| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Anukool A Bhopatkar, Nemil Bhatt, Md Anzarul Haque, Rhea Xavier, Leiana Fung, Cynthia Jerez, Rakez Kaye. MAPT mutations associated with familial tauopathies lead to formation of conformationally distinct oligomers that have cross-seeding ability. Protein science : a publication of the Protein Society. vol 33. issue 9. 2024-08-15. PMID:39145409. |
mutations within the mapt gene that encodes the tau protein form the genetic backdrop for familial forms of tauopathies, such as frontotemporal dementia (ftd), but the molecular consequences of such alterations and their pathological effects are unclear. |
2024-08-15 |
2024-08-17 |
Not clear |
| Abid Ali, Mikhail Matveyenka, Axell Rodriguez, Dmitry Kurousk. Under Heparin-Free Conditions Unsaturated Phospholipids Inhibit the Aggregation of 1N4R and 2N4R Tau. The journal of physical chemistry letters. 2024-08-14. PMID:39140785. |
a progressive aggregation of tau proteins in the brain is linked to both alzheimer's disease (ad) and various tauopathies. |
2024-08-14 |
2024-08-16 |
Not clear |
| Congcong Liu, Lanxia Meng, Yan Gao, Jiehui Chen, Min Zhu, Min Xiong, Tingting Xiao, Xiaoling Gu, Chaoyang Liu, Tao Li, Zhentao Zhan. PM2.5 triggers tau aggregation in a mouse model of tauopathy. JCI insight. vol 9. issue 14. 2024-08-12. PMID:39133647. |
the aggregation and prion-like propagation of tau are the hallmarks of alzheimer's disease (ad) and other tauopathies. |
2024-08-12 |
2024-08-16 |
mouse |
| Emilie Lesport, Lucie Commeau, Mélanie Genet, Etienne-Emile Baulieu, Marcel Tawk, Julien Giustinian. A decrease in Fkbp52 alters autophagosome maturation and A152T-tau clearance Frontiers in cellular neuroscience. vol 18. 2024-08-09. PMID:39119047. |
a decrease in fkbp52 alters autophagosome maturation and a152t-tau clearance the failure of the autophagy-lysosomal pathway to clear the pathogenic forms of tau exacerbates the pathogenesis of tauopathies. |
2024-08-09 |
2024-08-12 |
human |
| Xingyu Zhang, Jiangyu Wang, Zhentao Zhang, Keqiang Y. Tau in neurodegenerative diseases: molecular mechanisms, biomarkers, and therapeutic strategies. Translational neurodegeneration. vol 13. issue 1. 2024-08-07. PMID:39107835. |
the deposition of abnormal tau protein is characteristic of alzheimer's disease (ad) and a class of neurodegenerative diseases called tauopathies. |
2024-08-07 |
2024-08-09 |
Not clear |
| Xingyu Zhang, Jiangyu Wang, Zhentao Zhang, Keqiang Y. Tau in neurodegenerative diseases: molecular mechanisms, biomarkers, and therapeutic strategies. Translational neurodegeneration. vol 13. issue 1. 2024-08-07. PMID:39107835. |
pathologically, tau undergoes abnormal post-translational modifications and forms oligomers or fibrous aggregates in tauopathies. |
2024-08-07 |
2024-08-09 |
Not clear |
| Xingyu Zhang, Jiangyu Wang, Zhentao Zhang, Keqiang Y. Tau in neurodegenerative diseases: molecular mechanisms, biomarkers, and therapeutic strategies. Translational neurodegeneration. vol 13. issue 1. 2024-08-07. PMID:39107835. |
in this review, we briefly introduce several tauopathies and discuss the mechanisms mediating tau aggregation and propagation. |
2024-08-07 |
2024-08-09 |
Not clear |
| Ahmed Sabry Mohamed, Mahmoud ElKaffas, Karim Metwally, Mahmoud Abdelfattah, Eslam Ashraf Elsery, Ahmed Elshazly, Hossam Eldin Gomaa, Aziza Alsayed, Sara El-Desouky, Randa El-Gamal, Sara Elfarras. Impairment of Nrf2 signaling in the hippocampus of P301S tauopathy mice model aligns with the cognitive impairment and the associated neuroinflammation. Journal of inflammation (London, England). vol 21. issue 1. 2024-08-06. PMID:39107774. |
