| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Xingyu Zhang, Jiangyu Wang, Zhentao Zhang, Keqiang Y. Tau in neurodegenerative diseases: molecular mechanisms, biomarkers, and therapeutic strategies. Translational neurodegeneration. vol 13. issue 1. 2024-08-07. PMID:39107835. |
in this review, we briefly introduce several tauopathies and discuss the mechanisms mediating tau aggregation and propagation. |
2024-08-07 |
2024-08-09 |
Not clear |
| Ahmed Sabry Mohamed, Mahmoud ElKaffas, Karim Metwally, Mahmoud Abdelfattah, Eslam Ashraf Elsery, Ahmed Elshazly, Hossam Eldin Gomaa, Aziza Alsayed, Sara El-Desouky, Randa El-Gamal, Sara Elfarras. Impairment of Nrf2 signaling in the hippocampus of P301S tauopathy mice model aligns with the cognitive impairment and the associated neuroinflammation. Journal of inflammation (London, England). vol 21. issue 1. 2024-08-06. PMID:39107774. |
mice transgenic for human p301s tau protein exhibit many characteristics of the human tauopathies, including the formation of abundant hyperphoshorylated tau filaments, the associated neuroinflammation and disease phenotype. |
2024-08-06 |
2024-08-09 |
mouse |
| Sudershana Nair, Yixiang Jiang, Isabella S Marchal, Elizabeth Chernobelsky, Huai-Wei Huang, Sarah Suh, Ruimin Pan, Xiang-Peng Kong, Hyung Don Ryoo, Einar M Sigurdsso. Anti-tau single domain antibodies clear pathological tau and attenuate its toxicity and related functional defects. Cell death & disease. vol 15. issue 7. 2024-07-30. PMID:39079958. |
tauopathies are a group of neurodegenerative diseases characterized by the presence of tau inclusions. |
2024-07-30 |
2024-08-02 |
drosophila_melanogaster |
| Esteban Cruz, Rebecca M Nisbet, Pranesh Padmanabhan, Ashley J van Waardenberg, Mark E Graham, Godfrey Nkajja, Swara Tapaswi, Bradley J Connor, Phil Robinson, Jürgen Göt. Proteostasis as a fundamental principle of Tau immunotherapy. Brain : a journal of neurology. 2024-07-29. PMID:39074206. |
the microtubule-associated protein tau is a driver of neuronal dysfunction in alzheimer's disease and other tauopathies. |
2024-07-29 |
2024-08-02 |
mouse |
| Esteban Cruz, Rebecca M Nisbet, Pranesh Padmanabhan, Ashley J van Waardenberg, Mark E Graham, Godfrey Nkajja, Swara Tapaswi, Bradley J Connor, Phil Robinson, Jürgen Göt. Proteostasis as a fundamental principle of Tau immunotherapy. Brain : a journal of neurology. 2024-07-29. PMID:39074206. |
given the various loss- and gain-of-functions of tau in disease and the brain-wide changes in the proteome that characterise tauopathies, we asked whether targeting tau would restore the alterations in proteostasis observed in disease. |
2024-07-29 |
2024-08-02 |
mouse |
| Hidetomo Tanaka, Seojin Lee, Ivan Martinez-Valbuena, Blas Couto, Maria Carmela Tartaglia, Javier Sanchez-Ruiz de Gordoa, M Elena Erro, Anthony E Lang, Shelley L Forrest, Gabor G Kovac. Ageing-related tau astrogliopathy severely affecting the substantia nigra. Neuropathology and applied neurobiology. vol 50. issue 4. 2024-07-22. PMID:39036836. |
astrocytic tau pathology is a major feature of tauopathies and ageing-related tau astrogliopathy (artag). |
2024-07-22 |
2024-07-24 |
Not clear |
| Davide Di Lorenz. Tau Protein and Tauopathies: Exploring Tau Protein-Protein and Microtubule Interactions, Cross-Interactions and Therapeutic Strategies. ChemMedChem. 2024-07-20. PMID:39031682. |
tau protein and tauopathies: exploring tau protein-protein and microtubule interactions, cross-interactions and therapeutic strategies. |
2024-07-20 |
2024-07-24 |
Not clear |
| Davide Di Lorenz. Tau Protein and Tauopathies: Exploring Tau Protein-Protein and Microtubule Interactions, Cross-Interactions and Therapeutic Strategies. ChemMedChem. 2024-07-20. PMID:39031682. |
