| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| P Pastor, E Pastor, C Carnero, R Vela, T García, G Amer, E Tolosa, R Oliv. Familial atypical progressive supranuclear palsy associated with homozigosity for the delN296 mutation in the tau gene. Annals of neurology. vol 49. issue 2. 2001-03-29. PMID:11220749. |
this finding indicates that homozygous mutations in the tau gene may also cause hereditary tauopathies. |
2001-03-29 |
2023-08-12 |
Not clear |
| G F Hall, V M Lee, G Lee, J Ya. Staging of neurofibrillary degeneration caused by human tau overexpression in a unique cellular model of human tauopathy. The American journal of pathology. vol 158. issue 1. 2001-02-22. PMID:11141497. |
the hyperphosphorylation of human tau and its aggregation into neurofibrillary tangles are central pathogenic events in familial tauopathies and alzheimer's disease. |
2001-02-22 |
2023-08-12 |
human |
| C Mailliot, T Bussière, M Hamdane, N Sergeant, M L Caillet, A Delacourte, L Bué. Pathological tau phenotypes. The weight of mutations, polymorphisms, and differential neuronal vulnerabilities. Annals of the New York Academy of Sciences. vol 920. 2001-02-08. PMID:11193138. |
in tauopathies, comparative biochemistry of tau aggregates shows that they differ in both phosphorylation and content of tau isoforms. |
2001-02-08 |
2023-08-12 |
human |
| D Neary, J S Snowden, D M Man. Classification and description of frontotemporal dementias. Annals of the New York Academy of Sciences. vol 920. 2001-02-08. PMID:11193176. |
it has been suggested that these disorders should be regarded as tauopathies on the basis of the tau pathology seen in a number of cases and the mutations in the tau gene in some familial cases. |
2001-02-08 |
2023-08-12 |
Not clear |
| B Ghetti, J R Murrell, P Zolo, M G Spillantini, M Goeder. Progress in hereditary tauopathies: a mutation in the Tau gene (G389R) causes a Pick disease-like syndrome. Annals of the New York Academy of Sciences. vol 920. 2001-02-08. PMID:11193177. |
progress in hereditary tauopathies: a mutation in the tau gene (g389r) causes a pick disease-like syndrome. |
2001-02-08 |
2023-08-12 |
Not clear |
| K Spittaels, C Van den Haute, J Van Dorpe, H Geerts, M Mercken, K Bruynseels, R Lasrado, K Vandezande, I Laenen, T Boon, J Van Lint, J Vandenheede, D Moechars, R Loos, F Van Leuve. Glycogen synthase kinase-3beta phosphorylates protein tau and rescues the axonopathy in the central nervous system of human four-repeat tau transgenic mice. The Journal of biological chemistry. vol 275. issue 52. 2001-01-26. PMID:11007782. |
protein tau filaments in brain of patients suffering from alzheimer's disease, frontotemporal dementia, and other tauopathies consist of protein tau that is hyperphosphorylated. |
2001-01-26 |
2023-08-12 |
mouse |
| M van Slegtenhorst, J Lewis, M Hutto. The molecular genetics of the tauopathies. Experimental gerontology. vol 35. issue 4. 2000-12-22. PMID:10959034. |
in addition to the tau mutations, a common extended haplotype in the tau gene also appears to be a risk factor in the development of the apparently sporadic tauopathies progressive supranuclear palsy (psp) and corticobasal degeneration (cbd). |
2000-12-22 |
2023-08-12 |
Not clear |
| K A Jellinge. Morphological substrates of mental dysfunction in Lewy body disease: an update. Journal of neural transmission. Supplementum. vol 59. 2000-12-22. PMID:10961431. |
familial parkinsonism with dementia, linked to chromosome 17 (frontotemporal dementia with parkinsonism (ftdp-17), and other tauopathies pathologically resembling pd plus ad, are often related to mutations of the tau gene, whereas familial pd with alpha-synuclein and parkin mutations usually show no cognitive impairment. |
2000-12-22 |
2023-08-12 |
Not clear |
| K Iqbal, A D Alonso, J A Gondal, C X Gong, N Haque, S Khatoon, A Sengupta, J Z Wang, I Grundke-Iqba. Mechanism of neurofibrillary degeneration and pharmacologic therapeutic approach. Journal of neural transmission. Supplementum. vol 59. 2000-12-22. PMID:10961432. |
microtubule associated protein (map) tau, which is a major map of a normal mature neuron is abnormally hyperphosphorylated in tauopathies and is the major protein subunit of paired helical filaments (phf)/straight filaments (sf) which accumulate in the soma (as neurofibrillary tangles) and dystrophic neurites (as neuropil threads and as dystrophic neurites surrounding the beta-amyloid core in neuritic plaques in ad) of the affected neurons. |
2000-12-22 |
2023-08-12 |
Not clear |
| J Eidenmüller, T Fath, A Hellwig, J Reed, E Sontag, R Brand. Structural and functional implications of tau hyperphosphorylation: information from phosphorylation-mimicking mutated tau proteins. Biochemistry. vol 39. issue 43. 2000-11-30. PMID:11052669. |
they suggest that several mechanisms contribute to the abnormal tau accumulation observed during tauopathies, in particular a selective displacement of hyperphosphorylated tau from microtubules, a functional loss in promoting microtubule nucleation, and a failure to interact with phosphatases. |
