| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Valérie Buée-Scherrer, Michel Goeder. Phosphorylation of microtubule-associated protein tau by stress-activated protein kinases in intact cells. FEBS letters. vol 515. issue 1-3. 2002-05-10. PMID:11943212. |
these findings indicate that the aberrant activation of sap kinases, especially sapk3/p38gamma and sapk4/p38delta, could play an important role in the abnormal hyperphosphorylation of tau that is an invariant feature of the tauopathies. |
2002-05-10 |
2023-08-12 |
Not clear |
| Janet Hoenicka, Montserrat Arrasate, Justo Garcia de Yebenes, Jesús Avil. A two-hybrid screening of human Tau protein: interactions with Alu-derived domain. Neuroreport. vol 13. issue 3. 2002-05-02. PMID:11930135. |
the microtubule associated protein tau has been implicated in several neurodegenerative diseases, grouped as tauopathies. |
2002-05-02 |
2023-08-12 |
human |
| Janet Hoenicka, Montserrat Arrasate, Justo Garcia de Yebenes, Jesús Avil. A two-hybrid screening of human Tau protein: interactions with Alu-derived domain. Neuroreport. vol 13. issue 3. 2002-05-02. PMID:11930135. |
the possible interaction of these proteins with tau could play a role in its cellular localization, regulate the amount of phosphorylated tau and also be involved in the pathological processes of tauopathies. |
2002-05-02 |
2023-08-12 |
human |
| Petri Mattila, Takashi Togo, Dennis W Dickso. The subthalamic nucleus has neurofibrillary tangles in argyrophilic grain disease and advanced Alzheimer's disease. Neuroscience letters. vol 320. issue 1-2. 2002-04-18. PMID:11849769. |
neurofibrillary tangles (nft) are present in the subthalamic nucleus (stn) of progressive supranuclear palsy and corticobasal degeneration, two sporadic tauopathies with preferential accumulation of tau with four repeats in the microtubule binding domain (4r tau). |
2002-04-18 |
2023-08-12 |
Not clear |
| Y Yoshiyama, V M Lee, J Q Trojanowsk. Frontotemporal dementia and tauopathy. Current neurology and neuroscience reports. vol 1. issue 5. 2002-04-09. PMID:11898551. |
the presence of abundant neurofibrillary lesions made of hyperphosphorylated tau proteins is the characteristic neuropathology of a subset of neurodegenerative disorders classified as "tauopathies." |
2002-04-09 |
2023-08-12 |
mouse |
| Y Yoshiyama, V M Lee, J Q Trojanowsk. Frontotemporal dementia and tauopathy. Current neurology and neuroscience reports. vol 1. issue 5. 2002-04-09. PMID:11898551. |
although transgenic mice expressing wild-type human tau or variants thereof with an ftdp-17 mutation result in tau pathologies and brain degeneration similar to that seen in human tauopathies, the precise mechanisms leading to the onset and progression of neurodegenerative disorders remain incompletely understood. |
2002-04-09 |
2023-08-12 |
mouse |
| T G Mack, R Dayanandan, M Van Slegtenhorst, A Whone, M Hutton, S Lovestone, B H Anderto. Tau proteins with frontotemporal dementia-17 mutations have both altered expression levels and phosphorylation profiles in differentiated neuroblastoma cells. Neuroscience. vol 108. issue 4. 2002-03-14. PMID:11738505. |
pathologically, affected ftdp-17 brains share tau aggregates with other tauopathies, the most common being alzheimer's disease. |
2002-03-14 |
2023-08-12 |
Not clear |
| I Ferrer, R Blanco, M Carmona, B Pui. Phosphorylated mitogen-activated protein kinase (MAPK/ERK-P), protein kinase of 38 kDa (p38-P), stress-activated protein kinase (SAPK/JNK-P), and calcium/calmodulin-dependent kinase II (CaM kinase II) are differentially expressed in tau deposits in neurons and glial cells in tauopathies. Journal of neural transmission (Vienna, Austria : 1996). vol 108. issue 12. 2002-03-07. PMID:11810404. |
phosphorylated mitogen-activated protein kinase (mapk/erk-p), protein kinase of 38 kda (p38-p), stress-activated protein kinase (sapk/jnk-p), and calcium/calmodulin-dependent kinase ii (cam kinase ii) are differentially expressed in tau deposits in neurons and glial cells in tauopathies. |
2002-03-07 |
2023-08-12 |
Not clear |
| I Ferrer, R Blanco, M Carmona, B Pui. Phosphorylated mitogen-activated protein kinase (MAPK/ERK-P), protein kinase of 38 kDa (p38-P), stress-activated protein kinase (SAPK/JNK-P), and calcium/calmodulin-dependent kinase II (CaM kinase II) are differentially expressed in tau deposits in neurons and glial cells in tauopathies. Journal of neural transmission (Vienna, Austria : 1996). vol 108. issue 12. 2002-03-07. PMID:11810404. |
the study was carried out to increase understanding of the signals that may regulate tau phosphorylation in tauopathies. |
2002-03-07 |
2023-08-12 |
Not clear |
| I Ferrer, R Blanco, M Carmona, B Pui. Phosphorylated mitogen-activated protein kinase (MAPK/ERK-P), protein kinase of 38 kDa (p38-P), stress-activated protein kinase (SAPK/JNK-P), and calcium/calmodulin-dependent kinase II (CaM kinase II) are differentially expressed in tau deposits in neurons and glial cells in tauopathies. Journal of neural transmission (Vienna, Austria : 1996). vol 108. issue 12. 2002-03-07. PMID:11810404. |
