| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Khalid Iqbal, Alejandra del C Alonso, She Chen, M Omar Chohan, Ezzat El-Akkad, Cheng-Xin Gong, Sabiha Khatoon, Bin Li, Fei Liu, Abdur Rahman, Hitoshi Tanimukai, Inge Grundke-Iqba. Tau pathology in Alzheimer disease and other tauopathies. Biochimica et biophysica acta. vol 1739. issue 2-3. 2005-02-03. PMID:15615638. |
tau pathology in alzheimer disease and other tauopathies. |
2005-02-03 |
2023-08-12 |
Not clear |
| Khalid Iqbal, Alejandra del C Alonso, She Chen, M Omar Chohan, Ezzat El-Akkad, Cheng-Xin Gong, Sabiha Khatoon, Bin Li, Fei Liu, Abdur Rahman, Hitoshi Tanimukai, Inge Grundke-Iqba. Tau pathology in Alzheimer disease and other tauopathies. Biochimica et biophysica acta. vol 1739. issue 2-3. 2005-02-03. PMID:15615638. |
to date, the most established and the most compelling cause of dysfunctional tau in ad and other tauopathies is the abnormal hyperphosphorylation of tau. |
2005-02-03 |
2023-08-12 |
Not clear |
| Khalid Iqbal, Alejandra del C Alonso, She Chen, M Omar Chohan, Ezzat El-Akkad, Cheng-Xin Gong, Sabiha Khatoon, Bin Li, Fei Liu, Abdur Rahman, Hitoshi Tanimukai, Inge Grundke-Iqba. Tau pathology in Alzheimer disease and other tauopathies. Biochimica et biophysica acta. vol 1739. issue 2-3. 2005-02-03. PMID:15615638. |
inhibition of this tau abnormality is one of the most promising therapeutic approaches to ad and other tauopathies. |
2005-02-03 |
2023-08-12 |
Not clear |
| Garth F Hall, Jun Ya. Modeling tauopathy: a range of complementary approaches. Biochimica et biophysica acta. vol 1739. issue 2-3. 2005-02-03. PMID:15615641. |
the large group of neurodegenerative diseases which feature abnormal metabolism and accumulation of tau protein (tauopathies) characteristically produce a multiplicity of cellular and systemic abnormalities in human patients. |
2005-02-03 |
2023-08-12 |
human |
| Michel Goedert, Ross Jake. Mutations causing neurodegenerative tauopathies. Biochimica et biophysica acta. vol 1739. issue 2-3. 2005-02-03. PMID:15615642. |
at a practical level, the new work is leading to the production of experimental animal models that reproduce the essential molecular and cellular features of the human tauopathies, including the formation of abundant filaments made of hyperphosphorylated tau protein and nerve cell degeneration. |
2005-02-03 |
2023-08-12 |
human |
| Virginia M-Y Lee, Theresa K Kenyon, John Q Trojanowsk. Transgenic animal models of tauopathies. Biochimica et biophysica acta. vol 1739. issue 2-3. 2005-02-03. PMID:15615643. |
tauopathies are a group of neurodegenerative disorders that include alzheimer's disease, frontotemporal dementia with parkinsonism linked to chromosome 17 (ftdp-17) and other related diseases with prominent tau pathology. |
2005-02-03 |
2023-08-12 |
mouse |
| Virginia M-Y Lee, Theresa K Kenyon, John Q Trojanowsk. Transgenic animal models of tauopathies. Biochimica et biophysica acta. vol 1739. issue 2-3. 2005-02-03. PMID:15615643. |
research advances in the last several decades have characterized and defined tau neuropathologies of both neuron and glia in these diverse disorders and this has stimulated development of animal models of tauopathies. |
2005-02-03 |
2023-08-12 |
mouse |
| Jormay Lim, Kun Ping L. Pinning down phosphorylated tau and tauopathies. Biochimica et biophysica acta. vol 1739. issue 2-3. 2005-02-03. PMID:15615648. |
pinning down phosphorylated tau and tauopathies. |
2005-02-03 |
2023-08-12 |
mouse |
| Roland Brandt, Monika Hundelt, Neelam Shahan. Tau alteration and neuronal degeneration in tauopathies: mechanisms and models. Biochimica et biophysica acta. vol 1739. issue 2-3. 2005-02-03. PMID:15615650. |
tau alteration and neuronal degeneration in tauopathies: mechanisms and models. |
2005-02-03 |
2023-08-12 |
Not clear |
| Roland Brandt, Monika Hundelt, Neelam Shahan. Tau alteration and neuronal degeneration in tauopathies: mechanisms and models. Biochimica et biophysica acta. vol 1739. issue 2-3. 2005-02-03. PMID:15615650. |
tau becomes characteristically altered both functionally and structurally in several neurodegenerative diseases now collectively called tauopathies. |
2005-02-03 |
2023-08-12 |
Not clear |
| Roland Brandt, Monika Hundelt, Neelam Shahan. Tau alteration and neuronal degeneration in tauopathies: mechanisms and models. Biochimica et biophysica acta. vol 1739. issue 2-3. 2005-02-03. PMID:15615650. |
the review begins with a discussion about similarities and differences in tau alteration in paradigmatic tauopathies such as frontotemporal dementia and parkinsonism linked to chromosome 17 (ftdp-17) and alzheimer's disease (ad). |
2005-02-03 |
2023-08-12 |
Not clear |
