| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Sebastian N Roemer, Matthias Brendel, Johannes Gnoerich, Maura Malpetti, Mirlind Zaganjori, Andrea Quattrone, Mattes Gross, Anna Steward, Anna Dewenter, Fabian Wagner, Amir Dehsarvi, Christian Ferschmann, Stephan Wall, Carla Palleis, Boris S Rauchmann, Sabrina Katzdobler, Alexander Jaeck, Anna Stockbauer, Urban M Fietzek, Alexander M Bernhardt, Endy Weidinger, Andreas Zwergal, Sophia Stoecklein, Robert Perneczky, Henryk Barthel, Osama Sabri, Johannes Levin, Guenter U Hoeglinger, Nicolai Franzmeie. Subcortical tau is linked to hypoperfusion in connected cortical regions in 4-repeat tauopathies. Brain : a journal of neurology. 2024-06-06. PMID:38842726. |
4-repeat (4r) tauopathies are neurodegenerative diseases characterized by cerebral accumulation of 4r tau pathology. |
2024-06-06 |
2024-06-08 |
Not clear |
| Sebastian N Roemer, Matthias Brendel, Johannes Gnoerich, Maura Malpetti, Mirlind Zaganjori, Andrea Quattrone, Mattes Gross, Anna Steward, Anna Dewenter, Fabian Wagner, Amir Dehsarvi, Christian Ferschmann, Stephan Wall, Carla Palleis, Boris S Rauchmann, Sabrina Katzdobler, Alexander Jaeck, Anna Stockbauer, Urban M Fietzek, Alexander M Bernhardt, Endy Weidinger, Andreas Zwergal, Sophia Stoecklein, Robert Perneczky, Henryk Barthel, Osama Sabri, Johannes Levin, Guenter U Hoeglinger, Nicolai Franzmeie. Subcortical tau is linked to hypoperfusion in connected cortical regions in 4-repeat tauopathies. Brain : a journal of neurology. 2024-06-06. PMID:38842726. |
here, we hypothesized that subcortical tau pathology induces remote neuronal dysfunction in functionally connected cortical regions to test a pathophysiological model that mechanistically links subcortical tau accumulation to cortical neuronal dysfunction in 4r tauopathies. |
2024-06-06 |
2024-06-08 |
Not clear |
| C F de Veij Mestdagh, M E Witte, W Scheper, A B Smit, R H Henning, R E van Kestere. Torpor induces reversible tau hyperphosphorylation and accumulation in mice expressing human tau. Acta neuropathologica communications. vol 12. issue 1. 2024-06-05. PMID:38835043. |
tau protein hyperphosphorylation and aggregation are key pathological events in neurodegenerative tauopathies such as alzheimer's disease. |
2024-06-05 |
2024-06-07 |
mouse |
| C F de Veij Mestdagh, M E Witte, W Scheper, A B Smit, R H Henning, R E van Kestere. Torpor induces reversible tau hyperphosphorylation and accumulation in mice expressing human tau. Acta neuropathologica communications. vol 12. issue 1. 2024-06-05. PMID:38835043. |
in conclusion, daily torpor in mice offers a quick and standardized method to study tau phosphorylation, accumulation and clearance in mouse models relevant for neurodegeneration, as well as opportunities to discover new targets for the treatment of human tauopathies. |
2024-06-05 |
2024-06-07 |
mouse |
| Ly Thi Huong Luu Le, Jung Hoon Lee, Min Jae Le. Self-assembly of tau fragments as a key pathologic event in tauopathies. Neural regeneration research. vol 19. issue 12. 2024-05-29. PMID:38808983. |
self-assembly of tau fragments as a key pathologic event in tauopathies. |
2024-05-29 |
2024-06-03 |
Not clear |
| Zidi Yan, Yiwen Zhang, Jialong Jiang, Zhenwu Liu, He Wang, Ying Zhang, Jinsheng He, Tao Hon. [Human tau N-terminal domain-specific monoclonal antibodies: screening and application in blood detection]. Sheng wu gong cheng xue bao = Chinese journal of biotechnology. vol 40. issue 5. 2024-05-24. PMID:38783817. |
