| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| John Q Trojanowski, Virginia M Y Le. The role of tau in Alzheimer's disease. The Medical clinics of North America. vol 86. issue 3. 2002-08-22. PMID:12168561. |
moreover, development of additional animal models of tauopathies that more closely recapitulate human diseases will facilitate this undertaking, and this is likely to have implications for other neurodegenerative disorders since the aggregation of tau in ad and and related tauopathies is an example of abnormal protein-protein interactions resulting in the intracellular accumulation of filamentous proteins that is a common feature of many fatal cns diseases characterized by relentlessly progressive brain degeneration [1-3]. |
2002-08-22 |
2023-08-12 |
human |
| John Q Trojanowski, Takeshi Ishihara, Makoto Higuchi, Yasumasa Yoshiyama, Ming Hong, Bin Zhang, Mark S Forman, Victoria Zhukareva, Virginia M-Y Le. Amyotrophic lateral sclerosis/parkinsonism dementia complex: transgenic mice provide insights into mechanisms underlying a common tauopathy in an ethnic minority on Guam. Experimental neurology. vol 176. issue 1. 2002-08-16. PMID:12093078. |
intracytoplasmic filamentous tau inclusions are neuropathological hallmarks of amyotrophic lateral sclerosis/parkinsonism-dementia complex (als/pdc) of guam and the defining lesions of other neurodegenerative disorders known as tauopathies. |
2002-08-16 |
2023-08-12 |
mouse |
| John Q Trojanowski, Takeshi Ishihara, Makoto Higuchi, Yasumasa Yoshiyama, Ming Hong, Bin Zhang, Mark S Forman, Victoria Zhukareva, Virginia M-Y Le. Amyotrophic lateral sclerosis/parkinsonism dementia complex: transgenic mice provide insights into mechanisms underlying a common tauopathy in an ethnic minority on Guam. Experimental neurology. vol 176. issue 1. 2002-08-16. PMID:12093078. |
thus, tau tg mice recapitulate key phenotypic features of als/pdc neuropathology in an ethnic minority on guam, and these animal models provide new opportunities to discover novel therapies for this and related tauopathies. |
2002-08-16 |
2023-08-12 |
mouse |
| Mar P\\xc3\\xa9rez, F\\xc3\\xa9lix Hern\\xc3\\xa1ndez, Alberto G\\xc3\\xb3mez-Ramos, Mark Smith, George Perry, Jes\\xc3\\xbas Avil. Formation of aberrant phosphotau fibrillar polymers in neural cultured cells. European journal of biochemistry. vol 269. issue 5. 2002-07-19. PMID:11874463. |
the formation of such aberrant aggregates, similar to those occurring in vivo in alzheimer's disease and other tauopathies, requires okadaic acid, a phosphatase inhibitor, to increase the level of phosphorylated tau, and hydroxynonenal, a product of oxidative stress that selectively adducts and modifies phosphorylated tau. |
2002-07-19 |
2023-08-12 |
human |
| Takashi Togo, Naruhiko Sahara, Shu-Hui Yen, Natalie Cookson, Takashi Ishizawa, Mike Hutton, Rohan de Silva, Andrew Lees, Dennis W Dickso. Argyrophilic grain disease is a sporadic 4-repeat tauopathy. Journal of neuropathology and experimental neurology. vol 61. issue 6. 2002-07-08. PMID:12071638. |
the frequency of the extended tau haplotype was not different in agd compared to other sporadic 4r tauopathies, progressive supranuclear palsy (psp) and corticobasal degeneration (cbd). |
2002-07-08 |
2023-08-12 |
Not clear |
| Val\\xc3\\xa9rie Bu\\xc3\\xa9e-Scherrer, Michel Goeder. Phosphorylation of microtubule-associated protein tau by stress-activated protein kinases in intact cells. FEBS letters. vol 515. issue 1-3. 2002-05-10. PMID:11943212. |
tau is a microtubule-associated protein that is abnormally hyperphosphorylated in the filamentous lesions that define a number of neurodegenerative diseases collectively referred to as tauopathies. |
2002-05-10 |
2023-08-12 |
Not clear |
