| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Mark Rolfe, Laura E McLeod, Phillip F Pratt, Christopher G Prou. Activation of protein synthesis in cardiomyocytes by the hypertrophic agent phenylephrine requires the activation of ERK and involves phosphorylation of tuberous sclerosis complex 2 (TSC2). The Biochemical journal. vol 388. issue Pt 3. 2005-12-13. PMID:15757502. |
pe stimulation of cardiomyocytes induced the phosphorylation of tsc2 (tuberous sclerosis complex 2), a negative regulator of mtor activity. |
2005-12-13 |
2023-08-12 |
Not clear |
| Jaroslaw Jozwia. Hamartin and tuberin: working together for tumour suppression. International journal of cancer. vol 118. issue 1. 2005-12-13. PMID:16206276. |
tsc1 and tsc2 are two recently identified tumour suppressor genes encoding hamartin and tuberin, respectively, and involved in pathogenesis of tuberous sclerosis, neurological disorder connected with the development of hamartomas in numerous organ systems, including the brain, kidneys, heart and liver. |
2005-12-13 |
2023-08-12 |
Not clear |
| Aristotelis Astrinidis, Elizabeth P Hensk. Tuberous sclerosis complex: linking growth and energy signaling pathways with human disease. Oncogene. vol 24. issue 50. 2005-12-07. PMID:16288294. |
the most exciting advances in the tuberous sclerosis complex (tsc) field occurred in 1993 and 1997 with the cloning of the tsc2 and tsc1 genes, respectively, and in 2003 with the identification of rheb as the target of tuberin's (tsc2) gtpase activating protein (gap) domain. |
2005-12-07 |
2023-08-12 |
human |
| Aubrey Milunsky, Sung Han Shim, Masamichi Ito, Ronald K Jaekle, Lori L Bassett, Michael R Brumund, Jeff M Milunsk. Precise prenatal diagnosis of tuberous sclerosis by sequencing the TSC2 gene. Prenatal diagnosis. vol 25. issue 7. 2005-12-01. PMID:16032769. |
precise prenatal diagnosis of tuberous sclerosis by sequencing the tsc2 gene. |
2005-12-01 |
2023-08-12 |
Not clear |
| Elena Lesma, Vera Grande, Stephana Carelli, Diego Brancaccio, Maria Paola Canevini, Rosa Maria Alfano, Guido Coggi, Anna Maria Di Giulio, Alfredo Gori. Isolation and growth of smooth muscle-like cells derived from tuberous sclerosis complex-2 human renal angiomyolipoma: epidermal growth factor is the required growth factor. The American journal of pathology. vol 167. issue 4. 2005-11-21. PMID:16192644. |
tuberous sclerosis complex (tsc) is a tumor suppressor gene disorder characterized by mutations in the tsc1 or tsc2 genes. |
2005-11-21 |
2023-08-12 |
human |
| Kozo Kataoka, Koji Fujimoto, Daisuke Ito, Masayuki Koizumi, Eiji Toyoda, Tomohiko Mori, Kazuhiro Kami, Ryuichiro Do. Expression and prognostic value of tuberous sclerosis complex 2 gene product tuberin in human pancreatic cancer. Surgery. vol 138. issue 3. 2005-11-15. PMID:16213898. |
tuberous sclerosis complex (tsc) is an autosomal dominant disorder caused by mutation of either of 2 tumor suppressor genes, tsc1 or tsc2, which encode hamartin and tuberin, respectively. |
2005-11-15 |
2023-08-12 |
human |
| Lynsey Meikle, Julie R McMullen, Megan C Sherwood, Alan S Lader, Victoria Walker, Jennifer A Chan, David J Kwiatkowsk. A mouse model of cardiac rhabdomyoma generated by loss of Tsc1 in ventricular myocytes. Human molecular genetics. vol 14. issue 3. 2005-11-08. PMID:15601645. |