2000-11-30 |
2023-08-12 |
Not clear |
| J P Brio. [Neurofibrillary tangles and early modification of the neuronal cytoskeleton in Alzheimer's disease and in experimental models]. Bulletin et memoires de l'Academie royale de medecine de Belgique. vol 154. issue 6 Pt 2. 2000-10-05. PMID:10992876. |
neurofibrillary tangles, a hallmark neuropathological lesion of alzheimer's disease and of the other tauopathies, are composed of hyperphosphorylated tau proteins (a microtubule-associated protein) assembled in the form of abnormal filaments. |
2000-10-05 |
2023-08-12 |
Not clear |
| J Lewis, E McGowan, J Rockwood, H Melrose, P Nacharaju, M Van Slegtenhorst, K Gwinn-Hardy, M Paul Murphy, M Baker, X Yu, K Duff, J Hardy, A Corral, W L Lin, S H Yen, D W Dickson, P Davies, M Hutto. Neurofibrillary tangles, amyotrophy and progressive motor disturbance in mice expressing mutant (P301L) tau protein. Nature genetics. vol 25. issue 4. 2000-08-28. PMID:10932182. |
the phenotype of mice expressing p301l mutant tau mimics features of human tauopathies and provides a model for investigating the pathogenesis of diseases with nft. |
2000-08-28 |
2023-08-12 |
mouse |
| E Vanmechelen, H Vanderstichele, P Davidsson, E Van Kerschaver, B Van Der Perre, M Sjögren, N Andreasen, K Blenno. Quantification of tau phosphorylated at threonine 181 in human cerebrospinal fluid: a sandwich ELISA with a synthetic phosphopeptide for standardization. Neuroscience letters. vol 285. issue 1. 2000-08-22. PMID:10788705. |
hyperphosphorylation of the microtubule-associated protein tau is specifically found in those brain cells affected in several tauopathies. |
2000-08-22 |
2023-08-12 |
human |
| G F Hall, B Chu, G Lee, J Ya. Human tau filaments induce microtubule and synapse loss in an in vivo model of neurofibrillary degenerative disease. Journal of cell science. vol 113 ( Pt 8). 2000-07-31. PMID:10725221. |
the intracellular accumulation of tau protein and its aggregation into filamentous deposits is the intracellular hallmark of neurofibrillary degenerative diseases such as alzheimer's disease and familial tauopathies in which tau is now thought to play a critical pathogenic role. |
2000-07-31 |
2023-08-12 |
human |
| N Sahara, T Tomiyama, H Mor. Missense point mutations of tau to segregate with FTDP-17 exhibit site-specific effects on microtubule structure in COS cells: a novel action of R406W mutation. Journal of neuroscience research. vol 60. issue 3. 2000-06-02. PMID:10797541. |
thus, diverse effects of tau mutations on microtubules may explain the various clinicopathologies of ftdp-17 and related tauopathies. |
2000-06-02 |
2023-08-12 |
Not clear |
| G Roks, B Dermaut, P Heutink, A Julliams, H Backhovens, M Van de Broeck, S Serneels, A Hofman, C Van Broeckhoven, C M van Duijn, M Crut. Mutation screening of the tau gene in patients with early-onset Alzheimer's disease. Neuroscience letters. vol 277. issue 2. 2000-02-08. PMID:10624829. |
the gene encoding tau (mapt) was recently found mutated in frontotemporal dementia (ftd) and other tauopathies. |
2000-02-08 |
2023-08-12 |
Not clear |
| T Ishihara, M Hong, B Zhang, Y Nakagawa, M K Lee, J Q Trojanowski, V M Le. Age-dependent emergence and progression of a tauopathy in transgenic mice overexpressing the shortest human tau isoform. Neuron. vol 24. issue 3. 2000-01-04. PMID:10595524. |
filamentous tau aggregates are hallmarks of tauopathies, e.g., frontotemporal dementia with parkinsonism linked to chromosome 17 (ftdp-17) and amyotrophic lateral sclerosis/parkinsonism-dementia complex (als/pdc). |
2000-01-04 |
2023-08-12 |
mouse |
| T Ishihara, M Hong, B Zhang, Y Nakagawa, M K Lee, J Q Trojanowski, V M Le. Age-dependent emergence and progression of a tauopathy in transgenic mice overexpressing the shortest human tau isoform. Neuron. vol 24. issue 3. 2000-01-04. PMID:10595524. |
since ftdp-17 tau gene mutations alter levels/functions of tau, we overexpressed the smallest human tau isoform in the cns of transgenic (tg) mice to model tauopathies. |
2000-01-04 |
2023-08-12 |
mouse |
| K Spittaels, C Van den Haute, J Van Dorpe, K Bruynseels, K Vandezande, I Laenen, H Geerts, M Mercken, R Sciot, A Van Lommel, R Loos, F Van Leuve. Prominent axonopathy in the brain and spinal cord of transgenic mice overexpressing four-repeat human tau protein. The American journal of pathology. vol 155. issue 6. 1999-12-28. PMID:10595944. |
this transgenic model, overexpressing the longest isoform of human tau protein, recapitulates features of known neurodegenerative diseases, including alzheimer's disease and other tauopathies. |
1999-12-28 |
2023-08-12 |
mouse |
| D W Dickso. Neuropathologic differentiation of progressive supranuclear palsy and corticobasal degeneration. Journal of neurology. vol 246 Suppl 2. 1999-12-10. PMID:10525997. |
as such they can be considered sporadic tauopathies in contrast to familial tauopathies linked to mutations in the tau gene. |
1999-12-10 |
2023-08-12 |
Not clear |