| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Raymond S Yeun. Multiple roles of the tuberous sclerosis complex genes. Genes, chromosomes & cancer. vol 38. issue 4. 2004-01-05. PMID:14566857. |
today, the eker rat is one of the best characterized models of tuberous sclerosis complex (tsc) and has been used extensively for study of the function of the tsc2 tumor suppressor gene. |
2004-01-05 |
2023-08-12 |
rat |
| Andrew R Tee, Rana Anjum, John Bleni. Inactivation of the tuberous sclerosis complex-1 and -2 gene products occurs by phosphoinositide 3-kinase/Akt-dependent and -independent phosphorylation of tuberin. The Journal of biological chemistry. vol 278. issue 39. 2003-11-17. PMID:12867426. |
the tuberous sclerosis complex (tsc) is a genetic disorder that is caused through mutations in either one of the two tumor suppressor genes, tsc1 and tsc2, that encode hamartin and tuberin, respectively. |
2003-11-17 |
2023-08-12 |
Not clear |
| Hongbing Zhang, Gregor Cicchetti, Hiroaki Onda, Henry B Koon, Kirsten Asrican, Natalia Bajraszewski, Francisca Vazquez, Christopher L Carpenter, David J Kwiatkowsk. Loss of Tsc1/Tsc2 activates mTOR and disrupts PI3K-Akt signaling through downregulation of PDGFR. The Journal of clinical investigation. vol 112. issue 8. 2003-11-17. PMID:14561707. |
tuberous sclerosis (tsc) is a familial tumor syndrome due to mutations in tsc1 or tsc2, in which progression to malignancy is rare. |
2003-11-17 |
2023-08-12 |
mouse |
| Nisreen El-Hashemite, Victoria Walker, Hongbing Zhang, David J Kwiatkowsk. Loss of Tsc1 or Tsc2 induces vascular endothelial growth factor production through mammalian target of rapamycin. Cancer research. vol 63. issue 17. 2003-11-06. PMID:14500340. |
mutation in either tsc1 or tsc2 causes the autosomal dominant disorder tuberous sclerosis, in which widespread hamartomas are seen, some of which have a high level of vascularization. |
2003-11-06 |
2023-08-12 |
mouse |
| Ingrid Fackler, Jeffrey E DeClue, Heidi Rust, Phuong-Anh Vu, Heinz Kutzner, Arno Rütten, Steven Kaddu, Christian A Sander, Matthias Volkenandt, Michael W Johnson, Harry V Vinters, Ralf Wieneck. Loss of expression of tuberin and hamartin in tuberous sclerosis complex-associated but not in sporadic angiofibromas. Journal of cutaneous pathology. vol 30. issue 3. 2003-10-16. PMID:12641776. |
angiofibromas occur sporadically, and they develop in most patients with tuberous sclerosis complex (tsc), which is associated with alterations of the tumor suppressor genes tsc1 or tsc2. |
2003-10-16 |
2023-08-12 |
Not clear |
| Ariel F Castro, John F Rebhun, Geoffrey J Clark, Lawrence A Quillia. Rheb binds tuberous sclerosis complex 2 (TSC2) and promotes S6 kinase activation in a rapamycin- and farnesylation-dependent manner. The Journal of biological chemistry. vol 278. issue 35. 2003-10-02. PMID:12842888. |
rheb binds tuberous sclerosis complex 2 (tsc2) and promotes s6 kinase activation in a rapamycin- and farnesylation-dependent manner. |
2003-10-02 |
2023-08-12 |
Not clear |
| Ariel F Castro, John F Rebhun, Geoffrey J Clark, Lawrence A Quillia. Rheb binds tuberous sclerosis complex 2 (TSC2) and promotes S6 kinase activation in a rapamycin- and farnesylation-dependent manner. The Journal of biological chemistry. vol 278. issue 35. 2003-10-02. PMID:12842888. |
recently the tuberous sclerosis complex 2 (tsc2) tumor suppressor gene product has been identified as a negative regulator of protein synthesis upstream of the mtor and ribosomal s6 kinases. |
2003-10-02 |
2023-08-12 |
Not clear |
| Margit Rosner, Katja Hofer, Marion Kubista, Markus Hengstschläge. Cell size regulation by the human TSC tumor suppressor proteins depends on PI3K and FKBP38. Oncogene. vol 22. issue 31. 2003-09-10. PMID:12894220. |
tsc1 and tsc2 are responsible for the tumor suppressor gene syndrome tuberous sclerosis (tsc). |
2003-09-10 |
2023-08-12 |
human |
| G A Finlay, D S Hunter, C L Walker, K E Paulson, B L Fanbur. Regulation of PDGF production and ERK activation by estrogen is associated with TSC2 gene expression. American journal of physiology. Cell physiology. vol 285. issue 2. 2003-09-05. PMID:12700139. |
recently, loss of function of the tuberous sclerosis complex 2 (tsc2) gene has been associated with e2-related conditions that are characterized by benign cellular proliferation. |
2003-09-05 |
2023-08-12 |
Not clear |
| Satoshi Honda, Toshiyuki Kobayashi, Kazunori Kajino, Shinji Urakami, Mikio Igawa, Okio Hin. Ets protein Elf-1 bidirectionally suppresses transcriptional activities of the tumor suppressor Tsc2 gene and the repair-related Nth1 gene. Molecular carcinogenesis. vol 37. issue 3. 2003-09-03. PMID:12884363. |
