| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Wei-Na Jin, Samuel Xiang-Yu Shi, Zhiguo Li, Minshu Li, Kristofer Wood, Rayna J Gonzales, Qiang Li. Depletion of microglia exacerbates postischemic inflammation and brain injury. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. vol 37. issue 6. 2017-08-11. PMID:28273719. |
although depletion of microglia has been linked to worse stroke outcomes, it remains unclear to what extent and by what mechanisms activated microglia influence ischemia-induced inflammation and injury in the brain. |
2017-08-11 |
2023-08-13 |
mouse |
| Rosana S Lopes, Marcelo M Cardoso, Arthur O Sampaio, Mario Santos Barbosa, Celice C Souza, Michelle C DA Silva, Elane Magno N Ferreira, Marco Aurelio M Freire, Rafael Rodrigues Lima, Walace Gomes-Lea. Indomethacin treatment reduces microglia activation and increases numbers of neuroblasts in the subventricular zone and ischaemic striatum after focal ischaemia. Journal of biosciences. vol 41. issue 3. 2017-03-15. PMID:27581930. |
our results suggest that indomethacin treatment modulates microglia activation, contributing to increased neuroblast proliferation in the svz and migration to the ischaemic striatum following stroke. |
2017-03-15 |
2023-08-13 |
rat |
| Le Li, Creed M Star. Targeting Glial Mitochondrial Function for Protection from Cerebral Ischemia: Relevance, Mechanisms, and the Role of MicroRNAs. Oxidative medicine and cellular longevity. vol 2016. 2017-03-13. PMID:27777645. |
astrocytes and microglia play crucial roles in the response to cerebral ischemia and are effective targets for stroke therapy in animal models. |
2017-03-13 |
2023-08-13 |
Not clear |
| Yanni Lv, Yisong Qian, Aijun Ou-Yang, Longsheng F. Hydroxysafflor Yellow A Attenuates Neuron Damage by Suppressing the Lipopolysaccharide-Induced TLR4 Pathway in Activated Microglial Cells. Cellular and molecular neurobiology. vol 36. issue 8. 2017-02-21. PMID:26754542. |
microglia activation initiates a neurological deficit cascade that contributes to substantial neuronal damage and impairment following ischemia stroke. |
2017-02-21 |
2023-08-13 |
Not clear |
| Ana-Maria Buga, Ovidiu Ciobanu, George Mihai Bădescu, Catalin Bogdan, Ria Weston, Mark Slevin, Mario Di Napoli, Aurel Popa-Wagne. Up-regulation of serotonin receptor 2B mRNA and protein in the peri-infarcted area of aged rats and stroke patients. Oncotarget. vol 7. issue 14. 2017-02-09. PMID:27013593. |
we hypothesize that htr2b expression in the infarcted territory may render degenerating neurons susceptible to attack by activated microglia and thus aggravate the consequences of stroke. |
2017-02-09 |
2023-08-13 |
human |
| Bettina Hjelm Clausen, Kate Lykke Lambertsen, Frederik Dagnæs-Hansen, Alicia Anne Babcock, Christian Ulrich von Linstow, Michael Meldgaard, Bjarne Winther Kristensen, Tomas Deierborg, Bente Finse. Cell therapy centered on IL-1Ra is neuroprotective in experimental stroke. Acta neuropathologica. vol 131. issue 5. 2017-01-06. PMID:26860727. |
taken together, our results attribute distinct neuroprotective or neurotoxic functions to segregated subsets of microglia and suggest that treatment strategies increasing the production of il-1ra by infiltrating leukocytes or microglia may also be neuroprotective if applied early after stroke onset in patients. |
2017-01-06 |
2023-08-13 |
mouse |
| Maria Pannell, Maria Almut Meier, Frank Szulzewsky, Vitali Matyash, Matthias Endres, Golo Kronenberg, Vincent Prinz, Sonia Waiczies, Susanne A Wolf, Helmut Kettenman. The subpopulation of microglia expressing functional muscarinic acetylcholine receptors expands in stroke and Alzheimer's disease. Brain structure & function. vol 221. issue 2. 2016-12-14. PMID:25523105. |
the subpopulation of microglia expressing functional muscarinic acetylcholine receptors expands in stroke and alzheimer's disease. |
2016-12-14 |
2023-08-13 |
mouse |
| Sean I Savitz, Charles S Co. Concise Review: Cell Therapies for Stroke and Traumatic Brain Injury: Targeting Microglia. Stem cells (Dayton, Ohio). vol 34. issue 3. 2016-12-13. PMID:26844424. |
concise review: cell therapies for stroke and traumatic brain injury: targeting microglia. |
2016-12-13 |
2023-08-13 |
Not clear |
| Sean I Savitz, Charles S Co. Concise Review: Cell Therapies for Stroke and Traumatic Brain Injury: Targeting Microglia. Stem cells (Dayton, Ohio). vol 34. issue 3. 2016-12-13. PMID:26844424. |
we present a model hypothesis of how several types of cell therapies may target microglia as one of the principal cell types contributing to the inflammatory response after brain injury and discuss how imaging of brain inflammation could potentially be applied to develop biomarkers in patients with stroke and tbi enrolled into stem cell clinical trials. |
2016-12-13 |
2023-08-13 |
Not clear |
| D Bravo, C J Maturana, T Pelissier, A Hernández, L Constandi. Interactions of pannexin 1 with NMDA and P2X7 receptors in central nervous system pathologies: Possible role on chronic pain. Pharmacological research. vol 101. 2016-06-10. PMID:26211949. |
