| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Moumita Majumder, Debashis Dutt. Oligodendrocyte Dysfunction in Tauopathy: A Less Explored Area in Tau-Mediated Neurodegeneration. Cells. vol 13. issue 13. 2024-07-12. PMID:38994964. |
oligodendrocyte-specific tau pathology, in the form of fibrils and coiled coils, is evident in major tauopathies including progressive supranuclear palsy (psp), corticobasal degeneration (cbd), and pick's disease (pid). |
2024-07-12 |
2024-07-14 |
Not clear |
| Yiyang Zhu, Wade K Self, David M Holtzma. An emerging role for the gut microbiome in tauopathy. Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics. 2024-07-04. PMID:38964948. |
tauopathies constitute a group of neurodegenerative diseases characterized by abnormal aggregation of the protein tau, progressive neuronal and synaptic loss, and eventual cognitive and motor impairment. |
2024-07-04 |
2024-07-11 |
human |
| Sagar Gaikwad, Nicha Puangmalai, Minal Sonawane, Mauro Montalbano, Rachel Price, Malini S Iyer, Anamika Ray, Sandra Moreno, Rakez Kaye. Nasal tau immunotherapy clears intracellular tau pathology and improves cognitive functions in aged tauopathy mice. Science translational medicine. vol 16. issue 754. 2024-07-03. PMID:38959324. |
pathological tau aggregates cause cognitive decline in neurodegenerative tauopathies, including alzheimer's disease (ad). |
2024-07-03 |
2024-07-10 |
mouse |
| Sagar Gaikwad, Nicha Puangmalai, Minal Sonawane, Mauro Montalbano, Rachel Price, Malini S Iyer, Anamika Ray, Sandra Moreno, Rakez Kaye. Nasal tau immunotherapy clears intracellular tau pathology and improves cognitive functions in aged tauopathy mice. Science translational medicine. vol 16. issue 754. 2024-07-03. PMID:38959324. |
this study could be valuable in designing effective tau immunotherapies for ad and other tauopathies. |
2024-07-03 |
2024-07-10 |
mouse |
| Jing-Fen Su, Yue Xiao, Lin-Yu Wei, Hui-Yang Lei, Fei Sun, Wei-Xia Wang, Shi-Hong Li, Xiao-Chuan Wang, Jie Zheng, Jian-Zhi Wan. A new tau dephosphorylation-targeting chimera for the treatment of tauopathies. Acta pharmacologica Sinica. 2024-07-02. PMID:38956416. |
a new tau dephosphorylation-targeting chimera for the treatment of tauopathies. |
2024-07-02 |
2024-07-06 |
mouse |
| Jing-Fen Su, Yue Xiao, Lin-Yu Wei, Hui-Yang Lei, Fei Sun, Wei-Xia Wang, Shi-Hong Li, Xiao-Chuan Wang, Jie Zheng, Jian-Zhi Wan. A new tau dephosphorylation-targeting chimera for the treatment of tauopathies. Acta pharmacologica Sinica. 2024-07-02. PMID:38956416. |
abnormal accumulation of hyperphosphorylated tau protein plays a pivotal role in a collection of neurodegenerative diseases named tauopathies, including alzheimer's disease (ad). |
2024-07-02 |
2024-07-06 |
mouse |
| Kiran Bhaskar, Jonathan Hulse, Nicole Maphis, Julianne Peabody, Bryce Chackeria. Virus-like particle (VLP)-based vaccine targeting tau phosphorylated at Ser396/Ser404 (PHF1) site outperforms phosphorylated S199/S202 (AT8) site in reducing tau pathology and restoring cognitive deficits in the rTg4510 mouse model of tauopathy. Research square. 2024-07-01. PMID:38946961. |
tauopathies, including alzheimer's disease (ad) and frontotemporal dementia (ftd), are histopathologically defined by the aggregation of hyperphosphorylated pathological tau (ptau) as neurofibrillary tangles in the brain. |
2024-07-01 |
2024-07-03 |
mouse |
| Mohamed Aghyad Al Kabbani, Christoph Köhler, Hans Zempe. Effects of P301L-TAU on post-translational modifications of microtubules in human iPSC-derived cortical neurons and TAU transgenic mice. Neural regeneration research. 2024-06-27. PMID:38934386. |
