| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jongman Yoo, Jin-Ju Seo, Jang-Hyeon Eom, Dong-Youn Hwan. Enhanced recovery from chronic ischemic injury by bone marrow cells in a rat model of ischemic stroke. Cell transplantation. vol 24. issue 2. 2015-11-16. PMID:24152766. |
based on the reported anti-inflammatory role of cd25(+) regulatory t-cells in acute experimental stroke, we propose a working model delineating the positive effects of bmc transplantation during the chronic phase of stroke; infiltrating bmcs (mostly cd25(+) cells) reduce activated microglia, which leads to enhanced neural proliferation and enhanced recovery from neuronal damage in this rat model of chronic stroke. |
2015-11-16 |
2023-08-12 |
rat |
| F Sohrabji, M William. Stroke neuroprotection: oestrogen and insulin-like growth factor-1 interactions and the role of microglia. Journal of neuroendocrinology. vol 25. issue 11. 2015-10-23. PMID:23763366. |
stroke neuroprotection: oestrogen and insulin-like growth factor-1 interactions and the role of microglia. |
2015-10-23 |
2023-08-12 |
Not clear |
| F Sohrabji, M William. Stroke neuroprotection: oestrogen and insulin-like growth factor-1 interactions and the role of microglia. Journal of neuroendocrinology. vol 25. issue 11. 2015-10-23. PMID:23763366. |
here, we summarise the evidence that oestrogen-mediated neuroprotection is critically dependent on igf-1 signalling, and specifically focus on microglia as the source of igf-1 and the locus of oestrogen-igf-1 interactions in stroke neuroprotection. |
2015-10-23 |
2023-08-12 |
Not clear |
| Youngjeon Lee, Sang-Rae Lee, Sung S Choi, Hyeon-Gu Yeo, Kyu-Tae Chang, Hong J Le. Therapeutically targeting neuroinflammation and microglia after acute ischemic stroke. BioMed research international. vol 2014. 2015-10-06. PMID:25089266. |
in this review, we discuss the role of microglial mediators in acute ischemic stroke and elaborate on preclinical and clinical studies focused on microglia in stroke models. |
2015-10-06 |
2023-08-13 |
Not clear |
| Jens Neumann, Monika Riek-Burchardt, Josephine Herz, Thorsten R Doeppner, Rebecca König, Heiko Hütten, Eloho Etemire, Linda Männ, Anika Klingberg, Thomas Fischer, Michael W Görtler, Hans-Jochen Heinze, Peter Reichardt, Burkhart Schraven, Dirk M Hermann, Klaus G Reymann, Matthias Gunze. Very-late-antigen-4 (VLA-4)-mediated brain invasion by neutrophils leads to interactions with microglia, increased ischemic injury and impaired behavior in experimental stroke. Acta neuropathologica. vol 129. issue 2. 2015-09-21. PMID:25391494. |
very-late-antigen-4 (vla-4)-mediated brain invasion by neutrophils leads to interactions with microglia, increased ischemic injury and impaired behavior in experimental stroke. |
2015-09-21 |
2023-08-13 |
mouse |
| Jens Neumann, Monika Riek-Burchardt, Josephine Herz, Thorsten R Doeppner, Rebecca König, Heiko Hütten, Eloho Etemire, Linda Männ, Anika Klingberg, Thomas Fischer, Michael W Görtler, Hans-Jochen Heinze, Peter Reichardt, Burkhart Schraven, Dirk M Hermann, Klaus G Reymann, Matthias Gunze. Very-late-antigen-4 (VLA-4)-mediated brain invasion by neutrophils leads to interactions with microglia, increased ischemic injury and impaired behavior in experimental stroke. Acta neuropathologica. vol 129. issue 2. 2015-09-21. PMID:25391494. |
here, we have used intravital two-photon microscopy to document neutrophils and brain-resident microglia in mice after induction of experimental stroke. |
2015-09-21 |
2023-08-13 |
mouse |
| Valérie Jolivel, Frank Bicker, Fabien Binamé, Robert Ploen, Stefanie Keller, René Gollan, Betty Jurek, Jérôme Birkenstock, Laura Poisa-Beiro, Julia Bruttger, Verena Opitz, Serge C Thal, Ari Waisman, Tobias Bäuerle, Michael K Schäfer, Frauke Zipp, Mirko H H Schmid. Perivascular microglia promote blood vessel disintegration in the ischemic penumbra. Acta neuropathologica. vol 129. issue 2. 2015-09-21. PMID:25500713. |
