Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
Yanqing Wu, Ting Li, Xingjun Jiang, Jianmin Ling, Zaihua Zhao, Jiahui Zhu, Chongyang Chen, Qian Liu, Xifei Yang, Xuefeng Shen, Rong Ma, Gang Li, Gongping Li. (-)-Epicatechin Rescues Memory Deficits by Activation of Autophagy in a Mouse Model of Tauopathies. MedComm. vol 6. issue 4. 2025-03-26. PMID:40135197. |
in tauopathies, defects in autophagy-lysosomal protein degradation are thought to contribute to the abnormal accumulation of aggregated tau. |
2025-03-26 |
2025-03-28 |
mouse |
Yanqing Wu, Ting Li, Xingjun Jiang, Jianmin Ling, Zaihua Zhao, Jiahui Zhu, Chongyang Chen, Qian Liu, Xifei Yang, Xuefeng Shen, Rong Ma, Gang Li, Gongping Li. (-)-Epicatechin Rescues Memory Deficits by Activation of Autophagy in a Mouse Model of Tauopathies. MedComm. vol 6. issue 4. 2025-03-26. PMID:40135197. |
here, we found that epi rescued cognitive deficits in p301s tau transgenic mice, a model exhibiting characteristics of tauopathies like frontotemporal dementia and alzheimer's disease, and attenuated tau pathology through autophagy activation. |
2025-03-26 |
2025-03-28 |
mouse |
Yanqing Wu, Ting Li, Xingjun Jiang, Jianmin Ling, Zaihua Zhao, Jiahui Zhu, Chongyang Chen, Qian Liu, Xifei Yang, Xuefeng Shen, Rong Ma, Gang Li, Gongping Li. (-)-Epicatechin Rescues Memory Deficits by Activation of Autophagy in a Mouse Model of Tauopathies. MedComm. vol 6. issue 4. 2025-03-26. PMID:40135197. |
our findings suggest that epi promoted tau clearance by activating autophagy, indicating its potential as a promising therapeutic candidate for tauopathies. |
2025-03-26 |
2025-03-28 |
mouse |
Kai Chen, Fuyao Li, Shuwen Zhang, Yixing Chen, Tadafumi C Ikezu, Zonghua Li, Yuka A Martens, Wenhui Qiao, Axel Meneses, Yiyang Zhu, Gisela Xhafkollari, Guojun Bu, Na Zha. Enhancing TREM2 expression activates microglia and modestly mitigates tau pathology and neurodegeneration. Journal of neuroinflammation. vol 22. issue 1. 2025-03-24. PMID:40122810. |
these findings highlight the role of trem2 in modulating microglial activity and its influence on tau pathology and neurodegeneration, providing important insights for the future development of therapies targeting trem2 or microglial pathways in ad or other tauopathies. |
2025-03-24 |
2025-03-26 |
mouse |
Léa El Hajjar, Emmanuelle Boll, François-Xavier Cantrelle, Clarisse Bridot, Isabelle Landrieu, Caroline Smet-Nocc. Effect of PHF-1 hyperphosphorylation on the seeding activity of C-terminal Tau fragments. Scientific reports. vol 15. issue 1. 2025-03-23. PMID:40121258. |
tau proteins as neurofibrillary tangles are one of the molecular hallmarks of alzheimer's disease (ad) and play a central role in tauopathies, a group of age-related neurodegenerative disorders. |
2025-03-23 |
2025-03-26 |
Not clear |
Léa El Hajjar, Emmanuelle Boll, François-Xavier Cantrelle, Clarisse Bridot, Isabelle Landrieu, Caroline Smet-Nocc. Effect of PHF-1 hyperphosphorylation on the seeding activity of C-terminal Tau fragments. Scientific reports. vol 15. issue 1. 2025-03-23. PMID:40121258. |
the filament cores from diverse tauopathies share a common region of tau consisting of the r3-r4 microtubule-binding repeats and part of the c-terminal domain, but present a structural polymorphism. |
2025-03-23 |
2025-03-26 |
Not clear |
