| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| James P Quinn, Kate Fisher, Nicola J Corbett, Stacey Warwood, David Knight, Katherine Ab Kellett, Nigel M Hoope. Proteolysis of tau by granzyme A in tauopathies generates fragments that are aggregation prone. The Biochemical journal. 2024-09-09. PMID:39248243. |
proteolysis of tau by granzyme a in tauopathies generates fragments that are aggregation prone. |
2024-09-09 |
2024-09-11 |
human |
| James P Quinn, Kate Fisher, Nicola J Corbett, Stacey Warwood, David Knight, Katherine Ab Kellett, Nigel M Hoope. Proteolysis of tau by granzyme A in tauopathies generates fragments that are aggregation prone. The Biochemical journal. 2024-09-09. PMID:39248243. |
tauopathies, including alzheimer's disease, corticobasal degeneration and progressive supranuclear palsy, are characterised by the aggregation of tau into insoluble neurofibrillary tangles in the brain. |
2024-09-09 |
2024-09-11 |
human |
| James P Quinn, Kate Fisher, Nicola J Corbett, Stacey Warwood, David Knight, Katherine Ab Kellett, Nigel M Hoope. Proteolysis of tau by granzyme A in tauopathies generates fragments that are aggregation prone. The Biochemical journal. 2024-09-09. PMID:39248243. |
collectively, these results raise the possibility that gzma, released from infiltrating cytotoxic cd8+ t cells, proteolytically cleaves tau into fragments that may contribute to its pathological properties in tauopathies. |
2024-09-09 |
2024-09-11 |
human |
| Keisuke Takahata, Manabu Kubota, Shin Kurose, Makoto Higuch. [Tau Positron Emission Tomography: Applications in Diagnosis and Prognosis of Various Diseases]. Brain and nerve = Shinkei kenkyu no shinpo. vol 76. issue 9. 2024-09-09. PMID:39251223. |
studies have reported the diagnostic and prognostic value of tau pet in alzheimer's disease and other tauopathies. |
2024-09-09 |
2024-09-13 |
Not clear |
| Keisuke Takahata, Manabu Kubota, Shin Kurose, Makoto Higuch. [Tau Positron Emission Tomography: Applications in Diagnosis and Prognosis of Various Diseases]. Brain and nerve = Shinkei kenkyu no shinpo. vol 76. issue 9. 2024-09-09. PMID:39251223. |
however, the binding profiles of tau pet drugs vary widely across tauopathies; therefore, an accurate understanding of the disease-specific characteristics is essential for interpretation of tau pet findings. |
2024-09-09 |
2024-09-13 |
Not clear |
| Taisuke Tomit. [Novel Therapeutic Strategies for Alzheimer's Disease]. Brain and nerve = Shinkei kenkyu no shinpo. vol 76. issue 9. 2024-09-09. PMID:39251225. |
meanwhile, research on tau as a causative molecule in ad and various other tauopathies is advancing gradually. |
2024-09-09 |
2024-09-13 |
Not clear |
| Pablo Martinez, Nur Jury-Garfe, Henika Patel, Yanwen You, Abigail Perkins, Yingjan You, Audrey Lee-Gosselin, Ruben Vidal, Cristian A Lasagna-Reeve. Phosphorylation at serine 214 correlates with tau seeding activity in an age-dependent manner in two mouse models for tauopathies and is required for tau transsynaptic propagation. bioRxiv : the preprint server for biology. 2024-08-30. PMID:39211286. |
phosphorylation at serine 214 correlates with tau seeding activity in an age-dependent manner in two mouse models for tauopathies and is required for tau transsynaptic propagation. |
2024-08-30 |
2024-09-04 |
mouse |
