| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| S E O'Connor, D J Kwiatkowski, P S Roberts, R L Wollmann, P R Huttenloche. A family with seizures and minor features of tuberous sclerosis and a novel TSC2 mutation. Neurology. vol 61. issue 3. 2004-03-25. PMID:12913212. |
a family with seizures and minor features of tuberous sclerosis and a novel tsc2 mutation. |
2004-03-25 |
2023-08-12 |
Not clear |
| V Rames. Aspects of tuberous sclerosis complex (TSC) protein function in the brain. Biochemical Society transactions. vol 31. issue Pt 3. 2004-03-23. PMID:12773159. |
tuberous sclerosis complex (tsc), an autosomal dominant disease caused by mutations in either tsc1 or tsc2, is characterized by the development of hamartomas in a variety of organs. |
2004-03-23 |
2023-08-12 |
Not clear |
| C J Potter, L G Pedraza, H Huang, T X. The tuberous sclerosis complex (TSC) pathway and mechanism of size control. Biochemical Society transactions. vol 31. issue Pt 3. 2004-03-23. PMID:12773160. |
we have identified three groups of growth-constraint genes using mosaic genetic screens in drosophila melanogaster, including pten (phosphatase and tensin homologue deleted on chromosome 10), and the tuberous sclerosis complex (tsc) genes, tsc1 and tsc2. |
2004-03-23 |
2023-08-12 |
mouse |
| J R Sampso. TSC1 and TSC2: genes that are mutated in the human genetic disorder tuberous sclerosis. Biochemical Society transactions. vol 31. issue Pt 3. 2004-03-23. PMID:12773162. |
tsc1 and tsc2: genes that are mutated in the human genetic disorder tuberous sclerosis. |
2004-03-23 |
2023-08-12 |
human |
| J R Sampso. TSC1 and TSC2: genes that are mutated in the human genetic disorder tuberous sclerosis. Biochemical Society transactions. vol 31. issue Pt 3. 2004-03-23. PMID:12773162. |
the tuberous sclerosis complex genes tsc1 and tsc2 were first identified by positional cloning strategies in the heritable human disorder tuberous sclerosis. |
2004-03-23 |
2023-08-12 |
human |
| J R Sampso. TSC1 and TSC2: genes that are mutated in the human genetic disorder tuberous sclerosis. Biochemical Society transactions. vol 31. issue Pt 3. 2004-03-23. PMID:12773162. |
the phenotypic manifestations of tuberous sclerosis are extremely diverse and suggest normal roles for tsc1 and tsc2 in regulating the growth, proliferation, migration and differentiation of many cell types. |
2004-03-23 |
2023-08-12 |
human |
| M A Knowles, N Hornigold, E Pit. Tuberous sclerosis complex (TSC) gene involvement in sporadic tumours. Biochemical Society transactions. vol 31. issue Pt 3. 2004-03-23. PMID:12773163. |
in tuberous sclerosis patients, inactivation of the tuberous sclerosis complex tumour-suppressor genes tsc1 and tsc2 contributes to the development of a wide range of hamartomatous lesions. |
2004-03-23 |
2023-08-12 |
human |
| Yong Li, Michael N Corradetti, Ken Inoki, Kun-Liang Gua. TSC2: filling the GAP in the mTOR signaling pathway. Trends in biochemical sciences. vol 29. issue 1. 2004-03-17. PMID:14729330. |
the tumor-suppressor proteins tsc1 and tsc2 are associated with an autosomal dominant disorder known as tuberous sclerosis complex (tsc). |
2004-03-17 |
2023-08-12 |
Not clear |
| Markus Hengstschläger, Margit Rosner, Michael Fountoulakis, Gert Lube. Tuberous sclerosis genes regulate cellular 14-3-3 protein levels. Biochemical and biophysical research communications. vol 312. issue 3. 2004-03-12. PMID:14680818. |
the genes tsc1, encoding hamartin, and tsc2, encoding tuberin are responsible for tuberous sclerosis. |
2004-03-12 |
2023-08-12 |
human |
| Yavuz Ariyurek, Irma Lantinga-van Leeuwen, Lia Spruit, David Ravine, Martijn H Breuning, Dorien J M Peter. Large deletions in the polycystic kidney disease 1 (PKD1) gene. Human mutation. vol 23. issue 1. 2004-03-09. PMID:14695542. |
likely, patients with a deletion that also affects the neighbouring tuberous sclerosis complex 2 (tsc2) gene will be diagnosed as patients with tuberous sclerosis. |
2004-03-09 |
2023-08-12 |
Not clear |