the contribution of microglia to ischemic cortical stroke is of particular therapeutic interest because of the impact on the survival of brain tissue in the ischemic penumbra, a region that is potentially salvable upon a brain infarct. |
2015-09-21 |
2023-08-13 |
mouse |
| Valérie Jolivel, Frank Bicker, Fabien Binamé, Robert Ploen, Stefanie Keller, René Gollan, Betty Jurek, Jérôme Birkenstock, Laura Poisa-Beiro, Julia Bruttger, Verena Opitz, Serge C Thal, Ari Waisman, Tobias Bäuerle, Michael K Schäfer, Frauke Zipp, Mirko H H Schmid. Perivascular microglia promote blood vessel disintegration in the ischemic penumbra. Acta neuropathologica. vol 129. issue 2. 2015-09-21. PMID:25500713. |
to study the role of microglia in cortical stroke and blood vessel stability, cx3cr1(+/gfp) mice were subjected to transient middle cerebral artery occlusion and then microglia were investigated using time-lapse two-photon microscopy in vivo. |
2015-09-21 |
2023-08-13 |
mouse |
| Valérie Jolivel, Frank Bicker, Fabien Binamé, Robert Ploen, Stefanie Keller, René Gollan, Betty Jurek, Jérôme Birkenstock, Laura Poisa-Beiro, Julia Bruttger, Verena Opitz, Serge C Thal, Ari Waisman, Tobias Bäuerle, Michael K Schäfer, Frauke Zipp, Mirko H H Schmid. Perivascular microglia promote blood vessel disintegration in the ischemic penumbra. Acta neuropathologica. vol 129. issue 2. 2015-09-21. PMID:25500713. |
soon after reperfusion, microglia became activated in the stroke penumbra and started to expand cellular protrusions towards adjacent blood vessels. |
2015-09-21 |
2023-08-13 |
mouse |
| Valérie Jolivel, Frank Bicker, Fabien Binamé, Robert Ploen, Stefanie Keller, René Gollan, Betty Jurek, Jérôme Birkenstock, Laura Poisa-Beiro, Julia Bruttger, Verena Opitz, Serge C Thal, Ari Waisman, Tobias Bäuerle, Michael K Schäfer, Frauke Zipp, Mirko H H Schmid. Perivascular microglia promote blood vessel disintegration in the ischemic penumbra. Acta neuropathologica. vol 129. issue 2. 2015-09-21. PMID:25500713. |
potentially, medication directed at inhibiting microglia activation within the first day after stroke could stabilize blood vessels in the penumbra, increase blood flow, and serve as a valuable treatment for patients suffering from ischemic stroke. |
2015-09-21 |
2023-08-13 |
mouse |
| Zareen Amtul, Shawn N Whitehead, Robin J Keeley, John Bechberger, Alicia L Fisher, Robert J McDonald, Christian C Naus, David G Munoz, David F Cechett. Comorbid rat model of ischemia and β-amyloid toxicity: striatal and cortical degeneration. Brain pathology (Zurich, Switzerland). vol 25. issue 1. 2015-08-12. PMID:24725245. |
the results demonstrated ventricular enlargement, striatal atrophy, substantial increases in β-amyloid, ramified microglia and increases in neuritic retraction in the combined models of stroke and abeta toxicity. |
2015-08-12 |
2023-08-13 |
rat |
| Emanuel Monteiro Candeias, Inês Carolina Sebastião, Susana Maria Cardoso, Sónia Catarina Correia, Cristina Isabel Carvalho, Ana Isabel Plácido, Maria Sancha Santos, Catarina Resende Oliveira, Paula Isabel Moreira, Ana Isabel Duart. Gut-brain connection: The neuroprotective effects of the anti-diabetic drug liraglutide. World journal of diabetes. vol 6. issue 6. 2015-07-01. PMID:26131323. |
importantly, several preclinical studies showed anti-apoptotic, anti-inflammatory, anti-oxidant and neuroprotective effects of liraglutide against t2d, stroke and alzheimer disease (ad), whereas several clinical trials, demonstrated some surprising benefits of liraglutide on weight loss, microglia inhibition, behavior and cognition, and in ad biomarkers. |
2015-07-01 |
2023-08-13 |
Not clear |