however, aberrant modifications and pathological aggregations of tau are implicated in various neurodegenerative disorders, collectively known as tauopathies. |
2024-07-20 |
2024-07-24 |
Not clear |
| Panos Theofilas, Chao Wang, David Butler, Dulce O Morales, Cathrine Petersen, Andrew Ambrose, Brian Chin, Teddy Yang, Shireen Khan, Raymond Ng, Rakez Kayed, Celeste M Karch, Bruce L Miller, Jason E Gestwicki, Li Gan, Sally Temple, Michelle R Arkin, Lea T Grinber. iPSC-induced neurons with the V337M MAPT mutation are selectively vulnerable to caspase-mediated cleavage of tau and apoptotic cell death. Molecular and cellular neurosciences. 2024-07-20. PMID:39032719. |
tau post-translational modifications (ptms) result in the gradual build-up of abnormal tau and neuronal degeneration in tauopathies, encompassing variants of frontotemporal lobar degeneration (ftld) and alzheimer's disease (ad). |
2024-07-20 |
2024-07-24 |
Not clear |
| Panos Theofilas, Chao Wang, David Butler, Dulce O Morales, Cathrine Petersen, Andrew Ambrose, Brian Chin, Teddy Yang, Shireen Khan, Raymond Ng, Rakez Kayed, Celeste M Karch, Bruce L Miller, Jason E Gestwicki, Li Gan, Sally Temple, Michelle R Arkin, Lea T Grinber. iPSC-induced neurons with the V337M MAPT mutation are selectively vulnerable to caspase-mediated cleavage of tau and apoptotic cell death. Molecular and cellular neurosciences. 2024-07-20. PMID:39032719. |
therefore, therapeutic strategies against caspase cleaved-tau pathology could be necessary to modulate the extent of tau abnormalities in ad and other tauopathies. |
2024-07-20 |
2024-07-24 |
Not clear |
| Juan Lantero-Rodriguez, Elena Camporesi, Laia Montoliu-Gaya, Johan Gobom, Diana Piotrowska, Maria Olsson, Irena Matečko Burmann, Bruno Becker, Ann Brinkmalm, Björn M Burmann, Michael Perkinton, Nicholas J Ashton, Nick C Fox, Tammaryn Lashley, Henrik Zetterberg, Kaj Blennow, Gunnar Brinkmal. Tau protein profiling in tauopathies: a human brain study. Molecular neurodegeneration. vol 19. issue 1. 2024-07-19. PMID:39026372. |
tau protein profiling in tauopathies: a human brain study. |
2024-07-19 |
2024-07-21 |
human |
| Juan Lantero-Rodriguez, Elena Camporesi, Laia Montoliu-Gaya, Johan Gobom, Diana Piotrowska, Maria Olsson, Irena Matečko Burmann, Bruno Becker, Ann Brinkmalm, Björn M Burmann, Michael Perkinton, Nicholas J Ashton, Nick C Fox, Tammaryn Lashley, Henrik Zetterberg, Kaj Blennow, Gunnar Brinkmal. Tau protein profiling in tauopathies: a human brain study. Molecular neurodegeneration. vol 19. issue 1. 2024-07-19. PMID:39026372. |
abnormal accumulation of misfolded and hyperphosphorylated tau protein in brain is the defining feature of several neurodegenerative diseases called tauopathies, including alzheimer's disease (ad). |
2024-07-19 |
2024-07-21 |
human |
| Juan Lantero-Rodriguez, Elena Camporesi, Laia Montoliu-Gaya, Johan Gobom, Diana Piotrowska, Maria Olsson, Irena Matečko Burmann, Bruno Becker, Ann Brinkmalm, Björn M Burmann, Michael Perkinton, Nicholas J Ashton, Nick C Fox, Tammaryn Lashley, Henrik Zetterberg, Kaj Blennow, Gunnar Brinkmal. Tau protein profiling in tauopathies: a human brain study. Molecular neurodegeneration. vol 19. issue 1. 2024-07-19. PMID:39026372. |
interestingly, despite tau pathology being at the core of all tauopathies, csf tau biomarkers remain unchanged in certain tauopathies, e.g., progressive supranuclear palsy (psp), pick's disease (pid), and corticobasal neurodegeneration (cbd). |
2024-07-19 |
2024-07-21 |
human |
| Juan Lantero-Rodriguez, Elena Camporesi, Laia Montoliu-Gaya, Johan Gobom, Diana Piotrowska, Maria Olsson, Irena Matečko Burmann, Bruno Becker, Ann Brinkmalm, Björn M Burmann, Michael Perkinton, Nicholas J Ashton, Nick C Fox, Tammaryn Lashley, Henrik Zetterberg, Kaj Blennow, Gunnar Brinkmal. Tau protein profiling in tauopathies: a human brain study. Molecular neurodegeneration. vol 19. issue 1. 2024-07-19. PMID:39026372. |
