| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Sayuri Taniguchi, Nobuyuki Suzuki, Masami Masuda, Shin-ichi Hisanaga, Takeshi Iwatsubo, Michel Goedert, Masato Hasegaw. Inhibition of heparin-induced tau filament formation by phenothiazines, polyphenols, and porphyrins. The Journal of biological chemistry. vol 280. issue 9. 2005-04-07. PMID:15611092. |
identification of small molecule inhibitors of heparin-induced assembly of tau will form a starting point for the development of mechanism-based therapies for the tauopathies. |
2005-04-07 |
2023-08-12 |
Not clear |
| R Rademakers, M Cruts, C van Broeckhove. The role of tau (MAPT) in frontotemporal dementia and related tauopathies. Human mutation. vol 24. issue 4. 2005-03-31. PMID:15365985. |
the role of tau (mapt) in frontotemporal dementia and related tauopathies. |
2005-03-31 |
2023-08-12 |
mouse |
| Marcus Pickhardt, Zuzana Gazova, Martin von Bergen, Inna Khlistunova, Yipeng Wang, Antje Hascher, Eva-Maria Mandelkow, Jacek Biernat, Eckhard Mandelko. Anthraquinones inhibit tau aggregation and dissolve Alzheimer's paired helical filaments in vitro and in cells. The Journal of biological chemistry. vol 280. issue 5. 2005-03-22. PMID:15525637. |
thus, small molecule inhibitors could provide a basis for the development of tools for the treatment of tau pathology in ad and other tauopathies. |
2005-03-22 |
2023-08-12 |
Not clear |
| Bin Zhang, Arpita Maiti, Sharon Shively, Fara Lakhani, Gaye McDonald-Jones, Jennifer Bruce, Edward B Lee, Sharon X Xie, Sonali Joyce, Chi Li, Philip M Toleikis, Virginia M-Y Lee, John Q Trojanowsk. Microtubule-binding drugs offset tau sequestration by stabilizing microtubules and reversing fast axonal transport deficits in a tauopathy model. Proceedings of the National Academy of Sciences of the United States of America. vol 102. issue 1. 2005-03-10. PMID:15615853. |
we tested the hypothesis that microtubule (mt)-binding drugs could be therapeutically beneficial in tauopathies by functionally substituting for the mt-binding protein tau, which is sequestered into inclusions of human tauopathies and transgenic mouse models thereof. |
2005-03-10 |
2023-08-12 |
mouse |
| Bin Zhang, Arpita Maiti, Sharon Shively, Fara Lakhani, Gaye McDonald-Jones, Jennifer Bruce, Edward B Lee, Sharon X Xie, Sonali Joyce, Chi Li, Philip M Toleikis, Virginia M-Y Lee, John Q Trojanowsk. Microtubule-binding drugs offset tau sequestration by stabilizing microtubules and reversing fast axonal transport deficits in a tauopathy model. Proceedings of the National Academy of Sciences of the United States of America. vol 102. issue 1. 2005-03-10. PMID:15615853. |
thus, mt-stabilizing drugs could have therapeutic potential for treating neurodegenerative tauopathies by offsetting losses of tau function that result from the sequestration of this mt-stabilizing protein into filamentous inclusions. |
2005-03-10 |
2023-08-12 |
mouse |
| A C Bruni, T Kawarai, M G Spillantini, P H St-George Hyslop, A Leotta, S Lio, J-F Foncin, K H El Hachim. [Familial fronto-temporal dementia with brain stem ubiquitin-positive neuronal inclusions]. Revue neurologique. vol 160. issue 12. 2005-03-08. PMID:15602363. |
a few, such as tauopathies due to mutations of the gene coding for tau protein (maptau form a well-defined group. |
2005-03-08 |
2023-08-12 |
Not clear |
| Masato Hasegaw. [Frontotemporal dementia: tau mutations, deposition, and molecular mechanisms of neuronal cell death]. Rinsho shinkeigaku = Clinical neurology. vol 44. issue 11. 2005-03-04. PMID:15651320. |
in sporadic tauopathies, decreased levels of 3r tau mrna were detected not only in severely affected cases with progressive supranuclear palsy or corticobasal degeneration but also in cases with alzheimer's disease or pick's disease. |
2005-03-04 |
2023-08-12 |
Not clear |
| Masato Hasegaw. [Frontotemporal dementia: tau mutations, deposition, and molecular mechanisms of neuronal cell death]. Rinsho shinkeigaku = Clinical neurology. vol 44. issue 11. 2005-03-04. PMID:15651320. |
these results suggest that decreased levels of 3r tau mrna in sporadic tauopathies may be due to degeneration and loss of neurons that express 3r tau isoforms. |
2005-03-04 |
2023-08-12 |
Not clear |
| Masato Hasegaw. [Frontotemporal dementia: tau mutations, deposition, and molecular mechanisms of neuronal cell death]. Rinsho shinkeigaku = Clinical neurology. vol 44. issue 11. 2005-03-04. PMID:15651320. |
in tauopathies, neuronal cell death may occur with multiple defects or abnormalities arisen directly or indirectly from hyperphosphorylation of tau and formation of oligomer or filamentous tau. |
2005-03-04 |
2023-08-12 |
Not clear |
| J Avila, M Pérez, F Lim, A Gómez-Ramos, F Hernández, J J Luca. Tau in neurodegenerative diseases: tau phosphorylation and assembly. Neurotoxicity research. vol 6. issue 6. 2005-03-01. PMID:15639780. |
