| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| N Shahani, R Brand. Functions and malfunctions of the tau proteins. Cellular and molecular life sciences : CMLS. vol 59. issue 10. 2002-12-31. PMID:12475178. |
neurofibrillary changes of abnormally hyperphosphorylated tau are a key lesion in alzheimer's disease and a number of other tauopathies. |
2002-12-31 |
2023-08-12 |
Not clear |
| Patrice Verpillat, Sylvain Ricard, Didier Hannequin, Bruno Dubois, Jacqueline Bou, Agnès Camuzat, Laurent Pradier, Thierry Frebourg, Alexis Brice, Françoise Clerget-Darpoux, Jean-François Deleuze, Dominique Campio. Is the saitohin gene involved in neurodegenerative diseases? Annals of neurology. vol 52. issue 6. 2002-12-30. PMID:12447938. |
thus, the saitohin q allele, which is a novel determinant of the tau h1 haplotypes, might represent a causative factor involved in the determinism of several tauopathies. |
2002-12-30 |
2023-08-12 |
Not clear |
| Markus Tolnay, Nicolas Sergeant, Antoine Ghestem, Sonia Chalbot, Rob A I De Vos, Ernst N H Jansen Steur, Alphonse Probst, André Delacourt. Argyrophilic grain disease and Alzheimer's disease are distinguished by their different distribution of tau protein isoforms. Acta neuropathologica. vol 104. issue 4. 2002-12-27. PMID:12200631. |
prominent neuronal and glial tau filamentous inclusions are hallmarks of neurodegenerative tauopathies, among them alzheimer's disease (ad), progressive supranuclear palsy (psp), corticobasal degeneration (cbd), pick's disease (pid), and argyrophilic grain disease (agd). |
2002-12-27 |
2023-08-12 |
Not clear |
| D P Hanger, G M Gibb, R de Silva, A Boutajangout, J-P Brion, T Revesz, A J Lees, B H Anderto. The complex relationship between soluble and insoluble tau in tauopathies revealed by efficient dephosphorylation and specific antibodies. FEBS letters. vol 531. issue 3. 2002-12-24. PMID:12435607. |
the complex relationship between soluble and insoluble tau in tauopathies revealed by efficient dephosphorylation and specific antibodies. |
2002-12-24 |
2023-08-12 |
Not clear |
| D P Hanger, G M Gibb, R de Silva, A Boutajangout, J-P Brion, T Revesz, A J Lees, B H Anderto. The complex relationship between soluble and insoluble tau in tauopathies revealed by efficient dephosphorylation and specific antibodies. FEBS letters. vol 531. issue 3. 2002-12-24. PMID:12435607. |
phosphorylated tau is deposited as insoluble inclusion bodies in the tauopathies. |
2002-12-24 |
2023-08-12 |
Not clear |
| D P Hanger, G M Gibb, R de Silva, A Boutajangout, J-P Brion, T Revesz, A J Lees, B H Anderto. The complex relationship between soluble and insoluble tau in tauopathies revealed by efficient dephosphorylation and specific antibodies. FEBS letters. vol 531. issue 3. 2002-12-24. PMID:12435607. |
in some tauopathies, including alzheimer's disease and progressive supranuclear palsy, the pattern of insoluble tau isoforms reflected that of soluble tau. |
2002-12-24 |
2023-08-12 |
Not clear |
| D P Hanger, G M Gibb, R de Silva, A Boutajangout, J-P Brion, T Revesz, A J Lees, B H Anderto. The complex relationship between soluble and insoluble tau in tauopathies revealed by efficient dephosphorylation and specific antibodies. FEBS letters. vol 531. issue 3. 2002-12-24. PMID:12435607. |
therefore the overall expression of individual tau isoforms does not predict which tau isoforms are deposited in all tauopathies and different mechanisms must operate that result in the deposition of specific tau isoforms. |
2002-12-24 |
2023-08-12 |
Not clear |