alterations in the rat tuberous sclerosis gene (tsc2) cause renal cell carcinomas (rccs) with complete penetrance. |
2003-09-03 |
2023-08-12 |
rat |
| Ken Inoki, Yong Li, Tian Xu, Kun-Liang Gua. Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling. Genes & development. vol 17. issue 15. 2003-08-22. PMID:12869586. |
tuberous sclerosis complex (tsc) is a genetic disease caused by mutation in either tsc1 or tsc2. |
2003-08-22 |
2023-08-12 |
Not clear |
| D J Kwiatkowsk. Tuberous sclerosis: from tubers to mTOR. Annals of human genetics. vol 67. issue Pt 1. 2003-08-01. PMID:12556239. |
tuberous sclerosis (tsc) is an autosomal dominant hamartoma syndrome whose causative genes (tsc1 and tsc2) were identified 5 and 9 years ago respectively. |
2003-08-01 |
2023-08-12 |
drosophila_melanogaster |
| Yong Zhang, Xinsheng Gao, Leslie J Saucedo, Binggen Ru, Bruce A Edgar, Duojia Pa. Rheb is a direct target of the tuberous sclerosis tumour suppressor proteins. Nature cell biology. vol 5. issue 6. 2003-07-14. PMID:12771962. |
mutations in the tsc1 or tsc2 genes cause tuberous sclerosis, a benign tumour syndrome in humans. |
2003-07-14 |
2023-08-12 |
Not clear |
| Nelson Lau, Erik J Uhlmann, Friederike C Von Lintig, Andras Nagy, Gerry R Boss, David H Gutmann, Abhijit Guh. Rap1 activity is elevated in malignant astrocytomas independent of tuberous sclerosis complex-2 gene expression. International journal of oncology. vol 22. issue 1. 2003-06-16. PMID:12469204. |
individuals with tuberous sclerosis complex (tsc) develop astrocytoma-like tumors resulting from mutations in the tsc2 protein, tuberin, which is hypothesized to function as a rap1 gtpase activating protein (gap). |
2003-06-16 |
2023-08-12 |
Not clear |
| Nisreen El-Hashemite, Hongbing Zhang, Elizabeth P Henske, David J Kwiatkowsk. Mutation in TSC2 and activation of mammalian target of rapamycin signalling pathway in renal angiomyolipoma. Lancet (London, England). vol 361. issue 9366. 2003-06-12. PMID:12711473. |
mutations that inactivate either tsc1 or tsc2 cause tuberous sclerosis. |
2003-06-12 |
2023-08-12 |
Not clear |
| Yong Li, Ken Inoki, Panayiotis Vacratsis, Kun-Liang Gua. The p38 and MK2 kinase cascade phosphorylates tuberin, the tuberous sclerosis 2 gene product, and enhances its interaction with 14-3-3. The Journal of biological chemistry. vol 278. issue 16. 2003-05-22. PMID:12582162. |
tuberous sclerosis complex (tsc) is a genetic disease caused by mutations in either tsc1 or tsc2 tumor suppressor genes. |
2003-05-22 |
2023-08-12 |
Not clear |
| Anil Apak, Göknur Haliloğlu, Gülşen Köse, Engin Yilmaz, Banu Anlar, Sabiha Aysu. Mutation analysis of TSC2 gene in 33 Turkish familial cases with tuberous sclerosis. The Turkish journal of pediatrics. vol 45. issue 1. 2003-05-13. PMID:12718362. |
mutation analysis of tsc2 gene in 33 turkish familial cases with tuberous sclerosis. |
2003-05-13 |
2023-08-12 |
Not clear |
| Anil Apak, Göknur Haliloğlu, Gülşen Köse, Engin Yilmaz, Banu Anlar, Sabiha Aysu. Mutation analysis of TSC2 gene in 33 Turkish familial cases with tuberous sclerosis. The Turkish journal of pediatrics. vol 45. issue 1. 2003-05-13. PMID:12718362. |
the aim of this study was to determine tsc2 gene mutations by single stranded conformation polymorphism (sscp) analysis and direct sequencing in 33 familial cases with tuberous sclerosis who were followed up in the pediatric neurology departments of hacettepe university ihsan doğramaci and ankara social security children's hospitals. |
2003-05-13 |
2023-08-12 |
Not clear |
| Okio Hino, Toshiyuki Kobayashi, Shuji Momose, Yasushi Kikuchi, Hiroyuki Adachi, Kazuo Okimot. Renal carcinogenesis: genotype, phenotype and dramatype. Cancer science. vol 94. issue 2. 2003-05-08. PMID:12708488. |
forty years after the discovery of the eker rat in oslo, we and knudson's group independently identified a germline retrotransposon insertion in the rat homologue of the human tuberous sclerosis (tsc2) gene. |
2003-05-08 |
2023-08-12 |
human |
| Baldwin C Mak, Ken-Ichi Takemaru, Heidi L Kenerson, Randall T Moon, Raymond S Yeun. The tuberin-hamartin complex negatively regulates beta-catenin signaling activity. The Journal of biological chemistry. vol 278. issue 8. 2003-04-22. PMID:12511557. |
tuberous sclerosis complex (tsc) is characterized by the formation of hamartomas in multiple organs resulting from mutations in the tsc1 or tsc2 gene. |
2003-04-22 |
2023-08-12 |
Not clear |