| Pablo Martinez, Nur Jury-Garfe, Henika Patel, Yanwen You, Abigail Perkins, Yingjan You, Audrey Lee-Gosselin, Ruben Vidal, Cristian A Lasagna-Reeve. Phosphorylation at serine 214 correlates with tau seeding activity in an age-dependent manner in two mouse models for tauopathies and is required for tau transsynaptic propagation. bioRxiv : the preprint server for biology. 2024-08-30. PMID:39211286. |
pathological aggregation and propagation of hyperphosphorylated and aberrant forms of tau are critical features of the clinical progression of alzheimer's disease and other tauopathies. |
2024-08-30 |
2024-09-04 |
mouse |
| Pablo Martinez, Nur Jury-Garfe, Henika Patel, Yanwen You, Abigail Perkins, Yingjan You, Audrey Lee-Gosselin, Ruben Vidal, Cristian A Lasagna-Reeve. Phosphorylation at serine 214 correlates with tau seeding activity in an age-dependent manner in two mouse models for tauopathies and is required for tau transsynaptic propagation. bioRxiv : the preprint server for biology. 2024-08-30. PMID:39211286. |
to better understand the correlation between these pathological tau species and disease progression, we profiled the temporal progression of tau seeding activity and the levels of various phospho- and conformational tau species in the brains of two mouse models of human tauopathies. |
2024-08-30 |
2024-09-04 |
mouse |
| Pu Duan, Aurelio J Dregni, Hong Xu, Lakshmi Changolkar, Virginia M-Y Lee, Edward B Lee, Mei Hon. Alzheimer's Disease Seeded Tau Forms Paired Helical Filaments Yet Lacks Seeding Potential. The Journal of biological chemistry. 2024-08-30. PMID:39214304. |
therefore, the phf structure alone is insufficient for defining the pathological properties of ad tau, and other biochemical components such as tau posttranslational modifications, other proteins, polyanionic cofactors, and salt are required for the prion-like serial propagation of tauopathies. |
2024-08-30 |
2024-09-04 |
Not clear |
| Márcia F D Costa, Thomas W Rösler, Günter U Höglinge. Exploring the neuroprotective potential of Nrf2-pathway activators against annonacin toxicity. Scientific reports. vol 14. issue 1. 2024-08-29. PMID:39209951. |
modulation of the nrf2 pathway, a master regulator of the antioxidant response and cellular metabolism, has been suggested as a promising therapeutic strategy in tauopathies, a heterogeneous group of neurodegenerative disorders characterized by intracellular proteinaceous inclusions of abnormally phosphorylated tau. |
2024-08-29 |
2024-09-04 |
human |
| Itaru Nishida, Kaoru Yamada, Asami Sakamoto, Tomoko Wakabayashi, Takeshi Iwatsub. Chronic Neuronal Hyperexcitation Exacerbates Tau Propagation in a Mouse Model of Tauopathy. International journal of molecular sciences. vol 25. issue 16. 2024-08-29. PMID:39201689. |
the intracerebral spread of tau is a critical mechanism associated with functional decline in alzheimer's disease (ad) and other tauopathies. |
2024-08-29 |
2024-09-04 |
mouse |
| Vicky Ury-Thiery, Yann Fichou, Isabel Alves, Michael Molinari, Sophie Lecomte, Cécile Feuilli. Interaction of full-length Tau with negatively charged lipid membranes leads to polymorphic aggregates. Nanoscale. 2024-08-27. PMID:39189914. |
the tau protein is implicated in various diseases collectively known as tauopathies, including alzheimer's disease and frontotemporal dementia. |
2024-08-27 |
2024-08-30 |
Not clear |
| Lindsey D Goodman, Isha Ralhan, Xin Li, Shenzhao Lu, Matthew J Moulton, Ye-Jin Park, Pinghan Zhao, Oguz Kanca, Ziyaneh S Ghaderpour Taleghani, Julie Jacquemyn, Joshua M Shulman, Kanae Ando, Kai Sun, Maria S Ioannou, Hugo J Belle. Tau is required for glial lipid droplet formation and resistance to neuronal oxidative stress. Nature neuroscience. 2024-08-26. PMID:39187706. |
