| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Francisco Artime-Naveda, David Hevia, Rebeca Alonso-Arias, Carmen Martínez, Isabel Quirós-González, Rafael Cernuda-Cernuda, Alejando Alvarez-Artime, Iván Menéndez-Valle, Rosa M Sainz, Juan C May. Interplay between oxidative stress, neuroinflammatory cytokines and melatonin in Alzheimer's disease: Insights from cerebrospinal fluid analysis. Heliyon. vol 11. issue 2. 2025-02-03. PMID:39897852. |
while beta-amyloid (aβ) and tau biomarkers are currently used to discriminate ad from other tauopathies and dementias, additional indicators could enhance patient stratification for specific dementia types. |
2025-02-03 |
2025-02-05 |
Not clear |
| Melissa Huang, William A McEwa. Sensitive detection and propagation of brain-derived tau assemblies in HEK293 based wild-type tau seeding assays. The Journal of biological chemistry. 2025-01-29. PMID:39880096. |
the assembly of tau into filaments defines tauopathies, a group of neurodegenerative diseases including alzheimer's disease (ad), pick's disease (pid), corticobasal degeneration (cbd) and progressive supranuclear palsy (psp). |
2025-01-29 |
2025-02-01 |
human |
| John Hardy, Valentina Escott-Pric. The genetics of neurodegenerative diseases is the genetics of age-related damage clearance failure. Molecular psychiatry. 2025-01-29. PMID:39880902. |
in this perspective we draw together the data from the genome wide association studies for alzheimer's disease, parkinson's disease and the tauopathies and reach the conclusion that in each case, most of the risk loci are involved in the clearance of the deposited proteins: in alzheimer's disease, the microglial removal of aβ, in the synucleinopathies, the lysosomal clearance of synuclein and in the tauopathies, the removal of tau protein by the ubiquitin proteasome. |
2025-01-29 |
2025-02-01 |
Not clear |
| Claudia Balducci, Franca Orsini, Milica Cerovic, Marten Beeg, Beatrice Rocutto, Letizia Dacomo, Antonio Masone, Eleonora Busani, Ilaria Raimondi, Giada Lavigna, Po-Tao Chen, Susanna Leva, Laura Colombo, Chiara Zucchelli, Giovanna Musco, Nicholas M Kanaan, Marco Gobbi, Roberto Chiesa, Luana Fioriti, Gianluigi Forlon. Tau oligomers impair memory and synaptic plasticity through the cellular prion protein. Acta neuropathologica communications. vol 13. issue 1. 2025-01-28. PMID:39871396. |
deposition of abnormally phosphorylated tau aggregates is a central event leading to neuronal dysfunction and death in alzheimer's disease (ad) and other tauopathies. |
2025-01-28 |
2025-01-30 |
Not clear |
| Norhan N Elbadawy, Muhammed A Saad, Sara Elfarrash, Maha A E Ahmed, Noha F Abdelkade. The GLP-1 Agonist Semaglutide Ameliorates Cognitive Regression in P301S Tauopathy Mice Model via Autophagy/ACE2/SIRT1/FOXO1-Mediated Microglia Polarization. European journal of pharmacology. 2025-01-28. PMID:39875022. |
tau hyper-phosphorylation has been recognized as an essential contributor to neurodegeneration in alzheimer's disease (ad) and related tauopathies. |
2025-01-28 |
2025-01-31 |
mouse |
| Thomas G Beach, Geidy E Serrano, Erika D Driver-Dunckley, Lucia I Sue, Holly A Shill, Shyamal H Mehta, Christine M Belden, Ileana Lorenzini, Cecilia Tremblay, Parichita Choudhury, Alireza Atri, Charles H Adle. Parkinson Disease Neuropathological Comorbidities: Prevalences from Younger-Old to Older-Old, With Comparison to Non-Demented, Non-Parkinsonian Subjects. medRxiv : the preprint server for health sciences. 2025-01-27. PMID:39867383. |
non-ad tauopathies, including the major conditions of progressive supranuclear palsy (psp), and corticobasal degeneration (cbd), as well as the microscopic changes of argyrophilic grains (arg) and aging-related tau astrogliopathy (artag), also co-existed with pd, especially arg and artag, which ranged between 20% and 40% across decades for the former and up to 80% for the latter; we did not find significant associations of either with final mmse or updrs scores. |