to better understand commonalities and differences between tauopathies, we report a multiplex assay combining immunoprecipitation and high-resolution mass spectrometry capable of detecting and quantifying peptides from different tau protein isoforms as well as non-phosphorylated and phosphorylated peptides, including those carrying multiple phosphorylations. |
2024-07-19 |
2024-07-21 |
human |
| Juan Lantero-Rodriguez, Elena Camporesi, Laia Montoliu-Gaya, Johan Gobom, Diana Piotrowska, Maria Olsson, Irena Matečko Burmann, Bruno Becker, Ann Brinkmalm, Björn M Burmann, Michael Perkinton, Nicholas J Ashton, Nick C Fox, Tammaryn Lashley, Henrik Zetterberg, Kaj Blennow, Gunnar Brinkmal. Tau protein profiling in tauopathies: a human brain study. Molecular neurodegeneration. vol 19. issue 1. 2024-07-19. PMID:39026372. |
we investigated the tau proteoforms in soluble and insoluble fractions of brain tissue from subjects with autopsy-confirmed tauopathies, including sporadic ad (n = 10), psp (n = 11), pid (n = 10), and cbd (n = 10), and controls (n = 10). |
2024-07-19 |
2024-07-21 |
human |
| Juan Lantero-Rodriguez, Elena Camporesi, Laia Montoliu-Gaya, Johan Gobom, Diana Piotrowska, Maria Olsson, Irena Matečko Burmann, Bruno Becker, Ann Brinkmalm, Björn M Burmann, Michael Perkinton, Nicholas J Ashton, Nick C Fox, Tammaryn Lashley, Henrik Zetterberg, Kaj Blennow, Gunnar Brinkmal. Tau protein profiling in tauopathies: a human brain study. Molecular neurodegeneration. vol 19. issue 1. 2024-07-19. PMID:39026372. |
our results demonstrate that non-phosphorylated tau profiles differ across tauopathies, generally showing high abundance of microtubule-binding region (mtbr)-containing peptides in insoluble protein fractions compared with controls; the ad group showed 12-72 times higher levels of mtbr-containing aggregates. |
2024-07-19 |
2024-07-21 |
human |
| Celeste Parra Bravo, Sarah A Naguib, Li Ga. Cellular and pathological functions of tau. Nature reviews. Molecular cell biology. 2024-07-16. PMID:39014245. |
tauopathies are neurodegenerative diseases marked by the abnormal accumulation of tau protein aggregates in neurons, as seen, for example, in conditions such as frontotemporal dementia and alzheimer disease. |
2024-07-16 |
2024-07-19 |
human |
| Saskia J Pollack, Dina Dakkak, Tong Guo, George Chennell, Patricia Gomez-Suaga, Wendy Noble, Maria Jimenez-Sanchez, Diane P Hange. Truncated tau interferes with the autophagy and endolysosomal pathway and results in lipid accumulation. Cellular and molecular life sciences : CMLS. vol 81. issue 1. 2024-07-15. PMID:39009859. |
the autophagy-lysosomal pathway plays a critical role in the clearance of tau protein aggregates that deposit in the brain in tauopathies, and defects in this system are associated with disease pathogenesis. |
2024-07-15 |
2024-07-18 |
Not clear |
| Despoina Goniotaki, Francesco Tamagnini, Luca Biasetti, Svenja-Lotta Rumpf, Claire Troakes, Saskia J Pollack, Shalom Ukwesa, Haoyue Sun, Igor Kraev, Louise C Serpell, Wendy Noble, Kevin Staras, Diane P Hange. Tau-mediated synaptic dysfunction is coupled with HCN channelopathy. Alzheimer's & dementia : the journal of the Alzheimer's Association. 2024-07-12. PMID:38994745. |
in tauopathies, altered tau processing correlates with impairments in synaptic density and function. |
2024-07-12 |
2024-07-14 |
Not clear |
| Moumita Majumder, Debashis Dutt. Oligodendrocyte Dysfunction in Tauopathy: A Less Explored Area in Tau-Mediated Neurodegeneration. Cells. vol 13. issue 13. 2024-07-12. PMID:38994964. |
aggregation of the microtubule-associated protein tau (mapt) is the hallmark pathology in a spectrum of neurodegenerative disorders collectively called tauopathies. |
2024-07-12 |
2024-07-14 |
Not clear |