Elisa Uliassi, Maria Laura Bolognesi, Andrea Milell. Targeting Tau Protein with Proximity Inducing Modulators: A New Frontier to Combat Tauopathies. ACS pharmacology & translational science. vol 8. issue 3. 2025-03-20. PMID:40109749. |
targeting tau protein with proximity inducing modulators: a new frontier to combat tauopathies. |
2025-03-20 |
2025-03-22 |
Not clear |
Elisa Uliassi, Maria Laura Bolognesi, Andrea Milell. Targeting Tau Protein with Proximity Inducing Modulators: A New Frontier to Combat Tauopathies. ACS pharmacology & translational science. vol 8. issue 3. 2025-03-20. PMID:40109749. |
dysregulation of correct protein tau homeostasis represents the seed for the development of several devastating central nervous system disorders, known as tauopathies, that affect millions of people worldwide. |
2025-03-20 |
2025-03-22 |
Not clear |
Roberto Guzmán-Hernández, Silvia Fossat. Fibrillar tau alters cerebral endothelial cell metabolism, vascular inflammatory activation, and barrier function in vitro and in vivo. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 21. issue 3. 2025-03-20. PMID:40110691. |
the presence of tau aggregates in and around the brain vasculature in alzheimer's disease (ad) and tauopathies suggests its possible pathogenicity to cerebral endothelial cells (ecs). |
2025-03-20 |
2025-03-22 |
Not clear |
Dmytro Morderer, Melissa C Wren, Feilin Liu, Naomi Kouri, Anastasiia Maistrenko, Bilal Khalil, Nora Pobitzer, Michelle R Salemi, Brett S Phinney, Guojun Bu, Na Zhao, Dennis W Dickson, Melissa E Murray, Wilfried Rossol. Probe-dependent Proximity Profiling (ProPPr) Uncovers Similarities and Differences in Phospho-Tau-Associated Proteomes Between Tauopathies. Molecular neurodegeneration. vol 20. issue 1. 2025-03-14. PMID:40082954. |
tauopathies represent a diverse group of neurodegenerative disorders characterized by the abnormal aggregation of the microtubule-associated protein tau. |
2025-03-14 |
2025-03-16 |
Not clear |
Dmytro Morderer, Melissa C Wren, Feilin Liu, Naomi Kouri, Anastasiia Maistrenko, Bilal Khalil, Nora Pobitzer, Michelle R Salemi, Brett S Phinney, Guojun Bu, Na Zhao, Dennis W Dickson, Melissa E Murray, Wilfried Rossol. Probe-dependent Proximity Profiling (ProPPr) Uncovers Similarities and Differences in Phospho-Tau-Associated Proteomes Between Tauopathies. Molecular neurodegeneration. vol 20. issue 1. 2025-03-14. PMID:40082954. |
despite extensive research, the mechanisms underlying the diversity of neuronal and glial tau pathology in different tauopathies are poorly understood. |
2025-03-14 |
2025-03-16 |
Not clear |
Dmytro Morderer, Melissa C Wren, Feilin Liu, Naomi Kouri, Anastasiia Maistrenko, Bilal Khalil, Nora Pobitzer, Michelle R Salemi, Brett S Phinney, Guojun Bu, Na Zhao, Dennis W Dickson, Melissa E Murray, Wilfried Rossol. Probe-dependent Proximity Profiling (ProPPr) Uncovers Similarities and Differences in Phospho-Tau-Associated Proteomes Between Tauopathies. Molecular neurodegeneration. vol 20. issue 1. 2025-03-14. PMID:40082954. |
here we study the protein composition of tau aggregates in four major tauopathies: alzheimer's disease (ad), corticobasal degeneration (cbd), pick's disease (pid), and progressive supranuclear palsy (psp). |
2025-03-14 |
2025-03-16 |
Not clear |
Pengju Nie, You Wu, John Robinson, Shekar Mekala, Virginia M Y Lee, Yue-Ming L. ACS chemical biology. 2025-03-13. PMID:40079621. |
developing specific techniques that can isolate pathogenic tau from brain tissue is important for understanding tauopathies and advancing targeted therapies. |