| Masahito Kawabori, Rachid Kacimi, Tiina Kauppinen, Cyrus Calosing, Jong Youl Kim, Christine L Hsieh, Mary C Nakamura, Midori A Yenar. Triggering receptor expressed on myeloid cells 2 (TREM2) deficiency attenuates phagocytic activities of microglia and exacerbates ischemic damage in experimental stroke. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 35. issue 8. 2015-06-29. PMID:25716838. |
triggering receptor expressed on myeloid cells 2 (trem2) deficiency attenuates phagocytic activities of microglia and exacerbates ischemic damage in experimental stroke. |
2015-06-29 |
2023-08-13 |
mouse |
| Labchan Rajbhandari, Million Adane Tegenge, Shiva Shrestha, Nishant Ganesh Kumar, Adeel Malik, Aditya Mithal, Suneil Hosmane, Arun Venkatesa. Toll-like receptor 4 deficiency impairs microglial phagocytosis of degenerating axons. Glia. vol 62. issue 12. 2015-06-19. PMID:25042766. |
microglia are rapidly activated in the central nervous system (cns) in response to a variety of injuries, including inflammation, trauma, and stroke. |
2015-06-19 |
2023-08-13 |
mouse |
| Maureen Walberer, Sabine U Jantzen, Heiko Backes, Maria A Rueger, Meike H Keuters, Bernd Neumaier, Mathias Hoehn, Gereon R Fink, Rudolf Graf, Michael Schroete. In-vivo detection of inflammation and neurodegeneration in the chronic phase after permanent embolic stroke in rats. Brain research. vol 1581. 2015-05-21. PMID:24905627. |
neuroinflammation with microglia activation (ma) constitutes a key tissue response in acute stroke. |
2015-05-21 |
2023-08-13 |
rat |
| Stefano Fumagalli, Carlo Perego, Francesca Pischiutta, Elisa R Zanier, Maria-Grazia De Simon. The ischemic environment drives microglia and macrophage function. Frontiers in neurology. vol 6. 2015-04-23. PMID:25904895. |
we discuss the selective responses of microglia and macrophages to hypoxia after stroke and review relevant markers with the aim of defining the different subpopulations of myeloid cells that are recruited to the injured site. |
2015-04-23 |
2023-08-13 |
Not clear |
| Fiona E Burrows, Natasha Bray, Adam Denes, Stuart M Allan, Ingo Schiess. Delayed reperfusion deficits after experimental stroke account for increased pathophysiology. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. vol 35. issue 2. 2015-04-10. PMID:25407273. |
platelets, activated microglia, interleukin-1α, evidence of bbb breakdown and neuronal stress increase within the stroked hemisphere and correlate with the severity of the delayed reperfusion deficit but not with the Δhbo2 during stroke. |
2015-04-10 |
2023-08-13 |
mouse |
| Tracey A Ignatowski, Robert N Spengler, Krishnan M Dhandapani, Hedy Folkersma, Roger F Butterworth, Edward Tobinic. Perispinal etanercept for post-stroke neurological and cognitive dysfunction: scientific rationale and current evidence. CNS drugs. vol 28. issue 8. 2015-03-30. PMID:24861337. |
activated microglia release tnf, which mediates neurotoxicity in the stroke penumbra. |
2015-03-30 |
2023-08-13 |
Not clear |
| Iván Ballesteros, María Isabel Cuartero, Ana Moraga, Juan de la Parra, Ignacio Lizasoain, María Ángeles Mor. Stereological and flow cytometry characterization of leukocyte subpopulations in models of transient or permanent cerebral ischemia. Journal of visualized experiments : JoVE. issue 94. 2015-03-09. PMID:25590380. |
microglia activation, as well as extravasation of haematogenous macrophages and neutrophils, is believed to play a pivotal role in brain injury after stroke. |
2015-03-09 |
2023-08-13 |
mouse |
| Egle Cekanaviciute, Nancy Fathali, Kristian P Doyle, Aaron M Williams, Jullet Han, Marion S Buckwalte. Astrocytic transforming growth factor-beta signaling reduces subacute neuroinflammation after stroke in mice. Glia. vol 62. issue 8. 2015-02-04. PMID:24733756. |
we have previously demonstrated that tgfβs signal to astrocytes, neurons and microglia in the stroke border days after stroke. |
2015-02-04 |
2023-08-13 |
mouse |