| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Stefan Barghorn, Peter Davies, Eckhard Mandelko. Tau paired helical filaments from Alzheimer's disease brain and assembled in vitro are based on beta-structure in the core domain. Biochemistry. vol 43. issue 6. 2004-06-17. PMID:14769047. |
tau protein, a neuronal microtubule-associated protein, forms insoluble fibers ("paired helical filaments") in alzheimer's disease and other tauopathies. |
2004-06-17 |
2023-08-12 |
Not clear |
| Patrice Delobel, Christel Mailliot, Malika Hamdane, Anne-Véronique Sambo, Séverine Bégard, Anne Violleau, André Delacourte, Luc Bué. Stable-tau overexpression in human neuroblastoma cells: an open door for explaining neuronal death in tauopathies. Annals of the New York Academy of Sciences. vol 1010. 2004-06-15. PMID:15033802. |
many neurodegenerative disorders referred to as "tauopathies" are characterized by the accumulation and aggregation of tau proteins into filaments. |
2004-06-15 |
2023-08-12 |
human |
| Susanna Schraen-Maschke, Claire-Marie Dhaenens, André Delacourte, Bernard Sablonnièr. Microtubule-associated protein tau gene: a risk factor in human neurodegenerative diseases. Neurobiology of disease. vol 15. issue 3. 2004-05-27. PMID:15056452. |
aggregates of hyperphosphorylated forms of tau protein participate in the formation of neurofibrillary tangles, which characterize numerous neurodegenerative disorders named tauopathies. |
2004-05-27 |
2023-08-12 |
human |
| Susanna Schraen-Maschke, Claire-Marie Dhaenens, André Delacourte, Bernard Sablonnièr. Microtubule-associated protein tau gene: a risk factor in human neurodegenerative diseases. Neurobiology of disease. vol 15. issue 3. 2004-05-27. PMID:15056452. |
the analysis of tau gene and the study of familial cases of tauopathies have led to the discovery of tau gene mutations that cause inherited dementia designated as frontotemporal dementia (ftd) with parkinsonism linked to chromosome 17 (ftdp-17). |
2004-05-27 |
2023-08-12 |
human |
| Yuri Umeda, Sayuri Taniguchi, Kunimasa Arima, Yue-Shan Piao, Hitoshi Takahashi, Takeshi Iwatsubo, David Mann, Masato Hasegaw. Alterations in human tau transcripts correlate with those of neurofilament in sporadic tauopathies. Neuroscience letters. vol 359. issue 3. 2004-05-25. PMID:15050686. |
alterations in human tau transcripts correlate with those of neurofilament in sporadic tauopathies. |
2004-05-25 |
2023-08-12 |
human |
| Yuri Umeda, Sayuri Taniguchi, Kunimasa Arima, Yue-Shan Piao, Hitoshi Takahashi, Takeshi Iwatsubo, David Mann, Masato Hasegaw. Alterations in human tau transcripts correlate with those of neurofilament in sporadic tauopathies. Neuroscience letters. vol 359. issue 3. 2004-05-25. PMID:15050686. |
abnormalities in tau mrna splicing cause frontotemporal dementia and parkinsonism linked to chromosome 17, and similar alterations are suggested in sporadic tauopathies such as progressive supranuclear palsy (psp) or corticobasal degeneration (cbd). |
2004-05-25 |
2023-08-12 |
human |
| Yuri Umeda, Sayuri Taniguchi, Kunimasa Arima, Yue-Shan Piao, Hitoshi Takahashi, Takeshi Iwatsubo, David Mann, Masato Hasegaw. Alterations in human tau transcripts correlate with those of neurofilament in sporadic tauopathies. Neuroscience letters. vol 359. issue 3. 2004-05-25. PMID:15050686. |
we have analyzed the expression of three-repeat (3r) and four-repeat (4r) tau isoforms in brains with familial and sporadic tauopathies. |
2004-05-25 |
2023-08-12 |
human |
| Yuri Umeda, Sayuri Taniguchi, Kunimasa Arima, Yue-Shan Piao, Hitoshi Takahashi, Takeshi Iwatsubo, David Mann, Masato Hasegaw. Alterations in human tau transcripts correlate with those of neurofilament in sporadic tauopathies. Neuroscience letters. vol 359. issue 3. 2004-05-25. PMID:15050686. |
these results suggest that decrease of 3r tau mrna associated with loss of neuronal element may largely contribute to the increased ratio of 4r/3r tau mrna in sporadic tauopathies. |
2004-05-25 |
2023-08-12 |
human |
| Andrew D Hope, Tammaryn Lashley, Andrew J Lees, Rohan de Silv. Failure in heat-shock protein expression in response to UBB+1 protein in progressive supranuclear palsy in humans. Neuroscience letters. vol 359. issue 1-2. 2004-05-21. PMID:15050720. |
as hsps are involved in both normal tau and proteasome function, these findings may be relevant to the aetiology of psp and other tauopathies. |
2004-05-21 |
2023-08-12 |
Not clear |
| Félix Hernández, Raquel Cuadros, Jesús Avil. Zeta 14-3-3 protein favours the formation of human tau fibrillar polymers. Neuroscience letters. vol 357. issue 2. 2004-05-13. PMID:15036595. |
tau protein can aggregate, in an aberrant way, in alzheimer's disease and other tauopathies. |
2004-05-13 |
2023-08-12 |
human |
