| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jesús Avil. Tau phosphorylation and aggregation in Alzheimer's disease pathology. FEBS letters. vol 580. issue 12. 2006-07-27. PMID:16529745. |
tau is present in phosphorylated and aggregated form not only in ad, but in other pathologies (tauopathies). |
2006-07-27 |
2023-08-12 |
Not clear |
| Alejandra del C Alonso, Bin Li, Inge Grundke-Iqbal, Khalid Iqba. Polymerization of hyperphosphorylated tau into filaments eliminates its inhibitory activity. Proceedings of the National Academy of Sciences of the United States of America. vol 103. issue 23. 2006-07-19. PMID:16735465. |
accumulation of abnormally hyperphosphorylated tau (p-tau) in the form of tangles of paired helical filaments and/or straight filaments is one of the hallmarks of alzheimer's disease (ad) and other tauopathies. |
2006-07-19 |
2023-08-12 |
Not clear |
| Neelam Shahani, Srinivasa Subramaniam, Tobias Wolf, Christian Tackenberg, Roland Brand. Tau aggregation and progressive neuronal degeneration in the absence of changes in spine density and morphology after targeted expression of Alzheimer's disease-relevant tau constructs in organotypic hippocampal slices. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 26. issue 22. 2006-06-23. PMID:16738255. |
tau mutations in familial tauopathies confirmed a central role of tau pathology; however, the role of tau alteration and the sequence of tau-dependent neurodegeneration in ad remain elusive. |
2006-06-23 |
2023-08-12 |
Not clear |
| Giuseppina Amadoro, Maria Teresa Ciotti, Marco Costanzi, Vincenzo Cestari, Pietro Calissano, Nadia Can. NMDA receptor mediates tau-induced neurotoxicity by calpain and ERK/MAPK activation. Proceedings of the National Academy of Sciences of the United States of America. vol 103. issue 8. 2006-06-13. PMID:16477009. |
the altered function and/or structure of tau protein is postulated to cause cell death in tauopathies and alzheimer's disease. |
2006-06-13 |
2023-08-12 |
human |
| Giuseppina Amadoro, Maria Teresa Ciotti, Marco Costanzi, Vincenzo Cestari, Pietro Calissano, Nadia Can. NMDA receptor mediates tau-induced neurotoxicity by calpain and ERK/MAPK activation. Proceedings of the National Academy of Sciences of the United States of America. vol 103. issue 8. 2006-06-13. PMID:16477009. |
our findings unravel a cellular mechanism linking tau toxicity to nmdar activation and might be relevant to alzheimer's disease and tauopathies where nmdar-mediated toxicity is postulated to play a pivotal role. |
2006-06-13 |
2023-08-12 |
human |
| G Santpere, M Nieto, B Puig, I Ferre. Abnormal Sp1 transcription factor expression in Alzheimer disease and tauopathies. Neuroscience letters. vol 397. issue 1-2. 2006-05-25. PMID:16378688. |
since sp1 binding sites are present in the promoters of several genes involved in amyloid and tau, and sp1 is regulated by oxidative stress, the present findings suggest that sp1 deposition in hyper-phosphorylated tau deposits may have functional consequences in the pathology of ad and other tauopathies. |
2006-05-25 |
2023-08-12 |
Not clear |
| Yoshitaka Tatebayashi, Emmanuel Planel, De-Hua Chui, Shinji Sato, Tomohiro Miyasaka, Naruhiko Sahara, Miyuki Murayama, Naomi Kikuchi, Katsuji Yoshioka, Ravid Rivka, Akihiko Takashim. c-jun N-terminal kinase hyperphosphorylates R406W tau at the PHF-1 site during mitosis. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 20. issue 6. 2006-05-08. PMID:16478768. |