tuberous sclerosis is a hamartoma syndrome due to mutations in tsc1 or tsc2 in which cardiac rhabdomyomas are seen in approximately 60% of patients. |
2005-11-08 |
2023-08-12 |
mouse |
| Annett Hahn-Windgassen, Veronique Nogueira, Chia-Chen Chen, Jennifer E Skeen, Nahum Sonenberg, Nissim Ha. Akt activates the mammalian target of rapamycin by regulating cellular ATP level and AMPK activity. The Journal of biological chemistry. vol 280. issue 37. 2005-10-20. PMID:16027121. |
the known pathway by which akt activates mtor is via direct phosphorylation and inhibition of tuberous sclerosis complex 2 (tsc2), which is a negative regulator of mtor. |
2005-10-20 |
2023-08-12 |
Not clear |
| Catherine Wilson, Shelley Idziaszczyk, Lee Parry, Carol Guy, David F R Griffiths, Edward Lazda, Rosemary A L Bayne, Andrew J H Smith, Julian R Sampson, Jeremy P Cheadl. A mouse model of tuberous sclerosis 1 showing background specific early post-natal mortality and metastatic renal cell carcinoma. Human molecular genetics. vol 14. issue 13. 2005-10-11. PMID:15888477. |
tuberous sclerosis complex (tsc) is an autosomal dominant disorder caused by mutations in either the tsc1 or the tsc2 genes and characterized by the development of benign hamartomatous growths in multiple organ systems. |
2005-10-11 |
2023-08-12 |
mouse |
| Andrew R Tee, John Blenis, Christopher G Prou. Analysis of mTOR signaling by the small G-proteins, Rheb and RhebL1. FEBS letters. vol 579. issue 21. 2005-10-03. PMID:16098514. |
in this study, we show that rheb like-1 protein (rhebl1) rescues mtor signaling during nutrient withdrawal and that tuberous sclerosis complex-1 (tsc) and tsc2 impairs rhebl1-mediated signaling through mtor. |
2005-10-03 |
2023-08-12 |
Not clear |
| Mark Nellist, Peter C Burgers, Ans M W van den Ouweland, Dicky J J Halley, Theo M Luide. Phosphorylation and binding partner analysis of the TSC1-TSC2 complex. Biochemical and biophysical research communications. vol 333. issue 3. 2005-09-26. PMID:15963462. |
tuberous sclerosis complex (tsc) is an autosomal dominant benign tumour syndrome caused by mutations to either the tsc1 or tsc2 tumour suppressor gene. |
2005-09-26 |
2023-08-12 |
Not clear |
| Wen G Jiang, Julian Sampson, Tracey A Martin, Lisa Lee-Jones, Gareth Watkins, Anthony Douglas-Jones, Kefah Mokbel, Robert E Manse. Tuberin and hamartin are aberrantly expressed and linked to clinical outcome in human breast cancer: the role of promoter methylation of TSC genes. European journal of cancer (Oxford, England : 1990). vol 41. issue 11. 2005-09-12. PMID:15951164. |
the tuberous sclerosis (tsc) genes tsc1 and tsc2 encode the protein products hamartin and tuberin, respectively, and are putative tumour suppressor genes. |
2005-09-12 |
2023-08-12 |
human |
| Markus Hengstschläger, Margit Rosner, Michael Fountoulakis, Gert Lube. The cellular response to ectopic overexpression of the tuberous sclerosis genes, TSC1 and TSC2: a proteomic approach. International journal of oncology. vol 27. issue 3. 2005-09-12. PMID:16077935. |
the cellular response to ectopic overexpression of the tuberous sclerosis genes, tsc1 and tsc2: a proteomic approach. |
2005-09-12 |
2023-08-12 |
human |
| Markus Hengstschläger, Margit Rosner, Michael Fountoulakis, Gert Lube. The cellular response to ectopic overexpression of the tuberous sclerosis genes, TSC1 and TSC2: a proteomic approach. International journal of oncology. vol 27. issue 3. 2005-09-12. PMID:16077935. |