the antibodies to the microtubule-associated protein tau play a role in basic and clinical studies of alzheimer's disease (ad) and other tauopathies. |
2024-05-24 |
2024-05-27 |
mouse |
| Lorenzo Barolo, Ylenia Gigante, Lorenza Mautone, Silvia Ghirga, Alessandro Soloperto, Alessandra Giorgi, Francesca Ghirga, Martina Pitea, Alessio Incocciati, Francesco Mura, Giancarlo Ruocco, Alberto Boffi, Paola Baiocco, Silvia Di Angelantoni. Ferritin nanocage-enabled detection of pathological tau in living human retinal cells. Scientific reports. vol 14. issue 1. 2024-05-21. PMID:38773170. |
our experiments confirmed the colocalization of bt1 with pathological forms of tau in living retinal cells, highlighting the method's potential in identifying tauopathies. |
2024-05-21 |
2024-05-27 |
human |
| Lorenzo Barolo, Ylenia Gigante, Lorenza Mautone, Silvia Ghirga, Alessandro Soloperto, Alessandra Giorgi, Francesca Ghirga, Martina Pitea, Alessio Incocciati, Francesco Mura, Giancarlo Ruocco, Alberto Boffi, Paola Baiocco, Silvia Di Angelantoni. Ferritin nanocage-enabled detection of pathological tau in living human retinal cells. Scientific reports. vol 14. issue 1. 2024-05-21. PMID:38773170. |
this method offers a promising tool for the early detection of tau tangles in retinal tissue, with significant implications for improving the diagnosis and management of tauopathies. |
2024-05-21 |
2024-05-27 |
human |
| Ahlam S Soliman, Andrew Umstead, Jared Lamp, Irving E Veg. EFhd2 co-aggregates with monomeric and filamentous tau Frontiers in neuroscience. vol 18. 2024-05-21. PMID:38765673. |
efhd2 co-aggregates with monomeric and filamentous tau tauopathies are characterized by the abnormal buildup of tau protein, with early oligomeric forms associated with neurodegeneration and the later neurofibrillary tangles possibly conferring neuroprotection. |
2024-05-21 |
2024-05-27 |
Not clear |
| Itzhak Fischer, Theresa Connors, Julien Bouyer, Ying Ji. The unique properties of Big tau in the visual system. Cytoskeleton (Hoboken, N.J.). 2024-05-18. PMID:38761116. |
tau is a microtubule associated protein that plays important roles in regulating the properties of microtubules and axonal transport, as well as tauopathies associated with toxic aggregates leading to neurodegenerative diseases. |
2024-05-18 |
2024-05-27 |
rat |
| Afrooz Anbaraki, Zahra Dindar, Zahra Mousavi-Jarrahi, Atiyeh Ghasemi, Zahra Moeini, Mina Evini, Ali Akbar Saboury, Arefeh Seyedarab. The novel anti-fibrillary effects of volatile compounds α-asarone and β-caryophyllene on tau protein: Towards promising therapeutic agents for Alzheimer's disease. International journal of biological macromolecules. 2024-05-18. PMID:38761902. |
the abnormal deposition of tau protein is one of the critical causes of tauopathies including alzheimer's disease (ad). |
2024-05-18 |
2024-05-27 |
Not clear |
| Maria-Christina Zerva, Christos Triantafylloudis, Vassilis Paspaliaris, Efthimios M C Skoulakis, Katerina Papanikolopoulo. Choline Metabolites Reverse Differentially the Habituation Deficit and Elevated Memory of Tau Null Drosophila. Cells. vol 13. issue 9. 2024-05-10. PMID:38727282. |
this work can contribute to a broader knowledge about the physiologic function of tau, which may be translated into understanding the mechanisms of tauopathies. |
2024-05-10 |
2024-05-27 |
drosophila_melanogaster |
| Chang Jae Yoo, Youngtae Choi, Eugene Bok, Yuxi Lin, Mookyung Cheon, Young-Ho Lee, Jaekwang Ki. Complement receptor 4 mediates the clearance of extracellular tau fibrils by microglia. The FEBS journal. 2024-05-08. PMID:38715400. |