mice transgenic for human p301s tau protein exhibit many characteristics of the human tauopathies, including the formation of abundant hyperphoshorylated tau filaments, the associated neuroinflammation and disease phenotype. |
2024-08-06 |
2024-08-09 |
mouse |
| Sudershana Nair, Yixiang Jiang, Isabella S Marchal, Elizabeth Chernobelsky, Huai-Wei Huang, Sarah Suh, Ruimin Pan, Xiang-Peng Kong, Hyung Don Ryoo, Einar M Sigurdsso. Anti-tau single domain antibodies clear pathological tau and attenuate its toxicity and related functional defects. Cell death & disease. vol 15. issue 7. 2024-07-30. PMID:39079958. |
tauopathies are a group of neurodegenerative diseases characterized by the presence of tau inclusions. |
2024-07-30 |
2024-08-02 |
drosophila_melanogaster |
| Esteban Cruz, Rebecca M Nisbet, Pranesh Padmanabhan, Ashley J van Waardenberg, Mark E Graham, Godfrey Nkajja, Swara Tapaswi, Bradley J Connor, Phil Robinson, Jürgen Göt. Proteostasis as a fundamental principle of Tau immunotherapy. Brain : a journal of neurology. 2024-07-29. PMID:39074206. |
the microtubule-associated protein tau is a driver of neuronal dysfunction in alzheimer's disease and other tauopathies. |
2024-07-29 |
2024-08-02 |
mouse |
| Esteban Cruz, Rebecca M Nisbet, Pranesh Padmanabhan, Ashley J van Waardenberg, Mark E Graham, Godfrey Nkajja, Swara Tapaswi, Bradley J Connor, Phil Robinson, Jürgen Göt. Proteostasis as a fundamental principle of Tau immunotherapy. Brain : a journal of neurology. 2024-07-29. PMID:39074206. |
given the various loss- and gain-of-functions of tau in disease and the brain-wide changes in the proteome that characterise tauopathies, we asked whether targeting tau would restore the alterations in proteostasis observed in disease. |
2024-07-29 |
2024-08-02 |
mouse |
| Hidetomo Tanaka, Seojin Lee, Ivan Martinez-Valbuena, Blas Couto, Maria Carmela Tartaglia, Javier Sanchez-Ruiz de Gordoa, M Elena Erro, Anthony E Lang, Shelley L Forrest, Gabor G Kovac. Ageing-related tau astrogliopathy severely affecting the substantia nigra. Neuropathology and applied neurobiology. vol 50. issue 4. 2024-07-22. PMID:39036836. |
astrocytic tau pathology is a major feature of tauopathies and ageing-related tau astrogliopathy (artag). |
2024-07-22 |
2024-07-24 |
Not clear |
| Davide Di Lorenz. Tau Protein and Tauopathies: Exploring Tau Protein-Protein and Microtubule Interactions, Cross-Interactions and Therapeutic Strategies. ChemMedChem. 2024-07-20. PMID:39031682. |
tau protein and tauopathies: exploring tau protein-protein and microtubule interactions, cross-interactions and therapeutic strategies. |
2024-07-20 |
2024-07-24 |
Not clear |
| Davide Di Lorenz. Tau Protein and Tauopathies: Exploring Tau Protein-Protein and Microtubule Interactions, Cross-Interactions and Therapeutic Strategies. ChemMedChem. 2024-07-20. PMID:39031682. |
however, aberrant modifications and pathological aggregations of tau are implicated in various neurodegenerative disorders, collectively known as tauopathies. |
2024-07-20 |
2024-07-24 |
Not clear |
| Panos Theofilas, Chao Wang, David Butler, Dulce O Morales, Cathrine Petersen, Andrew Ambrose, Brian Chin, Teddy Yang, Shireen Khan, Raymond Ng, Rakez Kayed, Celeste M Karch, Bruce L Miller, Jason E Gestwicki, Li Gan, Sally Temple, Michelle R Arkin, Lea T Grinber. iPSC-induced neurons with the V337M MAPT mutation are selectively vulnerable to caspase-mediated cleavage of tau and apoptotic cell death. Molecular and cellular neurosciences. 2024-07-20. PMID:39032719. |