single and double-labeling immunohistochemistry to mapk/erk-p and p38-p disclosed that mapk/erk-p appeared at early stages of tau phosphorylation in neurons and glial cells in tauopathies, and that mapk/erk-p and p38-p co-localize only in a subset of neurons and glial cells with phosphorylated tau deposits. |
2002-03-07 |
2023-08-12 |
Not clear |
| I Ferrer, R Blanco, M Carmona, B Pui. Phosphorylated mitogen-activated protein kinase (MAPK/ERK-P), protein kinase of 38 kDa (p38-P), stress-activated protein kinase (SAPK/JNK-P), and calcium/calmodulin-dependent kinase II (CaM kinase II) are differentially expressed in tau deposits in neurons and glial cells in tauopathies. Journal of neural transmission (Vienna, Austria : 1996). vol 108. issue 12. 2002-03-07. PMID:11810404. |
these findings indicate that mapk/erk-p, sapk/jnk-p and p-38-p are differentially expressed in association with tau deposits in tauopathies. |
2002-03-07 |
2023-08-12 |
Not clear |
| I Ferrer, R Blanco, M Carmona, B Pui. Phosphorylated mitogen-activated protein kinase (MAPK/ERK-P), protein kinase of 38 kDa (p38-P), stress-activated protein kinase (SAPK/JNK-P), and calcium/calmodulin-dependent kinase II (CaM kinase II) are differentially expressed in tau deposits in neurons and glial cells in tauopathies. Journal of neural transmission (Vienna, Austria : 1996). vol 108. issue 12. 2002-03-07. PMID:11810404. |
these observations, together with previous results of in vitro studies, support the idea that several mapk/erk, sapk/jnk, p38 and cam kinase ii may participate in tau phosphorylation in tauopathies. |
2002-03-07 |
2023-08-12 |
Not clear |
| G Heidary, M E Fortin. Identification and characterization of the Drosophila tau homolog. Mechanisms of development. vol 108. issue 1-2. 2002-03-05. PMID:11578871. |
to elucidate the mechanisms by which tau dysfunction contributes to neuronal loss, we have sought to model human tauopathies in a genetically tractable organism. |
2002-03-05 |
2023-08-12 |
human |
| F Lim, F Hernández, J J Lucas, P Gómez-Ramos, M A Morán, J Avil. FTDP-17 mutations in tau transgenic mice provoke lysosomal abnormalities and Tau filaments in forebrain. Molecular and cellular neurosciences. vol 18. issue 6. 2002-02-21. PMID:11749044. |
the tauopathies, which include alzheimer's disease (ad) and frontotemporal dementias, are a group of neurodegenerative disorders characterized by filamentous tau aggregates. |
2002-02-21 |
2023-08-12 |
mouse |
| F Lim, F Hernández, J J Lucas, P Gómez-Ramos, M A Morán, J Avil. FTDP-17 mutations in tau transgenic mice provoke lysosomal abnormalities and Tau filaments in forebrain. Molecular and cellular neurosciences. vol 18. issue 6. 2002-02-21. PMID:11749044. |
our results show that tau modifications can provoke lysosomal aberrations and suggest that this may be a cause of neurodegeneration in tauopathies. |
2002-02-21 |
2023-08-12 |
mouse |
| C A Maurage, N Sergeant, M M Ruchoux, J J Hauw, A Delacourt. Paradoxical phosphorylation of the serine 199 on tau proteins from young individuals. Neuroreport. vol 12. issue 15. 2002-02-19. PMID:11711851. |
the microtubule-associated tau proteins are abnormally aggregated in many tauopathies. |
2002-02-19 |
2023-08-12 |
Not clear |
| M Farrer, D M Maraganore, P Lockhart, A Singleton, T G Lesnick, M de Andrade, A West, R de Silva, J Hardy, D Hernande. alpha-Synuclein gene haplotypes are associated with Parkinson's disease. Human molecular genetics. vol 10. issue 17. 2002-01-15. PMID:11532993. |
these genetic findings are analogous to the tau haplotype over-represented in progressive supranuclear palsy and further extend the similarity in the etiologies and pathogeneses of the synucleinopathies and tauopathies. |
2002-01-15 |
2023-08-12 |
Not clear |
| M Hutton, J Lewis, D Dickson, S H Yen, E McGowa. Analysis of tauopathies with transgenic mice. Trends in molecular medicine. vol 7. issue 10. 2002-01-09. PMID:11597522. |
intraneuronal filamentous inclusions composed of the microtubule-associated protein tau are a feature of several neurodegenerative diseases (including alzheimer's disease) known as tauopathies. |
2002-01-09 |
2023-08-12 |
mouse |
| M Hutton, J Lewis, D Dickson, S H Yen, E McGowa. Analysis of tauopathies with transgenic mice. Trends in molecular medicine. vol 7. issue 10. 2002-01-09. PMID:11597522. |
this demonstrated that tau dysfunction is sufficient to cause neurodegeneration, and indicated that tau is likely to play a crucial role in the pathogenesis of other tauopathies. |
2002-01-09 |
2023-08-12 |
mouse |
| I Ferrer, R Blanco, M Carmona, B Pui. Phosphorylated c-MYC expression in Alzheimer disease, Pick's disease, progressive supranuclear palsy and corticobasal degeneration. Neuropathology and applied neurobiology. vol 27. issue 5. 2001-12-31. PMID:11679086. |
previous studies have shown active ras and increased mitogen-activated protein kinase (mapk/erk) expression in neurones and glial cells with abnormal tau deposition in ad and other tauopathies. |
2001-12-31 |
2023-08-12 |
human |