| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Félix Hernández, Mar Pérez, José J Lucas, Ana M Mata, Ratan Bhat, Jesús Avil. Glycogen synthase kinase-3 plays a crucial role in tau exon 10 splicing and intranuclear distribution of SC35. Implications for Alzheimer's disease. The Journal of biological chemistry. vol 279. issue 5. 2004-03-11. PMID:14602710. |
our results demonstrate that gsk-3 plays a crucial role in tau exon 10 splicing, raising the possibility that gsk3 could contribute to tauopathies via aberrant tau splicing. |
2004-03-11 |
2023-08-12 |
Not clear |
| Félix Hernández, José J Lucas, Raquel Cuadros, Jesús Avil. GSK-3 dependent phosphoepitopes recognized by PHF-1 and AT-8 antibodies are present in different tau isoforms. Neurobiology of aging. vol 24. issue 8. 2004-03-11. PMID:14643380. |
it is widely known that the tau protein that forms the aggregates found in tauopathies like alzheimer's disease (ad) is hyperphosphorylated. |
2004-03-11 |
2023-08-12 |
Not clear |
| Deepa V Dabir, John Q Trojanowski, Christiane Richter-Landsberg, Virginia M-Y Lee, Mark S Forma. Expression of the small heat-shock protein alphaB-crystallin in tauopathies with glial pathology. The American journal of pathology. vol 164. issue 1. 2004-02-27. PMID:14695329. |
intracellular accumulations of filamentous material composed of tau proteins are defining features of sporadic and familial neurodegenerative disorders termed "tauopathies." |
2004-02-27 |
2023-08-12 |
Not clear |
| Deepa V Dabir, John Q Trojanowski, Christiane Richter-Landsberg, Virginia M-Y Lee, Mark S Forma. Expression of the small heat-shock protein alphaB-crystallin in tauopathies with glial pathology. The American journal of pathology. vol 164. issue 1. 2004-02-27. PMID:14695329. |
in alzheimer's disease, the most common tauopathy, tau pathology is predominantly localized within neurons; however, robust glial pathology occurs in other tauopathies. |
2004-02-27 |
2023-08-12 |
Not clear |
| Deepa V Dabir, John Q Trojanowski, Christiane Richter-Landsberg, Virginia M-Y Lee, Mark S Forma. Expression of the small heat-shock protein alphaB-crystallin in tauopathies with glial pathology. The American journal of pathology. vol 164. issue 1. 2004-02-27. PMID:14695329. |
although the pathogenesis of tauopathies remains primarily unknown, molecular chaperones such as heat-shock proteins (hsps) are implicated in these tau disorders as well as other neurodegenerative diseases characterized by the accumulation of insoluble protein aggregates such as alpha-synuclein in parkinson's disease and polyglutamine in huntington's disease. |
2004-02-27 |
2023-08-12 |
Not clear |
| Deepa V Dabir, John Q Trojanowski, Christiane Richter-Landsberg, Virginia M-Y Lee, Mark S Forma. Expression of the small heat-shock protein alphaB-crystallin in tauopathies with glial pathology. The American journal of pathology. vol 164. issue 1. 2004-02-27. PMID:14695329. |
although hsps are not found in neuronal tau inclusions, we demonstrate increased expression of the small hsp alphab-crystallin in glial inclusions of both sporadic and familial tauopathies. |
2004-02-27 |
2023-08-12 |
Not clear |
| Deepa V Dabir, John Q Trojanowski, Christiane Richter-Landsberg, Virginia M-Y Lee, Mark S Forma. Expression of the small heat-shock protein alphaB-crystallin in tauopathies with glial pathology. The American journal of pathology. vol 164. issue 1. 2004-02-27. PMID:14695329. |
alphab-crystallin was observed in a subset of astrocytic and oligodendrocytic tau inclusions as well as the neuropil thread pathology in cellular processes, but the co-expression of alphab-crystallin with tau inclusions was relatively specific to tauopathies with extensive glial pathology. |
2004-02-27 |
2023-08-12 |
Not clear |
| Tamas Revesz, Janice L Holto. Anatamopathological spectrum of tauopathies. Movement disorders : official journal of the Movement Disorder Society. vol 18 Suppl 6. 2004-02-24. PMID:14502651. |
in one category of such diseases, the neuronal inclusions occur in association with extracellular deposition of a second aggregated protein (secondary tauopathies), whereas in another, the filamentous inclusions composed of tau are the sole neuropathological abnormality (primary tauopathies). |
2004-02-24 |
2023-08-12 |
Not clear |
| Andrew J Lee. Parkinson's syndrome associated with neurofibrillary degeneration and tau pathologic findings. Movement disorders : official journal of the Movement Disorder Society. vol 18 Suppl 6. 2004-02-24. PMID:14502653. |
some of the sporadic disorders (progressive supranuclear palsy [psp] and corticobasal degeneration) have been referred to by molecular pathologists as primary tauopathies, implicating abnormalities of tau in their pathogenesis. |
2004-02-24 |
2023-08-12 |
Not clear |