tau post-translational modifications (ptms) result in the gradual build-up of abnormal tau and neuronal degeneration in tauopathies, encompassing variants of frontotemporal lobar degeneration (ftld) and alzheimer's disease (ad). |
2024-07-20 |
2024-07-24 |
Not clear |
| Panos Theofilas, Chao Wang, David Butler, Dulce O Morales, Cathrine Petersen, Andrew Ambrose, Brian Chin, Teddy Yang, Shireen Khan, Raymond Ng, Rakez Kayed, Celeste M Karch, Bruce L Miller, Jason E Gestwicki, Li Gan, Sally Temple, Michelle R Arkin, Lea T Grinber. iPSC-induced neurons with the V337M MAPT mutation are selectively vulnerable to caspase-mediated cleavage of tau and apoptotic cell death. Molecular and cellular neurosciences. 2024-07-20. PMID:39032719. |
therefore, therapeutic strategies against caspase cleaved-tau pathology could be necessary to modulate the extent of tau abnormalities in ad and other tauopathies. |
2024-07-20 |
2024-07-24 |
Not clear |
| Juan Lantero-Rodriguez, Elena Camporesi, Laia Montoliu-Gaya, Johan Gobom, Diana Piotrowska, Maria Olsson, Irena Matečko Burmann, Bruno Becker, Ann Brinkmalm, Björn M Burmann, Michael Perkinton, Nicholas J Ashton, Nick C Fox, Tammaryn Lashley, Henrik Zetterberg, Kaj Blennow, Gunnar Brinkmal. Tau protein profiling in tauopathies: a human brain study. Molecular neurodegeneration. vol 19. issue 1. 2024-07-19. PMID:39026372. |
tau protein profiling in tauopathies: a human brain study. |
2024-07-19 |
2024-07-21 |
human |
| Juan Lantero-Rodriguez, Elena Camporesi, Laia Montoliu-Gaya, Johan Gobom, Diana Piotrowska, Maria Olsson, Irena Matečko Burmann, Bruno Becker, Ann Brinkmalm, Björn M Burmann, Michael Perkinton, Nicholas J Ashton, Nick C Fox, Tammaryn Lashley, Henrik Zetterberg, Kaj Blennow, Gunnar Brinkmal. Tau protein profiling in tauopathies: a human brain study. Molecular neurodegeneration. vol 19. issue 1. 2024-07-19. PMID:39026372. |
abnormal accumulation of misfolded and hyperphosphorylated tau protein in brain is the defining feature of several neurodegenerative diseases called tauopathies, including alzheimer's disease (ad). |
2024-07-19 |
2024-07-21 |
human |
| Juan Lantero-Rodriguez, Elena Camporesi, Laia Montoliu-Gaya, Johan Gobom, Diana Piotrowska, Maria Olsson, Irena Matečko Burmann, Bruno Becker, Ann Brinkmalm, Björn M Burmann, Michael Perkinton, Nicholas J Ashton, Nick C Fox, Tammaryn Lashley, Henrik Zetterberg, Kaj Blennow, Gunnar Brinkmal. Tau protein profiling in tauopathies: a human brain study. Molecular neurodegeneration. vol 19. issue 1. 2024-07-19. PMID:39026372. |
interestingly, despite tau pathology being at the core of all tauopathies, csf tau biomarkers remain unchanged in certain tauopathies, e.g., progressive supranuclear palsy (psp), pick's disease (pid), and corticobasal neurodegeneration (cbd). |
2024-07-19 |
2024-07-21 |
human |
| Juan Lantero-Rodriguez, Elena Camporesi, Laia Montoliu-Gaya, Johan Gobom, Diana Piotrowska, Maria Olsson, Irena Matečko Burmann, Bruno Becker, Ann Brinkmalm, Björn M Burmann, Michael Perkinton, Nicholas J Ashton, Nick C Fox, Tammaryn Lashley, Henrik Zetterberg, Kaj Blennow, Gunnar Brinkmal. Tau protein profiling in tauopathies: a human brain study. Molecular neurodegeneration. vol 19. issue 1. 2024-07-19. PMID:39026372. |
to better understand commonalities and differences between tauopathies, we report a multiplex assay combining immunoprecipitation and high-resolution mass spectrometry capable of detecting and quantifying peptides from different tau protein isoforms as well as non-phosphorylated and phosphorylated peptides, including those carrying multiple phosphorylations. |
2024-07-19 |
2024-07-21 |
human |