| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| L A Reed, Z K Wszolek, M Hutto. Phenotypic correlations in FTDP-17. Neurobiology of aging. vol 22. issue 1. 2001-05-31. PMID:11164280. |
in contrast, mutations that affect the alternatively spliced exon 10 or its 5' splice regulatory region alter the ratio of the tau isoforms incorporated into the tangles and result in filamentous inclusions resembling those seen in the primary tauopathies, such as progressive supranuclear palsy, corticobasal degeneration, and pick's disease. |
2001-05-31 |
2023-08-12 |
Not clear |
| M S Forman, V M Lee, J Q Trojanowsk. New insights into genetic and molecular mechanisms of brain degeneration in tauopathies. Journal of chemical neuroanatomy. vol 20. issue 3-4. 2001-05-24. PMID:11207421. |
the discovery of multiple tau gene mutations that are pathogenic for hereditary frontotemporal dementia and parkinsonism linked to chromosome 17 in many kindreds, as well as the demonstration that tau polymorphisms are genetic risk factors for sporadic tauopathies, directly implicate tau abnormalities in the onset/progression of neurodegenerative disease. |
2001-05-24 |
2023-08-12 |
Not clear |
| M S Forman, V M Lee, J Q Trojanowsk. New insights into genetic and molecular mechanisms of brain degeneration in tauopathies. Journal of chemical neuroanatomy. vol 20. issue 3-4. 2001-05-24. PMID:11207421. |
however, since specific polymorphisms and mutations in the tau gene lead to diverse phenotypes, it is plausible that additional genetic or epigenetic factors influence the clinical and pathological manifestations of both familial and sporadic tauopathies. |
2001-05-24 |
2023-08-12 |
Not clear |
| M Tolnay, A Probs. Frontotemporal lobar degeneration. An update on clinical, pathological and genetic findings. Gerontology. vol 47. issue 1. 2001-05-21. PMID:11244285. |
these findings had a major impact on our understanding of neurodegenerative disorders characterized by tau filamentous inclusions in neurones and/or glial cells which are grouped under the generic term of tauopathies. |
2001-05-21 |
2023-08-12 |
Not clear |
| S F Fabre, C Forsell, M Viitanen, M Sjögren, A Wallin, K Blennow, M Blomberg, C Andersen, L O Wahlund, L Lannfel. Clinic-based cases with frontotemporal dementia show increased cerebrospinal fluid tau and high apolipoprotein E epsilon4 frequency, but no tau gene mutations. Experimental neurology. vol 168. issue 2. 2001-05-10. PMID:11259129. |
frontotemporal dementia (ftd) belongs to a group of neurodegenerative disorders known as tauopathies, characterized by intracellular aggregation of hyperphosphorylated tau protein in the brain. |
2001-05-10 |
2023-08-12 |
Not clear |
| S F Fabre, C Forsell, M Viitanen, M Sjögren, A Wallin, K Blennow, M Blomberg, C Andersen, L O Wahlund, L Lannfel. Clinic-based cases with frontotemporal dementia show increased cerebrospinal fluid tau and high apolipoprotein E epsilon4 frequency, but no tau gene mutations. Experimental neurology. vol 168. issue 2. 2001-05-10. PMID:11259129. |
some tauopathies, like alzheimer's disease (ad), consistently show increased levels of tau protein in cerebrospinal fluid (csf). |
2001-05-10 |
2023-08-12 |
Not clear |
| S F Fabre, C Forsell, M Viitanen, M Sjögren, A Wallin, K Blennow, M Blomberg, C Andersen, L O Wahlund, L Lannfel. Clinic-based cases with frontotemporal dementia show increased cerebrospinal fluid tau and high apolipoprotein E epsilon4 frequency, but no tau gene mutations. Experimental neurology. vol 168. issue 2. 2001-05-10. PMID:11259129. |
these findings support the present notion of a common pathogenic pathway in the disease processes for several tauopathies, with both apoe epsilon4 and csf tau being a pathological link between the different disorders. |
2001-05-10 |
2023-08-12 |
Not clear |
| C Russ, S Lovestone, M Baker, S M Pickering-Brown, P M Andersen, R Furlong, D Mann, J F Powel. The extended haplotype of the microtubule associated protein tau gene is not associated with Pick's disease. Neuroscience letters. vol 299. issue 1-2. 2001-05-03. PMID:11166961. |
pick's disease (pid) is a rare neurodegenerative condition and is a member of a heterogeneous group of disorders known as tauopathies, so-called because of the predominantly neuronal aberrant tau accumulations found in these diseases. |
2001-05-03 |
2023-08-12 |
Not clear |
| A C Ludolph, A Sperfeld, B M Collatz, A Storc. [Tauopathies--a new class of neurodegenerative diseases]. Der Nervenarzt. vol 72. issue 2. 2001-05-03. PMID:11256158. |
the discovery of mutations in the tau gene causing a distinct neurodegenerative disease in humans has firmly established the importance of the tau gene for neurodegenerative processes, not only in tauopathies but also in other degenerative disorders with tau pathology, such as corticobasal degeneration, supranuclear progressive paralysis, amyotropic lateral sclerosis, parkinsonism-dementia complex of guam, and alzheimer's disease. |
2001-05-03 |
2023-08-12 |
Not clear |
| E W Nagiec, K E Sampson, I Abraha. Mutated tau binds less avidly to microtubules than wildtype tau in living cells. Journal of neuroscience research. vol 63. issue 3. 2001-04-26. PMID:11170176. |