| Rohan de Silva, John Hardy, Julia Crook, Naheed Khan, Elizabeth A Graham, Christopher M Morris, Nicholas W Wood, Andrew J Lee. The tau locus is not significantly associated with pathologically confirmed sporadic Parkinson's disease. Neuroscience letters. vol 330. issue 2. 2002-12-17. PMID:12231446. |
mutations of the tau gene in frontotemporal dementia with parkinsonism and genetic association of the tau locus with progressive supranuclear palsy and corticobasal degeneration directly implicate the tau gene in the aetiology of these tauopathies. |
2002-12-17 |
2023-08-12 |
Not clear |
| Bridget Allen, Esther Ingram, Masaki Takao, Michael J Smith, Ross Jakes, Kanwar Virdee, Hirotaka Yoshida, Max Holzer, Molly Craxton, Piers C Emson, Cristiana Atzori, Antonio Migheli, R Anthony Crowther, Bernardino Ghetti, Maria Grazia Spillantini, Michel Goeder. Abundant tau filaments and nonapoptotic neurodegeneration in transgenic mice expressing human P301S tau protein. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 22. issue 21. 2002-11-25. PMID:12417659. |
sarkosyl-insoluble tau from brains and spinal cords of transgenic mice ran as a hyperphosphorylated 64 kda band, the same apparent molecular mass as that of the 383 aa tau isoform in the human tauopathies. |
2002-11-25 |
2023-08-12 |
mouse |
| H Mor. [Visualization of tau isoforms by splicing-site specific antibodies]. Rinsho shinkeigaku = Clinical neurology. vol 41. issue 12. 2002-11-08. PMID:12235809. |
however, the present result strongly suggest unequal occurrence of tau isoforms in alzheimer's nfts, indicating other isoform selection in ad than tauopathies. |
2002-11-08 |
2023-08-12 |
human |
| Emil Adamec, Panaiyur Mohan, Jean P Vonsattel, Ralph A Nixo. Calpain activation in neurodegenerative diseases: confocal immunofluorescence study with antibodies specifically recognizing the active form of calpain 2. Acta neuropathologica. vol 104. issue 1. 2002-09-13. PMID:12070670. |
in tauopathies, more pathological inclusions were labeled for hyperphosphorylated tau than for activated calpain 2. |
2002-09-13 |
2023-08-12 |
Not clear |
| Makoto Higuchi, Takeshi Ishihara, Bin Zhang, Ming Hong, Athena Andreadis, John Trojanowski, Virginia M-Y Le. Transgenic mouse model of tauopathies with glial pathology and nervous system degeneration. Neuron. vol 35. issue 3. 2002-09-04. PMID:12165467. |
frontotemporal dementias (ftds), including corticobasal degeneration (cbd) and progressive supranuclear palsy (psp), are neurodegenerative tauopathies characterized by widespread cns neuronal and glial tau pathologies, but there are no tau transgenic (tg) mice that model neurodegeneration with glia tau lesions. |
2002-09-04 |
2023-08-12 |
mouse |
| Luc Buée, Malika Hamdane, Patrice Delobel, Anne-Véronique Sambo, Séverine Bégard, Antoine Ghestem, Nicolas Sergeant, André Delacourt. [Tau story: from frontotemporal dementia to other tauopathies]. Journal de la Societe de biologie. vol 196. issue 1. 2002-08-23. PMID:12134624. |
[tau story: from frontotemporal dementia to other tauopathies]. |
2002-08-23 |
2023-08-12 |
human |
| John Q Trojanowski, Virginia M Y Le. The role of tau in Alzheimer's disease. The Medical clinics of North America. vol 86. issue 3. 2002-08-22. PMID:12168561. |
the finding that specific tau gene mutations lead to diverse ftdp-17 phenotypes raises the possibility that the clinical and pathological expression of hereditary and related sporadic tauopathies may be influenced by tau gene polymorphisms, other genetic factors and epigenetic events. |
2002-08-22 |
2023-08-12 |
human |
