| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| T Ishihara, M Hong, B Zhang, Y Nakagawa, M K Lee, J Q Trojanowski, V M Le. Age-dependent emergence and progression of a tauopathy in transgenic mice overexpressing the shortest human tau isoform. Neuron. vol 24. issue 3. 2000-01-04. PMID:10595524. |
filamentous tau aggregates are hallmarks of tauopathies, e.g., frontotemporal dementia with parkinsonism linked to chromosome 17 (ftdp-17) and amyotrophic lateral sclerosis/parkinsonism-dementia complex (als/pdc). |
2000-01-04 |
2023-08-12 |
mouse |
| T Ishihara, M Hong, B Zhang, Y Nakagawa, M K Lee, J Q Trojanowski, V M Le. Age-dependent emergence and progression of a tauopathy in transgenic mice overexpressing the shortest human tau isoform. Neuron. vol 24. issue 3. 2000-01-04. PMID:10595524. |
since ftdp-17 tau gene mutations alter levels/functions of tau, we overexpressed the smallest human tau isoform in the cns of transgenic (tg) mice to model tauopathies. |
2000-01-04 |
2023-08-12 |
mouse |
| K Spittaels, C Van den Haute, J Van Dorpe, K Bruynseels, K Vandezande, I Laenen, H Geerts, M Mercken, R Sciot, A Van Lommel, R Loos, F Van Leuve. Prominent axonopathy in the brain and spinal cord of transgenic mice overexpressing four-repeat human tau protein. The American journal of pathology. vol 155. issue 6. 1999-12-28. PMID:10595944. |
this transgenic model, overexpressing the longest isoform of human tau protein, recapitulates features of known neurodegenerative diseases, including alzheimer's disease and other tauopathies. |
1999-12-28 |
2023-08-12 |
mouse |
| D W Dickso. Neuropathologic differentiation of progressive supranuclear palsy and corticobasal degeneration. Journal of neurology. vol 246 Suppl 2. 1999-12-10. PMID:10525997. |
as such they can be considered sporadic tauopathies in contrast to familial tauopathies linked to mutations in the tau gene. |
1999-12-10 |
2023-08-12 |
Not clear |
| T Komor. Tau-positive glial inclusions in progressive supranuclear palsy, corticobasal degeneration and Pick's disease. Brain pathology (Zurich, Switzerland). vol 9. issue 4. 1999-11-16. PMID:10517506. |
nevertheless, these distinctive glial lesions most likely reflect fundamental alterations in isoform composition of tau as well as its specific cellular and regional expression in sporadic tauopathies. |
1999-11-16 |
2023-08-12 |
Not clear |
| L Buée, A Delacourt. Comparative biochemistry of tau in progressive supranuclear palsy, corticobasal degeneration, FTDP-17 and Pick's disease. Brain pathology (Zurich, Switzerland). vol 9. issue 4. 1999-11-16. PMID:10517507. |
neurodegenerative disorders referred to as tauopathies have cellular hyperphosphorylated tau protein aggregates in the absence of amyloid deposits. |
1999-11-16 |
2023-08-12 |
human |
| E Sontag, V Nunbhakdi-Craig, G Lee, R Brandt, C Kamibayashi, J Kuret, C L White, M C Mumby, G S Bloo. Molecular interactions among protein phosphatase 2A, tau, and microtubules. Implications for the regulation of tau phosphorylation and the development of tauopathies. The Journal of biological chemistry. vol 274. issue 36. 1999-10-07. PMID:10464280. |
implications for the regulation of tau phosphorylation and the development of tauopathies. |
1999-10-07 |
2023-08-12 |
Not clear |
| M Tolnay, A Probs. REVIEW: tau protein pathology in Alzheimer's disease and related disorders. Neuropathology and applied neurobiology. vol 25. issue 3. 1999-08-26. PMID:10417659. |
the impact of the recent finding of tau gene mutations in familial frontotemporal dementia and parkinsonism linked to chromosome 17 on other tauopathies is discussed in the second part. |
1999-08-26 |
2023-08-12 |
Not clear |