| David J Kwiatkowsk. Rhebbing up mTOR: new insights on TSC1 and TSC2, and the pathogenesis of tuberous sclerosis. Cancer biology & therapy. vol 2. issue 5. 2004-03-08. PMID:14614311. |
rhebbing up mtor: new insights on tsc1 and tsc2, and the pathogenesis of tuberous sclerosis. |
2004-03-08 |
2023-08-12 |
human |
| Vinodh Narayana. Tuberous sclerosis complex: genetics to pathogenesis. Pediatric neurology. vol 29. issue 5. 2004-02-24. PMID:14684235. |
although the majority of cases (65%) are sporadic, genetic linkage studies of familial cases led to the discovery of two separate genes linked to tuberous sclerosis complex: tsc1, located at chromosome 9q34, encoding a protein called hamartin; and tsc2, located at chromosome 16p13.3, encoding a protein called tuberin. |
2004-02-24 |
2023-08-12 |
rat |
| Thurl E Harris, John C Lawrenc. TOR signaling. Science's STKE : signal transduction knowledge environment. vol 2003. issue 212. 2004-02-23. PMID:14668532. |
the signaling pathway downstream of akt leading to mtor involves the protein products of the genes mutated in tuberous sclerosis, tsc1 and tsc2, and the small guanosine triphosphatase, rheb. |
2004-02-23 |
2023-08-12 |
Not clear |
| Vera P Krymskay. Tumour suppressors hamartin and tuberin: intracellular signalling. Cellular signalling. vol 15. issue 8. 2004-02-20. PMID:12781866. |
tumour suppressors hamartin and tuberin, encoded by tuberous sclerosis complex 1(tsc1) and tsc2 genes, respectively, are critical regulators of cell growth and proliferation. |
2004-02-20 |
2023-08-12 |
Not clear |
| Vera P Krymskay. Tumour suppressors hamartin and tuberin: intracellular signalling. Cellular signalling. vol 15. issue 8. 2004-02-20. PMID:12781866. |
mutations in tsc1 and tsc2 genes are the cause of an autosomal dominant disorder known as tuberous sclerosis complex (tsc). |
2004-02-20 |
2023-08-12 |
Not clear |
| Vanishree Murthy, Sangyeul Han, Roberta L Beauchamp, Nicole Smith, Luciana A Haddad, Naoto Ito, Vijaya Rames. Pam and its ortholog highwire interact with and may negatively regulate the TSC1.TSC2 complex. The Journal of biological chemistry. vol 279. issue 2. 2004-02-10. PMID:14559897. |
tuberous sclerosis complex (tsc) is an autosomal dominant disorder associated with mutations in tsc1, which codes for hamartin, or tsc2, which codes for tuberin. |
2004-02-10 |
2023-08-12 |
rat |
| Brendan D Manning, Lewis C Cantle. Rheb fills a GAP between TSC and TOR. Trends in biochemical sciences. vol 28. issue 11. 2004-01-29. PMID:14607085. |
there has been much interest in determining the molecular and cellular functions of hamartin and tuberin, which are encoded by the genes tsc1 and tsc2 that are mutated in the tuberous sclerosis complex disease. |
2004-01-29 |
2023-08-12 |
Not clear |
| Mahmood Ali, Satish C Girimaji, Arun Kuma. Identification of a core promoter and a novel isoform of the human TSC1 gene transcript and structural comparison with mouse homolog. Gene. vol 320. 2004-01-27. PMID:14597398. |
tuberous sclerosis complex (tsc) is an autosomal dominant disorder with loci on chromosome 9q34.12 (tsc1) and chromosome 16p13.3 (tsc2). |
2004-01-27 |
2023-08-12 |
mouse |
| Andrew R Tee, Brendan D Manning, Philippe P Roux, Lewis C Cantley, John Bleni. Tuberous sclerosis complex gene products, Tuberin and Hamartin, control mTOR signaling by acting as a GTPase-activating protein complex toward Rheb. Current biology : CB. vol 13. issue 15. 2004-01-23. PMID:12906785. |
tuberous sclerosis complex (tsc) is a genetic disorder that occurs through the loss of heterozygosity of either tsc1 or tsc2, which encode hamartin or tuberin, respectively. |
2004-01-23 |
2023-08-12 |
Not clear |
| Ken Inoki, Tianqing Zhu, Kun-Liang Gua. TSC2 mediates cellular energy response to control cell growth and survival. Cell. vol 115. issue 5. 2004-01-14. PMID:14651849. |
mutations in either the tsc1 or tsc2 tumor suppressor gene are responsible for tuberous sclerosis complex. |
2004-01-14 |
2023-08-12 |
Not clear |