the accumulation of reactive oxygen species (ros) is a common feature of tauopathies, defined by tau accumulations in neurons and glia. |
2024-08-26 |
2024-08-30 |
human |
| Lokeswara Rao Potnuru, Austin DuBose, Mesopotamia S Nowotarski, Michael Vigers, Boqin Zhang, Chung-Ta Han, Songi Ha. Phosphoryl group wires stabilize pathological tau fibrils as revealed by multiple quantum spin counting NMR. bioRxiv : the preprint server for biology. 2024-08-26. PMID:39185239. |
hyperphosphorylation of the protein tau is one of the biomarkers of neurodegenerative diseases in the category of tauopathies. |
2024-08-26 |
2024-08-28 |
Not clear |
| Nuo Jia, Dhasarathan Ganesan, Hongyuan Guan, Yu Young Jeong, Sinsuk Han, Gavesh Rajapaksha, Marialaina Nissenbaum, Alexander W Kusnecov, Qian Ca. Mitochondrial bioenergetics stimulates autophagy for pathological MAPT/Tau clearance in tauopathy neurons. Autophagy. 2024-08-22. PMID:39171695. |
hyperphosphorylation and aggregation of mapt (microtubule-associated protein tau) is a pathogenic hallmark of tauopathies and a defining feature of alzheimer disease (ad). |
2024-08-22 |
2024-08-24 |
mouse |
| Owen Dando, Robert McGeachan, Jamie McQueen, Paul Baxter, Nathan Rockley, Hannah McAlister, Adharsh Prasad, Xin He, Declan King, Jamie Rose, Phillip B Jones, Jane Tulloch, Siddharthan Chandran, Colin Smith, Giles Hardingham, Tara L Spires-Jone. Synaptic gene expression changes in frontotemporal dementia due to the MAPT 10 + 16 mutation. Neuropathology and applied neurobiology. vol 50. issue 4. 2024-08-21. PMID:39164997. |
mutations in the mapt gene encoding tau protein can cause autosomal dominant neurodegenerative tauopathies including frontotemporal dementia (often with parkinsonism). |
2024-08-21 |
2024-08-23 |
Not clear |
| Jacob Ayers, T Peter Lopez, Ian T Steele, Abby Oehler, Rigo Roman-Albarran, Elisa Cleveland, Alex Chong, George A Carlson, Carlo Condello, Stanley B Prusine. Severe neurodegeneration in brains of transgenic rats producing human tau prions. Acta neuropathologica. vol 148. issue 1. 2024-08-19. PMID:39160375. |
our studies argue that the regional propagation of tau prions and neurodegeneration in the tg12099 rats resembles that found in human primary tauopathies. |
2024-08-19 |
2024-08-22 |
human |
| Jacob Ayers, T Peter Lopez, Ian T Steele, Abby Oehler, Rigo Roman-Albarran, Elisa Cleveland, Alex Chong, George A Carlson, Carlo Condello, Stanley B Prusine. Severe neurodegeneration in brains of transgenic rats producing human tau prions. Acta neuropathologica. vol 148. issue 1. 2024-08-19. PMID:39160375. |
these findings seem likely to advance our understanding of human tauopathies and may lead to effective therapeutics for alzheimer's disease and other tau prion disorders. |
2024-08-19 |
2024-08-22 |
human |
| Anukool A Bhopatkar, Nemil Bhatt, Md Anzarul Haque, Rhea Xavier, Leiana Fung, Cynthia Jerez, Rakez Kaye. MAPT mutations associated with familial tauopathies lead to formation of conformationally distinct oligomers that have cross-seeding ability. Protein science : a publication of the Protein Society. vol 33. issue 9. 2024-08-15. PMID:39145409. |
the microtubule associated protein, tau, is implicated in a multitude of neurodegenerative disorders that are collectively termed as tauopathies. |
2024-08-15 |
2024-08-17 |
Not clear |