2025-01-27 |
2025-01-29 |
human |
| Jaime Vaquer-Alicea, Victor A Manon, Vaibhav Bommareddy, Peter Kunach, Ankit Gupta, Jim Monistrol, Valerie A Perez, Hung Tri Tran, Nil Saez-Calveras, Siling Du, Sushobhna Batra, Daniel Stoddard, Charles L White, Lukasz A Joachimiak, Sarah H Shahmoradian, Marc I Diamon. Functional classification of tauopathy strains reveals the role of protofilament core residues. Science advances. vol 11. issue 4. 2025-01-22. PMID:39841851. |
distinct tau amyloid assemblies underlie diverse tauopathies but defy rapid classification. |
2025-01-22 |
2025-01-25 |
Not clear |
| Gary Jen-Wei Chen, Ming-Yun Chang, Xin-Peng Lin, Debapriya Kundu, Yu-Jen Chang, Yun-Ru Che. Tau destabilization in a familial deletion mutant K280 accelerates its fibrillization and enhances the seeding effect. The Journal of biological chemistry. 2025-01-15. PMID:39814228. |
tauopathies cover a range of neurodegenerative diseases in which natively unfolded tau protein aggregates and spreads in the brain during disease progression. |
2025-01-15 |
2025-01-19 |
human |
| Gary Jen-Wei Chen, Ming-Yun Chang, Xin-Peng Lin, Debapriya Kundu, Yu-Jen Chang, Yun-Ru Che. Tau destabilization in a familial deletion mutant K280 accelerates its fibrillization and enhances the seeding effect. The Journal of biological chemistry. 2025-01-15. PMID:39814228. |
overall, these findings shed light on the fundamental mechanisms of tau structure/stability, aggregation, and seeding to facilitate future therapeutic development for tauopathies. |
2025-01-15 |
2025-01-19 |
human |
| Jinwang Ye, Suyue Zhong, Huali Wan, Xing Guo, Xuanbao Yao, Qiong Liu, Liming Chen, Jian-Zhi Wang, Shifeng Xia. Upregulated astrocyte HDAC7 induces Alzheimer-like tau pathologies via deacetylating transcription factor-EB and inhibiting lysosome biogenesis. Molecular neurodegeneration. vol 20. issue 1. 2025-01-14. PMID:39806423. |
astrocytes, the most abundant glial cell type in the brain, will convert into the reactive state in response to proteotoxic stress such as tau accumulation, a characteristic feature of alzheimer's disease (ad) and other tauopathies. |
2025-01-14 |
2025-01-31 |
Not clear |
| Nil Saez-Calveras, Jaime Vaquer-Alicea, Charles L White, Yogesh Tak, Stephanie Cosentino, Phyllis L Faust, Elan D Louis, Marc I Diamon. Essential tremor with tau pathology features seeds indistinguishable in conformation from Alzheimer's disease and primary age-related tauopathy. Acta neuropathologica. vol 149. issue 1. 2025-01-08. PMID:39775287. |
neurodegenerative tauopathies are characterized by the deposition of distinct fibrillar tau assemblies, whose rigid core structures correlate with defined neuropathological phenotypes. |
2025-01-08 |
2025-01-13 |
Not clear |
| Nil Saez-Calveras, Jaime Vaquer-Alicea, Charles L White, Yogesh Tak, Stephanie Cosentino, Phyllis L Faust, Elan D Louis, Marc I Diamon. Essential tremor with tau pathology features seeds indistinguishable in conformation from Alzheimer's disease and primary age-related tauopathy. Acta neuropathologica. vol 149. issue 1. 2025-01-08. PMID:39775287. |
we recently leveraged this species barrier to define tauopathies systematically by substituting alanine (ala) into the tau monomer and measuring its incorporation into seeded aggregates within biosensor cells. |
2025-01-08 |
2025-01-13 |
Not clear |
| Nil Saez-Calveras, Jaime Vaquer-Alicea, Charles L White, Yogesh Tak, Stephanie Cosentino, Phyllis L Faust, Elan D Louis, Marc I Diamon. Essential tremor with tau pathology features seeds indistinguishable in conformation from Alzheimer's disease and primary age-related tauopathy. Acta neuropathologica. vol 149. issue 1. 2025-01-08. PMID:39775287. |
