| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Alan M Pittman, Amanda J Myers, Jaime Duckworth, Leslie Bryden, Melissa Hanson, Patrick Abou-Sleiman, Nicholas W Wood, John Hardy, Andrew Lees, Rohan de Silv. The structure of the tau haplotype in controls and in progressive supranuclear palsy. Human molecular genetics. vol 13. issue 12. 2004-12-22. PMID:15115761. |
the group of neurodegenerative diseases collectively known as tauopathies are characterized by hallmark lesions consisting of fibrillar aggregates of the microtubule-associated protein, tau (mapt). |
2004-12-22 |
2023-08-12 |
Not clear |
| Arianna Bellucci, Andrew J Westwood, Esther Ingram, Fiorella Casamenti, Michel Goedert, Maria Grazia Spillantin. Induction of inflammatory mediators and microglial activation in mice transgenic for mutant human P301S tau protein. The American journal of pathology. vol 165. issue 5. 2004-12-17. PMID:15509534. |
mice transgenic for human p301s tau protein exhibit many characteristics of the human tauopathies, including the formation of abundant filaments made of hyperphosphorylated tau protein and neurodegeneration leading to nerve cell loss. |
2004-12-17 |
2023-08-12 |
mouse |
| Prudence M Stanford, William S Brooks, Erdahl T Teber, Marianne Hallupp, Catriona McLean, Glenda M Halliday, Ralph N Martins, John B J Kwok, Peter R Schofiel. Frequency of tau mutations in familial and sporadic frontotemporal dementia and other tauopathies. Journal of neurology. vol 251. issue 9. 2004-12-13. PMID:15372253. |
frequency of tau mutations in familial and sporadic frontotemporal dementia and other tauopathies. |
2004-12-13 |
2023-08-12 |
Not clear |
| Prudence M Stanford, William S Brooks, Erdahl T Teber, Marianne Hallupp, Catriona McLean, Glenda M Halliday, Ralph N Martins, John B J Kwok, Peter R Schofiel. Frequency of tau mutations in familial and sporadic frontotemporal dementia and other tauopathies. Journal of neurology. vol 251. issue 9. 2004-12-13. PMID:15372253. |
although tauopathies have been considered to result from genetic defects, screening for tau gene mutations in sporadic cases is not likely to identify pathogenic mutations. |
2004-12-13 |
2023-08-12 |
Not clear |
| Feng Chen, Della David, Alessandra Ferrari, Jürgen Göt. Posttranslational modifications of tau--role in human tauopathies and modeling in transgenic animals. Current drug targets. vol 5. issue 6. 2004-10-14. PMID:15270197. |
posttranslational modifications of tau--role in human tauopathies and modeling in transgenic animals. |
2004-10-14 |
2023-08-12 |
mouse |
| Feng Chen, Della David, Alessandra Ferrari, Jürgen Göt. Posttranslational modifications of tau--role in human tauopathies and modeling in transgenic animals. Current drug targets. vol 5. issue 6. 2004-10-14. PMID:15270197. |
tau pathology in the presence of scant or no beta-amyloid plaques characterizes additional neurodegenerative disorders collectively called tauopathies. |
2004-10-14 |
2023-08-12 |
mouse |
| Feng Chen, Della David, Alessandra Ferrari, Jürgen Göt. Posttranslational modifications of tau--role in human tauopathies and modeling in transgenic animals. Current drug targets. vol 5. issue 6. 2004-10-14. PMID:15270197. |
this review aims to provide insight into the complexity of tau modifications in human tauopathies such as ad and frontotemporal dementia with parkinsonism linked to chromosome 17 (ftdp-17). |
2004-10-14 |
2023-08-12 |
mouse |
| Hirotaka Yoshida, C James Hastie, Hilary McLauchlan, Philip Cohen, Michel Goeder. Phosphorylation of microtubule-associated protein tau by isoforms of c-Jun N-terminal kinase (JNK). Journal of neurochemistry. vol 90. issue 2. 2004-09-03. PMID:15228592. |
microtubule-associated protein tau in a hyperphosphorylated state is the major component of the filamentous lesions that define a number of neurodegenerative diseases commonly referred to as tauopathies. |
2004-09-03 |
2023-08-12 |
Not clear |
| Fei Liu, Khalid Iqbal, Inge Grundke-Iqbal, Gerald W Hart, Cheng-Xin Gon. O-GlcNAcylation regulates phosphorylation of tau: a mechanism involved in Alzheimer's disease. Proceedings of the National Academy of Sciences of the United States of America. vol 101. issue 29. 2004-08-26. PMID:15249677. |
microtubule-associated protein tau is abnormally hyperphosphorylated and aggregated into neurofibrillary tangles in brains of individuals with alzheimer's disease (ad) and other tauopathies. |
2004-08-26 |
2023-08-12 |
mouse |
| Fei Liu, Khalid Iqbal, Inge Grundke-Iqbal, Gerald W Hart, Cheng-Xin Gon. O-GlcNAcylation regulates phosphorylation of tau: a mechanism involved in Alzheimer's disease. Proceedings of the National Academy of Sciences of the United States of America. vol 101. issue 29. 2004-08-26. PMID:15249677. |
these results reveal a mechanism of regulation of tau phosphorylation and suggest that abnormal hyperphosphorylation of tau could result from decreased tau o-glcnacylation, which probably is induced by deficient brain glucose uptake/metabolism in ad and other tauopathies. |
2004-08-26 |
2023-08-12 |
mouse |