tauopathies such as alzheimer disease (ad) probably involve a type of phosphorylation imbalance causing the accumulation of abnormally hyperphosphorylated tau in neurons and/or glias. |
2006-05-08 |
2023-08-12 |
Not clear |
| Hanae Nakashima, Takeshi Ishihara, Pilar Suguimoto, Osamu Yokota, Etsuko Oshima, Aki Kugo, Seishi Terada, Takashi Hamamura, John Q Trojanowski, Virginia M-Y Lee, Shigetoshi Kurod. Chronic lithium treatment decreases tau lesions by promoting ubiquitination in a mouse model of tauopathies. Acta neuropathologica. vol 110. issue 6. 2006-05-05. PMID:16228182. |
chronic lithium treatment decreases tau lesions by promoting ubiquitination in a mouse model of tauopathies. |
2006-05-05 |
2023-08-12 |
mouse |
| Hanae Nakashima, Takeshi Ishihara, Pilar Suguimoto, Osamu Yokota, Etsuko Oshima, Aki Kugo, Seishi Terada, Takashi Hamamura, John Q Trojanowski, Virginia M-Y Lee, Shigetoshi Kurod. Chronic lithium treatment decreases tau lesions by promoting ubiquitination in a mouse model of tauopathies. Acta neuropathologica. vol 110. issue 6. 2006-05-05. PMID:16228182. |
thus, lithium could have therapeutic benefit in neurodegenerative tauopathies by reducing tau hyperphosphorylation. |
2006-05-05 |
2023-08-12 |
mouse |
| Andre Delacourt. Tauopathies: recent insights into old diseases. Folia neuropathologica. vol 43. issue 4. 2006-04-21. PMID:16416389. |
most of them have a specific defect on tau (mutation, aberrant splicing, abnormal phosphorylation, abnormal processing, neuronal or genotypic vulnerability), suggesting that, in fact, the etiology of most tauopathies is directly linked to tau dysfunction. |
2006-04-21 |
2023-08-12 |
human |
| Patrice Delobel, Isabelle Lavenir, Bernardino Ghetti, Max Holzer, Michel Goeder. Cell-cycle markers in a transgenic mouse model of human tauopathy: increased levels of cyclin-dependent kinase inhibitors p21Cip1 and p27Kip1. The American journal of pathology. vol 168. issue 3. 2006-04-19. PMID:16507903. |
recent evidence has suggested that an abnormal reactivation of the cell cycle may precede and cause the hyperphosphorylation and filament formation of tau protein in alzheimer's disease and other tauopathies. |
2006-04-19 |
2023-08-12 |
mouse |
| Patrice Delobel, Isabelle Lavenir, Bernardino Ghetti, Max Holzer, Michel Goeder. Cell-cycle markers in a transgenic mouse model of human tauopathy: increased levels of cyclin-dependent kinase inhibitors p21Cip1 and p27Kip1. The American journal of pathology. vol 168. issue 3. 2006-04-19. PMID:16507903. |
this mouse line recapitulates the essential molecular and cellular features of the human tauopathies, including hyperphosphorylation and filament formation of tau protein. |
2006-04-19 |
2023-08-12 |
mouse |
| Karin Boekhoorn, Dick Terwel, Barbara Biemans, Peter Borghgraef, Olof Wiegert, Ger J A Ramakers, Koos de Vos, Harm Krugers, Takami Tomiyama, Hiroshi Mori, Marian Joels, Fred van Leuven, Paul J Lucasse. Improved long-term potentiation and memory in young tau-P301L transgenic mice before onset of hyperphosphorylation and tauopathy. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 26. issue 13. 2006-04-18. PMID:16571759. |
the microtubule binding protein tau is implicated in neurodegenerative tauopathies, including frontotemporal dementia (ftd) with parkinsonism caused by diverse mutations in the tau gene. |
2006-04-18 |
2023-08-12 |
mouse |
| Karin Boekhoorn, Dick Terwel, Barbara Biemans, Peter Borghgraef, Olof Wiegert, Ger J A Ramakers, Koos de Vos, Harm Krugers, Takami Tomiyama, Hiroshi Mori, Marian Joels, Fred van Leuven, Paul J Lucasse. Improved long-term potentiation and memory in young tau-P301L transgenic mice before onset of hyperphosphorylation and tauopathy. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 26. issue 13. 2006-04-18. PMID:16571759. |