the possible link between tau phosphorylation and tau assembly in these neurodegenerative diseases known as tauopathies is described. |
2005-03-01 |
2023-08-12 |
mouse |
| I Ferre. Stress kinases involved in tau phosphorylation in Alzheimer's disease, tauopathies and APP transgenic mice. Neurotoxicity research. vol 6. issue 6. 2005-03-01. PMID:15658002. |
stress kinases involved in tau phosphorylation in alzheimer's disease, tauopathies and app transgenic mice. |
2005-03-01 |
2023-08-12 |
mouse |
| I Ferre. Stress kinases involved in tau phosphorylation in Alzheimer's disease, tauopathies and APP transgenic mice. Neurotoxicity research. vol 6. issue 6. 2005-03-01. PMID:15658002. |
hyperphosphorylation and accumulation of tau in neurons (and glial cells) is one of the main pathologic hallmarks in alzheimer's disease (ad) and other tauopathies, including pick's disease (pid), progressive supranuclear palsy, corticobasal degeneration, argyrophilic grain disease and familial frontotemporal dementia and parkinsonism linked to chromosome 17 due to mutations in the tau gene (ftdp-17-tau). |
2005-03-01 |
2023-08-12 |
mouse |
| P Delobel, O Leroy, M Hamdane, A V Sambo, A Delacourte, L Bué. Proteasome inhibition and Tau proteolysis: an unexpected regulation. FEBS letters. vol 579. issue 1. 2005-02-17. PMID:15620682. |
in this disease and other tauopathies, tau proteins are hyperphosphorylated and aggregated within degenerating neurons. |
2005-02-17 |
2023-08-12 |
Not clear |
| Li Sun, XiaoChuang Wang, Shengyuan Liu, Quan Wang, JianZhi Wang, Malika Bennecib, Cheng-Xin Gong, Amitabha Sengupta, Inge Grundke-Iqbal, Khalid Iqba. Bilateral injection of isoproterenol into hippocampus induces Alzheimer-like hyperphosphorylation of tau and spatial memory deficit in rat. FEBS letters. vol 579. issue 1. 2005-02-17. PMID:15620722. |
the abnormal hyperphosphorylation of tau protein is one of the hallmarks of alzheimer disease and other tauopathies; as yet the exact role of various tau kinases in this pathology is not fully understood. |
2005-02-17 |
2023-08-12 |
rat |
| Shi Jie Liu, Jia Yu Zhang, Hong Lian Li, Zheng Yu Fang, Qun Wang, Heng Mei Deng, Cheng Xin Gong, Inge Grundke-Iqbal, Khalid Iqbal, Jian Zhi Wan. Tau becomes a more favorable substrate for GSK-3 when it is prephosphorylated by PKA in rat brain. The Journal of biological chemistry. vol 279. issue 48. 2005-02-07. PMID:15375165. |
microtubule-associated protein tau is abnormally hyperphosphorylated in alzheimer's disease (ad) and other tauopathies and is believed to lead to neurodegeneration in this family of diseases. |
2005-02-07 |
2023-08-12 |
rat |
| Shi Jie Liu, Jia Yu Zhang, Hong Lian Li, Zheng Yu Fang, Qun Wang, Heng Mei Deng, Cheng Xin Gong, Inge Grundke-Iqbal, Khalid Iqbal, Jian Zhi Wan. Tau becomes a more favorable substrate for GSK-3 when it is prephosphorylated by PKA in rat brain. The Journal of biological chemistry. vol 279. issue 48. 2005-02-07. PMID:15375165. |
these data provide a novel mechanism of the hyperphosphorylation of tau and identify both pka and gsk-3 as promising therapeutic targets for ad and other tauopathies. |
2005-02-07 |
2023-08-12 |
rat |
| Li-Wen Ko, Michael DeTure, Naruhiko Sahara, Rifki Chihab, Irving E Vega, Shu-Hui Ye. Recent advances in experimental modeling of the assembly of tau filaments. Biochimica et biophysica acta. vol 1739. issue 2-3. 2005-02-03. PMID:15615632. |
intracellular assembly of microtubule-associated protein tau into filamentous inclusions is central to alzheimer's disease and related disorders collectively known as tauopathies. |
2005-02-03 |
2023-08-12 |
human |
| Nicolas Sergeant, André Delacourte, Luc Bué. Tau protein as a differential biomarker of tauopathies. Biochimica et biophysica acta. vol 1739. issue 2-3. 2005-02-03. PMID:15615637. |
tau protein as a differential biomarker of tauopathies. |
2005-02-03 |
2023-08-12 |
Not clear |
| Nicolas Sergeant, André Delacourte, Luc Bué. Tau protein as a differential biomarker of tauopathies. Biochimica et biophysica acta. vol 1739. issue 2-3. 2005-02-03. PMID:15615637. |
microtubule-associated tau proteins are the basic component of intraneuronal and glial inclusions observed in many neurological disorders, the so-called tauopathies. |
2005-02-03 |
2023-08-12 |
Not clear |
| Nicolas Sergeant, André Delacourte, Luc Bué. Tau protein as a differential biomarker of tauopathies. Biochimica et biophysica acta. vol 1739. issue 2-3. 2005-02-03. PMID:15615637. |
specific set of pathological tau proteins exhibiting a typical biochemical pattern, and a different regional and laminar distribution, could characterize five main classes of tauopathies. |
2005-02-03 |
2023-08-12 |
Not clear |