tauopathies exhibit a characteristic accumulation of misfolded tau aggregates in the brain. |
2024-05-08 |
2024-05-27 |
mouse |
| Chang Jae Yoo, Youngtae Choi, Eugene Bok, Yuxi Lin, Mookyung Cheon, Young-Ho Lee, Jaekwang Ki. Complement receptor 4 mediates the clearance of extracellular tau fibrils by microglia. The FEBS journal. 2024-05-08. PMID:38715400. |
therefore, identifying molecular mechanisms that prevent tau propagation is critical for developing therapeutic strategies for tauopathies. |
2024-05-08 |
2024-05-27 |
mouse |
| Kondalarao Bankapalli, Ruth E Thomas, Evelyn S Vincow, Gillian Milstein, Laura V Fisher, Leo J Pallanc. A bioRxiv : the preprint server for biology. 2024-05-07. PMID:38712083. |
previous work indicates that specific protein components of these aggregates are toxic, including tau in alzheimer's disease and related tauopathies. |
2024-05-07 |
2024-05-27 |
Not clear |
| Adriana N Santiago-Ruiz, Siewert Hugelier, Charles R Bond, Edward B Lee, Melike Lakadamyal. Super-Resolution Imaging Uncovers Nanoscale Tau Aggregate Hyperphosphorylation Patterns in Human Alzheimer's Disease Brain Tissue. bioRxiv : the preprint server for biology. 2024-05-07. PMID:38712162. |
the ability to detect and profile nanoscale tau aggregates in human brain tissue opens new avenues for studying the molecular underpinnings of tauopathies. |
2024-05-07 |
2024-05-27 |
human |
| Chanida Fongsaran, Krit Jirakanwisal, Bi-Hung Peng, Anna Fracassi, Giulio Taglialatela, Kelly T Dineley, Slobodan Paessler, Irma E Cisnero. Arbovirus infection increases the risk for the development of neurodegenerative disease pathology in the murine model. Brain, behavior, & immunity - health. vol 38. 2024-05-06. PMID:38706571. |
proteinopathies include synucleinopathies triggered by misfolded amyloid α-synuclein, tauopathies triggered by misfolded tau, and amyloidopathies triggered by misfolded amyloid of which alzheimer's disease (β-amyloid) is most prevalent. |
2024-05-06 |
2024-05-08 |
mouse |
| Jayvik Joshi, Minmin Yao, Aaron Kakazu, Yuxiao Ouyang, Wenzhen Duan, Manisha Aggarwa. Distinguishing microgliosis and tau deposition in the mouse brain using paramagnetic and diamagnetic susceptibility source separation. bioRxiv : the preprint server for biology. 2024-04-25. PMID:38659855. |
tauopathies, including alzheimer's disease (ad), are neurodegenerative disorders characterized by hyperphosphorylated tau protein aggregates in the brain. |
2024-04-25 |
2024-04-28 |
mouse |
| Nathalie Kyalu Ngoie Zola, Clémence Balty, Didier Vertommen, Bernard Jimmy Hanseeu. [Specific modifications of the soluble tau protein distinguish Alzheimer's disease from other tauopathies]. Medecine sciences : M/S. vol 40. issue 4. 2024-04-23. PMID:38651955. |
[specific modifications of the soluble tau protein distinguish alzheimer's disease from other tauopathies]. |
2024-04-23 |
2024-04-26 |
Not clear |
| Madia Lozupone, Vittorio Dibello, Antonio Daniele, Vincenzo Solfrizzi, Emanuela Resta, Francesco Panz. How can we manage progressive supranuclear palsy syndrome with pharmacotherapy? Expert opinion on pharmacotherapy. 2024-04-23. PMID:38653731. |
tauopathies are a spectrum of clinicopathological neurodegenerative disorders with increased aggregates included in glia and/or neurons of hyperphosphorylated insoluble tau protein, a microtubule-associated protein. |
2024-04-23 |
2024-04-26 |
Not clear |