the genes, tsc1 on chromosome 9q34, encoding hamartin, and tsc2 on chromosome 16p13.3, encoding tuberin, are responsible for tuberous sclerosis (tsc). |
2005-09-12 |
2023-08-12 |
human |
| Avi Sofer, Kui Lei, Cory M Johannessen, Leif W Ellise. Regulation of mTOR and cell growth in response to energy stress by REDD1. Molecular and cellular biology. vol 25. issue 14. 2005-09-01. PMID:15988001. |
the tuberous sclerosis tumor suppressors tsc1 and tsc2 regulate the mtor pathway to control translation and cell growth in response to nutrient and growth factor stimuli. |
2005-09-01 |
2023-08-12 |
Not clear |
| Ozgur Sancak, Mark Nellist, Miriam Goedbloed, Peter Elfferich, Cokkie Wouters, Anneke Maat-Kievit, Bernard Zonnenberg, Senno Verhoef, Dicky Halley, Ans van den Ouwelan. Mutational analysis of the TSC1 and TSC2 genes in a diagnostic setting: genotype--phenotype correlations and comparison of diagnostic DNA techniques in Tuberous Sclerosis Complex. European journal of human genetics : EJHG. vol 13. issue 6. 2005-08-18. PMID:15798777. |
mutational analysis of the tsc1 and tsc2 genes in a diagnostic setting: genotype--phenotype correlations and comparison of diagnostic dna techniques in tuberous sclerosis complex. |
2005-08-18 |
2023-08-12 |
Not clear |
| Michael Majores, Ingmar Blümcke, Horst Urbach, Alessandra Meroni, Volkmar Hans, Hans Holthausen, Christian E Elger, Johannes Schramm, Carlo Galli, Roberto Spreafico, Otmar D Wiestler, Albert J Becke. Distinct allelic variants of TSC1 and TSC2 in epilepsy-associated cortical malformations without balloon cells. Journal of neuropathology and experimental neurology. vol 64. issue 7. 2005-08-11. PMID:16042315. |
histopathologic similarities between mcds and dysplastic brain lesions in the autosomal inherited neurocutaneous phacomatosis tuberous sclerosis (tsc), which affects the tsc1 and/or tsc2 genes, suggest common pathogenetic mechanisms. |
2005-08-11 |
2023-08-12 |
Not clear |
| Paolo Curatolo, Roberta Bombardieri, Magda Verdecchia, Stefano Ser. Intractable seizures in tuberous sclerosis complex: from molecular pathogenesis to the rationale for treatment. Journal of child neurology. vol 20. issue 4. 2005-07-27. PMID:15921233. |
tuberous sclerosis complex is a multisystem autosomal dominant genetic disorder resulting from mutations in one of two genes, tsc1 and tsc2. |
2005-07-27 |
2023-08-12 |
Not clear |
| Ewan M Smith, Stephen G Finn, Andrew R Tee, Gareth J Browne, Christopher G Prou. The tuberous sclerosis protein TSC2 is not required for the regulation of the mammalian target of rapamycin by amino acids and certain cellular stresses. The Journal of biological chemistry. vol 280. issue 19. 2005-07-12. PMID:15772076. |
the tuberous sclerosis protein tsc2 is not required for the regulation of the mammalian target of rapamycin by amino acids and certain cellular stresses. |
2005-07-12 |
2023-08-12 |
Not clear |
| Ewan M Smith, Stephen G Finn, Andrew R Tee, Gareth J Browne, Christopher G Prou. The tuberous sclerosis protein TSC2 is not required for the regulation of the mammalian target of rapamycin by amino acids and certain cellular stresses. The Journal of biological chemistry. vol 280. issue 19. 2005-07-12. PMID:15772076. |
recent work demonstrated the importance of the tuberous sclerosis protein tsc2 for regulation of mtor by insulin. |
2005-07-12 |
2023-08-12 |
Not clear |