| Andrew Kertes. Pick's complex and FTDP-17. Movement disorders : official journal of the Movement Disorder Society. vol 18 Suppl 6. 2004-02-24. PMID:14502657. |
there are recently discovered overlaps between the three-repeat and four-repeat tauopathies, and the tau-negative varieties with or without motor neuron disease-type inclusions may be deficient in normal tau, therefore may be tauopathies also. |
2004-02-24 |
2023-08-12 |
Not clear |
| Z Zhao, L Ho, J Suh, W Qin, H Pyo, P Pompl, H Ksiezak-Reding, G M Pasinett. A role of P301L tau mutant in anti-apoptotic gene expression, cell cycle and apoptosis. Molecular and cellular neurosciences. vol 24. issue 2. 2004-01-23. PMID:14572459. |
in exploring the causative role of the most common pro(301)-to-leu (taup301l) tau missense mutation associated with neurodegenerative tauopathies, we examined taup301l-mediated apoptotic cell death and the expression of a cluster of genes involved in the inhibition of apoptosis (iaps) in human neuroblastoma sh-sy5y cells. |
2004-01-23 |
2023-08-12 |
human |
| Despina Yancopoulou, Maria Grazia Spillantin. Tau protein in familial and sporadic diseases. Neuromolecular medicine. vol 4. issue 1-2. 2004-01-21. PMID:14528051. |
filamentous deposits made of the microtubule-associated protein tau constitute a major defining characteristic of several neurodegenerative diseases known as tauopathies. |
2004-01-21 |
2023-08-12 |
Not clear |
| Despina Yancopoulou, Maria Grazia Spillantin. Tau protein in familial and sporadic diseases. Neuromolecular medicine. vol 4. issue 1-2. 2004-01-21. PMID:14528051. |
furthermore, some sporadic tauopathies are associated with tau gene polymorphisms. |
2004-01-21 |
2023-08-12 |
Not clear |
| Despina Yancopoulou, Maria Grazia Spillantin. Tau protein in familial and sporadic diseases. Neuromolecular medicine. vol 4. issue 1-2. 2004-01-21. PMID:14528051. |
although it is still debated how tau gene mutations lead to neuronal death, it is clear that different mutations lead to tau pathologies with characteristics similar to those found in sporadic tauopathies. |
2004-01-21 |
2023-08-12 |
Not clear |
| Despina Yancopoulou, Maria Grazia Spillantin. Tau protein in familial and sporadic diseases. Neuromolecular medicine. vol 4. issue 1-2. 2004-01-21. PMID:14528051. |
these findings have definitely shown that in tauopathies tau aggregation is directly associated with development of neurodegeneration and neuronal death. |
2004-01-21 |
2023-08-12 |
Not clear |
| Pankajavalli Ramakrishnan, Dennis W Dickson, Peter Davie. Pin1 colocalization with phosphorylated tau in Alzheimer's disease and other tauopathies. Neurobiology of disease. vol 14. issue 2. 2004-01-06. PMID:14572447. |
pin1 colocalization with phosphorylated tau in alzheimer's disease and other tauopathies. |
2004-01-06 |
2023-08-12 |
Not clear |
| Yasumasa Yoshiyama, Bin Zhang, Jennifer Bruce, John Q Trojanowski, Virginia M-Y Le. Reduction of detyrosinated microtubules and Golgi fragmentation are linked to tau-induced degeneration in astrocytes. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 23. issue 33. 2003-12-11. PMID:14627651. |
these results suggest that reduced stable glu-mts is a primary consequence of tau accumulation that initiates mechanisms underlying astrocyte dysfunction and death in human neurodegenerative glial tauopathies. |
2003-12-11 |
2023-08-12 |
human |
| Zhiming Suo, Min Wu, Bruce A Citron, Robert E Palazzo, Barry W Festof. Rapid tau aggregation and delayed hippocampal neuronal death induced by persistent thrombin signaling. The Journal of biological chemistry. vol 278. issue 39. 2003-11-17. PMID:12821672. |
tau hyperphosphorylation, leading to self-aggregation, is widely held to underlie the neurofibrillary degeneration found in alzheimer's disease (ad) and other tauopathies. |
2003-11-17 |
2023-08-12 |
Not clear |
| Brian C Kraemer, Bin Zhang, James B Leverenz, James H Thomas, John Q Trojanowski, Gerard D Schellenber. Neurodegeneration and defective neurotransmission in a Caenorhabditis elegans model of tauopathy. Proceedings of the National Academy of Sciences of the United States of America. vol 100. issue 17. 2003-10-29. PMID:12872001. |
subsequently, insoluble tau accumulates and both soluble and insoluble tau is phosphorylated at many of the sites hyperphosphorylated in ftdp-17, ad, and other tauopathies. |
2003-10-29 |
2023-08-12 |
human |
| Victoria Makrides, Ting E Shen, Rajinder Bhatia, Bettye L Smith, Julian Thimm, Ratneshwar Lal, Stuart C Feinstei. Microtubule-dependent oligomerization of tau. Implications for physiological tau function and tauopathies. The Journal of biological chemistry. vol 278. issue 35. 2003-10-02. PMID:12805366. |
implications for physiological tau function and tauopathies. |
2003-10-02 |
2023-08-12 |
Not clear |