| Bin Zhang, Makoto Higuchi, Yasumasa Yoshiyama, Takeshi Ishihara, Mark S Forman, Dan Martinez, Sonali Joyce, John Q Trojanowski, Virginia M-Y Le. Retarded axonal transport of R406W mutant tau in transgenic mice with a neurodegenerative tauopathy. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 24. issue 19. 2004-08-13. PMID:15140937. |
intracellular accumulations of filamentous tau inclusions are neuropathological hallmarks of neurodegenerative diseases known as tauopathies. |
2004-08-13 |
2023-08-12 |
mouse |
| Bin Zhang, Makoto Higuchi, Yasumasa Yoshiyama, Takeshi Ishihara, Mark S Forman, Dan Martinez, Sonali Joyce, John Q Trojanowski, Virginia M-Y Le. Retarded axonal transport of R406W mutant tau in transgenic mice with a neurodegenerative tauopathy. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 24. issue 19. 2004-08-13. PMID:15140937. |
to examine the effects of tau gene mutations and the role of tau abnormalities in neurodegenerative tauopathies, transgenic (tg) mice were engineered to express the longest human tau isoform (t40) with or without the r406w mutation (rw and hwt tg mice, respectively) that is pathogenic for ftdp-17 in several kindreds. |
2004-08-13 |
2023-08-12 |
mouse |
| Qingming Yu, Jun Guo, Jianhua Zho. A minimal length between tau exon 10 and 11 is required for correct splicing of exon 10. Journal of neurochemistry. vol 90. issue 1. 2004-08-06. PMID:15198676. |
mutations that stimulate exon 10 inclusion into the human tau mrna cause frontotemporal dementia with parkinsonism, associated with chromosome 17 (ftdp-17), and other tauopathies. |
2004-08-06 |
2023-08-12 |
human |
| Qingming Yu, Jun Guo, Jianhua Zho. A minimal length between tau exon 10 and 11 is required for correct splicing of exon 10. Journal of neurochemistry. vol 90. issue 1. 2004-08-06. PMID:15198676. |
to investigate the underlying splicing mechanism and identify potential therapeutic targets for tauopathies, we generated a series of mini-gene constructs with intron deletions from the full length of tau exons 9-11 mini-gene construct. |
2004-08-06 |
2023-08-12 |
human |
| Alberto Gómez-Ramos, Xabier Abad, Mónica López Fanarraga, Ratan Bhat, Juan Carlos Zabala, Jesús Avil. Expression of an altered form of tau in Sf9 insect cells results in the assembly of polymers resembling Alzheimer's paired helical filaments. Brain research. vol 1007. issue 1-2. 2004-07-19. PMID:15064135. |
tau is the main component of the paired helical filaments (phfs), aberrant structures that develop in the brain of alzheimer's disease (ad) patients and other tauopathies like frontotemporal dementia and parkinsonism associated to chromosome 17 (ftdp-17). |
2004-07-19 |
2023-08-12 |
Not clear |
| G Pezzoli, M Canesi, C Gall. An overview of parkinsonian syndromes: data from the literature and from an Italian data-base. Sleep medicine. vol 5. issue 2. 2004-07-02. PMID:15033141. |
recent molecular biology research on neurodegenerative diseases, including parkinsonisms, has identified mutations in the genes that code for the proteins alpha-synuclein and tau, which have been used to classify them into synucleinopathies and tauopathies. |
2004-07-02 |
2023-08-12 |
Not clear |
| Eduardo Tolosa, Daniela Calandrella, Marisol Gallard. Caribbean parkinsonism and other atypical parkinsonian disorders. Parkinsonism & related disorders. vol 10 Suppl 1. 2004-06-29. PMID:15109583. |
in this review we provide an update in etiology, neuropathology, diagnosis and treatment of atypical parkinsonian disorders associated with protein tau deposit, also known as tauopathies. |
2004-06-29 |
2023-08-12 |
Not clear |
| Victoria Zhukareva, John Q Trojanowski, Virginia M-Y Le. Assessment of pathological tau proteins in frontotemporal dementias: qualitative and quantitative approaches. The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry. vol 12. issue 2. 2004-06-18. PMID:15010343. |
a large group of clinically and neuropathologically heterogeneous frontotemporal dementias (ftds) is distinguished by the accumulation of filamentous tau proteins in neuronal and non-neuronal cells, and these disorders are collectively designated as tauopathies. |
2004-06-18 |
2023-08-12 |
Not clear |
| Victoria Zhukareva, John Q Trojanowski, Virginia M-Y Le. Assessment of pathological tau proteins in frontotemporal dementias: qualitative and quantitative approaches. The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry. vol 12. issue 2. 2004-06-18. PMID:15010343. |
recent advances in the development of new reagents and the utilization of new multidisciplinary approaches have made substantial progress in the extensive characterization of tau proteins in different tauopathies. |
2004-06-18 |
2023-08-12 |
Not clear |
| Victoria Zhukareva, John Q Trojanowski, Virginia M-Y Le. Assessment of pathological tau proteins in frontotemporal dementias: qualitative and quantitative approaches. The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry. vol 12. issue 2. 2004-06-18. PMID:15010343. |
in this review, the authors summarize recent findings of the unique biochemical tau signatures for a number of specific tauopathies. |
2004-06-18 |
2023-08-12 |
Not clear |