2025-03-13 |
2025-03-16 |
Not clear |
Evan Gallagher, Shihong Li, Hsiaoju Lee, Hong Xu, Virginia M-Y Lee, Robert H Mach, Meagan J McManu. Noninvasive Detection of Oxidative Stress in a Mouse Model of 4R Tauopathy via Positron Emission Tomography with [ International journal of molecular sciences. vol 26. issue 5. 2025-03-13. PMID:40076472. |
collectively, the 4r tauopathies are characterized by the progressive aggregation of tau protein isoforms with four microtubule-binding domains in and around brain cells. |
2025-03-13 |
2025-03-15 |
mouse |
Frida N Angehrn, Pu Duan, Jia Yi Zhang, Mei Hon. Binding Sites of a PET Ligand in Tau Fibrils with the Alzheimer's Disease Fold from Biochemistry. 2025-03-11. PMID:40068133. |
developing small molecules that bind these tau fibrils is important for the diagnosis and treatment of tauopathies. |
2025-03-11 |
2025-03-14 |
Not clear |
Edward Rockenstein, Kiren Ubhi, Michael Mante, Jazmin Florio, Anthony Adame, Stefan Winter, Hemma Brandstaetter, Dieter Meier, Eliezer Maslia. Retraction Note: Neuroprotective effects of Cerebrolysin in triple repeat Tau transgenic model of Pick's disease and fronto-temporal tauopathies. BMC neuroscience. vol 26. issue 1. 2025-03-11. PMID:40065222. |
retraction note: neuroprotective effects of cerebrolysin in triple repeat tau transgenic model of pick's disease and fronto-temporal tauopathies. |
2025-03-11 |
2025-03-13 |
Not clear |
Qi-Yi Huang, You Xiang, Jia-Hang Tang, Li-Jia Chen, Kun-Lin Li, Wei-Fang Zhao, Qian Wan. [Research progress on the mechanisms of Tau phosphorylation and its kinases in hypoxic-ischemic brain damage]. Sheng li xue bao : [Acta physiologica Sinica]. vol 77. issue 1. 2025-03-11. PMID:40065622. |
in pathological conditions, it leads to abnormal tau phosphorylation and influences its structure and functions, resulting in tauopathies. |
2025-03-11 |
2025-03-13 |
Not clear |
Jinyi Yao, Keying Li, Zhenli Fu, Jingjing Zheng, Zicong Chen, Jiahao Xu, Guoqing Lai, Yaomin Huang, Jinsheng Huang, Guanying You, Shuangxue Han, Zhijun He, Qiong Liu, Nan L. Human tau promotes Warburg effect-like glycolytic metabolism under acute hyperglycemia conditions. The Journal of biological chemistry. 2025-03-07. PMID:40054691. |
the neurofilaments formed by hyperphosphorylated tau is a hallmark of tauopathies. |
2025-03-07 |
2025-03-12 |
mouse |
E J Davidowitz, P Lopez, D Patel, H Jimenez, A Wolin, J Eun, L Adrien, J Koppel, D Morgan, P Davies, J G Mo. Therapeutic Treatment With OLX-07010 Inhibited Tau Aggregation and Ameliorated Motor Deficits in an Aged Mouse Model of Tauopathy. Journal of neurochemistry. vol 169. issue 3. 2025-03-07. PMID:40052227. |
targeting tau protein is a strategy for the development of disease-modifying therapeutics for alzheimer's disease (ad) and numerous rare tauopathies. |
2025-03-07 |
2025-03-09 |
mouse |
Emma Szegvari, Sara A M Holec, Amanda L Woerma. Limitations and Applications of Rodent Models in Tauopathy and Synucleinopathy Research. Journal of neurochemistry. vol 169. issue 3. 2025-03-03. PMID:40026260. |
these findings provided critical lessons for ongoing efforts to develop treatments for patients with neurodegenerative diseases caused by misfolding and accumulation of the proteins tau and α-synuclein, or tauopathies and synucleinopathies, respectively. |
2025-03-03 |
2025-03-06 |
human |