| Roland Brandt, Monika Hundelt, Neelam Shahan. Tau alteration and neuronal degeneration in tauopathies: mechanisms and models. Biochimica et biophysica acta. vol 1739. issue 2-3. 2005-02-03. PMID:15615650. |
the review ends with concluding remarks about a general mechanistic model of the role of tau alteration and neuronal degeneration in tauopathies and future perspectives. |
2005-02-03 |
2023-08-12 |
Not clear |
| Hanae Nakashima, Takeshi Ishihara, Osamu Yokota, Seishi Terada, John Q Trojanowski, Virginia M-Y Lee, Shigetoshi Kurod. Effects of alpha-tocopherol on an animal model of tauopathies. Free radical biology & medicine. vol 37. issue 2. 2005-01-31. PMID:15203189. |
we overexpressed the smallest human tau isoform (t44) in the mouse cns to model tauopathies. |
2005-01-31 |
2023-08-12 |
mouse |
| Hanae Nakashima, Takeshi Ishihara, Osamu Yokota, Seishi Terada, John Q Trojanowski, Virginia M-Y Lee, Shigetoshi Kurod. Effects of alpha-tocopherol on an animal model of tauopathies. Free radical biology & medicine. vol 37. issue 2. 2005-01-31. PMID:15203189. |
therefore, these tg mice are a model that can be exploited for drug discovery in studies that target amelioration of tau-induced neurodegeneration as well as for elucidating mechanisms of tau pathology in various neurodegenerative tauopathies. |
2005-01-31 |
2023-08-12 |
mouse |
| Hanae Nakashima, Takeshi Ishihara, Osamu Yokota, Seishi Terada, John Q Trojanowski, Virginia M-Y Lee, Shigetoshi Kurod. Effects of alpha-tocopherol on an animal model of tauopathies. Free radical biology & medicine. vol 37. issue 2. 2005-01-31. PMID:15203189. |
these results suggest that oxidative damage is involved in the pathological mechanisms of the tau tg mice and that treatment with antioxidative agents like alpha-tocopherol may prevent neurodegenerative tauopathies. |
2005-01-31 |
2023-08-12 |
mouse |
| C-A Maurage, T Bussière, N Sergeant, A Ghesteem, D Figarella-Branger, M-M Ruchoux, J-F Pellissier, A Delacourt. Tau aggregates are abnormally phosphorylated in inclusion body myositis and have an immunoelectrophoretic profile distinct from other tauopathies. Neuropathology and applied neurobiology. vol 30. issue 6. 2005-01-13. PMID:15541003. |
tau aggregates are abnormally phosphorylated in inclusion body myositis and have an immunoelectrophoretic profile distinct from other tauopathies. |
2005-01-13 |
2023-08-12 |
Not clear |
| C-A Maurage, T Bussière, N Sergeant, A Ghesteem, D Figarella-Branger, M-M Ruchoux, J-F Pellissier, A Delacourt. Tau aggregates are abnormally phosphorylated in inclusion body myositis and have an immunoelectrophoretic profile distinct from other tauopathies. Neuropathology and applied neurobiology. vol 30. issue 6. 2005-01-13. PMID:15541003. |
tau immunoblotting showed an electrophorectic profile of a doublet within the range of 60-62 kda isovariants, which was different from tauopathies of the central nervous system. |
2005-01-13 |
2023-08-12 |
Not clear |
| Muhammad Abdul Alim, Qiu-Lan Ma, Kazuya Takeda, Takako Aizawa, Mamoru Matsubara, Minako Nakamura, Akiko Asada, Taro Saito, Hiroyuki Kaji, Mitsunobu Yoshii, Shinichi Hisanaga, Kenji Uéd. Demonstration of a role for alpha-synuclein as a functional microtubule-associated protein. Journal of Alzheimer's disease : JAD. vol 6. issue 4. 2004-12-30. PMID:15345814. |
now we can see a striking resemblance between alpha-synuclein and tau: both have the same physiological function and pathological features, making abnormal structures in diseased brains known as synucleinopathies and tauopathies. |
2004-12-30 |
2023-08-12 |
Not clear |
| A Mudher, D Shepherd, T A Newman, P Mildren, J P Jukes, A Squire, A Mears, J A Drummond, S Berg, D MacKay, A A Asuni, R Bhat, S Loveston. GSK-3beta inhibition reverses axonal transport defects and behavioural phenotypes in Drosophila. Molecular psychiatry. vol 9. issue 5. 2004-12-22. PMID:14993907. |
the tauopathies are a group of disorders characterised by aggregation of the microtubule-associated protein tau and include alzheimer's disease (ad) and the fronto-temporal dementias (ftd). |
2004-12-22 |
2023-08-12 |
human |
| A Mudher, D Shepherd, T A Newman, P Mildren, J P Jukes, A Squire, A Mears, J A Drummond, S Berg, D MacKay, A A Asuni, R Bhat, S Loveston. GSK-3beta inhibition reverses axonal transport defects and behavioural phenotypes in Drosophila. Molecular psychiatry. vol 9. issue 5. 2004-12-22. PMID:14993907. |
these data show that tau abnormalities significantly disrupt neuronal function, in a phosphorylation-dependent manner, before the classical pathological hallmarks are evident and also suggest that the inhibition of gsk-3beta might have potential therapeutic benefits in tauopathies. |
2004-12-22 |
2023-08-12 |
human |