in the central nervous system (cns) panx1 is expressed in neurons, astrocytes and microglia, participating in the pathophysiology of some cns diseases, such as epilepsy, anoxic depolarization after stroke and neuroinflammation. |
2016-06-10 |
2023-08-13 |
Not clear |
| Soonmi Won, Jae-Kyung Lee, Donald G Stei. Recombinant tissue plasminogen activator promotes, and progesterone attenuates, microglia/macrophage M1 polarization and recruitment of microglia after MCAO stroke in rats. Brain, behavior, and immunity. vol 49. 2016-06-07. PMID:26093305. |
recombinant tissue plasminogen activator promotes, and progesterone attenuates, microglia/macrophage m1 polarization and recruitment of microglia after mcao stroke in rats. |
2016-06-07 |
2023-08-13 |
rat |
| Katja Derkow, Christina Krüger, Paul Dembny, Seija Lehnard. Microglia Induce Neurotoxic IL-17+ γδ T Cells Dependent on TLR2, TLR4, and TLR9 Activation. PloS one. vol 10. issue 8. 2016-05-17. PMID:26288016. |
both il-17+ γδ t cells and microglia, the major resident immune cells of the brain, are involved in various cns disorders such as multiple sclerosis and stroke. |
2016-05-17 |
2023-08-13 |
Not clear |
| Rodney M Ritzel, Anita R Patel, Jeremy M Grenier, Joshua Crapser, Rajkumar Verma, Evan R Jellison, Louise D McCulloug. Functional differences between microglia and monocytes after ischemic stroke. Journal of neuroinflammation. vol 12. 2016-05-03. PMID:26022493. |
the brain's initial innate response to stroke is primarily mediated by microglia, the resident macrophage of the cns. |
2016-05-03 |
2023-08-13 |
Not clear |
| Nicoletta Charolidi, Tom Schilling, Claudia Ede. Microglial Kv1.3 Channels and P2Y12 Receptors Differentially Regulate Cytokine and Chemokine Release from Brain Slices of Young Adult and Aged Mice. PloS one. vol 10. issue 5. 2016-04-27. PMID:26011191. |
brain tissue damage following stroke or traumatic brain injury is accompanied by neuroinflammatory processes, while microglia play a central role in causing and regulating neuroinflammation via production of proinflammatory substances, including cytokines and chemokines. |
2016-04-27 |
2023-08-13 |
mouse |
| Jie Pan, Jia-li Jin, Hui-ming Ge, Kai-lin Yin, Xiang Chen, Li-juan Han, Yan Chen, Lai Qian, Xiao-xi Li, Yun X. Malibatol A regulates microglia M1/M2 polarization in experimental stroke in a PPARγ-dependent manner. Journal of neuroinflammation. vol 12. 2016-03-07. PMID:25889216. |
malibatol a regulates microglia m1/m2 polarization in experimental stroke in a pparγ-dependent manner. |
2016-03-07 |
2023-08-13 |
Not clear |
| Jojanneke H J Huck, Dorette Freyer, Chotima Böttcher, Mihovil Mladinov, Claudia Muselmann-Genschow, Mareike Thielke, Nadine Gladow, Dana Bloomquist, Philipp Mergenthaler, Josef Prille. De novo expression of dopamine D2 receptors on microglia after stroke. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. vol 35. issue 11. 2016-02-16. PMID:26104289. |
de novo expression of dopamine d2 receptors on microglia after stroke. |
2016-02-16 |
2023-08-13 |
mouse |
| Bastian Zinnhardt, Thomas Viel, Lydia Wachsmuth, Alexis Vrachimis, Stefan Wagner, Hans-Jörg Breyholz, Andreas Faust, Sven Hermann, Klaus Kopka, Cornelius Faber, Frédéric Dollé, Sabina Pappata, Anna M Planas, Bertrand Tavitian, Michael Schäfers, Lydia M Sorokin, Michael T Kuhlmann, Andreas H Jacob. Multimodal imaging reveals temporal and spatial microglia and matrix metalloproteinase activity after experimental stroke. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. vol 35. issue 11. 2016-02-16. PMID:26126867. |
multimodal imaging reveals temporal and spatial microglia and matrix metalloproteinase activity after experimental stroke. |
2016-02-16 |
2023-08-13 |
Not clear |
| Bastian Zinnhardt, Thomas Viel, Lydia Wachsmuth, Alexis Vrachimis, Stefan Wagner, Hans-Jörg Breyholz, Andreas Faust, Sven Hermann, Klaus Kopka, Cornelius Faber, Frédéric Dollé, Sabina Pappata, Anna M Planas, Bertrand Tavitian, Michael Schäfers, Lydia M Sorokin, Michael T Kuhlmann, Andreas H Jacob. Multimodal imaging reveals temporal and spatial microglia and matrix metalloproteinase activity after experimental stroke. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. vol 35. issue 11. 2016-02-16. PMID:26126867. |
activation of microglia and matrix metalloproteinases (mmps) is involved in positively and negatively affecting stroke outcome. |
2016-02-16 |
2023-08-13 |
Not clear |
| Cong-Yuan Xia, Shuai Zhang, Yan Gao, Zhen-Zhen Wang, Nai-Hong Che. Selective modulation of microglia polarization to M2 phenotype for stroke treatment. International immunopharmacology. vol 25. issue 2. 2016-01-04. PMID:25704852. |
selective modulation of microglia polarization to m2 phenotype for stroke treatment. |
2016-01-04 |
2023-08-13 |
Not clear |
| Jong-Youl Kim, Nuri Kim, Midori A Yenar. Mechanisms and potential therapeutic applications of microglial activation after brain injury. CNS neuroscience & therapeutics. vol 21. issue 4. 2015-12-09. PMID:25475659. |
as the resident immune cells of the central nervous system, microglia rapidly respond to brain insults, including stroke and traumatic brain injury. |
2015-12-09 |
2023-08-13 |
Not clear |