| Val\\xc3\\xa9rie Bu\\xc3\\xa9e-Scherrer, Michel Goeder. Phosphorylation of microtubule-associated protein tau by stress-activated protein kinases in intact cells. FEBS letters. vol 515. issue 1-3. 2002-05-10. PMID:11943212. |
these findings indicate that the aberrant activation of sap kinases, especially sapk3/p38gamma and sapk4/p38delta, could play an important role in the abnormal hyperphosphorylation of tau that is an invariant feature of the tauopathies. |
2002-05-10 |
2023-08-12 |
Not clear |
| Janet Hoenicka, Montserrat Arrasate, Justo Garcia de Yebenes, Jes\\xc3\\xbas Avil. A two-hybrid screening of human Tau protein: interactions with Alu-derived domain. Neuroreport. vol 13. issue 3. 2002-05-02. PMID:11930135. |
the microtubule associated protein tau has been implicated in several neurodegenerative diseases, grouped as tauopathies. |
2002-05-02 |
2023-08-12 |
human |
| Janet Hoenicka, Montserrat Arrasate, Justo Garcia de Yebenes, Jes\\xc3\\xbas Avil. A two-hybrid screening of human Tau protein: interactions with Alu-derived domain. Neuroreport. vol 13. issue 3. 2002-05-02. PMID:11930135. |
the possible interaction of these proteins with tau could play a role in its cellular localization, regulate the amount of phosphorylated tau and also be involved in the pathological processes of tauopathies. |
2002-05-02 |
2023-08-12 |
human |
| Petri Mattila, Takashi Togo, Dennis W Dickso. The subthalamic nucleus has neurofibrillary tangles in argyrophilic grain disease and advanced Alzheimer's disease. Neuroscience letters. vol 320. issue 1-2. 2002-04-18. PMID:11849769. |
neurofibrillary tangles (nft) are present in the subthalamic nucleus (stn) of progressive supranuclear palsy and corticobasal degeneration, two sporadic tauopathies with preferential accumulation of tau with four repeats in the microtubule binding domain (4r tau). |
2002-04-18 |
2023-08-12 |
Not clear |
| Y Yoshiyama, V M Lee, J Q Trojanowsk. Frontotemporal dementia and tauopathy. Current neurology and neuroscience reports. vol 1. issue 5. 2002-04-09. PMID:11898551. |
the presence of abundant neurofibrillary lesions made of hyperphosphorylated tau proteins is the characteristic neuropathology of a subset of neurodegenerative disorders classified as "tauopathies." |
2002-04-09 |
2023-08-12 |
mouse |
| Y Yoshiyama, V M Lee, J Q Trojanowsk. Frontotemporal dementia and tauopathy. Current neurology and neuroscience reports. vol 1. issue 5. 2002-04-09. PMID:11898551. |
although transgenic mice expressing wild-type human tau or variants thereof with an ftdp-17 mutation result in tau pathologies and brain degeneration similar to that seen in human tauopathies, the precise mechanisms leading to the onset and progression of neurodegenerative disorders remain incompletely understood. |
2002-04-09 |
2023-08-12 |
mouse |
| T G Mack, R Dayanandan, M Van Slegtenhorst, A Whone, M Hutton, S Lovestone, B H Anderto. Tau proteins with frontotemporal dementia-17 mutations have both altered expression levels and phosphorylation profiles in differentiated neuroblastoma cells. Neuroscience. vol 108. issue 4. 2002-03-14. PMID:11738505. |
pathologically, affected ftdp-17 brains share tau aggregates with other tauopathies, the most common being alzheimer's disease. |
2002-03-14 |
2023-08-12 |
Not clear |
| I Ferrer, R Blanco, M Carmona, B Pui. Phosphorylated mitogen-activated protein kinase (MAPK/ERK-P), protein kinase of 38 kDa (p38-P), stress-activated protein kinase (SAPK/JNK-P), and calcium/calmodulin-dependent kinase II (CaM kinase II) are differentially expressed in tau deposits in neurons and glial cells in tauopathies. Journal of neural transmission (Vienna, Austria : 1996). vol 108. issue 12. 2002-03-07. PMID:11810404. |