because the mutations (v337m, p301l) are associated with genetic tauopathies, these results suggest that a factor in disease etiology of genetic tauopathies and other dementias with altered tau is a greater abundance of tau in the cytoplasm due to decreased binding to microtubules. |
2001-04-26 |
2023-08-12 |
human |
| E H Bigio, A M Lipton, S H Yen, M L Hutton, M Baker, P Nacharaju, C L White, P Davies, W Lin, D W Dickso. Frontal lobe dementia with novel tauopathy: sporadic multiple system tauopathy with dementia. Journal of neuropathology and experimental neurology. vol 60. issue 4. 2001-04-19. PMID:11305868. |
the unique cortical tau pathology in this case of sporadic multiple system tauopathy with dementia adds a new pathologic profile to the spectrum of tauopathies. |
2001-04-19 |
2023-08-12 |
Not clear |
| T Ishihara, B Zhang, M Higuchi, Y Yoshiyama, J Q Trojanowski, V M Le. Age-dependent induction of congophilic neurofibrillary tau inclusions in tau transgenic mice. The American journal of pathology. vol 158. issue 2. 2001-04-05. PMID:11159192. |
intraneuronal filamentous tau inclusions such as neurofibrillary tangles (nfts) are neuropathological hallmarks of alzheimer's disease (ad) and related sporadic and familial tauopathies. |
2001-04-05 |
2023-08-12 |
mouse |
| T Ishihara, B Zhang, M Higuchi, Y Yoshiyama, J Q Trojanowski, V M Le. Age-dependent induction of congophilic neurofibrillary tau inclusions in tau transgenic mice. The American journal of pathology. vol 158. issue 2. 2001-04-05. PMID:11159192. |
thus, overexpression of the smallest human brain tau isoform resulted in late onset and age-dependent formation of congophilic tau inclusions with properties similar to those in the tangles of human tauopathies, thereby implicating aging in the pathogenesis of fibrous tau inclusions. |
2001-04-05 |
2023-08-12 |
mouse |
| V Zhukareva, V Vogelsberg-Ragaglia, V M Van Deerlin, J Bruce, T Shuck, M Grossman, C M Clark, S E Arnold, E Masliah, D Galasko, J Q Trojanowski, V M Le. Loss of brain tau defines novel sporadic and familial tauopathies with frontotemporal dementia. Annals of neurology. vol 49. issue 2. 2001-03-29. PMID:11220736. |
loss of brain tau defines novel sporadic and familial tauopathies with frontotemporal dementia. |
2001-03-29 |
2023-08-12 |
Not clear |
| P Pastor, E Pastor, C Carnero, R Vela, T García, G Amer, E Tolosa, R Oliv. Familial atypical progressive supranuclear palsy associated with homozigosity for the delN296 mutation in the tau gene. Annals of neurology. vol 49. issue 2. 2001-03-29. PMID:11220749. |
this finding indicates that homozygous mutations in the tau gene may also cause hereditary tauopathies. |
2001-03-29 |
2023-08-12 |
Not clear |
| G F Hall, V M Lee, G Lee, J Ya. Staging of neurofibrillary degeneration caused by human tau overexpression in a unique cellular model of human tauopathy. The American journal of pathology. vol 158. issue 1. 2001-02-22. PMID:11141497. |
the hyperphosphorylation of human tau and its aggregation into neurofibrillary tangles are central pathogenic events in familial tauopathies and alzheimer's disease. |
2001-02-22 |
2023-08-12 |
human |
| C Mailliot, T Bussière, M Hamdane, N Sergeant, M L Caillet, A Delacourte, L Bué. Pathological tau phenotypes. The weight of mutations, polymorphisms, and differential neuronal vulnerabilities. Annals of the New York Academy of Sciences. vol 920. 2001-02-08. PMID:11193138. |
in tauopathies, comparative biochemistry of tau aggregates shows that they differ in both phosphorylation and content of tau isoforms. |
2001-02-08 |
2023-08-12 |
human |
| D Neary, J S Snowden, D M Man. Classification and description of frontotemporal dementias. Annals of the New York Academy of Sciences. vol 920. 2001-02-08. PMID:11193176. |
it has been suggested that these disorders should be regarded as tauopathies on the basis of the tau pathology seen in a number of cases and the mutations in the tau gene in some familial cases. |
2001-02-08 |
2023-08-12 |
Not clear |
| B Ghetti, J R Murrell, P Zolo, M G Spillantini, M Goeder. Progress in hereditary tauopathies: a mutation in the Tau gene (G389R) causes a Pick disease-like syndrome. Annals of the New York Academy of Sciences. vol 920. 2001-02-08. PMID:11193177. |
progress in hereditary tauopathies: a mutation in the tau gene (g389r) causes a pick disease-like syndrome. |
2001-02-08 |
2023-08-12 |
Not clear |
| K Spittaels, C Van den Haute, J Van Dorpe, H Geerts, M Mercken, K Bruynseels, R Lasrado, K Vandezande, I Laenen, T Boon, J Van Lint, J Vandenheede, D Moechars, R Loos, F Van Leuve. Glycogen synthase kinase-3beta phosphorylates protein tau and rescues the axonopathy in the central nervous system of human four-repeat tau transgenic mice. The Journal of biological chemistry. vol 275. issue 52. 2001-01-26. PMID:11007782. |
protein tau filaments in brain of patients suffering from alzheimer's disease, frontotemporal dementia, and other tauopathies consist of protein tau that is hyperphosphorylated. |
2001-01-26 |
2023-08-12 |
mouse |