| John Q Trojanowski, Virginia M Y Le. The role of tau in Alzheimer's disease. The Medical clinics of North America. vol 86. issue 3. 2002-08-22. PMID:12168561. |
moreover, development of additional animal models of tauopathies that more closely recapitulate human diseases will facilitate this undertaking, and this is likely to have implications for other neurodegenerative disorders since the aggregation of tau in ad and and related tauopathies is an example of abnormal protein-protein interactions resulting in the intracellular accumulation of filamentous proteins that is a common feature of many fatal cns diseases characterized by relentlessly progressive brain degeneration [1-3]. |
2002-08-22 |
2023-08-12 |
human |
| John Q Trojanowski, Takeshi Ishihara, Makoto Higuchi, Yasumasa Yoshiyama, Ming Hong, Bin Zhang, Mark S Forman, Victoria Zhukareva, Virginia M-Y Le. Amyotrophic lateral sclerosis/parkinsonism dementia complex: transgenic mice provide insights into mechanisms underlying a common tauopathy in an ethnic minority on Guam. Experimental neurology. vol 176. issue 1. 2002-08-16. PMID:12093078. |
intracytoplasmic filamentous tau inclusions are neuropathological hallmarks of amyotrophic lateral sclerosis/parkinsonism-dementia complex (als/pdc) of guam and the defining lesions of other neurodegenerative disorders known as tauopathies. |
2002-08-16 |
2023-08-12 |
mouse |
| John Q Trojanowski, Takeshi Ishihara, Makoto Higuchi, Yasumasa Yoshiyama, Ming Hong, Bin Zhang, Mark S Forman, Victoria Zhukareva, Virginia M-Y Le. Amyotrophic lateral sclerosis/parkinsonism dementia complex: transgenic mice provide insights into mechanisms underlying a common tauopathy in an ethnic minority on Guam. Experimental neurology. vol 176. issue 1. 2002-08-16. PMID:12093078. |
thus, tau tg mice recapitulate key phenotypic features of als/pdc neuropathology in an ethnic minority on guam, and these animal models provide new opportunities to discover novel therapies for this and related tauopathies. |
2002-08-16 |
2023-08-12 |
mouse |
| Mar Pérez, Félix Hernández, Alberto Gómez-Ramos, Mark Smith, George Perry, Jesús Avil. Formation of aberrant phosphotau fibrillar polymers in neural cultured cells. European journal of biochemistry. vol 269. issue 5. 2002-07-19. PMID:11874463. |
the formation of such aberrant aggregates, similar to those occurring in vivo in alzheimer's disease and other tauopathies, requires okadaic acid, a phosphatase inhibitor, to increase the level of phosphorylated tau, and hydroxynonenal, a product of oxidative stress that selectively adducts and modifies phosphorylated tau. |
2002-07-19 |
2023-08-12 |
human |
| Takashi Togo, Naruhiko Sahara, Shu-Hui Yen, Natalie Cookson, Takashi Ishizawa, Mike Hutton, Rohan de Silva, Andrew Lees, Dennis W Dickso. Argyrophilic grain disease is a sporadic 4-repeat tauopathy. Journal of neuropathology and experimental neurology. vol 61. issue 6. 2002-07-08. PMID:12071638. |
the frequency of the extended tau haplotype was not different in agd compared to other sporadic 4r tauopathies, progressive supranuclear palsy (psp) and corticobasal degeneration (cbd). |
2002-07-08 |
2023-08-12 |
Not clear |
| Valérie Buée-Scherrer, Michel Goeder. Phosphorylation of microtubule-associated protein tau by stress-activated protein kinases in intact cells. FEBS letters. vol 515. issue 1-3. 2002-05-10. PMID:11943212. |
tau is a microtubule-associated protein that is abnormally hyperphosphorylated in the filamentous lesions that define a number of neurodegenerative diseases collectively referred to as tauopathies. |
2002-05-10 |
2023-08-12 |
Not clear |