tau is missorted and aggregated in an array of diseases known as tauopathies. |
2024-06-27 |
2024-06-29 |
mouse |
| Zijian Wang, Jun-Ping Pan, Jiayuan Geng, Shijie Lv, Guisi Chen, Nian Fang, Zheng Zhang, Junliang Li, Xinke Xu, Rui Wang, Qing Zheng, Li Yan, Guobing Chen, Fei Xia. Nogo-A Drives Alzheimer's Disease Progression by Inducing Tauopathy Vulnerability. Aging and disease. 2024-06-25. PMID:38916730. |
tauopathies, a group of neurodegenerative disorders, are characterized by disrupted homeostasis of the microtubule binding protein tau. |
2024-06-25 |
2024-06-27 |
mouse |
| Zijian Wang, Jun-Ping Pan, Jiayuan Geng, Shijie Lv, Guisi Chen, Nian Fang, Zheng Zhang, Junliang Li, Xinke Xu, Rui Wang, Qing Zheng, Li Yan, Guobing Chen, Fei Xia. Nogo-A Drives Alzheimer's Disease Progression by Inducing Tauopathy Vulnerability. Aging and disease. 2024-06-25. PMID:38916730. |
together, our findings provide new insight into the function of nogo-a in regulating tau hyperphosphorylation and reveal an effective treatment strategy for tauopathies. |
2024-06-25 |
2024-06-27 |
mouse |
| Katriona L Hole, Bangfu Zhu, Laura Huggon, Jon T Brown, Jody M Mason, Robert J William. Tau Cell death & disease. vol 15. issue 6. 2024-06-18. PMID:38890273. |
tau tauopathies are characterised by the pathological accumulation of misfolded tau. |
2024-06-18 |
2024-06-21 |
human |
| Yuemang Yao, Megan Muench, Thibault Alle, Bin Zhang, Bobby Lucero, Roxanne Perez-Tremble, Dominic McGrosso, Mira Newman, David J Gonzalez, Virginia M-Y Lee, Carlo Ballatore, Kurt R Brunde. A small-molecule microtubule-stabilizing agent safely reduces Aβ plaque and tau pathology in transgenic mouse models of Alzheimer's disease. Alzheimer's & dementia : the journal of the Alzheimer's Association. 2024-06-17. PMID:38884283. |
intraneuronal inclusions composed of tau protein are found in alzheimer's disease (ad) and other tauopathies. |
2024-06-17 |
2024-06-19 |
mouse |
| Wenzhi Tan, Jayalakshmi Thiruppathi, Seol Hee Hong, Sao Puth, Sophea Pheng, Bo-Ram Mun, Won-Seok Choi, Kyung-Hwa Lee, Hyun-Sun Park, Duc Tien Nguyen, Min-Cheol Lee, Kwangjoon Jeong, Jin Hai Zheng, Young Kim, Shee Eun Lee, Joon Haeng Rhe. Development of an anti-tauopathy mucosal vaccine specifically targeting pathologic conformers. NPJ vaccines. vol 9. issue 1. 2024-06-15. PMID:38879560. |
alzheimer's disease (ad) and related tauopathies are associated with pathological tau protein aggregation, which plays an important role in neurofibrillary degeneration and dementia. |
2024-06-15 |
2024-06-18 |
mouse |
| Wenzhi Tan, Jayalakshmi Thiruppathi, Seol Hee Hong, Sao Puth, Sophea Pheng, Bo-Ram Mun, Won-Seok Choi, Kyung-Hwa Lee, Hyun-Sun Park, Duc Tien Nguyen, Min-Cheol Lee, Kwangjoon Jeong, Jin Hai Zheng, Young Kim, Shee Eun Lee, Joon Haeng Rhe. Development of an anti-tauopathy mucosal vaccine specifically targeting pathologic conformers. NPJ vaccines. vol 9. issue 1. 2024-06-15. PMID:38879560. |
because taurd forms the structural core of tau aggregates, the development of immunotherapies that selectively target taurd-induced pathological aggregates holds great promise for the modulation of tauopathies. |
2024-06-15 |
2024-06-18 |
mouse |
| Ilaria Linda Dellarole, Elena Vacchi, Inigo Ruiz-Barrio, Sandra Pinton, Andrea Raimondi, Stefania Rossi, Sara Morandi, Giovanni Bianco, Merve Begum Bacinoglu, Annalisa Lombardo, Luigi Celauro, Claudio Staedler, Salvatore Galati, Javier Pagonabarraga, Jaime Kulisevsky, Giuseppe Legname, Claudio Gobbi, Alain Kaelin-Lang, Fabio Moda, Giorgia Mell. Tau seeding activity in skin biopsy differentiates tauopathies from synucleinopathies. NPJ Parkinson's disease. vol 10. issue 1. 2024-06-15. PMID:38879633. |