phosphorylated mitogen-activated protein kinase (mapk/erk-p), protein kinase of 38 kda (p38-p), stress-activated protein kinase (sapk/jnk-p), and calcium/calmodulin-dependent kinase ii (cam kinase ii) are differentially expressed in tau deposits in neurons and glial cells in tauopathies. |
2002-03-07 |
2023-08-12 |
Not clear |
| I Ferrer, R Blanco, M Carmona, B Pui. Phosphorylated mitogen-activated protein kinase (MAPK/ERK-P), protein kinase of 38 kDa (p38-P), stress-activated protein kinase (SAPK/JNK-P), and calcium/calmodulin-dependent kinase II (CaM kinase II) are differentially expressed in tau deposits in neurons and glial cells in tauopathies. Journal of neural transmission (Vienna, Austria : 1996). vol 108. issue 12. 2002-03-07. PMID:11810404. |
the study was carried out to increase understanding of the signals that may regulate tau phosphorylation in tauopathies. |
2002-03-07 |
2023-08-12 |
Not clear |
| I Ferrer, R Blanco, M Carmona, B Pui. Phosphorylated mitogen-activated protein kinase (MAPK/ERK-P), protein kinase of 38 kDa (p38-P), stress-activated protein kinase (SAPK/JNK-P), and calcium/calmodulin-dependent kinase II (CaM kinase II) are differentially expressed in tau deposits in neurons and glial cells in tauopathies. Journal of neural transmission (Vienna, Austria : 1996). vol 108. issue 12. 2002-03-07. PMID:11810404. |
single and double-labeling immunohistochemistry to mapk/erk-p and p38-p disclosed that mapk/erk-p appeared at early stages of tau phosphorylation in neurons and glial cells in tauopathies, and that mapk/erk-p and p38-p co-localize only in a subset of neurons and glial cells with phosphorylated tau deposits. |
2002-03-07 |
2023-08-12 |
Not clear |
| I Ferrer, R Blanco, M Carmona, B Pui. Phosphorylated mitogen-activated protein kinase (MAPK/ERK-P), protein kinase of 38 kDa (p38-P), stress-activated protein kinase (SAPK/JNK-P), and calcium/calmodulin-dependent kinase II (CaM kinase II) are differentially expressed in tau deposits in neurons and glial cells in tauopathies. Journal of neural transmission (Vienna, Austria : 1996). vol 108. issue 12. 2002-03-07. PMID:11810404. |
these findings indicate that mapk/erk-p, sapk/jnk-p and p-38-p are differentially expressed in association with tau deposits in tauopathies. |
2002-03-07 |
2023-08-12 |
Not clear |
| I Ferrer, R Blanco, M Carmona, B Pui. Phosphorylated mitogen-activated protein kinase (MAPK/ERK-P), protein kinase of 38 kDa (p38-P), stress-activated protein kinase (SAPK/JNK-P), and calcium/calmodulin-dependent kinase II (CaM kinase II) are differentially expressed in tau deposits in neurons and glial cells in tauopathies. Journal of neural transmission (Vienna, Austria : 1996). vol 108. issue 12. 2002-03-07. PMID:11810404. |
these observations, together with previous results of in vitro studies, support the idea that several mapk/erk, sapk/jnk, p38 and cam kinase ii may participate in tau phosphorylation in tauopathies. |
2002-03-07 |
2023-08-12 |
Not clear |
| G Heidary, M E Fortin. Identification and characterization of the Drosophila tau homolog. Mechanisms of development. vol 108. issue 1-2. 2002-03-05. PMID:11578871. |
to elucidate the mechanisms by which tau dysfunction contributes to neuronal loss, we have sought to model human tauopathies in a genetically tractable organism. |
2002-03-05 |
2023-08-12 |
human |
| F Lim, F Hern\\xc3\\xa1ndez, J J Lucas, P G\\xc3\\xb3mez-Ramos, M A Mor\\xc3\\xa1n, J Avil. FTDP-17 mutations in tau transgenic mice provoke lysosomal abnormalities and Tau filaments in forebrain. Molecular and cellular neurosciences. vol 18. issue 6. 2002-02-21. PMID:11749044. |
the tauopathies, which include alzheimer's disease (ad) and frontotemporal dementias, are a group of neurodegenerative disorders characterized by filamentous tau aggregates. |
2002-02-21 |
2023-08-12 |
mouse |