| Félix Hernández, Raquel Cuadros, Jesús Avil. Zeta 14-3-3 protein favours the formation of human tau fibrillar polymers. Neuroscience letters. vol 357. issue 2. 2004-05-13. PMID:15036595. |
the involvement of a scaffolding protein like 14-3-3 in the generation of tau filaments in tauopathies, like ad, is suggested. |
2004-05-13 |
2023-08-12 |
human |
| T Chris Gamblin, Robert W Berry, Lester I Binde. Modeling tau polymerization in vitro: a review and synthesis. Biochemistry. vol 42. issue 51. 2004-05-04. PMID:14690409. |
here we discuss the advantages and disadvantages of the various techniques used to model tau polymerization and the discoveries arising from these techniques that have led to a better structural understanding of tau polymerization in relation to alzheimer's disease and other tauopathies. |
2004-05-04 |
2023-08-12 |
Not clear |
| Virginia M-Y Lee, Benoit I Giasson, John Q Trojanowsk. More than just two peas in a pod: common amyloidogenic properties of tau and alpha-synuclein in neurodegenerative diseases. Trends in neurosciences. vol 27. issue 3. 2004-05-03. PMID:15036877. |
thus, the ability of tau and alpha-synuclein to affect each other directly or indirectly might contribute to the overlap in the clinical and pathological features of tauopathies and synucleinopathies. |
2004-05-03 |
2023-08-12 |
Not clear |
| Jesus Avila, Jose J Lucas, Mar Perez, Felix Hernande. Role of tau protein in both physiological and pathological conditions. Physiological reviews. vol 84. issue 2. 2004-04-29. PMID:15044677. |
the purpose of this review is to define the role of tau protein under normal physiological conditions and to highlight the role of the protein in different tauopathies. |
2004-04-29 |
2023-08-12 |
Not clear |
| C Haase, J T Stieler, T Arendt, M Holze. Pseudophosphorylation of tau protein alters its ability for self-aggregation. Journal of neurochemistry. vol 88. issue 6. 2004-04-15. PMID:15009652. |
filamentous tau protein deposits are a pathological hallmark of a group of neurodegenerative disorders (tauopathies). |
2004-04-15 |
2023-08-12 |
Not clear |
| Manabu Wada, Chang-Hong Ren, Shingo Koyama, Shigeki Arawaka, Shinobu Kawakatsu, Hideki Kimura, Hikaru Nagasawa, Toru Kawanami, Keiji Kurita, Makoto Daimon, Asao Hirano, Takeo Kat. A human granin-like neuroendocrine peptide precursor (proSAAS) immunoreactivity in tau inclusions of Alzheimer's disease and parkinsonism-dementia complex on Guam. Neuroscience letters. vol 356. issue 1. 2004-03-29. PMID:14746899. |
however, it is unknown whether n-prosaas is widely accumulated in tau inclusions in other tauopathies. |
2004-03-29 |
2023-08-12 |
human |
| Isidro Ferrer, Isabel Hernández, Berta Puig, María Jesús Rey, Mario Ezquerra, Eduardo Tolosa, Merce Boad. Ubiquitin-negative mini-pick-like bodies in the dentate gyrus in p301l tauopathy. Journal of Alzheimer's disease : JAD. vol 5. issue 6. 2004-03-25. PMID:14757934. |
these findings indicate that the major sites of tau phosphorylation, and the expression of kinases involved in tau phosphorylation are active in p310l mutation as in ad and other tauopathies. |
2004-03-25 |
2023-08-12 |
Not clear |
| Mar Pérez, Félix Hernández, Filip Lim, Javier Díaz-Nido, Jesús Avil. Chronic lithium treatment decreases mutant tau protein aggregation in a transgenic mouse model. Journal of Alzheimer's disease : JAD. vol 5. issue 4. 2004-03-19. PMID:14624025. |
tau protein hyperphosphorylation and aggregation into neurofibrillary tangles are characteristic features of several neurodegenerative disorders referred to as tauopathies. |
2004-03-19 |
2023-08-12 |
mouse |
| Patrizia Rizzu, David A Hinkle, Victoria Zhukareva, Vincenzo Bonifati, Lies-Anne Severijnen, Daniel Martinez, Rivka Ravid, Wouter Kamphorst, James H Eberwine, Virginia M-Y Lee, John Q Trojanowski, Peter Heutin. DJ-1 colocalizes with tau inclusions: a link between parkinsonism and dementia. Annals of neurology. vol 55. issue 1. 2004-03-12. PMID:14705119. |
because the pathological role of this protein is unknown, we examined the issue here and report the colocalization of dj-1 protein within a subset of pathological tau inclusions in a diverse group of neurodegenerative disorders known as tauopathies. |
2004-03-12 |
2023-08-12 |
Not clear |
| Félix Hernández, Mar Pérez, José J Lucas, Ana M Mata, Ratan Bhat, Jesús Avil. Glycogen synthase kinase-3 plays a crucial role in tau exon 10 splicing and intranuclear distribution of SC35. Implications for Alzheimer's disease. The Journal of biological chemistry. vol 279. issue 5. 2004-03-11. PMID:14602710. |
tauopathies, including alzheimer's disease, are neurodegenerative disorders in which tau protein accumulates as a consequence of alterations in its metabolism. |
2004-03-11 |
2023-08-12 |
Not clear |