowska Wieslawa, Joanna Lewin-Kowalik, Katarzyna Kotulska, David J Kwiatkowsk. Pathogenesis of tuberous sclerosis subependymal giant cell astrocytomas: biallelic inactivation of TSC1 or TSC2 leads to mTOR activation. Journal of neuropathology and experimental neurology. vol 63. issue 12. 2005-01-14. PMID:15624760. |
pathogenesis of tuberous sclerosis subependymal giant cell astrocytomas: biallelic inactivation of tsc1 or tsc2 leads to mtor activation. |
2005-01-14 |
2023-08-12 |
Not clear |
| Margit Rosner, Markus Hengstschläge. Tuberin binds p27 and negatively regulates its interaction with the SCF component Skp2. The Journal of biological chemistry. vol 279. issue 47. 2005-01-11. PMID:15355997. |
tsc1 (tuberous sclerosis complex 1) encoding hamartin and tsc2 encoding tuberin are tumor suppressor genes responsible for the autosomal dominantly inherited disease tuberous sclerosis. |
2005-01-11 |
2023-08-12 |
Not clear |
| Jixin Dong, Duojia Pa. Tsc2 is not a critical target of Akt during normal Drosophila development. Genes & development. vol 18. issue 20. 2004-12-27. PMID:15466161. |
it was reported that akt, an essential component of the insulin pathway, stimulates growth by phosphorylating and inhibiting tuberous sclerosis complex 2 (tsc2). |
2004-12-27 |
2023-08-12 |
drosophila_melanogaster |
| Kit-Sing Au, Aimee T Williams, Michael J Gambello, Hope Northru. Molecular genetic basis of tuberous sclerosis complex: from bench to bedside. Journal of child neurology. vol 19. issue 9. 2004-12-22. PMID:15563017. |
either of two genes, tsc1 or tsc2, can be mutated, resulting in the tuberous sclerosis complex phenotype. |
2004-12-22 |
2023-08-12 |
Not clear |
| Kit-Sing Au, Aimee T Williams, Michael J Gambello, Hope Northru. Molecular genetic basis of tuberous sclerosis complex: from bench to bedside. Journal of child neurology. vol 19. issue 9. 2004-12-22. PMID:15563017. |
the protein products of the tuberous sclerosis complex genes, hamartin (tsc1) and tuberin (tsc2), have been discovered to play important roles in several cell-signaling pathways. |
2004-12-22 |
2023-08-12 |
Not clear |
| Peter B Crin. Molecular pathogenesis of tuber formation in tuberous sclerosis complex. Journal of child neurology. vol 19. issue 9. 2004-12-22. PMID:15563019. |
tuberous sclerosis complex results from mutations in the tsc1 (hamartin) and tsc2 (tuberin) genes. |
2004-12-22 |
2023-08-12 |
Not clear |
| Takahiro Nobukini, George Thoma. The mTOR/S6K signalling pathway: the role of the TSC1/2 tumour suppressor complex and the proto-oncogene Rheb. Novartis Foundation symposium. vol 262. 2004-12-21. PMID:15562827. |
mutations in either tsc1 or tsc2 are genetically linked to tuberous sclerosis complex (tsc) syndrome, which can lead to severe pathological consequences, including mental retardation, epilepsy and autism, as well as cardiac, pulmonary and renal failure. |
2004-12-21 |
2023-08-12 |
mouse |
| Martin W Laass, Miriam Spiegel, Anna Jauch, Gabriele Hahn, Edgar Rupprecht, Christian Vogelberg, Oliver Bartsch, Angela Huebne. Tuberous sclerosis and polycystic kidney disease in a 3-month-old infant. Pediatric nephrology (Berlin, Germany). vol 19. issue 6. 2004-12-15. PMID:15007723. |
the tsc2 gene for tuberous sclerosis is localized on chromosome 16p13.3 immediately adjacent to pkd1, the gene for autosomal dominant polycystic kidney disease (adpkd). |
2004-12-15 |
2023-08-12 |
Not clear |
| Rosemary Ekong, Steve Jeremiah, David Judah, Ordan Lehmann, Farideh Mirzayans, Ying-Chun Hung, Michael A Walter, Shomi Bhattacharya, Timothy W Gant, Sue Povey, Jonathan Wolf. Chromosomal anomalies on 6p25 in iris hypoplasia and Axenfeld-Rieger syndrome patients defined on a purpose-built genomic microarray. Human mutation. vol 24. issue 1. 2004-11-08. PMID:15221791. |
we have explored the application of array-cgh to the detection of such changes on a set of 20 samples consisting of patients with eye diseases associated with changes on chromosome 6p25 together with unaffected individuals, as well as two samples from tuberous sclerosis 2 (tsc2)-affected patients. |
2004-11-08 |
2023-08-12 |
human |
| Philippe P Roux, Bryan A Ballif, Rana Anjum, Steven P Gygi, John Bleni. Tumor-promoting phorbol esters and activated Ras inactivate the tuberous sclerosis tumor suppressor complex via p90 ribosomal S6 kinase. Proceedings of the National Academy of Sciences of the United States of America. vol 101. issue 37. 2004-10-26. PMID:15342917. |
tuberous sclerosis complex (tsc) is a genetic disorder caused by mutations in either of the two tumor suppressor genes tsc1 or tsc2, which encode hamartin and tuberin, respectively. |
2004-10-26 |
2023-08-12 |
Not clear |
| Yong Li, Ken Inoki, Kun-Liang Gua. Biochemical and functional characterizations of small GTPase Rheb and TSC2 GAP activity. Molecular and cellular biology. vol 24. issue 18. 2004-10-07. PMID:15340059. |
tuberous sclerosis complex (tsc) is a genetic disease caused by a mutation in either the tsc1 or tsc2 tumor suppressor gene. |
2004-10-07 |
2023-08-12 |
Not clear |
| H Jürgen Wenzel, Leena S Patel, Carol A Robbins, Adriana Emmi, Raymond S Yeung, Philip A Schwartzkroi. Morphology of cerebral lesions in the Eker rat model of tuberous sclerosis. Acta neuropathologica. vol 108. issue 2. 2004-09-20. PMID:15185103. |
tuberous sclerosis (tsc) is an autosomal dominant disorder, caused by mutations of either the tsc1 or tsc2 gene. |
2004-09-20 |
2023-08-12 |
human |