we conclude that protein tau plays an important beneficial role in normal neuronal processes of hippocampal memory, and conversely, that not tau mutations per se, but the ensuing hyperphosphorylation must be critical for cognitive decline in tauopathies. |
2006-04-18 |
2023-08-12 |
mouse |
| Daniela C Glatz, Dan Rujescu, Yesheng Tang, Frank J Berendt, Annette M Hartmann, Frank Faltraco, Carlyn Rosenberg, Christine Hulette, Kurt Jellinger, Harald Hampel, Peter Riederer, Hans-J Möller, Athena Andreadis, Kerstin Henkel, Stefan Stam. The alternative splicing of tau exon 10 and its regulatory proteins CLK2 and TRA2-BETA1 changes in sporadic Alzheimer's disease. Journal of neurochemistry. vol 96. issue 3. 2006-03-30. PMID:16371011. |
pathological inclusions containing fibrillar aggregates of hyperphosphorylated tau protein are a characteristic feature in tauopathies, which include alzheimer's disease (ad). |
2006-03-30 |
2023-08-12 |
human |
| Yi Wen, Shaohua Yang, Ran Liu, James W Simpkin. Transient cerebral ischemia induces site-specific hyperphosphorylation of tau protein. Brain research. vol 1022. issue 1-2. 2006-03-23. PMID:15353210. |
the hyperphosphorylated tau presents a conformation similar to those present in human tauopathies, and colocalizes largely with signs of apoptosis. |
2006-03-23 |
2023-08-12 |
human |
| Deepa V Dabir, Michael B Robinson, Eric Swanson, Bin Zhang, John Q Trojanowski, Virginia M-Y Lee, Mark S Forma. Impaired glutamate transport in a mouse model of tau pathology in astrocytes. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 26. issue 2. 2006-03-17. PMID:16407562. |
filamentous tau inclusions in neurons and glia are neuropathological hallmarks of tauopathies. |
2006-03-17 |
2023-08-12 |
mouse |
| Deepa V Dabir, Michael B Robinson, Eric Swanson, Bin Zhang, John Q Trojanowski, Virginia M-Y Lee, Mark S Forma. Impaired glutamate transport in a mouse model of tau pathology in astrocytes. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 26. issue 2. 2006-03-17. PMID:16407562. |
both wild-type and ftdp-17 mutant gfap/tau tg animals manifest an age-dependent accumulation of tau inclusions in astrocytes that resembles the pathology observed in human tauopathies. |
2006-03-17 |
2023-08-12 |
mouse |
| Makoto Higuchi, Bin Zhang, Mark S Forman, Yasumasa Yoshiyama, John Q Trojanowski, Virginia M-Y Le. Axonal degeneration induced by targeted expression of mutant human tau in oligodendrocytes of transgenic mice that model glial tauopathies. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 25. issue 41. 2006-03-13. PMID:16221853. |
axonal degeneration induced by targeted expression of mutant human tau in oligodendrocytes of transgenic mice that model glial tauopathies. |
2006-03-13 |
2023-08-12 |
mouse |
| Makoto Higuchi, Bin Zhang, Mark S Forman, Yasumasa Yoshiyama, John Q Trojanowski, Virginia M-Y Le. Axonal degeneration induced by targeted expression of mutant human tau in oligodendrocytes of transgenic mice that model glial tauopathies. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 25. issue 41. 2006-03-13. PMID:16221853. |
abundant filamentous tau inclusions in oligodendrocytes (olgs) are hallmarks of neurodegenerative tauopathies, including sporadic corticobasal degeneration and hereditary frontotemporal dementia with parkinsonism linked to chromosome 17 (ftdp-17). |
2006-03-13 |
2023-08-12 |
mouse |