this ala scan precisely classified the conformation of tau seeds from various tauopathies. |
2025-01-08 |
2025-01-13 |
Not clear |
| Nil Saez-Calveras, Jaime Vaquer-Alicea, Charles L White, Yogesh Tak, Stephanie Cosentino, Phyllis L Faust, Elan D Louis, Marc I Diamon. Essential tremor with tau pathology features seeds indistinguishable in conformation from Alzheimer's disease and primary age-related tauopathy. Acta neuropathologica. vol 149. issue 1. 2025-01-08. PMID:39775287. |
we further examined 8 of these et cases using the ala scan and found that the amino acid requirements for tau monomer incorporation into aggregates seeded from et brain homogenates were identical to those of alzheimer's disease (ad) and primary age-related tauopathy (part), and distinct from other tauopathies, such as corticobasal degeneration (cbd), chronic traumatic encephalopathy (cte), and progressive supranuclear palsy (psp). |
2025-01-08 |
2025-01-13 |
Not clear |
| Sushobhna Batra, Jaime Vaquer-Alicea, Clarissa Valdez, Skyler P Taylor, Victor A Manon, Anthony R Vega, Omar M Kashmer, Sourav Kolay, Andrew Lemoff, Nigel J Cairns, Charles L White, Marc I Diamon. VCP regulates early tau seed amplification via specific cofactors. Molecular neurodegeneration. vol 20. issue 1. 2025-01-08. PMID:39773263. |
neurodegenerative tauopathies may progress based on seeding by pathological tau assemblies, whereby an aggregate is released from one cell, gains entry to an adjacent or connected cell, and serves as a specific template for its own replication in the cytoplasm. |
2025-01-08 |
2025-01-13 |
Not clear |
| Abid Ali, Mikhail Matveyenka, Davis N Pickett, Axell Rodriguez, Dmitry Kurousk. Tubulin-Binding Region Modulates Cholesterol-Triggered Aggregation of Tau Proteins. Journal of neurochemistry. vol 169. issue 1. 2025-01-08. PMID:39777699. |
a hallmark of alzheimer disease (ad) and tauopathies, severe neurodegenerative diseases, is the progressive aggregation of tau, also known as microtubule-associated tau protein. |
2025-01-08 |
2025-01-13 |
Not clear |
| Helen Breuer, Michael Bell-Simons, Hans Zempe. Axodendritic targeting of TAU and MAP2 and microtubule polarization in iPSC-derived versus SH-SY5Y-derived human neurons. Open life sciences. vol 19. issue 1. 2025-01-06. PMID:39759106. |
in tauopathies, such as alzheimer's disease (ad), tau sorting, and neuronal polarity are disrupted, leading to mt loss. |
2025-01-06 |
2025-01-08 |
mouse |
| Himanshi Singh, Jianfeng Xiao, Sazzad Khan, Asmita Das, Tayebeh Pourmotabbed, Mohammad Moshahid Kha. Basic Science and Pathogenesis. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 20 Suppl 1. 2025-01-03. PMID:39750597. |
tauopathies are a group of neurological disorders including alzheimer's disease that involve progressive neurodegeneration, behavioral deficits, and aberrant tau accumulation. |
2025-01-03 |
2025-01-05 |
mouse |
| Xiaohuan Sun, Peter W Baas, Celeste M Karch, Liang Qian. Basic Science and Pathogenesis. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 20 Suppl 1. 2025-01-03. PMID:39750738. |
in tauopathies, such as frontotemporal dementia (ftd), tau loses association with microtubules (mts) and forms neurofibrillary tangles. |
2025-01-03 |
2025-01-05 |
Not clear |
| Xiaohuan Sun, Peter W Baas, Celeste M Karch, Liang Qian. Basic Science and Pathogenesis. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 20 Suppl 1. 2025-01-03. PMID:39750738. |
the situation is further confounded in tauopathies because the pathological tau may elicit certain gain-of-toxicities on axonal mts. |
2025-01-03 |
2025-01-05 |
Not clear |