tau seeding activity in skin biopsy differentiates tauopathies from synucleinopathies. |
2024-06-15 |
2024-06-18 |
human |
| Ilaria Linda Dellarole, Elena Vacchi, Inigo Ruiz-Barrio, Sandra Pinton, Andrea Raimondi, Stefania Rossi, Sara Morandi, Giovanni Bianco, Merve Begum Bacinoglu, Annalisa Lombardo, Luigi Celauro, Claudio Staedler, Salvatore Galati, Javier Pagonabarraga, Jaime Kulisevsky, Giuseppe Legname, Claudio Gobbi, Alain Kaelin-Lang, Fabio Moda, Giorgia Mell. Tau seeding activity in skin biopsy differentiates tauopathies from synucleinopathies. NPJ Parkinson's disease. vol 10. issue 1. 2024-06-15. PMID:38879633. |
since tau protein is highly expressed in skin of tauopathies patients, we aimed to exploit the ultrasensitive seeding activity assay (saa) to assess tau seeding activity in skin of patients with tauopathies. |
2024-06-15 |
2024-06-18 |
human |
| Kapali Suri, Madhu Ramesh, Mansi Bhandari, Vishakha Gupta, Virendra Kumar, Thimmaiah Govindaraju, N Arul Muruga. Role of Amyloidogenic and Non-Amyloidogenic Protein Spaces in Neurodegenerative Diseases and their Mitigation Using Theranostic Agents. Chembiochem : a European journal of chemical biology. 2024-06-14. PMID:38668376. |
recent advances in the cryogenic electron microscopy reported distinctly different microstructures for tau fibrils associated with different tauopathies highlighting the possibility to develop tauopathy-specific imaging agents and therapeutics. |
2024-06-14 |
2024-06-16 |
Not clear |
| Sushobhna Batra, Jaime Iii Vaquer-Alicea, Clarissa Valdez, Skyler P Taylor, Victor A Manon, Anthony R Vega, Omar M Kashmer, Sourav Kolay, Andrew Lemoff, Nigel J Cairns, Charles L White, Marc I Diamon. VCP regulates early tau seed amplification via specific cofactors. Research square. 2024-06-10. PMID:38826306. |
neurodegenerative tauopathies may progress based on seeding by pathological tau assemblies, whereby an aggregate is released from one cell, gains entry to an adjacent or connected cell, and serves as a specific template for its own replication in the cytoplasm. |
2024-06-10 |
2024-06-14 |
Not clear |
| Kanishka Pushpitha Maha Thananthirige, Nitin Chitranshi, Devaraj Basavarajappa, Rashi Rajput, Mojdeh Abbasi, Viswanthram Palanivel, Veer Bala Gupta, Joao A Paulo, Maya Koronyo-Hamaoui, Mehdi Mirzaei, Stuart L Graham, Vivek Gupt. Tau modulation through AAV9 therapy augments Akt/Erk survival signalling in glaucoma mitigating the retinal degenerative phenotype. Acta neuropathologica communications. vol 12. issue 1. 2024-06-07. PMID:38845058. |
the microtubule-associated protein tau is a key player in various neurodegenerative conditions, including alzheimer's disease (ad) and tauopathies, where its hyperphosphorylation disrupts neuronal microtubular lattice stability. |
2024-06-07 |
2024-06-10 |
Not clear |
| Sebastian N Roemer, Matthias Brendel, Johannes Gnoerich, Maura Malpetti, Mirlind Zaganjori, Andrea Quattrone, Mattes Gross, Anna Steward, Anna Dewenter, Fabian Wagner, Amir Dehsarvi, Christian Ferschmann, Stephan Wall, Carla Palleis, Boris S Rauchmann, Sabrina Katzdobler, Alexander Jaeck, Anna Stockbauer, Urban M Fietzek, Alexander M Bernhardt, Endy Weidinger, Andreas Zwergal, Sophia Stoecklein, Robert Perneczky, Henryk Barthel, Osama Sabri, Johannes Levin, Guenter U Hoeglinger, Nicolai Franzmeie. Subcortical tau is linked to hypoperfusion in connected cortical regions in 4-repeat tauopathies. Brain : a journal of neurology. 2024-06-06. PMID:38842726. |
subcortical tau is linked to hypoperfusion in connected cortical regions in 4-repeat tauopathies. |
2024-06-06 |
2024-06-08 |
Not clear |